Opendata, web and dolomites


Stilbene and entomopathogenic nematodes: Unlocking the potential

Total Cost €


EC-Contrib. €






 STEPN-UP project word cloud

Explore the words cloud of the STEPN-UP project. It provides you a very rough idea of what is the project "STEPN-UP" about.

animal    scientist    model    soil    employing    pertaining    signals    photorhabdus    training    interact    evolutionary    entomopathogenic    intimate    suggesting    utilize    understand    aids    provides    epns    st    produces    college    virulence    inter    attend    university    organisms    dwelling    epn    aside    fellowship    skills    metabolite    antibiotic    behavior    writing    grant    independent    me    poorly    interaction    send    molecular    kingdom    plans    occurs    heterorhabditis    molecule    beneficial    synthesis    presentation    secondary    cork    bacterium    roles    techniques    symbiont    symbiotic    scientific    career    stilbene    public    fundamental    frequently    molecules    bacteria    interactions    workshops    ucc    eukaryotic    associations    science    evolution    proteins    underlying    bioactive    laboratory    insect    critical    bacterial    form    mechanisms    vein    history    functions    host    kill    engineering    expertise    signalling    nematode   

Project "STEPN-UP" data sheet

The following table provides information about the project.


Organization address
city: Cork
postcode: T12 YN60

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Ireland [IE]
 Total cost 175˙866 €
 EC max contribution 175˙866 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2015
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2017
 Duration (year-month-day) from 2017-01-01   to  2018-12-31


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 


 Project objective

Bacteria frequently form intimate associations with a eukaryotic host where they may have critical roles in the development, behavior, and/or functions of their animal symbiont. While the underlying molecular mechanisms are poorly understood there is increasing evidence that the bacteria are employing proteins or molecules to send signals to their host. My goal is to understand the inter-kingdom signalling that occurs between a bacterium and its animal host using, as a model, the interaction between an entomopathogenic nematode (EPN) called Heterorhabditis and its symbiotic bacterium, Photorhabdus.

EPNs are soil-dwelling organisms that utilize a bacterial symbiont to kill their insect targets. Photorhabdus produces a bioactive secondary metabolite called stilbene (ST). ST is used as an antibiotic and a virulence factor. Furthermore, ST is required for nematode growth and development suggesting that ST may be an important inter-kingdom signalling molecule. In this vein, the proposed project will investigate fundamental aspects pertaining to host-symbiont evolution and interactions by: 1) investigating the evolutionary history of ST synthesis proteins, 2) determining the nematode response to ST, and 3) engineering increased ST production.

Aside from scientific advances, this fellowship would enable me to attend University College Cork (UCC) where beneficial training and knowledge will be obtained. For example, UCC provides training workshops on presentation skills, project management, and grant writing among others and aids in career management plans. Furthermore, I will learn new laboratory techniques and knowledge from this project. On the other hand, I will be able to bring my expertise in bacterial research to the host laboratory. This fellowship will have a significant impact on my career as an independent research scientist and will provide me opportunities to interact with the general public to enhance an overall knowledge of science.

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The information about "STEPN-UP" are provided by the European Opendata Portal: CORDIS opendata.

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