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STRATIFY SIGNED

Brain network based stratification of mental illness

Total Cost €

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EC-Contrib. €

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Partnership

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 STRATIFY project word cloud

Explore the words cloud of the STRATIFY project. It provides you a very rough idea of what is the project "STRATIFY" about.

pharmaceutical    neurobehaviourally    adulthood    300    establishment    cohort    burden    genomic    brain    diagnostic    applicable    links    configurations    paradigmatic    genomics    longitudinal    comorbidity    quantifiable    trials    optimize    adhd    clusters    meta    precision    innovative    reduce    informed    subtypes    individuals    artifical    gt    imaging    stratification    neurobehavioural    learning    neural    fundamental    phenotyping    characterising    imagen    population    cognitive    machine    neurobiological    discriminative    intelligence    validated    examples    period    serve    disease    modalities    900    disorder    network    function    adolescence    markers    identification    alcohol    framework    behaviours    neuroimaging    correspond    emotional    carry    disorders    patients    ing    mental    components    spanning    predict    prevalent    generate    functional    targetted    classification    predictors    psychopathology    diagnoses    structure    clinical    depression    deep    data    structural    intervention    interventions    endpoints    2000    controls    environmental    formidable   

Project "STRATIFY" data sheet

The following table provides information about the project.

Coordinator
KING'S COLLEGE LONDON 

Organization address
address: STRAND
city: LONDON
postcode: WC2R 2LS
website: www.kcl.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Project website https://imagen-europe.com/
 Total cost 3˙394˙214 €
 EC max contribution 3˙394˙214 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2015-AdG
 Funding Scheme ERC-ADG
 Starting year 2016
 Duration (year-month-day) from 2016-10-01   to  2021-09-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    KING'S COLLEGE LONDON UK (LONDON) coordinator 2˙352˙066.00
2    UNIVERSITY OF SOUTHAMPTON UK (SOUTHAMPTON) participant 354˙385.00
3    THE UNIVERSITY OF NOTTINGHAM UK (NOTTINGHAM) participant 314˙162.00
4    CHARITE - UNIVERSITAETSMEDIZIN BERLIN DE (BERLIN) participant 191˙000.00
5    THE PROVOST, FELLOWS, FOUNDATION SCHOLARS & THE OTHER MEMBERS OF BOARD OF THE COLLEGE OF THE HOLY & UNDIVIDED TRINITY OF QUEEN ELIZABETH NEAR DUBLIN IE (DUBLIN) participant 182˙601.00

Map

 Project objective

To reduce the burden of mental disorders it is a formidable aim to identify widely applicable disease markers based on neural processes, which predict psychopathology and allow for targeted interventions. We will generate a neurobehavioural framework for stratification of psychopathology by characterising links between network properties of brain function and structure and reinforcement–related behaviours, which are fundamental components of some of the most prevalent mental disorders, major depression, alcohol use disorder and ADHD. We will assess if network configurations define subtypes within and if they correspond to comorbidity across these diagnoses. We will identify discriminative data modalities and characterize predictors of future psychopathology. To identify specific neurobehavioural clusters we will carry out precision phenotyping of 900 patients with major depression, ADHD and alcohol use disorders and 300 controls, which we will investigate with innovative deep machine learning methods derived from artifical intelligence research. Development of these methods will optimize exploitation of a wide range of assessment modalities, including functional and structural neuroimaging, cognitive, emotional as well as environmental measures. The neurobehavioural clusters resulting from this analysis will be validated in a longitudinal population-based imaging genomics cohort, the IMAGEN sample of over 2000 participants spanning the period from adolescence to adulthood and integrated with information generated from genomic and imaging-genomic meta-analyses of >300.000 individuals. By targeting specific neural processes the resulting stratification markers will serve as paradigmatic examples for a diagnostic classification, which is based upon quantifiable neurobiological measures, thus enabling targetted early intervention, identification of novel pharmaceutical targets and the establishment of neurobehaviourally informed endpoints for clinical trials.

