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SCoTMOF SIGNED

Combined Chemo- and Radiotherapies by Controlling the Surface Chemistry of Truncated Metal Organic Framework Nanoparticles

Total Cost €

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EC-Contrib. €

0

Partnership

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 SCoTMOF project word cloud

Explore the words cloud of the SCoTMOF project. It provides you a very rough idea of what is the project "SCoTMOF" about.

vivo    nanoparticulate    self    entirely    location    linkers    incorporation    sophisticated    concerted    transport    installation    mofs    multidisciplinary    sirna    ones    disease    molecular    amenability    efficiency    separations    mechanisms    biotargeting    therapeutic    populations    joints    pi    world    organic    treatment    chemistry    considerable    units    technological    chelates    fundamental    released    effort    surface    chemistries    avenues    prepare    comprised    release    cancers    medicinal    metal    treatments    stimuli    aptamers    selective    biosciences    storage    functionalization    syntheses    peptides    75    drugs    rapid    drug    pet    30    assembly    microwave    efficient    promise    porous    alternative    mof    responsive    incorporated    radionuclides    supramolecular    death    diseased    mitigate    site    carriers    vectors    dramatic    synthetic    streamlining    expertise    theranostic    tissues    generate    medicines    unprecedented    derivatives    clean    capacities    vitro    imaging    age    chance    patients    body    experiences    catalysis    cargo    breakthroughs    emerged    materials    toxic    frameworks    trapping   

Project "SCoTMOF" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITY OF GLASGOW 

Organization address
address: UNIVERSITY AVENUE
city: GLASGOW
postcode: G12 8QQ
website: www.gla.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Project website http://www.forganlab.com
 Total cost 1˙493˙777 €
 EC max contribution 1˙493˙777 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2015-STG
 Funding Scheme ERC-STG
 Starting year 2016
 Duration (year-month-day) from 2016-09-01   to  2021-08-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITY OF GLASGOW UK (GLASGOW) coordinator 1˙493˙777.00

Map

 Project objective

Cancers are the leading cause of death in the developed world, with populations facing a 30% chance of developing the disease by the age of 75. As part of a concerted effort to open up new treatments and improve patients’ experiences with existing ones, the concept of drug delivery – using non-toxic carriers to transport medicines directly to the location of disease – has emerged. Metal-organic frameworks (MOFs), porous materials comprised of organic linkers and metal joints, show considerable promise as drug delivery vectors due to their high storage capacities, amenability to functionalization and the ability to prepare entirely non-toxic nanoparticulate derivatives. This proposal will use the PI’s expertise in advanced MOF synthetic methods to facilitate dramatic technological breakthroughs through unprecedented control of MOF self-assembly and surface chemistry. Management of MOF surface chemistry will allow installation of stimuli responsive release mechanisms and offer control over the trapping and release of cargo within MOFs, ensuring drugs are released only at the site of disease in the body. Surface incorporation of sophisticated biotargeting units such as peptides and aptamers will facilitate selective uptake of the MOFs by diseased tissues only. Rapid clean microwave syntheses will allow metal radionuclides to be incorporated for PET imaging, offering a novel alternative to traditional chelates. Comprehensive in vitro and in vivo testing will ensure that this multidisciplinary streamlining of materials, supramolecular and medicinal chemistries with the biosciences will generate highly efficient theranostic devices, offering more efficient, targeted drug delivery to improve treatment efficiency, mitigate side effects and open up new therapeutic avenues such as siRNA delivery. The fundamental advances required to generate these novel materials will also impact across the many applications of MOFs, from molecular storage and separations to catalysis.

 Publications

year authors and title journal last update
List of publications.
2019 Dominic Bara, Claire Wilson, Max Mörtel, Marat M. Khusniyarov, Sanliang Ling, Ben Slater, Stephen Sproules, Ross S. Forgan
Kinetic Control of Interpenetration in Fe–Biphenyl-4,4′-dicarboxylate Metal–Organic Frameworks by Coordination and Oxidation Modulation
published pages: , ISSN: 0002-7863, DOI: 10.1021/jacs.9b03269
Journal of the American Chemical Society 2019-06-06
2018 Isabel Abánades Lázaro, Sandra Abánades Lázaro, Ross S. Forgan
Enhancing anticancer cytotoxicity through bimodal drug delivery from ultrasmall Zr MOF nanoparticles
published pages: 2792-2795, ISSN: 1359-7345, DOI: 10.1039/c7cc09739e
Chemical Communications 54/22 2019-06-06
2019 Isabel Abánades Lázaro, Ross S. Forgan
Application of zirconium MOFs in drug delivery and biomedicine
published pages: 230-259, ISSN: 0010-8545, DOI: 10.1016/j.ccr.2018.09.009
Coordination Chemistry Reviews 380 2019-06-06
2018 Isabel Abánades Lázaro, Salame Haddad, Jose M. Rodrigo-Muñoz, Ross J. Marshall, Beatriz Sastre, Victoria del Pozo, David Fairen-Jimenez, Ross S. Forgan
Surface-Functionalization of Zr-Fumarate MOF for Selective Cytotoxicity and Immune System Compatibility in Nanoscale Drug Delivery
published pages: 31146-31157, ISSN: 1944-8244, DOI: 10.1021/acsami.8b11652
ACS Applied Materials & Interfaces 10/37 2019-06-06

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