Explore the words cloud of the FUTURE project. It provides you a very rough idea of what is the project "FUTURE" about.
The following table provides information about the project.
AGENCIA ESTATAL CONSEJO SUPERIOR DEINVESTIGACIONES CIENTIFICAS
|Coordinator Country||Spain [ES]|
|Total cost||170˙121 €|
|EC max contribution||170˙121 € (100%)|
1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
|Duration (year-month-day)||from 2016-10-01 to 2018-09-30|
Take a look of project's partnership.
|1||AGENCIA ESTATAL CONSEJO SUPERIOR DEINVESTIGACIONES CIENTIFICAS||ES (MADRID)||coordinator||170˙121.00|
Lignocellulose is the most abundant organic matter on Earth and important constituent of agricultural and industrial wastes. Lignocellulose-derived monomeric sugars and aromatic compounds can serve as a cheap substrates for biotechnological production of numerous value-added chemicals (VAC). However, a well-defined bacterial platform that could efficiently utilize lignocellulose for biosynthesis of VAC in a single step is still missing. The saprophytic bacterium Pseudomonas putida KT2440, a robust laboratory workhorse with versatile metabolism, has wide potential to utilize lignocellulose-derived sugars and aromatics for VAC formation. But the need for enzymatic pretreatment of the recalcitrant lignocellulose components hinders the development of a cost-effective processes. This challenge could be solved by expanding the biocatalytic functions of P. putida using cellulosomes, efficient enzymatic nanomachines displayed on the surface of certain cellulolytic microorganisms. Synthetic cellulosomes were successfully engineered in biofuel-generating yeast, but never in a Gram-negative bacterium. The applicant will adopt state-of-the-art approaches and tools of synthetic biology, systems biology and metabolic engineering in order to construct P. putida displaying designer cellulosomes and forming valuable biopolymers directly from cellulosic waste. This task requires a rational orchestration of distinct physiological features of the host in order to achieve the desired qualities without compromising cell viability. In this context, the study will also propose a roadmap for massive refactoring and enrichment of native metabolic properties of environmental bacteria. Thus, the project will not only allow the applicant to enhance his research skills, but will also contribute to both understanding fundamentals of model biological systems and corporate effort aimed at establishing FUTURE knowledge-based bio-economy in Europe.
|year||authors and title||journal||last update|
Pavel DvoÅ™Ã¡k, VÃctor de Lorenzo
Refactoring the upper sugar metabolism of Pseudomonas putida for co-utilization of cellobiose, xylose, and glucose
published pages: 94-108, ISSN: 1096-7176, DOI: 10.1016/j.ymben.2018.05.019
|Metabolic Engineering 48||2019-06-13|
Pavel DvoÅ™Ã¡k, Pablo I. Nikel, JiÅ™Ã DamborskÃ½, VÃctor de Lorenzo
Bioremediation 3 . 0 : Engineering pollutant-removing bacteria in the times of systemic biology
published pages: 845-866, ISSN: 0734-9750, DOI: 10.1016/j.biotechadv.2017.08.001
|Biotechnology Advances 35/7||2019-06-13|
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