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METAFLUIDICS SIGNED

Advanced toolbox for rapid and cost-effective functional metagenomic screening - microbiology meets microfluidics.

Total Cost €

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EC-Contrib. €

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Partnership

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 METAFLUIDICS project word cloud

Explore the words cloud of the METAFLUIDICS project. It provides you a very rough idea of what is the project "METAFLUIDICS" about.

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Project "METAFLUIDICS" data sheet

The following table provides information about the project.

Coordinator
UNIVERSIDAD AUTONOMA DE MADRID 

Organization address
address: CALLE EINSTEIN 3 CIUDAD UNIV CANTOBLANCO RECTORADO
city: MADRID
postcode: 28049
website: http://www.uam.es

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Spain [ES]
 Project website http://www.metafluidics.eu
 Total cost 8˙808˙363 €
 EC max contribution 8˙808˙363 € (100%)
 Programme 1. H2020-EU.2.1.4. (INDUSTRIAL LEADERSHIP - Leadership in enabling and industrial technologies – Biotechnology)
 Code Call H2020-LEIT-BIO-2015-1
 Funding Scheme RIA
 Starting year 2016
 Duration (year-month-day) from 2016-06-01   to  2020-05-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSIDAD AUTONOMA DE MADRID ES (MADRID) coordinator 1˙233˙729.00
2    THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE UK (CAMBRIDGE) participant 1˙120˙190.00
3    NORGES TEKNISK-NATURVITENSKAPELIGE UNIVERSITET NTNU NO (TRONDHEIM) participant 840˙357.00
4    NOVOZYMES A/S DK (BAGSVAERD) participant 821˙729.00
5    INSTITUT NATIONAL DES SCIENCES APPLIQUEES DE TOULOUSE FR (TOULOUSE) participant 722˙255.00
6    AGENCIA ESTATAL CONSEJO SUPERIOR DEINVESTIGACIONES CIENTIFICAS ES (MADRID) participant 636˙282.00
7    UNIVERSIDAD DE ALICANTE ES (ALICANTE) participant 595˙600.00
8    PROZOMIX LIMITED UK (HALTWHISTLE) participant 546˙806.00
9    QIAGEN AARHUS AS DK (AARHUS) participant 463˙750.00
10    SINTEF AS NO (TRONDHEIM) participant 461˙247.00
11    BIOILIBERIS RESEARCH AND DEVELOPMENT SL ES (ARMILLA GRANADA) participant 460˙000.00
12    CENTRO DE NEUROCIENCIAS E BIOLOGIACELULAR ASSOCIACAO PT (COIMBRA) participant 407˙590.00
13    STIFTELSEN SINTEF NO (TRONDHEIM) participant 291˙006.00
14    DROP-TECH LTD UK (Cambridge) participant 207˙820.00

Map

 Project objective

Metagenomes comprise enormous reservoirs coding for proteins with useful activities. Unfortunately, harvesting this reservoir is difficult, because useful candidates are rare and hidden in an overwhelming majority of irrelevant genes. Screening campaigns of metagenomic libraries thus require massive capital-expenditure for robotic systems and much manpower, making them expensive, slow and available to very few users. To enable valorisation of the potential of the metagenome, this project assembles an interdisciplinary and intersectoral consortium that will integrate a range of technologies into a platform designed to beat the odds of identifying library hits faster, more efficiently and by a wider user base. Exploration and exploitation of the metagenome will be made faster and more successful by (i) ultrahigh-throughput screening in picoliter droplets that dramatically lowers the cost per assay to well below 0.01 cents and allows throughput of 10e7 assays per hour; (ii) workflows that streamline and increase the yield of library construction and functional expression and (iii) workflows for efficient bioinformatic analysis of hits based on user-friendly software solutions for metagenome analysis. Emphasis is put on technologies that are straightforwardly implemented in non-specialist labs, maximising the impact of METAFLUIDICS. This platform will be used to identify enzymes for biosynthesis of therapeutic small molecules, for green bioenergy conversion, bioremediation, food chemistry and other industrial applications

 Deliverables

List of deliverables.
Scientific publications or patents Websites, patent fillings, videos etc. 2020-04-23 03:22:16
Posts, press releases and news items Websites, patent fillings, videos etc. 2020-04-23 03:22:16
Visual identity package Websites, patent fillings, videos etc. 2020-04-23 03:22:16
Standards document and revisions Documents, reports 2020-04-23 03:22:16
Website Websites, patent fillings, videos etc. 2020-04-23 03:22:16
Certifications for biosafety, GMO manipulation, animal experimentation Documents, reports 2020-04-23 03:22:16
Quality assurance form for deliverables and exchanged materials Documents, reports 2020-04-23 03:22:16

Take a look to the deliverables list in detail:  detailed list of METAFLUIDICS deliverables.