 Publications

year authors and title journal last update
List of publications.
2019 Hongtao Ruan, Yunyi Zhou, Qiang Luo, Gabriel H. Robert, Sylvane Desrivières, Erin Burke Quinlan, ZhaoWen Liu, Tobias Banaschewski, Arun L.W. Bokde, Uli Bromberg, Christian Büchel, Herta Flor, Vincent Frouin, Hugh Garavan, Penny Gowland, Andreas Heinz, Bernd Ittermann, Jean-Luc Martinot, Marie-Laure Paillère Martinot, Frauke Nees, Dimitri Papadopoulos Orfanos, Luise Poustka, Sarah Hohmann, Julia
Adolescent binge drinking disrupts normal trajectories of brain functional organization and personality maturation
published pages: 101804, ISSN: 2213-1582, DOI: 10.1016/j.nicl.2019.101804
NeuroImage: Clinical 22 2020-04-08
2018 Christine Macare, Francesca Ducci, Yuning Zhang, Barbara Ruggeri, Tianye Jia, Marika Kaakinen, Gursharan Kalsi, Pimphen Charoen, Filippo Casoni, Jan Peters, Uli Bromberg, Matthew Hill, Jessica Buxton, Alexandra Blakemore, Juha Veijola, Christian Büchel, Tobias Banaschewski, Arun L.W. Bokde, Patricia Conrod, Herta Flor, Vincent Frouin, Jürgen Gallinat, Hugh Garavan, Penny A. Gowland, Andreas Hein
A neurobiological pathway to smoking in adolescence: TTC12-ANKK1-DRD2 variants and reward response
published pages: 1103-1114, ISSN: 0924-977X, DOI: 10.1016/j.euroneuro.2018.07.101
European Neuropsychopharmacology 28/10 2020-04-08
2019 Philip A. Spechler, Bader Chaarani, Catherine Orr, Scott Mackey, Stephen T. Higgins, Tobias Banaschewski, Arun L.W. Bokde, Uli Bromberg, Christian Büchel, Erin Burke Quinlan, Patricia J. Conrod, Sylvane Desrivières, Herta Flor, Vincent Frouin, Penny Gowland, Andreas Heinz, Bernd Ittermann, Jean-Luc Martinot, Frauke Nees, Dimitri Papadopoulos Orfanos, Luise Poustka, Juliane H. Fröhner, Michael N
Neuroimaging Evidence for Right Orbitofrontal Cortex Differences in Adolescents With Emotional and Behavioral Dysregulation
published pages: , ISSN: 0890-8567, DOI: 10.1016/j.jaac.2019.01.021
Journal of the American Academy of Child & Adolescent Psychiatry 2020-04-08
2019 Edward D Barker, Alex Ing, Francesca Biondo, Tianye Jia, Jean-Baptiste Pingault, Ebba Du Rietz, Yuning Zhang, Barbara Ruggeri, Tobias Banaschewski, Sarah Hohmann, Arun L. W Bokde, Uli Bromberg, Christian Büchel, Erin Burke Quinlan, Edmund Sounga-Barke, April B. Bowling, Sylvane Desrivières, Herta Flor, Vincent Frouin, Hugh Garavan, Philip Asherson, Penny Gowland, Andreas Heinz, Bernd Ittermann,
Do ADHD-impulsivity and BMI have shared polygenic and neural correlates?
published pages: , ISSN: 1359-4184, DOI: 10.1038/s41380-019-0444-y
Molecular Psychiatry 2020-04-08
2018 Evangelos Papanastasiou, Elias Mouchlianitis, Dan W. Joyce, Philip McGuire, Tobias Banaschewski, Arun L. W. Bokde, Uli Bromberg, Christian Büchel, Erin Burke Quinlan, Sylvane Desrivières, Herta Flor, Vincent Frouin, Hugh Garavan, Philip Spechler, Penny Gowland, Andreas Heinz, Bernd Ittermann, Jean-Luc Martinot, Marie-Laure Paillère Martinot, Eric Artiges, Frauke Nees, Dimitri Papadopoulos Orfan
Examination of the Neural Basis of Psychoticlike Experiences in Adolescence During Reward Processing
published pages: 1043, ISSN: 2168-622X, DOI: 10.1001/jamapsychiatry.2018.1973
JAMA Psychiatry 75/10 2020-04-08
2019 Savani Bartholdy, Owen G. O’Daly, Iain C. Campbell, Tobias Banaschewski, Gareth Barker, Arun L.W. Bokde, Uli Bromberg, Christian Büchel, Erin Burke Quinlan, Sylvane Desrivières, Herta Flor, Vincent Frouin, Hugh Garavan, Penny Gowland, Andreas Heinz, Bernd Ittermann, Jean-Luc Martinot, Marie-Laure Paillère Martinot, Frauke Nees, Dimitri Papadopoulos Orfanos, Luise Poustka, Sarah Hohmann, Julia
