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MESO_BRAIN SIGNED

Custom architecturally defined 3D stem cell derived functional human neural networks for transformative progress in neuroscience and medicine

Total Cost €

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EC-Contrib. €

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Partnership

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 MESO_BRAIN project word cloud

Explore the words cloud of the MESO_BRAIN project. It provides you a very rough idea of what is the project "MESO_BRAIN" about.

recording    grown    promise    medical    laser    patients    disappointing    stem    signalling    designed    selectively    regeneration    tissue    drug    nano    pursued    neurons    physiologically    developmental    cues    cell    platform    module    dementia    parkinson    vivo    scaffolds    utilise    realistic    human    imaging    mimic    endogenous    envisage    15    issue    date    neuronal    interactions    fabricated    scaffold    functional    printed    display    neural    regenerative    integrating    central    neuroscience    points    brain    cells    sheet    trauma    simultaneous    individual    technological    cellular    differentiate    nor    connectivity    dimensions    receive    confounding    polymerisation    pharmaceutical    reproducible    generate    re    therapies    electrical    biological    nervous    maturation    architecture    networks    function    foundational    interrogate    treat    myriad    stimulation    disease    network    outside    discovery    implanted    era    isolate    femtosecond    dimensional    attempts    cortical    excited    transformed    seeded    types    ipsc    light   

Project "MESO_BRAIN" data sheet

The following table provides information about the project.

Coordinator
ASTON UNIVERSITY 

Organization address
address: ASTON TRIANGLE
city: BIRMINGHAM
postcode: B4 7ET
website: www.aston.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Project website https://www.mesobrain.eu/
 Total cost 3˙225˙891 €
 EC max contribution 3˙225˙890 € (100%)
 Programme 1. H2020-EU.1.2.1. (FET Open)
 Code Call H2020-FETOPEN-2014-2015-RIA
 Funding Scheme RIA
 Starting year 2016
 Duration (year-month-day) from 2016-09-01   to  2020-02-29

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    ASTON UNIVERSITY UK (BIRMINGHAM) coordinator 839˙016.00
2    AXOL BIOSCIENCE LTD UK (CAMBRIDGE) participant 711˙480.00
3    FUNDACIO INSTITUT DE CIENCIES FOTONIQUES ES (Castelldefels) participant 558˙125.00
4    LZH LASERZENTRUM HANNOVER EV DE (HANNOVER) participant 520˙625.00
5    UNIVERSITAT DE BARCELONA ES (BARCELONA) participant 484˙986.00
6    DLM CONSULTANCY SERVICES LTD UK (HUDDERSFIELD) participant 88˙052.00
7    KITE INNOVATION (EUROPE) LIMITED UK (HUDDERSFIELD) participant 23˙605.00

Map

 Project objective

The development of methods to isolate and generate human stem cells along with technology to selectively differentiate them into specific cell and tissue types has excited many with the promise of the ability to study human cell function and utilise them for regeneration in disease and trauma. However, to date, attempts to develop regenerative brain and central nervous system therapies have been disappointing, with the introduced stem cell derived neurons not integrating nor signalling physiologically with endogenous cells. A major confounding issue has been that derived neurons are grown in two dimensions, which does not mimic the in vivo three dimensional interactions nor the myriad developmental cues they would receive in vivo. We will develop functional three dimensional human stem cell derived neural networks of defined and reproducible architecture, based on that of a brain cortical module that will display in vivo connectivity and activity. The networks will be seeded on nano-scale designed femtosecond laser printed scaffolds using novel polymerisation methods that will allow electrical stimulation, simultaneous recording and light sheet imaging during development and at maturation to interrogate network function. Cells will be seeded at and will develop at specific, defined points on the network scaffold, enabling the growth of realistic and reproducible functional neuronal networks. The proposal seeks to provide fabricated reproducible scaffolds that can be produced on a large scale. These concepts are far outside what is currently pursued in the field. The development of such a technological platform will be foundational for a new era of biological and medical research based on human neural networks. Cellular neuroscience research and pharmaceutical drug discovery will be transformed and we envisage that within 15 years iPSC derived networks from individual patients will be re-implanted to treat conditions such as Parkinson’s disease, dementia and trauma

 Deliverables

List of deliverables.
Use and Dissemination 2 Websites, patent fillings, videos etc. 2020-04-08 09:21:57
Optimal imaging conditions Documents, reports 2020-04-08 09:21:57
Press Releases Websites, patent fillings, videos etc. 2020-04-08 09:21:57
Website Development Websites, patent fillings, videos etc. 2020-04-08 09:21:57
Tools for functional connectivity analysis 1 Documents, reports 2020-04-08 09:21:57
Use and Dissemination 1 Websites, patent fillings, videos etc. 2020-04-08 09:21:57
Physiological chamber Demonstrators, pilots, prototypes 2020-04-08 09:21:57

Take a look to the deliverables list in detail:  detailed list of MESO_BRAIN deliverables.

 Publications

year authors and title journal last update
List of publications.
2017 Oxana Semyachkina-Glushkovskaya, Jürgen Kurths, Ekaterina Borisova, Sergei Sokolovski, Vanya Mantareva, Ivan Angelov, Alexander Shirokov, Nikita Navolokin, Natalia Shushunova, Alexander Khorovodov, Maria Ulanova, Madina Sagatova, Ilana Agranivich, Olga Sindeeva, Artem Gekalyuk, Anastasiya Bodrova, and Edik Rafailov
Photodynamic opening of blood-brain barrier
published pages: , ISSN: 2156-7085, DOI: 10.1364/boe.8.005040
Biomedical Optics Express 2020-04-08
2019 Carles Calatayud, Giulia Carola, Irene Fernández-Carasa, Marco Valtorta, Senda Jiménez-Delgado, Mònica Díaz, Jordi Soriano-Fradera, Graziella Cappelletti, Javier García-Sancho, Ángel Raya, Antonella Consiglio
CRISPR/Cas9-mediated generation of a tyrosine hydroxylase reporter iPSC line for live imaging and isolation of dopaminergic neurons
published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-019-43080-2
Scientific Reports 9/1 2020-04-08
2017 David Artigas, David Merino, Christoph Polzer, Pablo Loza-Alvarez
Sub-diffraction discrimination with polarization-resolved two-photon excited fluorescence microscopy
published pages: 911, ISSN: 2334-2536, DOI: 10.1364/optica.4.000911
Optica 4/8 2020-04-08
2017 David Merino, Arrate Mallabiabarrena, Jordi Andilla, David Artigas, Timo Zimmermann, Pablo Loza-Alvarez
STED imaging performance estimation by means of Fourier transform analysis
published pages: 2472, ISSN: 2156-7085, DOI: 10.1364/BOE.8.002472
Biomedical Optics Express 8/5 2020-04-08
2017 Gerardo García-Díaz Barriga, Albert Giralt, Marta Anglada-Huguet, Nuria Gaja-Capdevila, Javier G. Orlandi, Jordi Soriano, Josep-Maria Canals, Jordi Alberch
7,8-dihydroxyflavone ameliorates cognitive and motor deficits in a Huntington’s disease mouse model through specific activation of the PLCγ1 pathway
published pages: 3144–3160, ISSN: 0964-6906, DOI: 10.1093/hmg/ddx198
Human Molecular Genetics Vol26, No 16 2020-04-08

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