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BiomCatOx SIGNED

Biomimetic Dicopper Architecture for Catalytic Oxygen Activation

Total Cost €

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EC-Contrib. €

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Partnership

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 BiomCatOx project word cloud

Explore the words cloud of the BiomCatOx project. It provides you a very rough idea of what is the project "BiomCatOx" about.

stepwise    hydrocarbon    o2    metal    insertion    center    benign    reaction    peptide    plan    catalysis    custom    internationally    novelty    synthetic    gain    hydrocarbons    covalent    ch    career    protein    transfer    active    competence    strict    bioinorganic    catalysts    ros    electron    dicopper    bond    complexes    university    enzymology    personalized    conjugate    communication    skills    soft    academic    provides    rigorously    consists    interface    scientific    fundamental    powerful    rationally    leader    activation    interdisciplinary    training    perspectives    site    convey    bern    copper    discloses    uk    relay    oxidation    nottingham    sites    iet    reactivity    spectroscopy    oxygen    lies    boost    nhc    selective    skill    efficient    connecting    chemistry    homogeneous    connection    explore    insights    biomcatox    catalytic    reactive    organometallic    truncated    heavily    merges    cheap    trainings    catalyst    species    azurin    secondment    intramolecular    oxidant    mild   

Project "BiomCatOx" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITAET BERN 

Organization address
address: HOCHSCHULSTRASSE 6
city: BERN
postcode: 3012
website: http://www.unibe.ch

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Switzerland [CH]
 Total cost 175˙419 €
 EC max contribution 175˙419 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2017
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2018
 Duration (year-month-day) from 2018-03-01   to  2020-02-29

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITAET BERN CH (BERN) coordinator 175˙419.00

Map

 Project objective

BiomCatOx will explore a unique catalyst design for the valorisation of hydrocarbons by oxygen insertion into a C–H bond under mild reaction conditions and using O2 as cheap and benign oxidant. The key concept of BiomCatOx is to rigorously control the activation of O2 and the formation of metal-based reactive oxygen species (ROS) to accomplish selective and catalytic oxidation of hydrocarbons. The novelty of BiomCatOx lies in the design of the catalyst that consists in connecting a heavily truncated protein as electron relay for controllable intramolecular electron transfer (IET) to a synthetic oxidation catalyst. The intramolecular electron transfer can be rationally custom-tailored and therefore provides strict control on the reactivity of the catalytic center and on the formation of the ROS. BiomCatOx will use a stepwise approach involving (i) the development of copper-NHC complexes as powerful catalysts for the formation of ROS and hydrocarbon oxidation, (ii) the development of a copper peptide derived from the azurin active site for efficient electron transfer, and (iii) the covalent connection of the two copper sites into a peptide-complex dicopper conjugate for controlled intramolecular electron transfer. The implementation of BiomCatOx will provide efficient catalytic systems and fundamental insights into electron transfer, and discloses a new catalyst design concept. BiomCatOx is highly interdisciplinary and merges organometallic chemistry, homogeneous catalysis, enzymology, and spectroscopy. This training at the University of Bern (CH) and of Nottingham (UK, secondment) will convey a unique skill set. Together with the personalized career development plan, I will gain significant scientific and soft skills to boost my career and to become an internationally recognized academic leader in Europe at the bioinorganic chemistry/catalysis interface. Communication and management trainings will increase my competence and strongly support my career perspectives.

 Publications

year authors and title journal last update
List of publications.
2018 Matteo Planchestainer, Nathalie Segaud, Muralidharan Shanmugam, Jonathan McMaster, Francesca Paradisi, Martin Albrecht
Carbene in Cupredoxin Protein Scaffolds: Replacement of a Histidine Ligand in the Active Site Substantially Alters Copper Redox Properties
published pages: 10677-10682, ISSN: 1433-7851, DOI: 10.1002/anie.201807168
Angewandte Chemie International Edition 57/33 2020-04-03
2019 Nathalie Ségaud, Jonathan McMaster, Gerard van Koten, Martin Albrecht
Imidazolylidene Cu(II) Complexes: Synthesis Using Imidazolium Carboxylate Precursors and Structure Rearrangement Pathways
published pages: 16047-16058, ISSN: 0020-1669, DOI: 10.1021/acs.inorgchem.9b02568
Inorganic Chemistry 58/23 2020-04-03

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