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BiMetArylation

Bimetallic catalytic arylation of simple arenes

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 BiMetArylation project word cloud

Explore the words cloud of the BiMetArylation project. It provides you a very rough idea of what is the project "BiMetArylation" about.

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Project "BiMetArylation" data sheet

The following table provides information about the project.

Coordinator
THE UNIVERSITY OF MANCHESTER 

Organization address
address: OXFORD ROAD
city: MANCHESTER
postcode: M13 9PL
website: www.manchester.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Project website https://personalpages.manchester.ac.uk/staff/igor.larrosa/index.html
 Total cost 183˙454 €
 EC max contribution 183˙454 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2015
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2016
 Duration (year-month-day) from 2016-10-01   to  2018-09-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    THE UNIVERSITY OF MANCHESTER UK (MANCHESTER) coordinator 183˙454.00

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 Project objective

The development of new methodologies for the preparation of biologically and industrially interesting compounds remains one of the fundamental challenges in chemistry. Aryl-aryl bond formation is one of the most important tools in modern organic synthesis. These biaryl motifs are very often found in pharmaceutical, agrochemicals, organic materials and natural products. Given the abundance of C–H bonds in organic molecules, the selective activation and use of these bonds in controlled synthetically useful transformations is an immensely important topic. In this context, direct C–H arylation has emerged as a powerful methodology for the synthesis of biaryls. However, in most methodologies described so far, the arene substrate must fulfil certain requirements such as containing strong electron-withdrawing or electron-donating groups, or bearing special directing groups. Substrates lacking this feature either are unreactive or must be used in large excess (often as solvents). The coupling of ‘simple arenes’, which are not considered as pi-electron-deficient or -rich remains challenging.

The research outlined in this proposal aims at developing a new bimetallic catalytic methodology able to couple equimolecular amounts of ‘simple arenes’ under mild conditions. To do so, we envision a strategy involving a bimetallic double catalytic system. The pi-coordination of the non-activated arene to a metal fragment facilitates the C-H arylation catalysed by palladium complexes which followed by a ligand exchange gives the desired biaryl product, regenerating the initial arene catalyst.

The realisation of the objectives of this project would result in a powerful tool for the synthesis of biaryls, coming from simple arenes, improving atom economy, efficiency and sustainability of the reactions, while reducing waste production.

 Publications

year authors and title journal last update
List of publications.
2017 Daniel Whitaker, María Batuecas, Paolo Ricci, Igor Larrosa
A Direct Arylation-Cyclisation Reaction for the Construction of Medium-Sized Rings
published pages: 12763-12766, ISSN: 0947-6539, DOI: 10.1002/chem.201703527
Chemistry - A European Journal 23/52 2019-07-26

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