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Bioinformatics4Breeding SIGNED

Harnessing the power of bioinformatic analysis to improve genetic selection for fertility in dairy cows

Total Cost €

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EC-Contrib. €

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Partnership

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 Bioinformatics4Breeding project word cloud

Explore the words cloud of the Bioinformatics4Breeding project. It provides you a very rough idea of what is the project "Bioinformatics4Breeding" about.

bioinformatics    reproductive    combines    genic    dna    longevity    genomic    culling    agricoltura    train    fertile    dc    agraria    researcher    rvc    royal    cattle    genotyping    ricerca    crea    infertility    understand    efficiency    animal    wathes    professor    groups    industry    buggiotti    larkin    genetic    longlasting    polymorphisms    beneficial    conserved    uk    evolutionary    dr    genomics    events    regulatory    gene    dell    genes    farm    scientists    decreasing    variants    trend    genetics    fertility    tools    snp    function    la    consiglio    cows    supplement    veterinary    found    return    expertise    larger    met    incoming    economia    analisi    mobility    detection    networks    closely    datasets    influence    reducing    dm    alongside    college    senior    yielding    phenotypes    sustainability    genome    she    reversed    transfer    phenotypic    breed    data    containing    italy    coding    molecular    committed    breeding    back    recommend    selective    dairy    expression    regions    highlight    cow    appropriate    candidate   

Project "Bioinformatics4Breeding" data sheet

The following table provides information about the project.

Coordinator
THE ROYAL VETERINARY COLLEGE 

Organization address
address: ROYAL COLLEGE STREET
city: LONDON
postcode: NW1 OTU
website: www.rvc.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
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 Coordinator Country United Kingdom [UK]
 Project website https://www.rvc.ac.uk/Media/Default/staff/files/lbuggiotti-publishable-summary-mariecurie-lb.pdf
 Total cost 195˙454 €
 EC max contribution 195˙454 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2015
 Funding Scheme MSCA-IF-EF-CAR
 Starting year 2016
 Duration (year-month-day) from 2016-05-01   to  2018-04-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    THE ROYAL VETERINARY COLLEGE UK (LONDON) coordinator 195˙454.00

Map

 Project objective

Genetic selection for high yielding dairy cows has been associated with reduced fertility. Infertility remains the major reason for culling, decreasing longevity and reducing production efficiency. We propose that this trend could be reversed by identifying key genes involving reproductive function and selective breeding of more longlasting cows. The specific research objectives are: 1) to train the incoming researcher in bioinformatics methodologies related to analysis of large genomic datasets including SNP detection, genotyping, and evolutionary conserved DNA elements detection; 2) to use the methodologies to analyse dairy phenotypic and genomic data to highlight potential genic and regulatory regions of the cattle genome containing polymorphisms which are beneficial, with a particular focus on fertility; 3) to use appropriate tools to investigate the likely effects of both coding and regulatory variants on the expression of the candidate genes found in these regions; 4) to use pathway analysis to understand how the candidate genes may influence key molecular events and larger gene networks involved in reproductive phenotypes; 5) to recommend appropriate selection procedures to the EU dairy breeding industry to supplement current genomic methods. The project combines the expertise of Consiglio per la Ricerca in Agricoltura e l’analisi dell’Economia agraria, Italy (CREA) and the Royal Veterinary College, UK (RVC) in farm animal genetics and genomics and dairy cow production. The objectives will be met by the mobility of Dr L Buggiotti to the UK, where she will work closely alongside two senior RVC scientists, Dr DM Larkin and Professor DC Wathes. She will transfer this expertise back to CREA on her return. Both groups are experienced in knowledge transfer to the dairy industry and are committed to use the information generated to breed more fertile cows, so improving longevity and promoting sustainability of the EU dairy industry.

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