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Stilbene and entomopathogenic nematodes: Unlocking the potential

Total Cost €


EC-Contrib. €






 STEPN-UP project word cloud

Explore the words cloud of the STEPN-UP project. It provides you a very rough idea of what is the project "STEPN-UP" about.

understand    dwelling    symbiont    behavior    frequently    underlying    synthesis    signals    secondary    university    antibiotic    molecule    mechanisms    st    techniques    send    virulence    provides    occurs    epn    workshops    training    vein    kingdom    public    ucc    intimate    pertaining    roles    molecular    college    evolution    proteins    independent    employing    nematode    critical    scientific    bacteria    suggesting    skills    inter    laboratory    photorhabdus    form    history    interact    eukaryotic    interaction    utilize    bioactive    scientist    metabolite    bacterial    stilbene    writing    insect    engineering    molecules    bacterium    symbiotic    plans    me    grant    produces    presentation    aids    science    aside    cork    career    host    expertise    fundamental    evolutionary    kill    interactions    associations    soil    signalling    fellowship    model    heterorhabditis    functions    organisms    animal    epns    beneficial    attend    poorly    entomopathogenic   

Project "STEPN-UP" data sheet

The following table provides information about the project.


Organization address
city: Cork
postcode: T12 YN60

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Ireland [IE]
 Total cost 175˙866 €
 EC max contribution 175˙866 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2015
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2017
 Duration (year-month-day) from 2017-01-01   to  2018-12-31


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 


 Project objective

Bacteria frequently form intimate associations with a eukaryotic host where they may have critical roles in the development, behavior, and/or functions of their animal symbiont. While the underlying molecular mechanisms are poorly understood there is increasing evidence that the bacteria are employing proteins or molecules to send signals to their host. My goal is to understand the inter-kingdom signalling that occurs between a bacterium and its animal host using, as a model, the interaction between an entomopathogenic nematode (EPN) called Heterorhabditis and its symbiotic bacterium, Photorhabdus.

EPNs are soil-dwelling organisms that utilize a bacterial symbiont to kill their insect targets. Photorhabdus produces a bioactive secondary metabolite called stilbene (ST). ST is used as an antibiotic and a virulence factor. Furthermore, ST is required for nematode growth and development suggesting that ST may be an important inter-kingdom signalling molecule. In this vein, the proposed project will investigate fundamental aspects pertaining to host-symbiont evolution and interactions by: 1) investigating the evolutionary history of ST synthesis proteins, 2) determining the nematode response to ST, and 3) engineering increased ST production.

Aside from scientific advances, this fellowship would enable me to attend University College Cork (UCC) where beneficial training and knowledge will be obtained. For example, UCC provides training workshops on presentation skills, project management, and grant writing among others and aids in career management plans. Furthermore, I will learn new laboratory techniques and knowledge from this project. On the other hand, I will be able to bring my expertise in bacterial research to the host laboratory. This fellowship will have a significant impact on my career as an independent research scientist and will provide me opportunities to interact with the general public to enhance an overall knowledge of science.

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The information about "STEPN-UP" are provided by the European Opendata Portal: CORDIS opendata.

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