Explore the words cloud of the MESO_BRAIN project. It provides you a very rough idea of what is the project "MESO_BRAIN" about.
The following table provides information about the project.
|Coordinator Country||United Kingdom [UK]|
|Total cost||3˙225˙891 €|
|EC max contribution||3˙225˙890 € (100%)|
1. H2020-EU.1.2.1. (FET Open)
|Duration (year-month-day)||from 2016-09-01 to 2020-02-29|
Take a look of project's partnership.
|1||ASTON UNIVERSITY||UK (BIRMINGHAM)||coordinator||839˙016.00|
|2||AXOL BIOSCIENCE LTD||UK (CAMBRIDGE)||participant||711˙480.00|
|3||FUNDACIO INSTITUT DE CIENCIES FOTONIQUES||ES (Castelldefels)||participant||558˙125.00|
|4||LZH LASERZENTRUM HANNOVER EV||DE (HANNOVER)||participant||520˙625.00|
|5||UNIVERSITAT DE BARCELONA||ES (BARCELONA)||participant||484˙986.00|
|6||DLM CONSULTANCY SERVICES LTD||UK (HUDDERSFIELD)||participant||88˙052.00|
|7||KITE INNOVATION (EUROPE) LIMITED||UK (HUDDERSFIELD)||participant||23˙605.00|
The development of methods to isolate and generate human stem cells along with technology to selectively differentiate them into specific cell and tissue types has excited many with the promise of the ability to study human cell function and utilise them for regeneration in disease and trauma. However, to date, attempts to develop regenerative brain and central nervous system therapies have been disappointing, with the introduced stem cell derived neurons not integrating nor signalling physiologically with endogenous cells. A major confounding issue has been that derived neurons are grown in two dimensions, which does not mimic the in vivo three dimensional interactions nor the myriad developmental cues they would receive in vivo. We will develop functional three dimensional human stem cell derived neural networks of defined and reproducible architecture, based on that of a brain cortical module that will display in vivo connectivity and activity. The networks will be seeded on nano-scale designed femtosecond laser printed scaffolds using novel polymerisation methods that will allow electrical stimulation, simultaneous recording and light sheet imaging during development and at maturation to interrogate network function. Cells will be seeded at and will develop at specific, defined points on the network scaffold, enabling the growth of realistic and reproducible functional neuronal networks. The proposal seeks to provide fabricated reproducible scaffolds that can be produced on a large scale. These concepts are far outside what is currently pursued in the field. The development of such a technological platform will be foundational for a new era of biological and medical research based on human neural networks. Cellular neuroscience research and pharmaceutical drug discovery will be transformed and we envisage that within 15 years iPSC derived networks from individual patients will be re-implanted to treat conditions such as Parkinson’s disease, dementia and trauma
|Use and Dissemination 2||Websites, patent fillings, videos etc.||2020-04-08 09:21:57|
|Optimal imaging conditions||Documents, reports||2020-04-08 09:21:57|
|Press Releases||Websites, patent fillings, videos etc.||2020-04-08 09:21:57|
|Website Development||Websites, patent fillings, videos etc.||2020-04-08 09:21:57|
|Tools for functional connectivity analysis 1||Documents, reports||2020-04-08 09:21:57|
|Use and Dissemination 1||Websites, patent fillings, videos etc.||2020-04-08 09:21:57|
|Physiological chamber||Demonstrators, pilots, prototypes||2020-04-08 09:21:57|
Take a look to the deliverables list in detail: detailed list of MESO_BRAIN deliverables.
|year||authors and title||journal||last update|
Oxana Semyachkina-Glushkovskaya, JÃ¼rgen Kurths, Ekaterina Borisova, Sergei Sokolovski, Vanya Mantareva, Ivan Angelov, Alexander Shirokov, Nikita Navolokin, Natalia Shushunova, Alexander Khorovodov, Maria Ulanova, Madina Sagatova, Ilana Agranivich, Olga Sindeeva, Artem Gekalyuk, Anastasiya Bodrova, and Edik Rafailov
Photodynamic opening of blood-brain barrier
published pages: , ISSN: 2156-7085, DOI: 10.1364/boe.8.005040
|Biomedical Optics Express||2020-04-08|
Carles Calatayud, Giulia Carola, Irene FernÃ¡ndez-Carasa, Marco Valtorta, Senda JimÃ©nez-Delgado, MÃ²nica DÃaz, Jordi Soriano-Fradera, Graziella Cappelletti, Javier GarcÃa-Sancho, Ãngel Raya, Antonella Consiglio
CRISPR/Cas9-mediated generation of a tyrosine hydroxylase reporter iPSC line for live imaging and isolation of dopaminergic neurons
published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-019-43080-2
|Scientific Reports 9/1||2020-04-08|
David Artigas, David Merino, Christoph Polzer, Pablo Loza-Alvarez
Sub-diffraction discrimination with polarization-resolved two-photon excited fluorescence microscopy
published pages: 911, ISSN: 2334-2536, DOI: 10.1364/optica.4.000911
David Merino, Arrate Mallabiabarrena, Jordi Andilla, David Artigas, Timo Zimmermann, Pablo Loza-Alvarez
STED imaging performance estimation by means of Fourier transform analysis
published pages: 2472, ISSN: 2156-7085, DOI: 10.1364/BOE.8.002472
|Biomedical Optics Express 8/5||2020-04-08|
Gerardo GarcÃa-DÃaz Barriga, Albert Giralt, Marta Anglada-Huguet, Nuria Gaja-Capdevila, Javier G. Orlandi, Jordi Soriano, Josep-Maria Canals, Jordi Alberch
7,8-dihydroxyflavone ameliorates cognitive and motor deficits in a Huntingtonâ€™s disease mouse model through specific activation of the PLCÎ³1 pathway
published pages: 3144â€“3160, ISSN: 0964-6906, DOI: 10.1093/hmg/ddx198
|Human Molecular Genetics Vol26, No 16||2020-04-08|
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