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BiomCatOx SIGNED

Biomimetic Dicopper Architecture for Catalytic Oxygen Activation

Total Cost €

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EC-Contrib. €

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Partnership

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 BiomCatOx project word cloud

Explore the words cloud of the BiomCatOx project. It provides you a very rough idea of what is the project "BiomCatOx" about.

hydrocarbons    biomcatox    perspectives    personalized    rigorously    custom    reactivity    career    stepwise    plan    boost    dicopper    insights    university    organometallic    electron    selective    reaction    benign    metal    mild    enzymology    ros    fundamental    protein    academic    connecting    transfer    cheap    relay    leader    activation    nottingham    secondment    bern    gain    conjugate    bioinorganic    ch    active    provides    oxidant    scientific    soft    center    reactive    peptide    competence    internationally    interface    iet    strict    copper    skills    uk    catalyst    efficient    rationally    merges    interdisciplinary    site    catalytic    o2    truncated    communication    species    covalent    oxygen    heavily    powerful    connection    consists    lies    spectroscopy    convey    trainings    complexes    hydrocarbon    discloses    bond    synthetic    catalysts    chemistry    catalysis    sites    oxidation    azurin    insertion    skill    novelty    explore    training    intramolecular    homogeneous    nhc   

Project "BiomCatOx" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITAET BERN 

Organization address
address: HOCHSCHULSTRASSE 6
city: BERN
postcode: 3012
website: http://www.unibe.ch

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Switzerland [CH]
 Total cost 175˙419 €
 EC max contribution 175˙419 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2017
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2018
 Duration (year-month-day) from 2018-03-01   to  2020-02-29

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITAET BERN CH (BERN) coordinator 175˙419.00

Map

 Project objective

BiomCatOx will explore a unique catalyst design for the valorisation of hydrocarbons by oxygen insertion into a C–H bond under mild reaction conditions and using O2 as cheap and benign oxidant. The key concept of BiomCatOx is to rigorously control the activation of O2 and the formation of metal-based reactive oxygen species (ROS) to accomplish selective and catalytic oxidation of hydrocarbons. The novelty of BiomCatOx lies in the design of the catalyst that consists in connecting a heavily truncated protein as electron relay for controllable intramolecular electron transfer (IET) to a synthetic oxidation catalyst. The intramolecular electron transfer can be rationally custom-tailored and therefore provides strict control on the reactivity of the catalytic center and on the formation of the ROS. BiomCatOx will use a stepwise approach involving (i) the development of copper-NHC complexes as powerful catalysts for the formation of ROS and hydrocarbon oxidation, (ii) the development of a copper peptide derived from the azurin active site for efficient electron transfer, and (iii) the covalent connection of the two copper sites into a peptide-complex dicopper conjugate for controlled intramolecular electron transfer. The implementation of BiomCatOx will provide efficient catalytic systems and fundamental insights into electron transfer, and discloses a new catalyst design concept. BiomCatOx is highly interdisciplinary and merges organometallic chemistry, homogeneous catalysis, enzymology, and spectroscopy. This training at the University of Bern (CH) and of Nottingham (UK, secondment) will convey a unique skill set. Together with the personalized career development plan, I will gain significant scientific and soft skills to boost my career and to become an internationally recognized academic leader in Europe at the bioinorganic chemistry/catalysis interface. Communication and management trainings will increase my competence and strongly support my career perspectives.

 Publications

year authors and title journal last update
List of publications.
2018 Matteo Planchestainer, Nathalie Segaud, Muralidharan Shanmugam, Jonathan McMaster, Francesca Paradisi, Martin Albrecht
Carbene in Cupredoxin Protein Scaffolds: Replacement of a Histidine Ligand in the Active Site Substantially Alters Copper Redox Properties
published pages: 10677-10682, ISSN: 1433-7851, DOI: 10.1002/anie.201807168
Angewandte Chemie International Edition 57/33 2020-04-03
2019 Nathalie Ségaud, Jonathan McMaster, Gerard van Koten, Martin Albrecht
Imidazolylidene Cu(II) Complexes: Synthesis Using Imidazolium Carboxylate Precursors and Structure Rearrangement Pathways
published pages: 16047-16058, ISSN: 0020-1669, DOI: 10.1021/acs.inorgchem.9b02568
Inorganic Chemistry 58/23 2020-04-03

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