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STEPN-UP

Stilbene and entomopathogenic nematodes: Unlocking the potential

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 STEPN-UP project word cloud

Explore the words cloud of the STEPN-UP project. It provides you a very rough idea of what is the project "STEPN-UP" about.

entomopathogenic    symbiotic    photorhabdus    model    insect    st    independent    bacteria    ucc    scientist    beneficial    antibiotic    career    dwelling    university    secondary    kill    frequently    synthesis    training    molecules    vein    form    employing    mechanisms    organisms    critical    history    utilize    stilbene    roles    skills    heterorhabditis    molecular    kingdom    fundamental    plans    interact    aids    cork    bioactive    fellowship    poorly    attend    occurs    writing    scientific    send    understand    techniques    college    suggesting    bacterial    provides    signalling    interaction    interactions    underlying    presentation    host    inter    symbiont    epn    me    nematode    laboratory    soil    evolution    grant    virulence    aside    epns    science    engineering    public    evolutionary    eukaryotic    intimate    functions    animal    expertise    bacterium    workshops    molecule    produces    signals    associations    proteins    pertaining    metabolite    behavior   

Project "STEPN-UP" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITY COLLEGE CORK - NATIONAL UNIVERSITY OF IRELAND, CORK 

Organization address
address: WESTERN ROAD
city: Cork
postcode: T12 YN60
website: www.ucc.ie

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Ireland [IE]
 Total cost 175˙866 €
 EC max contribution 175˙866 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2015
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2017
 Duration (year-month-day) from 2017-01-01   to  2018-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITY COLLEGE CORK - NATIONAL UNIVERSITY OF IRELAND, CORK IE (Cork) coordinator 175˙866.00

Map

 Project objective

Bacteria frequently form intimate associations with a eukaryotic host where they may have critical roles in the development, behavior, and/or functions of their animal symbiont. While the underlying molecular mechanisms are poorly understood there is increasing evidence that the bacteria are employing proteins or molecules to send signals to their host. My goal is to understand the inter-kingdom signalling that occurs between a bacterium and its animal host using, as a model, the interaction between an entomopathogenic nematode (EPN) called Heterorhabditis and its symbiotic bacterium, Photorhabdus.

EPNs are soil-dwelling organisms that utilize a bacterial symbiont to kill their insect targets. Photorhabdus produces a bioactive secondary metabolite called stilbene (ST). ST is used as an antibiotic and a virulence factor. Furthermore, ST is required for nematode growth and development suggesting that ST may be an important inter-kingdom signalling molecule. In this vein, the proposed project will investigate fundamental aspects pertaining to host-symbiont evolution and interactions by: 1) investigating the evolutionary history of ST synthesis proteins, 2) determining the nematode response to ST, and 3) engineering increased ST production.

Aside from scientific advances, this fellowship would enable me to attend University College Cork (UCC) where beneficial training and knowledge will be obtained. For example, UCC provides training workshops on presentation skills, project management, and grant writing among others and aids in career management plans. Furthermore, I will learn new laboratory techniques and knowledge from this project. On the other hand, I will be able to bring my expertise in bacterial research to the host laboratory. This fellowship will have a significant impact on my career as an independent research scientist and will provide me opportunities to interact with the general public to enhance an overall knowledge of science.

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The information about "STEPN-UP" are provided by the European Opendata Portal: CORDIS opendata.

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