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Custom architecturally defined 3D stem cell derived functional human neural networks for transformative progress in neuroscience and medicine

Total Cost €


EC-Contrib. €






 MESO_BRAIN project word cloud

Explore the words cloud of the MESO_BRAIN project. It provides you a very rough idea of what is the project "MESO_BRAIN" about.

dimensions    technological    grown    electrical    fabricated    generate    excited    regeneration    treat    module    receive    cells    points    networks    sheet    cues    drug    architecture    nano    disease    vivo    nor    recording    nervous    physiologically    pursued    stem    cellular    disappointing    types    imaging    scaffold    simultaneous    myriad    regenerative    individual    parkinson    dementia    functional    femtosecond    neurons    signalling    platform    function    scaffolds    printed    tissue    confounding    differentiate    neural    patients    cortical    dimensional    15    re    reproducible    envisage    date    maturation    light    laser    outside    developmental    interactions    integrating    network    trauma    promise    polymerisation    endogenous    discovery    human    central    neuronal    era    display    medical    issue    ipsc    stimulation    transformed    foundational    therapies    pharmaceutical    utilise    isolate    cell    interrogate    brain    attempts    realistic    mimic    neuroscience    seeded    biological    selectively    connectivity    implanted    designed   

Project "MESO_BRAIN" data sheet

The following table provides information about the project.


Organization address
postcode: B4 7ET

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Project website
 Total cost 3˙225˙891 €
 EC max contribution 3˙225˙890 € (100%)
 Programme 1. H2020-EU.1.2.1. (FET Open)
 Code Call H2020-FETOPEN-2014-2015-RIA
 Funding Scheme RIA
 Starting year 2016
 Duration (year-month-day) from 2016-09-01   to  2020-02-29


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    ASTON UNIVERSITY UK (BIRMINGHAM) coordinator 839˙016.00
2    AXOL BIOSCIENCE LTD UK (CAMBRIDGE) participant 711˙480.00
3    FUNDACIO INSTITUT DE CIENCIES FOTONIQUES ES (Castelldefels) participant 558˙125.00
4    LZH LASERZENTRUM HANNOVER EV DE (HANNOVER) participant 520˙625.00
5    UNIVERSITAT DE BARCELONA ES (BARCELONA) participant 484˙986.00


 Project objective

The development of methods to isolate and generate human stem cells along with technology to selectively differentiate them into specific cell and tissue types has excited many with the promise of the ability to study human cell function and utilise them for regeneration in disease and trauma. However, to date, attempts to develop regenerative brain and central nervous system therapies have been disappointing, with the introduced stem cell derived neurons not integrating nor signalling physiologically with endogenous cells. A major confounding issue has been that derived neurons are grown in two dimensions, which does not mimic the in vivo three dimensional interactions nor the myriad developmental cues they would receive in vivo. We will develop functional three dimensional human stem cell derived neural networks of defined and reproducible architecture, based on that of a brain cortical module that will display in vivo connectivity and activity. The networks will be seeded on nano-scale designed femtosecond laser printed scaffolds using novel polymerisation methods that will allow electrical stimulation, simultaneous recording and light sheet imaging during development and at maturation to interrogate network function. Cells will be seeded at and will develop at specific, defined points on the network scaffold, enabling the growth of realistic and reproducible functional neuronal networks. The proposal seeks to provide fabricated reproducible scaffolds that can be produced on a large scale. These concepts are far outside what is currently pursued in the field. The development of such a technological platform will be foundational for a new era of biological and medical research based on human neural networks. Cellular neuroscience research and pharmaceutical drug discovery will be transformed and we envisage that within 15 years iPSC derived networks from individual patients will be re-implanted to treat conditions such as Parkinson’s disease, dementia and trauma


List of deliverables.
Use and Dissemination 2 Websites, patent fillings, videos etc. 2020-04-08 09:21:57
Optimal imaging conditions Documents, reports 2020-04-08 09:21:57
Press Releases Websites, patent fillings, videos etc. 2020-04-08 09:21:57
Website Development Websites, patent fillings, videos etc. 2020-04-08 09:21:57
Tools for functional connectivity analysis 1 Documents, reports 2020-04-08 09:21:57
Use and Dissemination 1 Websites, patent fillings, videos etc. 2020-04-08 09:21:57
Physiological chamber Demonstrators, pilots, prototypes 2020-04-08 09:21:57

Take a look to the deliverables list in detail:  detailed list of MESO_BRAIN deliverables.


year authors and title journal last update
List of publications.
2017 Oxana Semyachkina-Glushkovskaya, Jürgen Kurths, Ekaterina Borisova, Sergei Sokolovski, Vanya Mantareva, Ivan Angelov, Alexander Shirokov, Nikita Navolokin, Natalia Shushunova, Alexander Khorovodov, Maria Ulanova, Madina Sagatova, Ilana Agranivich, Olga Sindeeva, Artem Gekalyuk, Anastasiya Bodrova, and Edik Rafailov
Photodynamic opening of blood-brain barrier
published pages: , ISSN: 2156-7085, DOI: 10.1364/boe.8.005040
Biomedical Optics Express 2020-04-08
2019 Carles Calatayud, Giulia Carola, Irene Fernández-Carasa, Marco Valtorta, Senda Jiménez-Delgado, Mònica Díaz, Jordi Soriano-Fradera, Graziella Cappelletti, Javier García-Sancho, Ángel Raya, Antonella Consiglio
CRISPR/Cas9-mediated generation of a tyrosine hydroxylase reporter iPSC line for live imaging and isolation of dopaminergic neurons
published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-019-43080-2
Scientific Reports 9/1 2020-04-08
2017 David Artigas, David Merino, Christoph Polzer, Pablo Loza-Alvarez
Sub-diffraction discrimination with polarization-resolved two-photon excited fluorescence microscopy
published pages: 911, ISSN: 2334-2536, DOI: 10.1364/optica.4.000911
Optica 4/8 2020-04-08
2017 David Merino, Arrate Mallabiabarrena, Jordi Andilla, David Artigas, Timo Zimmermann, Pablo Loza-Alvarez
STED imaging performance estimation by means of Fourier transform analysis
published pages: 2472, ISSN: 2156-7085, DOI: 10.1364/BOE.8.002472
Biomedical Optics Express 8/5 2020-04-08
2017 Gerardo García-Díaz Barriga, Albert Giralt, Marta Anglada-Huguet, Nuria Gaja-Capdevila, Javier G. Orlandi, Jordi Soriano, Josep-Maria Canals, Jordi Alberch
7,8-dihydroxyflavone ameliorates cognitive and motor deficits in a Huntington’s disease mouse model through specific activation of the PLCγ1 pathway
published pages: 3144–3160, ISSN: 0964-6906, DOI: 10.1093/hmg/ddx198
Human Molecular Genetics Vol26, No 16 2020-04-08

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