The following table provides information about the project.
AGENCIA ESTATAL CONSEJO SUPERIOR DEINVESTIGACIONES CIENTIFICAS
|Coordinator Country||Spain [ES]|
|Total cost||5˙000˙000 €|
|EC max contribution||3˙000˙000 € (60%)|
1. H2020-EU.3.2.6. (Bio-based Industries Joint Technology Initiative (BBI-JTI))
|Duration (year-month-day)||from 2016-11-01 to 2019-10-31|
Take a look of project's partnership.
|1||AGENCIA ESTATAL CONSEJO SUPERIOR DEINVESTIGACIONES CIENTIFICAS||ES (MADRID)||coordinator||1˙306˙000.00|
|2||TECHNISCHE UNIVERSITAET DRESDEN||DE (DRESDEN)||participant||450˙000.00|
|3||TECHNISCHE UNIVERSITEIT DELFT||NL (DELFT)||participant||400˙000.00|
|4||Chiracon GmbH||DE (LUCKENWALDE)||participant||250˙000.00|
|5||JENABIOS GMBH||DE (JENA)||participant||244˙000.00|
|6||UNIVERSIDAD DE SANTIAGO DE COMPOSTELA||ES (SANTIAGO DE COMPOSTELA)||participant||200˙000.00|
|7||AIMPLAS - ASOCIACION DE INVESTIGACION DE MATERIALES PLASTICOS Y CONEXAS||ES (PATERNA VALENCIA)||participant||150˙000.00|
|8||AVA BIOCHEM BSL AG||CH (MUTTENZ)||participant||0.00|
|9||CLEA TECHNOLOGIES BV||NL (DELFT)||participant||0.00|
|10||FIRMENICH SA||CH (GENEVE)||participant||0.00|
|11||NOVOZYMES A/S||DK (BAGSVAERD)||participant||0.00|
Sustainable production of chemical building blocks and other added value products from plant biomass is required for a bio-based economy. However, the biomass biorefineries should benefit not only from the use of renewable feedstocks but also from greener and more efficient bio-chemical technologies. Previous projects have shown the potential of oxidative enzymes in the production of some added value compounds from biomass components. Of special interest are still unexplored oxidation/oxyfunctionalization reactions (of sugar and lipid compounds) by microbial oxidoreductases, including new (self-sufficient) heme-thiolate peroxygenases. In this context, EnzOx2 plans to develop a 100% biochemical conversion of bio-based 5-hydroxymethylfurfural (HMF) into diformylfuran, a platform chemical, and 2,5-furandicarboxylic acid (FDCA), a plastic building-block. Oxidases (flavo and copper/radical) and peroxygenases will be used to perform the three-step oxidation of HMF to FDCA in a co-substrate and side-product free, one-pot conversion. On the other hand, highly (regio/stereo) selective hydroxylation of plant lipids (such as fatty acids, terpenes and steroids) by peroxygenases will be optimized for cost-effective production of flavours and fragrances (F&F), active pharmaceutical ingredients (APIs) and others. ENZOX2 aims to solve some main bottlenecks in these industrial processes by the use of bio-chemical tools (new/engineered enzymes and optimized biotransformations), to be later validated at the pilot/flagship scale. To attain this objective the consortium includes: i) two world leaders in industrial enzymes (Novozymes) and F&F (Firmenich); ii) two chemical SMEs producing HMF and chiral APIs (AVA-Biochem and Chiracon); iii) two specialized biotechnology SMEs (JenaBios and CLEA); iv) one technology centre in the Plastics sector (AIMPLAS); and v) three CSIC institutes and two universities (Dresden and Delft) with expertise in enzyme reactions and bioprocess implementation.
Work performed, outcomes and results: advancements report(s)
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The information about "ENZOX2" are provided by the European Opendata Portal: CORDIS opendata.
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