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BiomCatOx SIGNED

Biomimetic Dicopper Architecture for Catalytic Oxygen Activation

Total Cost €

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EC-Contrib. €

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Partnership

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 BiomCatOx project word cloud

Explore the words cloud of the BiomCatOx project. It provides you a very rough idea of what is the project "BiomCatOx" about.

provides    benign    boost    selective    career    personalized    interdisciplinary    training    catalyst    catalytic    gain    hydrocarbons    stepwise    catalysis    center    copper    custom    oxygen    merges    enzymology    ch    active    chemistry    university    academic    internationally    sites    cheap    powerful    dicopper    perspectives    lies    scientific    protein    hydrocarbon    heavily    rationally    conjugate    insertion    reactive    discloses    mild    azurin    explore    reaction    bern    activation    bioinorganic    fundamental    complexes    nottingham    nhc    bond    rigorously    synthetic    species    trainings    spectroscopy    insights    plan    biomcatox    communication    transfer    oxidant    organometallic    peptide    connecting    relay    strict    electron    convey    iet    novelty    site    ros    truncated    reactivity    intramolecular    soft    skill    connection    covalent    catalysts    consists    oxidation    leader    o2    homogeneous    uk    competence    skills    efficient    secondment    metal    interface   

Project "BiomCatOx" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITAET BERN 

Organization address
address: HOCHSCHULSTRASSE 6
city: BERN
postcode: 3012
website: http://www.unibe.ch

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Switzerland [CH]
 Total cost 175˙419 €
 EC max contribution 175˙419 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2017
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2018
 Duration (year-month-day) from 2018-03-01   to  2020-02-29

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITAET BERN CH (BERN) coordinator 175˙419.00

Map

 Project objective

BiomCatOx will explore a unique catalyst design for the valorisation of hydrocarbons by oxygen insertion into a C–H bond under mild reaction conditions and using O2 as cheap and benign oxidant. The key concept of BiomCatOx is to rigorously control the activation of O2 and the formation of metal-based reactive oxygen species (ROS) to accomplish selective and catalytic oxidation of hydrocarbons. The novelty of BiomCatOx lies in the design of the catalyst that consists in connecting a heavily truncated protein as electron relay for controllable intramolecular electron transfer (IET) to a synthetic oxidation catalyst. The intramolecular electron transfer can be rationally custom-tailored and therefore provides strict control on the reactivity of the catalytic center and on the formation of the ROS. BiomCatOx will use a stepwise approach involving (i) the development of copper-NHC complexes as powerful catalysts for the formation of ROS and hydrocarbon oxidation, (ii) the development of a copper peptide derived from the azurin active site for efficient electron transfer, and (iii) the covalent connection of the two copper sites into a peptide-complex dicopper conjugate for controlled intramolecular electron transfer. The implementation of BiomCatOx will provide efficient catalytic systems and fundamental insights into electron transfer, and discloses a new catalyst design concept. BiomCatOx is highly interdisciplinary and merges organometallic chemistry, homogeneous catalysis, enzymology, and spectroscopy. This training at the University of Bern (CH) and of Nottingham (UK, secondment) will convey a unique skill set. Together with the personalized career development plan, I will gain significant scientific and soft skills to boost my career and to become an internationally recognized academic leader in Europe at the bioinorganic chemistry/catalysis interface. Communication and management trainings will increase my competence and strongly support my career perspectives.

 Publications

year authors and title journal last update
List of publications.
2018 Matteo Planchestainer, Nathalie Segaud, Muralidharan Shanmugam, Jonathan McMaster, Francesca Paradisi, Martin Albrecht
Carbene in Cupredoxin Protein Scaffolds: Replacement of a Histidine Ligand in the Active Site Substantially Alters Copper Redox Properties
published pages: 10677-10682, ISSN: 1433-7851, DOI: 10.1002/anie.201807168
Angewandte Chemie International Edition 57/33 2020-04-03
2019 Nathalie Ségaud, Jonathan McMaster, Gerard van Koten, Martin Albrecht
Imidazolylidene Cu(II) Complexes: Synthesis Using Imidazolium Carboxylate Precursors and Structure Rearrangement Pathways
published pages: 16047-16058, ISSN: 0020-1669, DOI: 10.1021/acs.inorgchem.9b02568
Inorganic Chemistry 58/23 2020-04-03

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