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AmpiDots

Exponential Amplification and Rapid Detection of miRNAs using DNA-Quantum Dot Bioconjugates for Disease Diagnostics

Total Cost €

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EC-Contrib. €

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Partnership

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Project "AmpiDots" data sheet

The following table provides information about the project.

Coordinator
EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH 

Organization address
address: Raemistrasse 101
city: ZUERICH
postcode: 8092
website: https://www.ethz.ch/de.html

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Switzerland [CH]
 Project website https://demellogroup.ethz.ch/en/people
 Total cost 187˙419 €
 EC max contribution 187˙419 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2015
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2017
 Duration (year-month-day) from 2017-01-01   to  2018-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH CH (ZUERICH) coordinator 187˙419.00

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 Project objective

Accurate and timely diagnosis is critical in the treatment of all diseases. Researchers are constantly discovering new links between specific biomolecules and diseases, often uncovering ‘panels’ of markers with high sensitivity and specificity for disease diagnostics. However, our current diagnostic tools are unable to take advantage of these panels as they lack sensitivity, or are too costly and slow for practical application. Accordingly, new technologies that can help transform these fundamental discoveries into revolutionary clinical tools are in high demand. These must be rapid, efficient, robust and cost-effective. To this end, I will develop a new rapid diagnostic assay that combines the unique functional properties of fluorescent nanomaterials and enzymes. The core technology is an advanced nanoparticle-biomolecule construct consisting of highly fluorescent ‘quantum dot’ inorganic nanoparticles coated with DNA. These nanobioconjugates (termed ‘AmpiDots’) act simultaneously as both templates for isothermal amplification of target miRNAs and as highly sensitive fluorescent sensors. The result will be a rapid, highly sensitive, versatile and efficient assay that can detect multiple targets simultaneously and give a robust signal for assay readout. A critical aspect of the work will be the use of advanced microfluidic-based analytical systems to optimise the assay and to study the unique phenomena that arise when enzymes interact with nanoparticles.

 Publications

year authors and title journal last update
List of publications.
2018 Ye Wang, Philip D. Howes, Eunjung Kim, Christopher D. Spicer, Michael R. Thomas, Yiyang Lin, Spencer W. Crowder, Isaac J. Pence, Molly M. Stevens
Duplex-Specific Nuclease-Amplified Detection of MicroRNA Using Compact Quantum Dot–DNA Conjugates
published pages: 28290-28300, ISSN: 1944-8244, DOI: 10.1021/acsami.8b07250
ACS Applied Materials & Interfaces 10/34 2019-05-20
2018 Oliver J. Dressler, Philip D. Howes, Jaebum Choo, Andrew J. deMello
Reinforcement Learning for Dynamic Microfluidic Control
published pages: 10084-10091, ISSN: 2470-1343, DOI: 10.1021/acsomega.8b01485
ACS Omega 3/8 2019-05-20

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