Neural Correlates of Failed Inhibitory Control as an Early Marker of Disordered Eating in Adolescents
published pages: 956-965, ISSN: 0006-3223, DOI: 10.1016/j.biopsych.2019.01.027
Biological Psychiatry 85/11 2020-04-08
2019 Matthew D. Albaugh, James. J. Hudziak, Alex Ing, Bader Chaarani, Edward Barker, Tianye Jia, Herve Lemaitre, Richard Watts, Catherine Orr, Philip A. Spechler, Claude Lepage, Vladimir Fonov, Louis Collins, Pierre Rioux, Alan C. Evans, Tobias Banaschewski, Arun L. W. Bokde, Uli Bromberg, Christian Büchel, Erin Burke Quinlan, Sylvane Desrivières, Herta Flor, Vincent Frouin, Penny Gowland, Andreas He
White matter microstructure is associated with hyperactive/inattentive symptomatology and polygenic risk for attention-deficit/hyperactivity disorder in a population-based sample of adolescents
published pages: , ISSN: 0893-133X, DOI: 10.1038/s41386-019-0383-y
Neuropsychopharmacology 2020-04-08
2019 Monique Ernst, Brenda Benson, Eric Artiges, Adam X. Gorka, Herve Lemaitre, Tiffany Lago, Ruben Miranda, Tobias Banaschewski, Arun L. W. Bokde, Uli Bromberg, Rüdiger Brühl, Christian Büchel, Anna Cattrell, Patricia Conrod, Sylvane Desrivières, Tahmine Fadai, Herta Flor, Antoine Grigis, Juergen Gallinat, Hugh Garavan, Penny Gowland, Yvonne Grimmer, Andreas Heinz, Viola Kappel, Frauke Nees, Dimit
Pubertal maturation and sex effects on the default-mode network connectivity implicated in mood dysregulation
published pages: , ISSN: 2158-3188, DOI: 10.1038/s41398-019-0433-6
Translational Psychiatry 9/1 2020-04-08
2019 Wei Cheng, Edmund T Rolls, Trevor W Robbins, Weikang Gong, Zhaowen Liu, Wujun Lv, Jingnan Du, Hongkai Wen, Liang Ma, Erin Burke Quinlan, Hugh Garavan, Eric Artiges, Dimitri Papadopoulos Orfanos, Michael N Smolka, Gunter Schumann, Keith Kendrick, Jianfeng Feng
Decreased brain connectivity in smoking contrasts with increased connectivity in drinking
published pages: , ISSN: 2050-084X, DOI: 10.7554/elife.40765
eLife 8 2020-04-08
2018 Frida Bayard, Charlotte Nymberg Thunell, Christoph Abé, Rita Almeida, Tobias Banaschewski, Gareth Barker, Arun L. W. Bokde, Uli Bromberg, Christian Büchel, Erin Burke Quinlan, Sylvane Desrivières, Herta Flor, Vincent Frouin, Hugh Garavan, Penny Gowland, Andreas Heinz, Bernd Ittermann, Jean-Luc Martinot, Marie-Laure Paillère Martinot, Frauke Nees, Dimitri Papadopoulos Orfanos, Tomáš Paus, Lui
Distinct brain structure and behavior related to ADHD and conduct disorder traits
published pages: , ISSN: 1359-4184, DOI: 10.1038/s41380-018-0202-6
Molecular Psychiatry 2020-04-08
2017 Sarah J. Brislin, Christopher J. Patrick, Herta Flor, Frauke Nees, Angela Heinrich, Laura E. Drislane, James R. Yancey, Tobias Banaschewski, Arun L. W. Bokde, Uli Bromberg, Christian Büchel, Erin Burke Quinlan, Sylvane Desrivières, Vincent Frouin, Hugh Garavan, Penny Gowland, Andreas Heinz, Bernd Ittermann, Jean-Luc Martinot, Marie-Laure Paillère Martinot, Dimitri Papadopoulos Orfanos, Luise Po
Extending the Construct Network of Trait Disinhibition to the Neuroimaging Domain: Validation of a Bridging Scale for Use in the European IMAGEN Project
published pages: 567-581, ISSN: 1073-1911, DOI: 10.1177/1073191118759748
Assessment 26/4 2020-04-08
