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FUTURE

Re-factoring Pseudomonas putida for biosynthesis of vaIue-added polymers from cellulosic waste

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 FUTURE project word cloud

Explore the words cloud of the FUTURE project. It provides you a very rough idea of what is the project "FUTURE" about.

environmental    hinders    rational    roadmap    orchestration    viability    desired    laboratory    organic    fundamentals    certain    biofuel    metabolism    added    physiological    wastes    cellulosomes    sugars    kt2440    never    earth    gram    establishing    aromatics    forming    economy    substrates    utilize    cellulosic    effort    successfully    solved    biosynthesis    platform    biotechnological    biocatalytic    industrial    expanding    refactoring    biopolymers    generating    single    workhorse    microorganisms    aromatic    bacterial    bio    displaying    displayed    chemicals    versatile    construct    serve    tools    biological    corporate    enrichment    bacteria    pretreatment    cellulolytic    qualities    yeast    skills    missing    functions    native    model    compromising    vac    negative    saprophytic    compounds    efficient    synthetic    abundant    engineered    putida    agricultural    biology    cheap    bacterium    waste    constituent    components    metabolic    designer    monomeric    enzymatic    lignocellulose    context    host    valuable    cell    surface    massive    nanomachines    pseudomonas    recalcitrant    engineering   

Project "FUTURE" data sheet

The following table provides information about the project.

Coordinator
AGENCIA ESTATAL CONSEJO SUPERIOR DEINVESTIGACIONES CIENTIFICAS 

Organization address
address: CALLE SERRANO 117
city: MADRID
postcode: 28006
website: http://www.csic.es

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Spain [ES]
 Project website http://wwwuser.cnb.csic.es/
 Total cost 170˙121 €
 EC max contribution 170˙121 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2015
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2016
 Duration (year-month-day) from 2016-10-01   to  2018-09-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    AGENCIA ESTATAL CONSEJO SUPERIOR DEINVESTIGACIONES CIENTIFICAS ES (MADRID) coordinator 170˙121.00

Map

 Project objective

Lignocellulose is the most abundant organic matter on Earth and important constituent of agricultural and industrial wastes. Lignocellulose-derived monomeric sugars and aromatic compounds can serve as a cheap substrates for biotechnological production of numerous value-added chemicals (VAC). However, a well-defined bacterial platform that could efficiently utilize lignocellulose for biosynthesis of VAC in a single step is still missing. The saprophytic bacterium Pseudomonas putida KT2440, a robust laboratory workhorse with versatile metabolism, has wide potential to utilize lignocellulose-derived sugars and aromatics for VAC formation. But the need for enzymatic pretreatment of the recalcitrant lignocellulose components hinders the development of a cost-effective processes. This challenge could be solved by expanding the biocatalytic functions of P. putida using cellulosomes, efficient enzymatic nanomachines displayed on the surface of certain cellulolytic microorganisms. Synthetic cellulosomes were successfully engineered in biofuel-generating yeast, but never in a Gram-negative bacterium. The applicant will adopt state-of-the-art approaches and tools of synthetic biology, systems biology and metabolic engineering in order to construct P. putida displaying designer cellulosomes and forming valuable biopolymers directly from cellulosic waste. This task requires a rational orchestration of distinct physiological features of the host in order to achieve the desired qualities without compromising cell viability. In this context, the study will also propose a roadmap for massive refactoring and enrichment of native metabolic properties of environmental bacteria. Thus, the project will not only allow the applicant to enhance his research skills, but will also contribute to both understanding fundamentals of model biological systems and corporate effort aimed at establishing FUTURE knowledge-based bio-economy in Europe.

 Publications

year authors and title journal last update
List of publications.
2018 Pavel Dvořák, Víctor de Lorenzo
Refactoring the upper sugar metabolism of Pseudomonas putida for co-utilization of cellobiose, xylose, and glucose
published pages: 94-108, ISSN: 1096-7176, DOI: 10.1016/j.ymben.2018.05.019
Metabolic Engineering 48 2019-06-13
2017 Pavel Dvořák, Pablo I. Nikel, Jiří Damborský, Víctor de Lorenzo
Bioremediation 3 . 0 : Engineering pollutant-removing bacteria in the times of systemic biology
published pages: 845-866, ISSN: 0734-9750, DOI: 10.1016/j.biotechadv.2017.08.001
Biotechnology Advances 35/7 2019-06-13

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The information about "FUTURE" are provided by the European Opendata Portal: CORDIS opendata.

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