Explore the words cloud of the VIBRANT-BIO project. It provides you a very rough idea of what is the project "VIBRANT-BIO" about.
The following table provides information about the project.
ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE
|Coordinator Country||Switzerland [CH]|
|Total cost||2˙562˙325 €|
|EC max contribution||2˙562˙325 € (100%)|
1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
|Duration (year-month-day)||from 2017-01-01 to 2021-12-31|
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|1||ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE||CH (LAUSANNE)||coordinator||2˙562˙325.00|
Devastating diseases such as Alzheimer’s, Parkinson’s and various cancers are still without cures, continue to undermine the quality of life for millions of people and impose significant economic burdens. Misfolded toxic proteins constitute the microscopic basis of these diseases, but little is understood about their structure and biological function. This is due the fact that current technologies are severely limited for molecular-level identification of protein structures and high-throughput analysis of biomolecular interactions. VIBRANT-BIO aims to introduce breakthrough mid-infrared spectroscopy technologies, including the first spectroscopic microarray, to overcome the limitations of current methods by enabling complete profiling of biomolecules from identification of their structure and composition to their biological function. To achieve its ambitious goals, VIBRANT-BIO will exploit plasmonics and newly discovered two-dimensional nanomaterials such as graphene and explore the ultimate limits of light-matter interaction to demonstrate biosensors with extreme sensitivity, throughput and functionality, well beyond the state-of the art. It will innovatively integrate nanoplasmonics with advanced photonics and bioanalytical tools to dramatically enhance sensor performance and introduce new functionalities. The proposed technologies will be applied to study toxic amyloid-beta proteins and their interaction with lipid membranes for understanding the molecular mechanisms underlying Alzheimer’s disease. VIBRANT-BIO will contribute to define the road-map for next generation biosensor and spectroscopy technologies through interdisciplinary research covering physics, engineering, chemistry and biology. The capability of the proposed systems to analyze a broad range and ultra-low quantities of molecules and chemicals provides a general-purpose toolkit that can impact numerous fields such as bioscience, material science, pharmaceutical industry, and homeland security.
|year||authors and title||journal||last update|
Andreas Tittl, Filiz Yesilkoy, Hatice Altug, Stefan A. Maier, Yuri S. Kivshar
Dielectric Metasurfaces for Surface-Enhanced Spectroscopies
published pages: , ISSN: , DOI:
Aleksandrs Leitis, Andreas Tittl, Mingkai Liu, Bang Hyun Lee, Man Bock Gu, Yuri S. Kivshar, Hatice Altug
Angle-multiplexed all-dielectric metasurfaces for broadband molecular fingerprint retrieval
published pages: eaaw2871, ISSN: 2375-2548, DOI: 10.1126/sciadv.aaw2871
|Science Advances 5/5||2019-08-29|
Andreas Tittl, Aurelian John-Herpin, Aleksandrs Leitis, Eduardo R. Arvelo, Hatice Altug
Metasurface-Based Molecular Biosensing Aided by Artificial Intelligence
published pages: , ISSN: 1433-7851, DOI: 10.1002/anie.201901443
|Angewandte Chemie International Edition||2019-08-29|
Sang-Hyun Oh, Hatice Altug
Performance metrics and enabling technologies for nanoplasmonic biosensors
published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-018-06419-3
|Nature Communications 9/1||2019-08-29|
Filiz Yesilkoy, Eduardo R. Arvelo, Yasaman Jahani, Mingkai Liu, Andreas Tittl, Volkan Cevher, Yuri Kivshar, Hatice Altug
Ultrasensitive hyperspectral imaging and biodetection enabled by dielectric metasurfaces
published pages: 390-396, ISSN: 1749-4885, DOI: 10.1038/s41566-019-0394-6
|Nature Photonics 13/6||2019-08-29|
Aurelian John-Herpin, Andreas Tittl, Hatice Altug
Quantifying the Limits of Detection of Surface-Enhanced Infrared Spectroscopy with Grating Order-Coupled Nanogap Antennas
published pages: 4117-4124, ISSN: 2330-4022, DOI: 10.1021/acsphotonics.8b00847
|ACS Photonics 5/10||2019-08-29|
Daniel Rodrigo, Andreas Tittl, Aurelian John-Herpin, Odeta Limaj, Hatice Altug
Self-Similar Multiresonant Nanoantenna Arrays for Sensing from Near- to Mid-Infrared
published pages: 4903-4911, ISSN: 2330-4022, DOI: 10.1021/acsphotonics.8b01050
|ACS Photonics 5/12||2019-08-29|
Daniel Rodrigo, Andreas Tittl, Nadine Ait-Bouziad, Aurelian John-Herpin, Odeta Limaj, Christopher Kelly, Daehan Yoo, Nathan J. Wittenberg, Sang-Hyun Oh, Hilal A. Lashuel, Hatice Altug
Resolving molecule-specific information in dynamic lipid membrane processes with multi-resonant infrared metasurfaces
published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-018-04594-x
|Nature Communications 9/1||2019-06-18|
Dordaneh Etezadi, John B Warner IV, Francesco S Ruggeri, Giovanni Dietler, Hilal A Lashuel, Hatice Altug
Nanoplasmonic mid-infrared biosensor for in vitro protein secondary structure detection
published pages: e17029, ISSN: 2047-7538, DOI: 10.1038/lsa.2017.29
|Light: Science & Applications 6/8||2019-06-18|
Daehan Yoo, Daniel A. Mohr, Ferran Vidal-Codina, Aurelian John-Herpin, Minsik Jo, Sunghwan Kim, Joseph Matson, Joshua D. Caldwell, Heonsu Jeon, Ngoc-Cuong Nguyen, Luis Martin-Moreno, Jaime Peraire, Hatice Altug, Sang-Hyun Oh
High-Contrast Infrared Absorption Spectroscopy via Mass-Produced Coaxial Zero-Mode Resonators with Sub-10 nm Gaps
published pages: 1930-1936, ISSN: 1530-6984, DOI: 10.1021/acs.nanolett.7b05295
|Nano Letters 18/3||2019-06-18|
Dordaneh Etezadi, John B. Warner, Hilal A. Lashuel, Hatice Altug
Real-Time In Situ Secondary Structure Analysis of Protein Monolayer with Mid-Infrared Plasmonic Nanoantennas
published pages: 1109-1117, ISSN: 2379-3694, DOI: 10.1021/acssensors.8b00115
|ACS Sensors 3/6||2019-06-18|
Andreas Tittl, Aleksandrs Leitis, Mingkai Liu, Filiz Yesilkoy, Duk-Yong Choi, Dragomir N. Neshev, Yuri S. Kivshar, Hatice Altug
Imaging-based molecular barcoding with pixelated dielectric metasurfaces
published pages: 1105-1109, ISSN: 0036-8075, DOI: 10.1126/science.aas9768
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