2018 Sambu Seo, Anne Beck, Caroline Matthis, Alexander Genauck, Tobias Banaschewski, Arun L.W. Bokde, Uli Bromberg, Christian Büchel, Erin Burke Quinlan, Herta Flor, Vincent Frouin, Hugh Garavan, Penny Gowland, Bernd Ittermann, Jean‐Luc Martinot, Marie‐Laure Paillère Martinot, Frauke Nees, Dimitri Papadopoulos Orfanos, Luise Poustka, Sarah Hohmann, Juliane H. Fröhner, Michael N. Smolka, Henrik W
Risk profiles for heavy drinking in adolescence: differential effects of gender
published pages: 787-801, ISSN: 1355-6215, DOI: 10.1111/adb.12636
Addiction Biology 24/4 2020-04-08
2018 Erin Burke Quinlan, Edward D. Barker, Qiang Luo, Tobias Banaschewski, Arun L. W. Bokde, Uli Bromberg, Christian Büchel, Sylvane Desrivières, Herta Flor, Vincent Frouin, Hugh Garavan, Bader Chaarani, Penny Gowland, Andreas Heinz, Rüdiger Brühl, Jean-Luc Martinot, Marie-Laure Paillère Martinot, Frauke Nees, Dimitri Papadopoulos Orfanos, Tomáš Paus, Luise Poustka, Sarah Hohmann, Michael N. Smo
Peer victimization and its impact on adolescent brain development and psychopathology
published pages: , ISSN: 1359-4184, DOI: 10.1038/s41380-018-0297-9
Molecular Psychiatry 2020-04-08
2018 Zhipeng Cao, Marc Bennett, Catherine Orr, Ilknur Icke, Tobias Banaschewski, Gareth J. Barker, Arun L. W. Bokde, Uli Bromberg, Christian Büchel, Erin Burke Quinlan, Sylvane Desrivières, Herta Flor, Vincent Frouin, Hugh Garavan, Penny Gowland, Andreas Heinz, Bernd Ittermann, Jean‐Luc Martinot, Frauke Nees, Dimitri Papadopoulos Orfanos, Tomáš Paus, Luise Poustka, Sarah Hohmann, Juliane H. Fröh
Mapping adolescent reward anticipation, receipt, and prediction error during the monetary incentive delay task
published pages: 262-283, ISSN: 1065-9471, DOI: 10.1002/hbm.24370
Human Brain Mapping 40/1 2020-04-08
2019 Nicole Tay, Christine Macare, Yun Liu, Barbara Ruggeri, Tianye Jia, Congying Chu, Francesca Biondo, Alex Ing, Qiang Luo, Daniil Sarkysian, Tobias Banaschewski, Gareth J. Barker, Arun L.W. Bokde, Uli Bromberg, Christian Büchel, Erin Burke Quinlan, Sylvane Desrivières, Herta Flor, Vincent Frouin, Hugh Garavan, Penny Gowland, Andreas Heinz, Bernd Ittermann, Jean-Luc Martinot, Eric Artiges, Frauke N
Allele-Specific Methylation of SPDEF : A Novel Moderator of Psychosocial Stress and Substance Abuse
published pages: 146-155, ISSN: 0002-953X, DOI: 10.1176/appi.ajp.2018.17121360
American Journal of Psychiatry 176/2 2020-04-08
2018 Eva Velthorst, Sean Froudist-Walsh, Eli Stahl, Douglas Ruderfer, Ilyan Ivanov, Joseph Buxbaum, Tobias Banaschewski, Arun L. W. Bokde, Uli Bromberg Dipl-Psych, Christian Büchel, Erin Burke Quinlan, Sylvane Desrivières, Herta Flor, Vincent Frouin, Hugh Garavan, Penny Gowland, Andreas Heinz, Bernd Ittermann, Marie-Laure Paillère Martinot, Eric Artiges, Frauke Nees, Dimitri Papadopoulos Orfanos, To
Genetic risk for schizophrenia and autism, social impairment and developmental pathways to psychosis
published pages: , ISSN: 2158-3188, DOI: 10.1038/s41398-018-0229-0
Translational Psychiatry 8/1 2020-04-08
2019 Matthew D. Albaugh, James. J. Hudziak, Catherine Orr, Philip A. Spechler, Bader Chaarani, Scott Mackey, Claude Lepage, Vladimir Fonov, Pierre Rioux, Alan C. Evans, Tobias Banaschewski, Arun L. W. Bokde, Uli Bromberg, Christian Büchel, Erin Burke Quinlan, Sylvane Desrivières, Herta Flor, Antoine Grigis, Penny Gowland, Andreas Heinz, Bernd Ittermann, Jean-Luc Martinot, Marie-Laure Paillère Martin
