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High-throughput vibrational fingerprinting by nanoplasmonics for disease biology

Total Cost €


EC-Contrib. €






 VIBRANT-BIO project word cloud

Explore the words cloud of the VIBRANT-BIO project. It provides you a very rough idea of what is the project "VIBRANT-BIO" about.

function    interaction    overcome    nanomaterials    map    spectroscopic    constitute    security    sensor    impose    provides    light    cancers    spectroscopy    bioanalytical    millions    complete    people    introduce    quality    discovered    dramatically    biological    biomolecules    toxic    material    molecular    toolkit    plasmonics    cures    misfolded    devastating    limited    performance    quantities    proteins    analyze    microarray    newly    bio    interactions    capability    limitations    amyloid    photonics    engineering    fact    nanoplasmonics    undermine    disease    industry    alzheimer    protein    lipid    mechanisms    purpose    science    biosensors    molecules    innovatively    economic    biology    integrate    microscopic    profiling    first    beta    road    functionalities    homeland    interdisciplinary    explore    generation    dimensional    parkinson    limits    membranes    infrared    throughput    technologies    identification    tools    pharmaceutical    structure    continue    underlying    extreme    ultra    chemicals    biomolecular    graphene    structures    physics    ultimate    composition    burdens    bioscience    diseases    mid    broad    life    biosensor    breakthrough    goals    basis    little    vibrant    chemistry    sensitivity    severely   

Project "VIBRANT-BIO" data sheet

The following table provides information about the project.


Organization address
address: BATIMENT CE 3316 STATION 1
postcode: 1015

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Switzerland [CH]
 Total cost 2˙562˙325 €
 EC max contribution 2˙562˙325 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2015-CoG
 Funding Scheme ERC-COG
 Starting year 2017
 Duration (year-month-day) from 2017-01-01   to  2021-12-31


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 


 Project objective

Devastating diseases such as Alzheimer’s, Parkinson’s and various cancers are still without cures, continue to undermine the quality of life for millions of people and impose significant economic burdens. Misfolded toxic proteins constitute the microscopic basis of these diseases, but little is understood about their structure and biological function. This is due the fact that current technologies are severely limited for molecular-level identification of protein structures and high-throughput analysis of biomolecular interactions. VIBRANT-BIO aims to introduce breakthrough mid-infrared spectroscopy technologies, including the first spectroscopic microarray, to overcome the limitations of current methods by enabling complete profiling of biomolecules from identification of their structure and composition to their biological function. To achieve its ambitious goals, VIBRANT-BIO will exploit plasmonics and newly discovered two-dimensional nanomaterials such as graphene and explore the ultimate limits of light-matter interaction to demonstrate biosensors with extreme sensitivity, throughput and functionality, well beyond the state-of the art. It will innovatively integrate nanoplasmonics with advanced photonics and bioanalytical tools to dramatically enhance sensor performance and introduce new functionalities. The proposed technologies will be applied to study toxic amyloid-beta proteins and their interaction with lipid membranes for understanding the molecular mechanisms underlying Alzheimer’s disease. VIBRANT-BIO will contribute to define the road-map for next generation biosensor and spectroscopy technologies through interdisciplinary research covering physics, engineering, chemistry and biology. The capability of the proposed systems to analyze a broad range and ultra-low quantities of molecules and chemicals provides a general-purpose toolkit that can impact numerous fields such as bioscience, material science, pharmaceutical industry, and homeland security.


