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Bioinformatics4Breeding SIGNED

Harnessing the power of bioinformatic analysis to improve genetic selection for fertility in dairy cows

Total Cost €

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EC-Contrib. €

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Partnership

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 Bioinformatics4Breeding project word cloud

Explore the words cloud of the Bioinformatics4Breeding project. It provides you a very rough idea of what is the project "Bioinformatics4Breeding" about.

alongside    highlight    events    beneficial    longlasting    scientists    reducing    professor    college    dna    royal    economia    regulatory    culling    mobility    wathes    expertise    decreasing    selective    yielding    appropriate    candidate    tools    incoming    larkin    dairy    sustainability    return    coding    phenotypic    cattle    groups    longevity    la    genomic    consiglio    committed    polymorphisms    understand    genic    ricerca    train    genomics    bioinformatics    variants    researcher    cows    reversed    dell    infertility    networks    supplement    industry    dm    she    italy    trend    combines    analisi    phenotypes    recommend    genetic    datasets    buggiotti    larger    senior    uk    genotyping    agraria    reproductive    function    containing    genome    genetics    expression    gene    dr    rvc    snp    back    dc    crea    detection    fertile    breed    regions    closely    animal    found    transfer    farm    breeding    genes    data    molecular    agricoltura    cow    influence    veterinary    met    efficiency    conserved    fertility    evolutionary   

Project "Bioinformatics4Breeding" data sheet

The following table provides information about the project.

Coordinator
THE ROYAL VETERINARY COLLEGE 

Organization address
address: ROYAL COLLEGE STREET
city: LONDON
postcode: NW1 OTU
website: www.rvc.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
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 Coordinator Country United Kingdom [UK]
 Project website https://www.rvc.ac.uk/Media/Default/staff/files/lbuggiotti-publishable-summary-mariecurie-lb.pdf
 Total cost 195˙454 €
 EC max contribution 195˙454 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2015
 Funding Scheme MSCA-IF-EF-CAR
 Starting year 2016
 Duration (year-month-day) from 2016-05-01   to  2018-04-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    THE ROYAL VETERINARY COLLEGE UK (LONDON) coordinator 195˙454.00

Map

 Project objective

Genetic selection for high yielding dairy cows has been associated with reduced fertility. Infertility remains the major reason for culling, decreasing longevity and reducing production efficiency. We propose that this trend could be reversed by identifying key genes involving reproductive function and selective breeding of more longlasting cows. The specific research objectives are: 1) to train the incoming researcher in bioinformatics methodologies related to analysis of large genomic datasets including SNP detection, genotyping, and evolutionary conserved DNA elements detection; 2) to use the methodologies to analyse dairy phenotypic and genomic data to highlight potential genic and regulatory regions of the cattle genome containing polymorphisms which are beneficial, with a particular focus on fertility; 3) to use appropriate tools to investigate the likely effects of both coding and regulatory variants on the expression of the candidate genes found in these regions; 4) to use pathway analysis to understand how the candidate genes may influence key molecular events and larger gene networks involved in reproductive phenotypes; 5) to recommend appropriate selection procedures to the EU dairy breeding industry to supplement current genomic methods. The project combines the expertise of Consiglio per la Ricerca in Agricoltura e l’analisi dell’Economia agraria, Italy (CREA) and the Royal Veterinary College, UK (RVC) in farm animal genetics and genomics and dairy cow production. The objectives will be met by the mobility of Dr L Buggiotti to the UK, where she will work closely alongside two senior RVC scientists, Dr DM Larkin and Professor DC Wathes. She will transfer this expertise back to CREA on her return. Both groups are experienced in knowledge transfer to the dairy industry and are committed to use the information generated to breed more fertile cows, so improving longevity and promoting sustainability of the EU dairy industry.

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