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Combined Chemo- and Radiotherapies by Controlling the Surface Chemistry of Truncated Metal Organic Framework Nanoparticles

Total Cost €


EC-Contrib. €






 SCoTMOF project word cloud

Explore the words cloud of the SCoTMOF project. It provides you a very rough idea of what is the project "SCoTMOF" about.

dramatic    efficiency    responsive    drugs    disease    aptamers    treatments    fundamental    vectors    breakthroughs    populations    separations    mechanisms    amenability    mitigate    selective    treatment    pi    functionalization    mofs    medicinal    released    world    patients    promise    nanoparticulate    chelates    self    sophisticated    mof    prepare    catalysis    incorporation    entirely    porous    effort    location    frameworks    ones    clean    organic    experiences    emerged    incorporated    drug    materials    sirna    30    therapeutic    multidisciplinary    radionuclides    pet    cargo    carriers    toxic    surface    expertise    medicines    stimuli    synthetic    imaging    capacities    cancers    storage    derivatives    body    biosciences    death    concerted    joints    tissues    rapid    units    microwave    75    alternative    comprised    molecular    biotargeting    chance    installation    assembly    chemistries    vitro    age    efficient    supramolecular    considerable    peptides    streamlining    syntheses    diseased    trapping    vivo    transport    avenues    generate    metal    technological    site    chemistry    release    theranostic    linkers    unprecedented   

Project "SCoTMOF" data sheet

The following table provides information about the project.


Organization address
postcode: G12 8QQ

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Project website
 Total cost 1˙493˙777 €
 EC max contribution 1˙493˙777 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2015-STG
 Funding Scheme ERC-STG
 Starting year 2016
 Duration (year-month-day) from 2016-09-01   to  2021-08-31


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITY OF GLASGOW UK (GLASGOW) coordinator 1˙493˙777.00


 Project objective

Cancers are the leading cause of death in the developed world, with populations facing a 30% chance of developing the disease by the age of 75. As part of a concerted effort to open up new treatments and improve patients’ experiences with existing ones, the concept of drug delivery – using non-toxic carriers to transport medicines directly to the location of disease – has emerged. Metal-organic frameworks (MOFs), porous materials comprised of organic linkers and metal joints, show considerable promise as drug delivery vectors due to their high storage capacities, amenability to functionalization and the ability to prepare entirely non-toxic nanoparticulate derivatives. This proposal will use the PI’s expertise in advanced MOF synthetic methods to facilitate dramatic technological breakthroughs through unprecedented control of MOF self-assembly and surface chemistry. Management of MOF surface chemistry will allow installation of stimuli responsive release mechanisms and offer control over the trapping and release of cargo within MOFs, ensuring drugs are released only at the site of disease in the body. Surface incorporation of sophisticated biotargeting units such as peptides and aptamers will facilitate selective uptake of the MOFs by diseased tissues only. Rapid clean microwave syntheses will allow metal radionuclides to be incorporated for PET imaging, offering a novel alternative to traditional chelates. Comprehensive in vitro and in vivo testing will ensure that this multidisciplinary streamlining of materials, supramolecular and medicinal chemistries with the biosciences will generate highly efficient theranostic devices, offering more efficient, targeted drug delivery to improve treatment efficiency, mitigate side effects and open up new therapeutic avenues such as siRNA delivery. The fundamental advances required to generate these novel materials will also impact across the many applications of MOFs, from molecular storage and separations to catalysis.


year authors and title journal last update
List of publications.
2019 Dominic Bara, Claire Wilson, Max Mörtel, Marat M. Khusniyarov, Sanliang Ling, Ben Slater, Stephen Sproules, Ross S. Forgan
Kinetic Control of Interpenetration in Fe–Biphenyl-4,4′-dicarboxylate Metal–Organic Frameworks by Coordination and Oxidation Modulation
published pages: , ISSN: 0002-7863, DOI: 10.1021/jacs.9b03269
Journal of the American Chemical Society 2019-06-06
2018 Isabel Abánades Lázaro, Sandra Abánades Lázaro, Ross S. Forgan
Enhancing anticancer cytotoxicity through bimodal drug delivery from ultrasmall Zr MOF nanoparticles
published pages: 2792-2795, ISSN: 1359-7345, DOI: 10.1039/c7cc09739e
Chemical Communications 54/22 2019-06-06
2019 Isabel Abánades Lázaro, Ross S. Forgan
Application of zirconium MOFs in drug delivery and biomedicine
published pages: 230-259, ISSN: 0010-8545, DOI: 10.1016/j.ccr.2018.09.009
Coordination Chemistry Reviews 380 2019-06-06
2018 Isabel Abánades Lázaro, Salame Haddad, Jose M. Rodrigo-Muñoz, Ross J. Marshall, Beatriz Sastre, Victoria del Pozo, David Fairen-Jimenez, Ross S. Forgan
Surface-Functionalization of Zr-Fumarate MOF for Selective Cytotoxicity and Immune System Compatibility in Nanoscale Drug Delivery
published pages: 31146-31157, ISSN: 1944-8244, DOI: 10.1021/acsami.8b11652
ACS Applied Materials & Interfaces 10/37 2019-06-06

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