Explore the words cloud of the SCoTMOF project. It provides you a very rough idea of what is the project "SCoTMOF" about.
The following table provides information about the project.
UNIVERSITY OF GLASGOW
|Coordinator Country||United Kingdom [UK]|
|Total cost||1˙493˙777 €|
|EC max contribution||1˙493˙777 € (100%)|
1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
|Duration (year-month-day)||from 2016-09-01 to 2021-08-31|
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|1||UNIVERSITY OF GLASGOW||UK (GLASGOW)||coordinator||1˙493˙777.00|
Cancers are the leading cause of death in the developed world, with populations facing a 30% chance of developing the disease by the age of 75. As part of a concerted effort to open up new treatments and improve patients’ experiences with existing ones, the concept of drug delivery – using non-toxic carriers to transport medicines directly to the location of disease – has emerged. Metal-organic frameworks (MOFs), porous materials comprised of organic linkers and metal joints, show considerable promise as drug delivery vectors due to their high storage capacities, amenability to functionalization and the ability to prepare entirely non-toxic nanoparticulate derivatives. This proposal will use the PI’s expertise in advanced MOF synthetic methods to facilitate dramatic technological breakthroughs through unprecedented control of MOF self-assembly and surface chemistry. Management of MOF surface chemistry will allow installation of stimuli responsive release mechanisms and offer control over the trapping and release of cargo within MOFs, ensuring drugs are released only at the site of disease in the body. Surface incorporation of sophisticated biotargeting units such as peptides and aptamers will facilitate selective uptake of the MOFs by diseased tissues only. Rapid clean microwave syntheses will allow metal radionuclides to be incorporated for PET imaging, offering a novel alternative to traditional chelates. Comprehensive in vitro and in vivo testing will ensure that this multidisciplinary streamlining of materials, supramolecular and medicinal chemistries with the biosciences will generate highly efficient theranostic devices, offering more efficient, targeted drug delivery to improve treatment efficiency, mitigate side effects and open up new therapeutic avenues such as siRNA delivery. The fundamental advances required to generate these novel materials will also impact across the many applications of MOFs, from molecular storage and separations to catalysis.
|year||authors and title||journal||last update|
Dominic Bara, Claire Wilson, Max MÃ¶rtel, Marat M. Khusniyarov, Sanliang Ling, Ben Slater, Stephen Sproules, Ross S. Forgan
Kinetic Control of Interpenetration in Feâ€“Biphenyl-4,4â€²-dicarboxylate Metalâ€“Organic Frameworks by Coordination and Oxidation Modulation
published pages: , ISSN: 0002-7863, DOI: 10.1021/jacs.9b03269
|Journal of the American Chemical Society||2019-06-06|
Isabel AbÃ¡nades LÃ¡zaro, Sandra AbÃ¡nades LÃ¡zaro, Ross S. Forgan
Enhancing anticancer cytotoxicity through bimodal drug delivery from ultrasmall Zr MOF nanoparticles
published pages: 2792-2795, ISSN: 1359-7345, DOI: 10.1039/c7cc09739e
|Chemical Communications 54/22||2019-06-06|
Isabel AbÃ¡nades LÃ¡zaro, Ross S. Forgan
Application of zirconium MOFs in drug delivery and biomedicine
published pages: 230-259, ISSN: 0010-8545, DOI: 10.1016/j.ccr.2018.09.009
|Coordination Chemistry Reviews 380||2019-06-06|
Isabel AbÃ¡nades LÃ¡zaro, Salame Haddad, Jose M. Rodrigo-MuÃ±oz, Ross J. Marshall, Beatriz Sastre, Victoria del Pozo, David Fairen-Jimenez, Ross S. Forgan
Surface-Functionalization of Zr-Fumarate MOF for Selective Cytotoxicity and Immune System Compatibility in Nanoscale Drug Delivery
published pages: 31146-31157, ISSN: 1944-8244, DOI: 10.1021/acsami.8b11652
|ACS Applied Materials & Interfaces 10/37||2019-06-06|
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