Amygdalar reactivity is associated with prefrontal cortical thickness in a large population-based sample of adolescents
published pages: e0216152, ISSN: 1932-6203, DOI: 10.1371/journal.pone.0216152
PLOS ONE 14/5 2020-04-08
2017 Josiane Bourque, Philip A. Spechler, Stéphane Potvin, Robert Whelan, Tobias Banaschewski, Arun L.W. Bokde, Uli Bromberg, Christian Büchel, Erin Burke Quinlan, Sylvane Desrivières, Herta Flor, Vincent Frouin, Penny Gowland, Andreas Heinz, Bernd Ittermann, Jean-Luc Martinot, Marie-Laure Paillère-Martinot, Sarah C. McEwen, Frauke Nees, Dimitri Papadopoulos Orfanos, Tomáš Paus, Luise Poustka, Mi
Functional Neuroimaging Predictors of Self-Reported Psychotic Symptoms in Adolescents
published pages: 566-575, ISSN: 0002-953X, DOI: 10.1176/appi.ajp.2017.16080897
American Journal of Psychiatry 174/6 2020-04-08
2017 D A Gonzalez, T Jia, J H Pinzón, S F Acevedo, S A Ojelade, B Xu, N Tay, S Desrivières, J L Hernandez, T Banaschewski, C Büchel, A L W Bokde, P J Conrod, H Flor, V Frouin, J Gallinat, H Garavan, P A Gowland, A Heinz, B Ittermann, M Lathrop, J-L Martinot, T Paus, M N Smolka, A R Rodan, G Schumann, A Rothenfluh
The Arf6 activator Efa6/PSD3 confers regional specificity and modulates ethanol consumption in Drosophila and humans
published pages: 621-628, ISSN: 1359-4184, DOI: 10.1038/mp.2017.112
Molecular Psychiatry 23/3 2020-04-08
2017 Erin Burke Quinlan, Anna Cattrell, Tianye Jia, Eric Artiges, Tobias Banaschewski, Gareth Barker, Arun L.W. Bokde, Uli Bromberg, Christian Büchel, Rüdiger Brühl, Patricia J. Conrod, Sylvane Desrivieres, Herta Flor, Vincent Frouin, Jürgen Gallinat, Hugh Garavan, Penny Gowland, Andreas Heinz, Jean-Luc Martinot, Marie-Laure Paillère Martinot, Frauke Nees, Dimitri Papadopoulos-Orfanos, Tomáš Paus, Luise Poustka, Michael N. Smolka, Nora C. Vetter, Henrik Walter, Robert Whelan, Jeffrey C. Glennon, Jan K. Buitelaar, Francesca Happé, Eva Loth, Edward D. Barker, Gunter Schumann
Psychosocial Stress and Brain Function in Adolescent Psychopathology
published pages: 785-794, ISSN: 0002-953X, DOI: 10.1176/appi.ajp.2017.16040464
American Journal of Psychiatry 174/8 2020-04-08
2018 Nicholas D\'Alberto, Bader Chaarani, Catherine A. Orr, Philip A. Spechler, Matthew D. Albaugh, Nicholas Allgaier, Alexander Wonnell, Tobias Banaschewski, Arun L.W. Bokde, Uli Bromberg, Christian Büchel, Erin Burke Quinlan, Patricia J. Conrod, Sylvane Desrivières, Herta Flor, Juliane H. Fröhner, Vincent Frouin, Penny Gowland, Andreas Heinz, Bernd Itterman, Jean-Luc Martinot, Marie-Laure Paillère Martinot, Eric Artiges, Frauke Nees, Dimitri Papadopoulos Orfanos, Luise Poustka, Trevor W. Robbins, Michael N. Smolka, Henrik Walter, Robert Whelan, Gunter Schumann, Alexandra S. Potter, Hugh Garavan
Individual differences in stop-related activity are inflated by the adaptive algorithm in the stop signal task
published pages: , ISSN: 1065-9471, DOI: 10.1002/hbm.24075
Human Brain Mapping 2020-04-08
2018 F. Nemmi, C. Nymberg, F. Darki, T. Banaschewski, A.L.W. Bokde, C. Büchel, H. Flor, V. Frouin, H. Garavan, P. Gowland, A. Heinz, J.-L. Martinot, F. Nees, T. Paus, M.N. Smolka, T.W. Robbins, G. Schumann, T. Klingberg
Interaction between striatal volume and DAT1 polymorphism predicts working memory development during adolescence
published pages: 191-199, ISSN: 1878-9293, DOI: 10.1016/j.dcn.2018.03.006
Developmental Cognitive Neuroscience 30 2020-04-08

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