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Pectin

The microbial degradation and utilization of complex pectins by Bacteroides in the human intestine

Total Cost €

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EC-Contrib. €

0

Partnership

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 Pectin project word cloud

Explore the words cloud of the Pectin project. It provides you a very rough idea of what is the project "Pectin" about.

nutrients    beneficial    harness    dominance    nutrition    nutraceutical    fp7    health    evolution    allocation    anaerobic    capitalize    significantly    microbial    unparalleled    community    host    expression    glycan    initial    termed    structural    probiotic    metabolized    bacterial    lack    genomic    microbiology    resource    microbes    molecular    strategies    mechanisms    bioinformatics    ecology    italian    genetic    network    prebiotic    vivo    portugal    student    glycans    data    she    potentially    pectin    functional    metabolism    bowel    walltrac    sequence    metagenomic    context    ecosystem    enzyme    newcastle    opportunity    critical    inform    training    microbiota    human    wealth    turn    dietary    skills    colonized    diet    maximise    influence    positive    glycanase    university    organisms    lisboa    predictive    encourage    enzymology    adanced    bioinformatic    protein    biology    laboratory    phd    restricted    throughput    excellent    fellow    understand    manipulation    screening    functions    decisive    mechanistic   

Project "Pectin" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITY OF NEWCASTLE UPON TYNE 

Organization address
address: KINGS GATE
city: NEWCASTLE UPON TYNE
postcode: NE1 7RU
website: http://www.ncl.ac.uk/

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
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 Coordinator Country United Kingdom [UK]
 Project website http://www.ncl.ac.uk/camb/staff/profile/harrygilbert.html
 Total cost 195˙454 €
 EC max contribution 195˙454 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2015
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2016
 Duration (year-month-day) from 2016-04-01   to  2018-03-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITY OF NEWCASTLE UPON TYNE UK (NEWCASTLE UPON TYNE) coordinator 195˙454.00

Map

 Project objective

The large bowel is colonized by a community of microbes, the microbiota, which has a significant impact on human health and nutrition. The major nutrients available to these organisms are dietary glycans. Thus, glycan-based dietary and nutraceutical strategies can, potentially, be deployed to encourage the dominance of beneficial microbes within the microbiota, ensuring the microbial ecosystem has a positive influence on human health. This approach, however, is greatly restricted by a critical lack of understanding of the mechanisms by which complex glycans are metabolized by the microbiota. Significantly, the wealth of genomic/metagenomic microbiota sequence data now available, presents an exciting and unparalleled opportunity to make decisive advances in our understanding of glycan metabolism in the human large bowel. This project seeks to capitalize on this genomic information, in harness with recent functional data from the host laboratory, to understand the mechanisms by which pectin, the major component of the human diet that is metabolized by the microbiota. The data will inform novel prebiotic and probiotic strategies to maximise the impact of the microbiota on human health. At a generic level, understanding glycan resource allocation in the microbiota represents an excellent system for studying the molecular mechanisms that lead to the evolution of novel glycanase functions, which, in turn, will provide a robust functional context to bioinformatic-based predictive biology. The fellow is Italian and has recently completed her PhD student at the University of Lisboa, Portugal, with the project FP7 Initial Training Network termed WallTraC. The fellow has experience in high throughput protein expression, enzyme activity screening and structural biology. At Newcastle University she will have the opportunity to develop skills in adanced mechanistic enzymology, anaerobic microbiology, bioinformatics, in vivo bacterial genetic manipulation and microbial ecology.

 Publications

year authors and title journal last update
List of publications.
2016 Immacolata Venditto, Ana S. Luis, Maja Rydahl, Julia Schückel, Vânia O. Fernandes, Silvia Vidal-Melgosa, Pedro Bule, Arun Goyal, Virginia M. R. Pires, Catarina G. Dourado, Luís M. A. Ferreira, Pedro M. Coutinho, Bernard Henrissat, J. Paul Knox, Arnaud Baslé, Shabir Najmudin, Harry J. Gilbert, William G. T. Willats, Carlos M. G. A. Fontes
Complexity of the Ruminococcus flavefaciens cellulosome reflects an expansion in glycan recognition
published pages: 7136-7141, ISSN: 0027-8424, DOI: 10.1073/pnas.1601558113
Proceedings of the National Academy of Sciences 113/26 2019-06-13
2017 Didier Ndeh, Artur Rogowski, Alan Cartmell, Ana S. Luis, Arnaud Baslé, Joseph Gray, Immacolata Venditto, Jonathon Briggs, Xiaoyang Zhang, Aurore Labourel, Nicolas Terrapon, Fanny Buffetto, Sergey Nepogodiev, Yao Xiao, Robert A. Field, Yanping Zhu, Malcolm A. O’Neill, Breeanna R. Urbanowicz, William S. York, Gideon J. Davies, D. Wade Abbott, Marie-Christine Ralet, Eric C. Martens, Bernard Henrissat, Harry J. Gilbert
Complex pectin metabolism by gut bacteria reveals novel catalytic functions
published pages: 65-70, ISSN: 0028-0836, DOI: 10.1038/nature21725
Nature 544/7648 2019-06-13
2018 Ana S. Luis, Jonathon Briggs, Xiaoyang Zhang, Benjamin Farnell, Didier Ndeh, Aurore Labourel, Arnaud Baslé, Alan Cartmell, Nicolas Terrapon, Katherine Stott, Elisabeth C. Lowe, Richard McLean, Kaitlyn Shearer, Julia Schückel, Immacolata Venditto, Marie-Christine Ralet, Bernard Henrissat, Eric C. Martens, Steven C. Mosimann, D. Wade Abbott, Harry J. Gilbert
Dietary pectic glycans are degraded by coordinated enzyme pathways in human colonic Bacteroides
published pages: 210-219, ISSN: 2058-5276, DOI: 10.1038/s41564-017-0079-1
Nature Microbiology 3/2 2019-06-13

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