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CANDICE SIGNED

CEREBRAL ASYMMETRY: NEW DIRECTIONS IN CORRELATES AND ETIOLOGY

Total Cost €

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EC-Contrib. €

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Partnership

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 CANDICE project word cloud

Explore the words cloud of the CANDICE project. It provides you a very rough idea of what is the project "CANDICE" about.

organisation    dose    network    cerebral    lateralisation    fmri    similarity    leap    patterns    data    maintains    opposite    misph    neuropsychological    arise    chromosome    neurexin    nous    sex    egrave    individual    optimal    consistent    parlons    quintessentially    twin    hit    eacute    predicts    model    human    flow    simulations    bias    rearrangements    predictions    magnetic    blood    brain    circuit    reconciled    argue    functions    genetic    re    broca    people    combining    viz    additional    laterality    mutations    hypothesis    asymmetry    represented    impaired    impairment    150    transcranial    literature    tested    gauche    inconsistent    literacy    doppler    caused    left    double    differences    extra    avec    individuals    neurodevelopmental    dissociation    look    prediction    structural    combine    imaging    cotwin    ftcd    ultrasound    hemispheres    seminal    risk    language    departure    rare    models    hemisphere    behavioural    deficits    depends    efficiency    statement    functional    neuroligin    contradictory    abnormalities    resonance   

Project "CANDICE" data sheet

The following table provides information about the project.

Coordinator
THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD 

Organization address
address: WELLINGTON SQUARE UNIVERSITY OFFICES
city: OXFORD
postcode: OX1 2JD
website: www.ox.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Project website https://www.psy.ox.ac.uk/research/oxford-study-of-children-s-communication-impairments
 Total cost 2˙497˙907 €
 EC max contribution 2˙497˙907 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2015-AdG
 Funding Scheme ERC-ADG
 Starting year 2016
 Duration (year-month-day) from 2016-10-01   to  2021-09-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD UK (OXFORD) coordinator 2˙497˙907.00

Map

 Project objective

'150 years after Broca's seminal statement 'Nous parlons avec l'hémisphère gauche' we still do not know how or why we have this bias. I propose that by studying cases of impaired language development and combining genetic and neuropsychological approaches we will be able to make a leap forward in our understanding of the quintessentially human characteristic of functional cerebral asymmetry. I argue that contradictory findings in the literature may be reconciled if we adopt a novel approach to cerebral asymmetry. In particular, I propose a network efficiency hypothesis which maintains that optimal development depends on organisation of key language functions within the same cerebral hemisphere.

In project A, I will combine behavioural measures with functional transcranial Doppler ultrasound (fTCD) measures of blood flow and functional magnetic resonance imaging (fMRI) to identify individual differences in patterns of dissociation between language functions in lateralisation. In project B I will test the prediction that risk for language and literacy impairment is increased if different language functions are represented in opposite hemispheres. For project C, simulations of predictions from genetic models will be tested using data on twin-cotwin similarity in language lateralisation. Project D will test a 'double hit' genetic model that predicts that neurodevelopmental abnormalities, including language deficits and inconsistent asymmetry, arise when there is more than one hit on a functional brain circuit. For this study we will use an existing sample of individuals already known to have one 'hit' on the neuroligin-neurexin circuit, viz people with an additional dose of neuroligin caused by an extra sex chromosome. Project E will focus on individuals with inconsistent patterns of language laterality and will look for rare genetic mutations and structural rearrangements associated with a departure from consistent left hemisphere language.'

 Publications

year authors and title journal last update
List of publications.
2017 Abigail R. Bradshaw, Dorothy V.M. Bishop, Zoe V.J. Woodhead
Methodological considerations in assessment of language lateralisation with fMRI: a systematic review
published pages: e3557, ISSN: 2167-8359, DOI: 10.7717/peerj.3557
PeerJ 5 2019-06-13
2018 Dianne F. Newbury, Nuala H. Simpson, Paul A. Thompson, Dorothy V. M. Bishop
Stage 1 Registered Report: Variation in neurodevelopmental outcomes in children with sex chromosome trisomies: protocol for a test of the double hit hypothesis
published pages: 10, ISSN: 2398-502X, DOI: 10.12688/wellcomeopenres.13828.1
Wellcome Open Research 3 2019-06-13
2017 Abigail R. Bradshaw, Paul A. Thompson, Alexander C. Wilson, Dorothy V.M. Bishop, Zoe V.J. Woodhead
Measuring language lateralisation with different language tasks: a systematic review
published pages: e3929, ISSN: 2167-8359, DOI: 10.7717/peerj.3929
PeerJ 5 2019-06-13
2018 Alexander C. Wilson, Dorothy V.M. Bishop
Resounding failure to replicate links between developmental language disorder and cerebral lateralisation
published pages: e4217, ISSN: 2167-8359, DOI: 10.7717/peerj.4217
PeerJ 6 2019-06-13
2018 Zoe V.J. Woodhead, Holly A. Rutherford, Dorothy V.M. Bishop
Measurement of language laterality using functional transcranial Doppler ultrasound: a comparison of different tasks
published pages: 104, ISSN: 2398-502X, DOI: 10.12688/wellcomeopenres.14720.2
Wellcome Open Research 3 2019-05-27
2019 Alexander C. Wilson, Dorothy V.M. Bishop
\"\"\"If you catch my drift...\"\": ability to infer implied meaning is distinct from vocabulary and grammar skills\"
published pages: 68, ISSN: 2398-502X, DOI: 10.12688/wellcomeopenres.15210.1
Wellcome Open Research 4 2019-05-27
2018 Alexander C Wilson, Dorothy V M Bishop
Sex chromosome trisomies are not associated with atypical lateralization for language
published pages: 1132-1139, ISSN: 0012-1622, DOI: 10.1111/dmcn.13929
Developmental Medicine & Child Neurology 60/11 2019-05-27
2019 Z. V. J. Woodhead, A. R. Bradshaw, A. C. Wilson, P. A. Thompson, D. V. M. Bishop
Testing the unitary theory of language lateralization using functional transcranial Doppler sonography in adults
published pages: 181801, ISSN: 2054-5703, DOI: 10.1098/rsos.181801
Royal Society Open Science 6/3 2019-05-27
2019 Alexander C. Wilson, Judith King, Dorothy V.M. Bishop
Autism and social anxiety in children with sex chromosome trisomies: an observational study
published pages: 32, ISSN: 2398-502X, DOI: 10.12688/wellcomeopenres.15095.1
Wellcome Open Research 4 2019-05-27

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