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READCELL SIGNED

System for the efficient and non-invasive harvesting and RElease of ADherent CELLs controlled by light

Total Cost €

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EC-Contrib. €

0

Partnership

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 READCELL project word cloud

Explore the words cloud of the READCELL project. It provides you a very rough idea of what is the project "READCELL" about.

localised    nanostructured    euros    biopharmaceuticals    interaction    least    found    cells    mainly    device    introduce    experiments    certain    patent    rate    ing    exposure    automated    gold    introducing    attack    biopharmaceutical    treatment    productivity    patterns    external    poses    adherent    therapy    damaging    efficient    shape    locations    surface    basis    risk    volumetric    source    immobilized    culture    annual    lags    successful    coming    harsh    recovery    radiation    nanoparticles    environment    biochemical    submitted    geometrical    automation    types    manually    immobilising    interacts    enzymes    enzymatic    nature    share    modifications    point    preliminary    valued    turn    release    hydrolyzing    hyperthermal    contained    energy    imbalance    contaminating    150    disrupting    driving    market    harvest    electromagnetic    adhesion    manual    attached    proof    invasive    idea    suspension    size    cultured    performed    cell    million   

Project "READCELL" data sheet

The following table provides information about the project.

Coordinator
ASOCIACION CENTRO DE INVESTIGACION COOPERATIVA EN BIOMATERIALES- CIC biomaGUNE 

Organization address
address: PASEO MIRAMON 182, PARQUE TECNOLOGICO DE SAN SEBASTIAN EDIFICIO EMPRESARIAL C
city: SAN SEBASTIAN
postcode: 20009
website: www.cicbiomagune.es

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Spain [ES]
 Total cost 149˙940 €
 EC max contribution 149˙940 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2015-PoC
 Funding Scheme ERC-POC
 Starting year 2016
 Duration (year-month-day) from 2016-05-01   to  2017-10-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    ASOCIACION CENTRO DE INVESTIGACION COOPERATIVA EN BIOMATERIALES- CIC biomaGUNE ES (SAN SEBASTIAN) coordinator 149˙940.00

Map

 Project objective

The Biopharmaceuticals market is currently valued at about 150,000 million euros with an annual growth rate of 6 %. Biopharmaceutical products are mainly obtained from cells cultured in contained systems. Adherent cells represent an important share of the cell types used in production processes and are the major source of cell therapy products. Productivity of current processes for adherent cells culture lags behind those based on suspension cells and the reasons for this imbalance are to be found mainly on the low volumetric productivity and automation of current processes for adherent cells culture. Recovery of cells from the surface they are attached to, the so-called cell harvest is commonly performed by disrupting the interaction of the cells with the support by manually introducing hydrolyzing enzymes into the culture device. These enzymes attack the cell at the adhesion point driving them into suspension for further recovery. Due to the manual nature of the cell harvest step, the exposure of cells to the external environment during the enzymatic treatment and the harsh biochemical conditions, this is one of the least efficient steps in the production process and poses an important risk of damaging and contaminating the culture. The idea proposed in this project for Proof of Concept will turn the cell harvest step into an automated, non-invasive and efficient step in the cell culture process. To achieve this goal we will introduce nanostructured modifications in the cell culture support by immobilising gold nanoparticles of defined size and shape, in certain geometrical patterns. The resulting cell culture support interacts with low energy electromagnetic radiation coming from an external and non-invasive source, creating localised hyperthermal effects at the locations of the immobilized nanoparticles and leading to the release of growing cells. Results of successful preliminary experiments are the basis of a recently submitted patent application.

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The information about "READCELL" are provided by the European Opendata Portal: CORDIS opendata.

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