 Publications

year authors and title journal last update
List of publications.
2018 Esther Rubio-Portillo, Juan F. Gago, Manuel Martínez-García, Luigi Vezzulli, Ramon Rosselló-Móra, Josefa Antón, Alfonso A. Ramos-Esplá
Vibrio communities in scleractinian corals differ according to health status and geographic location in the Mediterranean Sea
published pages: 131-138, ISSN: 0723-2020, DOI: 10.1016/j.syapm.2017.11.007
Systematic and Applied Microbiology 41/2 2020-04-23
2018 Luciana Albuquerque, Ana Rita M. Polónia, Cristina Barroso, Hugo J. C. Froufe, Olga Lage, Alexandre Lobo-da-Cunha, Conceição Egas, Milton S. da Costa
Raineya orbicola gen. nov., sp. nov. a slightly thermophilic bacterium of the phylum Bacteroidetes and the description of Raineyaceae fam. nov.
published pages: 982-989, ISSN: 1466-5026, DOI: 10.1099/ijsem.0.002556
International Journal of Systematic and Evolutionary Microbiology 68/4 2020-04-23
2019 Alba Blesa, Mercedes Sánchez, Eva Sacristán-Horcajada, Sandra González-de la Fuente, Ramón Peiró, José Berenguer
Into the Thermus Mobilome: Presence, Diversity and Recent Activities of Insertion Sequences Across Thermus spp.
published pages: 25, ISSN: 2076-2607, DOI: 10.3390/microorganisms7010025
Microorganisms 7/1 2020-04-23
2019 Pedro Raposo, Tomeu Viver, Luciana Albuquerque, Hugo Froufe, Cristina Barroso, Conceição Egas, Ramon Rosselló-Móra, Milton S. da Costa
Transfer of Meiothermus chliarophilus (Tenreiro et al.1995) Nobre et al. 1996, Meiothermus roseus Ming et al. 2016, Meiothermus terrae Yu et al. 2014 and Meiothermus timidus Pires et al. 2005, to Calidithermus gen. nov., as Calidithermus chliarophilus comb. nov., Calidithermus roseus comb. nov., Calidithermus terrae comb. nov. and Calidithermus timidus comb. nov., respectively, and emended descrip
published pages: 1060-1069, ISSN: 1466-5026, DOI: 10.1099/ijsem.0.003270
International Journal of Systematic and Evolutionary Microbiology 69/4 2020-04-23
2018 Rosa Margesin, Luciana Albuquerque, De-Chao Zhang, Hugo J. C. Froufe, Rita Severino, Inês Roxo, Conceição Egas, Milton S. da Costa
Solimicrobium silvestre gen. nov., sp. nov., isolated from alpine forest soil
published pages: 2491-2498, ISSN: 1466-5026, DOI: 10.1099/ijsem.0.002861
International Journal of Systematic and Evolutionary Microbiology 68/8 2020-04-23
2016 Udaondo Domínguez, Zulema
Análisis del Pangenoma de Pseudomonas putida
published pages: , ISSN: , DOI:
1 2020-04-23
2017 Laura Alvarez, Nieves G. Quintáns, Alba Blesa, Ignacio Baquedano, Mario Mencía, Carlos Bricio, José Berenguer
Hierarchical Control of Nitrite Respiration by Transcription Factors Encoded within Mobile Gene Clusters of Thermus thermophilus
published pages: 361, ISSN: 2073-4425, DOI: 10.3390/genes8120361
Genes 8/12 2020-04-23
2018 Esther Rubio-Portillo, Diego K. Kersting, Cristina Linares, Alfonso A. Ramos-Esplá, Josefa Antón
Biogeographic Differences in the Microbiome and Pathobiome of the Coral Cladocora caespitosa in the Western Mediterranean Sea
published pages: , ISSN: 1664-302X, DOI: 10.3389/fmicb.2018.00022
Frontiers in Microbiology 9 2020-04-23
2017 Lisa Ufarté, Elisabeth Laville, Sophie Duquesne, Diego Morgavi, Patrick Robe, Christophe Klopp, Angeline Rizzo, Sandra Pizzut-Serin, Gabrielle Potocki-Veronese
Discovery of carbamate degrading enzymes by functional metagenomics
published pages: e0189201, ISSN: 1932-6203, DOI: 10.1371/journal.pone.0189201
PLOS ONE 12/12 2020-04-23
2017 Alejandra L. Ibáñez de Aldecoa, Olga Zafra, José E. González-Pastor
Mechanisms and Regulation of Extracellular DNA Release and Its Biological Roles in Microbial Communities
published pages: , ISSN: 1664-302X, DOI: 10.3389/fmicb.2017.01390
Frontiers in Microbiology 8 2020-04-23
2017 Berenguer, José; Mencía, Mario; Hidalgo, Aurelio
Are in vivo selections on the path to extinction?
published pages: 46-49, ISSN: 1751-7915, DOI: 10.1111/1751-7915.12490
Microbial Biotechnology 1 2020-04-23
2017 Alba Blesa, Nieves Quintans, Ignacio Baquedano, Carlos Mata, José Castón, José Berenguer
Role of Archaeal HerA Protein in the Biology of the Bacterium Thermus thermophilus
published pages: 130, ISSN: 2073-4425, DOI: 10.3390/genes8050130
Genes 8/5 2020-04-23
2019 Rita Severino, Hugo J. C. Froufe, Cristina Barroso, Luciana Albuquerque, Alexandre Lobo‐da‐Cunha, Milton S. da Costa, Conceição Egas
High‐quality draft genome sequence of Gaiella occulta isolated from a 150 meter deep mineral water borehole and comparison with the genome sequences of other deep‐branching lineages of the phylum Actinobacteria
published pages: e840, ISSN: 2045-8827, DOI: 10.1002/mbo3.840
MicrobiologyOpen 2020-04-23

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