Explore the words cloud of the NORVAS project. It provides you a very rough idea of what is the project "NORVAS" about.
The following table provides information about the project.
|Coordinator Country||Sweden [SE]|
|Total cost||1˙493˙125 €|
|EC max contribution||1˙493˙125 € (100%)|
1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
|Duration (year-month-day)||from 2016-05-01 to 2021-04-30|
Take a look of project's partnership.
|1||KAROLINSKA INSTITUTET||SE (STOCKHOLM)||coordinator||1˙493˙125.00|
|2||KLINIKUM RECHTS DER ISAR DER TECHNISCHEN UNIVERSITAT MUNCHEN||DE (MUENCHEN)||participant||0.00|
The contribution of cardiovascular disease to human morbidity and mortality continues to steadily increase in our aging European society. In response, extraordinary efforts have been launched to determine the molecular and pathophysiological characteristics of its etiology. The collective work of multiple research groups has uncovered a complex transcriptional and post-transcriptional regulatory milieu, which is believed to be essential for maintaining cardiovascular homeostasis. Recently, non-coding RNAs, especially the ones with antisense capabilities such as microRNAs or ‘natural antisense transcripts’ (NATs) have received much attention. They have been identified as important transcriptional and post-transcriptional inhibitors of gene expression. This current proposal describes the development of novel diagnostic and therapeutic strategies to limit the burden of cardiovascular disease in general, and abdominal aortic aneurysms as well as carotid stenosis and subsequent stroke in particular. Using transcriptomic profiling techniques on human diseased tissue samples, we have identified two NATs (SLFNL-AS1 and NUDT6) as novel crucial regulators of smooth muscle cell survival via targeting CTPS1 and the fibroblast growth factor 2 (FGF2) in the vascular system. We are using disease-relevant experimental in vivo models (rodents and LDLR-/- mini-pigs) to functionally assess how inhibition of these two NATs influences aneurysm progression and atherosclerotic plaque vulnerability. One focus of our studies is to utilize local delivery mechanisms for non-coding RNA modulators, such as drug eluting balloons and stents, to enhance the translational feasibility of our findings. Furthermore, we have access to unique human plasma material from patients with early and advanced forms of aneurysm disease, enabling us to investigate the biomarker value of non-coding RNAs in recognizing patients with acutely ruptured aneurysms, as well as predicting the future risk of rupture.
|year||authors and title||journal||last update|
Antonio Di Gennaro, Ana Carolina AraÃºjo, Albert Busch, Hong Jin, Dick WÃ¥gsÃ¤ter, Emina Vorkapic, Kenneth Caidahl, Per Eriksson, Bengt Samuelsson, Lars Maegdefessel, Jesper Z. HaeggstrÃ¶m
Cysteinyl leukotriene receptor 1 antagonism prevents experimental abdominal aortic aneurysm
published pages: 1907-1912, ISSN: 0027-8424, DOI: 10.1073/pnas.1717906115
|Proceedings of the National Academy of Sciences 115/8||2019-05-10|
Nicholas J Leeper, Lars Maegdefessel
Non-coding RNAs: key regulators of smooth muscle cell fate in vascular disease
published pages: 611-621, ISSN: 0008-6363, DOI: 10.1093/cvr/cvx249
|Cardiovascular Research 114/4||2019-05-10|
Sandeep Kumar, Reinier A. Boon, Lars Maegdefessel, Stefanie Dimmeler, Hanjoong Jo
Role of Noncoding RNAs in the Pathogenesis of Abdominal Aortic Aneurysm
published pages: 619-630, ISSN: 0009-7330, DOI: 10.1161/circresaha.118.312438
|Circulation Research 124/4||2019-05-10|
Yuhuang Li, Lars Maegdefessel
Non-coding RNA Contribution to Thoracic and Abdominal Aortic Aneurysm Disease Development and Progression
published pages: , ISSN: 1664-042X, DOI: 10.3389/fphys.2017.00429
|Frontiers in Physiology 8||2019-05-10|
Daniel Y. Li, Albert Busch, Hong Jin, Ekaterina Chernogubova, Jaroslav Pelisek, Joakim Karlsson, Bengt Sennblad, Shengliang Liu, Shen Lao, Patrick Hofmann, Alexandra BÃ¤cklund, Suzanne M. Eken, Joy Roy, Per Eriksson, Brian Dacken, Deepak Ramanujam, Anne Dueck, Stefan Engelhardt, Reinier A. Boon, Hans-Henning Eckstein, Joshua M. Spin, Philip S. Tsao, Lars Maegdefessel
H19 Induces Abdominal Aortic Aneurysm Development and Progression
published pages: 1551-1568, ISSN: 0009-7322, DOI: 10.1161/CIRCULATIONAHA.117.032184
Suzanne M. Eken, Tinna Christersdottir, Greg Winski, Traimate Sangsuwan, Hong Jin, Ekaterina Chernogubova, John Pirault, Changyan Sun, Nancy Simon, Hanna Winter, Alexandra Backlund, Siamak Haghdoost, GÃ¶ran K. Hansson, Martin Halle, Lars Maegdefessel
miR-29b Mediates the ChronicÂ Inflammatory Response in Radiotherapy-Induced Vascular Disease
published pages: 72-82, ISSN: 2452-302X, DOI: 10.1016/j.jacbts.2018.10.006
|JACC: Basic to Translational Science 4/1||2019-05-09|
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