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CANDICE SIGNED

CEREBRAL ASYMMETRY: NEW DIRECTIONS IN CORRELATES AND ETIOLOGY

Total Cost €

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EC-Contrib. €

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Partnership

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 CANDICE project word cloud

Explore the words cloud of the CANDICE project. It provides you a very rough idea of what is the project "CANDICE" about.

mutations    language    optimal    imaging    hypothesis    misph    leap    functional    prediction    rare    similarity    seminal    individuals    differences    impaired    laterality    models    individual    consistent    broca    deficits    magnetic    cotwin    doppler    eacute    look    simulations    hemisphere    argue    tested    represented    neurodevelopmental    bias    reconciled    cerebral    literacy    functions    twin    asymmetry    extra    inconsistent    network    fmri    organisation    ultrasound    additional    efficiency    behavioural    left    predictions    data    abnormalities    neuroligin    neurexin    viz    sex    structural    hemispheres    impairment    brain    statement    hit    caused    transcranial    gauche    quintessentially    predicts    genetic    arise    re    nous    flow    parlons    maintains    ftcd    departure    depends    dose    avec    dissociation    human    opposite    neuropsychological    combine    lateralisation    rearrangements    blood    literature    chromosome    combining    egrave    150    circuit    resonance    contradictory    people    model    patterns    double    risk   

Project "CANDICE" data sheet

The following table provides information about the project.

Coordinator
THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD 

Organization address
address: WELLINGTON SQUARE UNIVERSITY OFFICES
city: OXFORD
postcode: OX1 2JD
website: www.ox.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Project website https://www.psy.ox.ac.uk/research/oxford-study-of-children-s-communication-impairments
 Total cost 2˙497˙907 €
 EC max contribution 2˙497˙907 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2015-AdG
 Funding Scheme ERC-ADG
 Starting year 2016
 Duration (year-month-day) from 2016-10-01   to  2021-09-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD UK (OXFORD) coordinator 2˙497˙907.00

Map

 Project objective

'150 years after Broca's seminal statement 'Nous parlons avec l'hémisphère gauche' we still do not know how or why we have this bias. I propose that by studying cases of impaired language development and combining genetic and neuropsychological approaches we will be able to make a leap forward in our understanding of the quintessentially human characteristic of functional cerebral asymmetry. I argue that contradictory findings in the literature may be reconciled if we adopt a novel approach to cerebral asymmetry. In particular, I propose a network efficiency hypothesis which maintains that optimal development depends on organisation of key language functions within the same cerebral hemisphere.

In project A, I will combine behavioural measures with functional transcranial Doppler ultrasound (fTCD) measures of blood flow and functional magnetic resonance imaging (fMRI) to identify individual differences in patterns of dissociation between language functions in lateralisation. In project B I will test the prediction that risk for language and literacy impairment is increased if different language functions are represented in opposite hemispheres. For project C, simulations of predictions from genetic models will be tested using data on twin-cotwin similarity in language lateralisation. Project D will test a 'double hit' genetic model that predicts that neurodevelopmental abnormalities, including language deficits and inconsistent asymmetry, arise when there is more than one hit on a functional brain circuit. For this study we will use an existing sample of individuals already known to have one 'hit' on the neuroligin-neurexin circuit, viz people with an additional dose of neuroligin caused by an extra sex chromosome. Project E will focus on individuals with inconsistent patterns of language laterality and will look for rare genetic mutations and structural rearrangements associated with a departure from consistent left hemisphere language.'

 Publications

year authors and title journal last update
List of publications.
2017 Abigail R. Bradshaw, Dorothy V.M. Bishop, Zoe V.J. Woodhead
Methodological considerations in assessment of language lateralisation with fMRI: a systematic review
published pages: e3557, ISSN: 2167-8359, DOI: 10.7717/peerj.3557
PeerJ 5 2019-06-13
2018 Dianne F. Newbury, Nuala H. Simpson, Paul A. Thompson, Dorothy V. M. Bishop
Stage 1 Registered Report: Variation in neurodevelopmental outcomes in children with sex chromosome trisomies: protocol for a test of the double hit hypothesis
published pages: 10, ISSN: 2398-502X, DOI: 10.12688/wellcomeopenres.13828.1
Wellcome Open Research 3 2019-06-13
2017 Abigail R. Bradshaw, Paul A. Thompson, Alexander C. Wilson, Dorothy V.M. Bishop, Zoe V.J. Woodhead
Measuring language lateralisation with different language tasks: a systematic review
published pages: e3929, ISSN: 2167-8359, DOI: 10.7717/peerj.3929
PeerJ 5 2019-06-13
2018 Alexander C. Wilson, Dorothy V.M. Bishop
Resounding failure to replicate links between developmental language disorder and cerebral lateralisation
published pages: e4217, ISSN: 2167-8359, DOI: 10.7717/peerj.4217
PeerJ 6 2019-06-13
2018 Zoe V.J. Woodhead, Holly A. Rutherford, Dorothy V.M. Bishop
Measurement of language laterality using functional transcranial Doppler ultrasound: a comparison of different tasks
published pages: 104, ISSN: 2398-502X, DOI: 10.12688/wellcomeopenres.14720.2
Wellcome Open Research 3 2019-05-27
2019 Alexander C. Wilson, Dorothy V.M. Bishop
\"\"\"If you catch my drift...\"\": ability to infer implied meaning is distinct from vocabulary and grammar skills\"
published pages: 68, ISSN: 2398-502X, DOI: 10.12688/wellcomeopenres.15210.1
Wellcome Open Research 4 2019-05-27
2018 Alexander C Wilson, Dorothy V M Bishop
Sex chromosome trisomies are not associated with atypical lateralization for language
published pages: 1132-1139, ISSN: 0012-1622, DOI: 10.1111/dmcn.13929
Developmental Medicine & Child Neurology 60/11 2019-05-27
2019 Z. V. J. Woodhead, A. R. Bradshaw, A. C. Wilson, P. A. Thompson, D. V. M. Bishop
Testing the unitary theory of language lateralization using functional transcranial Doppler sonography in adults
published pages: 181801, ISSN: 2054-5703, DOI: 10.1098/rsos.181801
Royal Society Open Science 6/3 2019-05-27
2019 Alexander C. Wilson, Judith King, Dorothy V.M. Bishop
Autism and social anxiety in children with sex chromosome trisomies: an observational study
published pages: 32, ISSN: 2398-502X, DOI: 10.12688/wellcomeopenres.15095.1
Wellcome Open Research 4 2019-05-27

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