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EnzOx2 SIGNED

New enzymatic oxidation/oxyfunctionalization technologies for added value bio-based products

Total Cost €

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EC-Contrib. €

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Partnership

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Project "EnzOx2" data sheet

The following table provides information about the project.

Coordinator
AGENCIA ESTATAL CONSEJO SUPERIOR DEINVESTIGACIONES CIENTIFICAS 

Organization address
address: CALLE SERRANO 117
city: MADRID
postcode: 28006
website: http://www.csic.es

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Spain [ES]
 Total cost 5˙000˙000 €
 EC max contribution 3˙000˙000 € (60%)
 Programme 1. H2020-EU.3.2.6. (Bio-based Industries Joint Technology Initiative (BBI-JTI))
 Code Call H2020-BBI-PPP-2015-2-1
 Funding Scheme /BBI-RIA
 Starting year 2016
 Duration (year-month-day) from 2016-11-01   to  2019-10-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    AGENCIA ESTATAL CONSEJO SUPERIOR DEINVESTIGACIONES CIENTIFICAS ES (MADRID) coordinator 1˙306˙000.00
2    TECHNISCHE UNIVERSITAET DRESDEN DE (DRESDEN) participant 450˙000.00
3    TECHNISCHE UNIVERSITEIT DELFT NL (DELFT) participant 400˙000.00
4    Chiracon GmbH DE (LUCKENWALDE) participant 250˙000.00
5    JENABIOS GMBH DE (JENA) participant 244˙000.00
6    UNIVERSIDAD DE SANTIAGO DE COMPOSTELA ES (SANTIAGO DE COMPOSTELA) participant 200˙000.00
7    AIMPLAS - ASOCIACION DE INVESTIGACION DE MATERIALES PLASTICOS Y CONEXAS ES (PATERNA VALENCIA) participant 150˙000.00
8    AVA BIOCHEM BSL AG CH (MUTTENZ) participant 0.00
9    CLEA TECHNOLOGIES BV NL (DELFT) participant 0.00
10    FIRMENICH SA CH (GENEVE) participant 0.00
11    NOVOZYMES A/S DK (BAGSVAERD) participant 0.00

Mappa

 Project objective

Sustainable production of chemical building blocks and other added value products from plant biomass is required for a bio-based economy. However, the biomass biorefineries should benefit not only from the use of renewable feedstocks but also from greener and more efficient bio-chemical technologies. Previous projects have shown the potential of oxidative enzymes in the production of some added value compounds from biomass components. Of special interest are still unexplored oxidation/oxyfunctionalization reactions (of sugar and lipid compounds) by microbial oxidoreductases, including new (self-sufficient) heme-thiolate peroxygenases. In this context, EnzOx2 plans to develop a 100% biochemical conversion of bio-based 5-hydroxymethylfurfural (HMF) into diformylfuran, a platform chemical, and 2,5-furandicarboxylic acid (FDCA), a plastic building-block. Oxidases (flavo and copper/radical) and peroxygenases will be used to perform the three-step oxidation of HMF to FDCA in a co-substrate and side-product free, one-pot conversion. On the other hand, highly (regio/stereo) selective hydroxylation of plant lipids (such as fatty acids, terpenes and steroids) by peroxygenases will be optimized for cost-effective production of flavours and fragrances (F&F), active pharmaceutical ingredients (APIs) and others. ENZOX2 aims to solve some main bottlenecks in these industrial processes by the use of bio-chemical tools (new/engineered enzymes and optimized biotransformations), to be later validated at the pilot/flagship scale. To attain this objective the consortium includes: i) two world leaders in industrial enzymes (Novozymes) and F&F (Firmenich); ii) two chemical SMEs producing HMF and chiral APIs (AVA-Biochem and Chiracon); iii) two specialized biotechnology SMEs (JenaBios and CLEA); iv) one technology centre in the Plastics sector (AIMPLAS); and v) three CSIC institutes and two universities (Dresden and Delft) with expertise in enzyme reactions and bioprocess implementation.

 Work performed, outcomes and results:  advancements report(s) 

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The information about "ENZOX2" are provided by the European Opendata Portal: CORDIS opendata.

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