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STEPN-UP

Stilbene and entomopathogenic nematodes: Unlocking the potential

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 STEPN-UP project word cloud

Explore the words cloud of the STEPN-UP project. It provides you a very rough idea of what is the project "STEPN-UP" about.

host    understand    molecular    nematode    fellowship    history    attend    virulence    stilbene    molecule    college    science    mechanisms    presentation    ucc    occurs    secondary    skills    soil    beneficial    insect    interaction    aids    model    eukaryotic    heterorhabditis    scientist    interactions    poorly    aside    underlying    behavior    laboratory    frequently    molecules    university    synthesis    scientific    provides    expertise    proteins    functions    bioactive    bacterial    suggesting    cork    send    symbiotic    career    entomopathogenic    public    utilize    plans    organisms    techniques    roles    epns    inter    engineering    signalling    st    critical    epn    produces    associations    symbiont    kill    metabolite    vein    workshops    training    animal    form    interact    evolutionary    antibiotic    signals    kingdom    pertaining    writing    dwelling    intimate    evolution    bacteria    me    grant    fundamental    bacterium    photorhabdus    independent    employing   

Project "STEPN-UP" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITY COLLEGE CORK - NATIONAL UNIVERSITY OF IRELAND, CORK 

Organization address
address: WESTERN ROAD
city: Cork
postcode: T12 YN60
website: www.ucc.ie

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Ireland [IE]
 Total cost 175˙866 €
 EC max contribution 175˙866 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2015
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2017
 Duration (year-month-day) from 2017-01-01   to  2018-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITY COLLEGE CORK - NATIONAL UNIVERSITY OF IRELAND, CORK IE (Cork) coordinator 175˙866.00

Map

 Project objective

Bacteria frequently form intimate associations with a eukaryotic host where they may have critical roles in the development, behavior, and/or functions of their animal symbiont. While the underlying molecular mechanisms are poorly understood there is increasing evidence that the bacteria are employing proteins or molecules to send signals to their host. My goal is to understand the inter-kingdom signalling that occurs between a bacterium and its animal host using, as a model, the interaction between an entomopathogenic nematode (EPN) called Heterorhabditis and its symbiotic bacterium, Photorhabdus.

EPNs are soil-dwelling organisms that utilize a bacterial symbiont to kill their insect targets. Photorhabdus produces a bioactive secondary metabolite called stilbene (ST). ST is used as an antibiotic and a virulence factor. Furthermore, ST is required for nematode growth and development suggesting that ST may be an important inter-kingdom signalling molecule. In this vein, the proposed project will investigate fundamental aspects pertaining to host-symbiont evolution and interactions by: 1) investigating the evolutionary history of ST synthesis proteins, 2) determining the nematode response to ST, and 3) engineering increased ST production.

Aside from scientific advances, this fellowship would enable me to attend University College Cork (UCC) where beneficial training and knowledge will be obtained. For example, UCC provides training workshops on presentation skills, project management, and grant writing among others and aids in career management plans. Furthermore, I will learn new laboratory techniques and knowledge from this project. On the other hand, I will be able to bring my expertise in bacterial research to the host laboratory. This fellowship will have a significant impact on my career as an independent research scientist and will provide me opportunities to interact with the general public to enhance an overall knowledge of science.

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The information about "STEPN-UP" are provided by the European Opendata Portal: CORDIS opendata.

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