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CentSatRegFunc SIGNED

Dissecting the function and regulation of centriolar satellites: key regulators of the centrosome/cilium complex

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EC-Contrib. €

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Project "CentSatRegFunc" data sheet

The following table provides information about the project.

Coordinator
KOC UNIVERSITY 

Organization address
address: RUMELI FENERI YOLU SARIYER
city: ISTANBUL
postcode: 34450
website: www.ku.edu.tr

contact info
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surname: n.a.
function: n.a.
email: n.a.
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 Coordinator Country Turkey [TR]
 Project website http://mysite.ku.edu.tr/ekaralar/projects/
 Total cost 1˙499˙818 €
 EC max contribution 1˙499˙818 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2015-STG
 Funding Scheme ERC-STG
 Starting year 2016
 Duration (year-month-day) from 2016-06-01   to  2021-05-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    KOC UNIVERSITY TR (ISTANBUL) coordinator 1˙499˙818.00

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 Project objective

Centrosomes are the main microtubule-organizing centers of animal cells. They influence the morphology of the microtubule cytoskeleton and function as the base of primary cilium, a nexus for important signaling pathways. Structural and functional defects in centrosome/cilium complex cause a variety of human diseases including cancer, ciliopathies and microcephaly. To understand the relationship between human diseases and centrosome/cilium abnormalities, it is essential to elucidate the biogenesis of centrosome/cilium complex and the control mechanisms that regulate their structure and function. To tackle these fundamental problems, we will dissect the function and regulation of centriolar satellites, the array of granules that localize around the centrosome/cilium complex in mammalian cells. Only recently interest in the satellites has grown because mutations affecting satellite components were shown to cause ciliopathies, microcephaly and schizophrenia. Remarkably, many centrosome/cilium proteins localize to these structures and we lack understanding of when, why and how these proteins localize to satellites. The central hypothesis of this grant is that satellites ensure proper centrosome/cilium complex structure and function by acting as transit paths for modification, assembly, storage, stability and trafficking of centrosome/cilium proteins. In Aim 1, we will identify the nature of regulatory and molecular relationship between satellites and the centrosome/cilium complex. In Aim 2, we will elucidate the role of satellites in proteostasis of centrosome/cilium proteins. In Aim 3, we will investigate the functional significance of satellite-localization of centrosome/cilium proteins during processes that go awry in human disease. Using a multidisciplinary approach, the proposed research will expand our knowledge of the spatiotemporal regulation of the centrosome/cilium complex and provide new insights into pathogenesis of ciliopathies and primary microcephaly.

 Publications

year authors and title journal last update
List of publications.
2019 Ezgi Odabasi, Seref Gul, Ibrahim H Kavakli, Elif N Firat‐Karalar
Centriolar satellites are required for efficient ciliogenesis and ciliary content regulation
published pages: e47723, ISSN: 1469-221X, DOI: 10.15252/embr.201947723
EMBO reports 2019-05-27
2018 Elif Nur FIRAT-KARALAR
The ciliopathy gene product Cep290 is required for primary cilium formation and microtubule network organization
published pages: 371-381, ISSN: 1300-0152, DOI: 10.3906/biy-1805-25
TURKISH JOURNAL OF BIOLOGY 42/5 2019-05-15
2017 Deniz Conkar, Efraim Culfa, Ezgi Odabasi, Navin Rauniyar, John R. Yates, Elif N. Firat-Karalar
The centriolar satellite protein CCDC66 interacts with CEP290 and functions in cilium formation and trafficking
published pages: 1450-1462, ISSN: 0021-9533, DOI: 10.1242/jcs.196832
Journal of Cell Science 130/8 2019-06-19

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