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IN VIVO MOSSY SIGNED

Is the hippocampal mossy fiber synapse a detonator in vivo?

Total Cost €

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EC-Contrib. €

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Partnership

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 IN VIVO MOSSY project word cloud

Explore the words cloud of the IN VIVO MOSSY project. It provides you a very rough idea of what is the project "IN VIVO MOSSY" about.

input    trisynaptic    active    distinguish    neurons    pattern    presynaptic    track    calcium    associative    spatial    minor    techniques    local    cortical    pyramidal    detonation    optogenetic    synapse    me    firing    navigation    photon    action    implications    entorhinal    color    single    hippocampus    whereby    weight    thousands    concerted    preparation    memory    behavior    cajal    learning    mossy    conclusively    circuit    awake    mice    terminals    detonator    postsynaptic    navigating    additional    neuron    boutons    receives    generally    manipulation    recognition    individual    termed    synaptic    translate    true    repeated    models    effect    conjunctive    interneurons    powerful    subdetonator    cortex    simultaneous    synapses    heavily    ca3    rule    permit    quantify    tens    spiking    inputs    inconclusive    connection    maxim    spike    simultaneously    confirm    imaging    linear    hypothesis    substantial    fiber    transfer    conditional   

Project "IN VIVO MOSSY" data sheet

The following table provides information about the project.

Coordinator
INSTITUTE OF SCIENCE AND TECHNOLOGYAUSTRIA 

Organization address
address: Am Campus 1
city: KLOSTERNEUBURG
postcode: 3400
website: www.ist.ac.at

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Austria [AT]
 Project website https://ist.ac.at/en/research-groups-pages/welcome-to-the-jonas-lab/team/benjamin-suter/
 Total cost 166˙156 €
 EC max contribution 166˙156 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2015
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2016
 Duration (year-month-day) from 2016-04-01   to  2018-03-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    INSTITUTE OF SCIENCE AND TECHNOLOGYAUSTRIA AT (KLOSTERNEUBURG) coordinator 166˙156.00

Map

 Project objective

A commonly repeated maxim is that an individual cortical neuron receives synaptic input from tens of thousands of presynaptic partners, with each individual connection carrying only minor weight. In that case, concerted firing by many presynaptic neurons is required to cause an action potential in the postsynaptic neuron. However, there is inconclusive evidence that the mossy fiber synapse (the second connection in Cajal’s heavily studied “trisynaptic circuit” of the hippocampus) is powerful enough to translate a single presynaptic spike into a postsynaptic spike - termed “detonation”. If true, this would have substantial implications for our understanding of learning and memory, spatial navigation, and pattern recognition. I propose to use simultaneous two-color, two-photon calcium imaging of presynaptic mossy fiber terminals and postsynaptic CA3 pyramidal neurons in awake mice navigating along a linear track, in order to conclusively confirm or rule out the detonation hypothesis. This preparation will allow me to distinguish between detonator, conditional detonator, and subdetonator synapses, and more generally to quantify the number of simultaneously active mossy fiber boutons necessary to cause CA3 spiking during behavior. These results would have substantial implications for established models of associative memory and spatial navigation, and more generally for information transfer in the hippocampus. Furthermore, the techniques developed will permit future studies whereby the conjunctive effect of additional inputs (e.g. from entorhinal cortex, and local interneurons) can be studied by optogenetic manipulation.

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