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FUTURE

Re-factoring Pseudomonas putida for biosynthesis of vaIue-added polymers from cellulosic waste

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 FUTURE project word cloud

Explore the words cloud of the FUTURE project. It provides you a very rough idea of what is the project "FUTURE" about.

missing    generating    enrichment    never    effort    designer    cheap    construct    cellulosic    displayed    substrates    context    waste    constituent    pretreatment    pseudomonas    hinders    added    certain    desired    biological    forming    establishing    metabolic    massive    fundamentals    successfully    surface    biology    bio    abundant    gram    microorganisms    workhorse    cell    valuable    native    synthetic    nanomachines    engineering    chemicals    physiological    enzymatic    biosynthesis    organic    environmental    negative    agricultural    lignocellulose    bacteria    model    aromatic    displaying    versatile    components    industrial    biopolymers    bacterial    single    vac    corporate    recalcitrant    utilize    cellulosomes    saprophytic    skills    rational    biofuel    viability    serve    biocatalytic    monomeric    platform    biotechnological    laboratory    sugars    earth    functions    tools    compounds    compromising    aromatics    orchestration    roadmap    economy    bacterium    host    yeast    engineered    cellulolytic    qualities    expanding    refactoring    solved    putida    kt2440    metabolism    efficient    wastes   

Project "FUTURE" data sheet

The following table provides information about the project.

Coordinator
AGENCIA ESTATAL CONSEJO SUPERIOR DEINVESTIGACIONES CIENTIFICAS 

Organization address
address: CALLE SERRANO 117
city: MADRID
postcode: 28006
website: http://www.csic.es

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Spain [ES]
 Project website http://wwwuser.cnb.csic.es/
 Total cost 170˙121 €
 EC max contribution 170˙121 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2015
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2016
 Duration (year-month-day) from 2016-10-01   to  2018-09-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    AGENCIA ESTATAL CONSEJO SUPERIOR DEINVESTIGACIONES CIENTIFICAS ES (MADRID) coordinator 170˙121.00

Map

 Project objective

Lignocellulose is the most abundant organic matter on Earth and important constituent of agricultural and industrial wastes. Lignocellulose-derived monomeric sugars and aromatic compounds can serve as a cheap substrates for biotechnological production of numerous value-added chemicals (VAC). However, a well-defined bacterial platform that could efficiently utilize lignocellulose for biosynthesis of VAC in a single step is still missing. The saprophytic bacterium Pseudomonas putida KT2440, a robust laboratory workhorse with versatile metabolism, has wide potential to utilize lignocellulose-derived sugars and aromatics for VAC formation. But the need for enzymatic pretreatment of the recalcitrant lignocellulose components hinders the development of a cost-effective processes. This challenge could be solved by expanding the biocatalytic functions of P. putida using cellulosomes, efficient enzymatic nanomachines displayed on the surface of certain cellulolytic microorganisms. Synthetic cellulosomes were successfully engineered in biofuel-generating yeast, but never in a Gram-negative bacterium. The applicant will adopt state-of-the-art approaches and tools of synthetic biology, systems biology and metabolic engineering in order to construct P. putida displaying designer cellulosomes and forming valuable biopolymers directly from cellulosic waste. This task requires a rational orchestration of distinct physiological features of the host in order to achieve the desired qualities without compromising cell viability. In this context, the study will also propose a roadmap for massive refactoring and enrichment of native metabolic properties of environmental bacteria. Thus, the project will not only allow the applicant to enhance his research skills, but will also contribute to both understanding fundamentals of model biological systems and corporate effort aimed at establishing FUTURE knowledge-based bio-economy in Europe.

 Publications

year authors and title journal last update
List of publications.
2018 Pavel Dvořák, Víctor de Lorenzo
Refactoring the upper sugar metabolism of Pseudomonas putida for co-utilization of cellobiose, xylose, and glucose
published pages: 94-108, ISSN: 1096-7176, DOI: 10.1016/j.ymben.2018.05.019
Metabolic Engineering 48 2019-06-13
2017 Pavel Dvořák, Pablo I. Nikel, Jiří Damborský, Víctor de Lorenzo
Bioremediation 3 . 0 : Engineering pollutant-removing bacteria in the times of systemic biology
published pages: 845-866, ISSN: 0734-9750, DOI: 10.1016/j.biotechadv.2017.08.001
Biotechnology Advances 35/7 2019-06-13

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The information about "FUTURE" are provided by the European Opendata Portal: CORDIS opendata.

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