year authors and title journal last update
List of publications.
2018 Andreas Tittl, Filiz Yesilkoy, Hatice Altug, Stefan A. Maier, Yuri S. Kivshar
Dielectric Metasurfaces for Surface-Enhanced Spectroscopies
published pages: , ISSN: , DOI:
2019 Aleksandrs Leitis, Andreas Tittl, Mingkai Liu, Bang Hyun Lee, Man Bock Gu, Yuri S. Kivshar, Hatice Altug
Angle-multiplexed all-dielectric metasurfaces for broadband molecular fingerprint retrieval
published pages: eaaw2871, ISSN: 2375-2548, DOI: 10.1126/sciadv.aaw2871
Science Advances 5/5 2019-08-29
2019 Andreas Tittl, Aurelian John-Herpin, Aleksandrs Leitis, Eduardo R. Arvelo, Hatice Altug
Metasurface-Based Molecular Biosensing Aided by Artificial Intelligence
published pages: , ISSN: 1433-7851, DOI: 10.1002/anie.201901443
Angewandte Chemie International Edition 2019-08-29
2018 Sang-Hyun Oh, Hatice Altug
Performance metrics and enabling technologies for nanoplasmonic biosensors
published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-018-06419-3
Nature Communications 9/1 2019-08-29
2019 Filiz Yesilkoy, Eduardo R. Arvelo, Yasaman Jahani, Mingkai Liu, Andreas Tittl, Volkan Cevher, Yuri Kivshar, Hatice Altug
Ultrasensitive hyperspectral imaging and biodetection enabled by dielectric metasurfaces
published pages: 390-396, ISSN: 1749-4885, DOI: 10.1038/s41566-019-0394-6
Nature Photonics 13/6 2019-08-29
2018 Aurelian John-Herpin, Andreas Tittl, Hatice Altug
Quantifying the Limits of Detection of Surface-Enhanced Infrared Spectroscopy with Grating Order-Coupled Nanogap Antennas
published pages: 4117-4124, ISSN: 2330-4022, DOI: 10.1021/acsphotonics.8b00847
ACS Photonics 5/10 2019-08-29
2018 Daniel Rodrigo, Andreas Tittl, Aurelian John-Herpin, Odeta Limaj, Hatice Altug
Self-Similar Multiresonant Nanoantenna Arrays for Sensing from Near- to Mid-Infrared
published pages: 4903-4911, ISSN: 2330-4022, DOI: 10.1021/acsphotonics.8b01050
ACS Photonics 5/12 2019-08-29
2018 Daniel Rodrigo, Andreas Tittl, Nadine Ait-Bouziad, Aurelian John-Herpin, Odeta Limaj, Christopher Kelly, Daehan Yoo, Nathan J. Wittenberg, Sang-Hyun Oh, Hilal A. Lashuel, Hatice Altug
Resolving molecule-specific information in dynamic lipid membrane processes with multi-resonant infrared metasurfaces
published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-018-04594-x
Nature Communications 9/1 2019-06-18
2017 Dordaneh Etezadi, John B Warner IV, Francesco S Ruggeri, Giovanni Dietler, Hilal A Lashuel, Hatice Altug
Nanoplasmonic mid-infrared biosensor for in vitro protein secondary structure detection
published pages: e17029, ISSN: 2047-7538, DOI: 10.1038/lsa.2017.29
Light: Science & Applications 6/8 2019-06-18
2018 Daehan Yoo, Daniel A. Mohr, Ferran Vidal-Codina, Aurelian John-Herpin, Minsik Jo, Sunghwan Kim, Joseph Matson, Joshua D. Caldwell, Heonsu Jeon, Ngoc-Cuong Nguyen, Luis Martin-Moreno, Jaime Peraire, Hatice Altug, Sang-Hyun Oh
High-Contrast Infrared Absorption Spectroscopy via Mass-Produced Coaxial Zero-Mode Resonators with Sub-10 nm Gaps
published pages: 1930-1936, ISSN: 1530-6984, DOI: 10.1021/acs.nanolett.7b05295
Nano Letters 18/3 2019-06-18
2018 Dordaneh Etezadi, John B. Warner, Hilal A. Lashuel, Hatice Altug
Real-Time In Situ Secondary Structure Analysis of Protein Monolayer with Mid-Infrared Plasmonic Nanoantennas
published pages: 1109-1117, ISSN: 2379-3694, DOI: 10.1021/acssensors.8b00115
ACS Sensors 3/6 2019-06-18
2018 Andreas Tittl, Aleksandrs Leitis, Mingkai Liu, Filiz Yesilkoy, Duk-Yong Choi, Dragomir N. Neshev, Yuri S. Kivshar, Hatice Altug
Imaging-based molecular barcoding with pixelated dielectric metasurfaces
published pages: 1105-1109, ISSN: 0036-8075, DOI: 10.1126/science.aas9768
Science 360/6393 2019-06-18

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