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OXYTRAIN SIGNED

Harnessing the power of enzymatic oxygen activation

Total Cost €

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EC-Contrib. €

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Partnership

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Project "OXYTRAIN" data sheet

The following table provides information about the project.

Coordinator
RIJKSUNIVERSITEIT GRONINGEN 

Organization address
address: Broerstraat 5
city: GRONINGEN
postcode: 9712CP
website: www.rug.nl

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Netherlands [NL]
 Project website https://www.oxytrain.eu/
 Total cost 3˙076˙435 €
 EC max contribution 3˙076˙435 € (100%)
 Programme 1. H2020-EU.1.3.1. (Fostering new skills by means of excellent initial training of researchers)
 Code Call H2020-MSCA-ITN-2016
 Funding Scheme MSCA-ITN-ETN
 Starting year 2017
 Duration (year-month-day) from 2017-01-01   to  2021-03-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    RIJKSUNIVERSITEIT GRONINGEN NL (GRONINGEN) coordinator 922˙184.00
2    NORGES MILJO-OG BIOVITENSKAPLIGE UNIVERSITET NO (AS) participant 286˙275.00
3    UNIVERSITY OF YORK UK (YORK NORTH YORKSHIRE) participant 273˙287.00
4    UNIVERSITA DEGLI STUDI DI PAVIA IT (PAVIA) participant 258˙061.00
5    TECHNISCHE UNIVERSITAET GRAZ AT (GRAZ) participant 255˙934.00
6    DSM FOOD SPECIALTIES BV NL (DELFT) participant 255˙374.00
7    RHEINISCH-WESTFAELISCHE TECHNISCHE HOCHSCHULE AACHEN DE (AACHEN) participant 249˙216.00
8    SESAM-BIOTECH GMBH DE (AACHEN) participant 249˙216.00
9    WESTFAELISCHE WILHELMS-UNIVERSITAET MUENSTER DE (MUENSTER) participant 249˙216.00
10    SANKO TEKSTIL ISLETMELERI SANAYI VETICARET ANONIM SIRKETI TR (BURSA) participant 77˙668.00
11    bisy e.U. AT (Hofstaetten / Raab) partner 0.00
12    BORREGAARD AS NO (SARPSBORG) partner 0.00
13    DSM CHEMICAL TECHNOLOGY R & D BV NL (SITTARD) partner 0.00
14    INGENZA LIMITED UK (ROSLIN) partner 0.00
15    SYNCOM BV NL (GRONINGEN) partner 0.00

Map

 Project objective

For the selective and effective incorporation of oxygen into biological molecules (oxygenation reaction), several enzyme types have evolved in nature. They catalyse crucial reactions in various metabolic routes. The chemistry feasible with these biocatalysts is unrivalled when compared with conventional chemical methods. Therefore, these oxygenating enzymes are very promising tools in biotechnological approaches. However, when compared with other enzyme classes, such as hydrolases, oxygenases are still in their infancy considering their biotechnological potential. To fully exploit the catalytic power of oxygenases, several hurdles have to be taken for which a higher level of knowledge on these enzymes is needed while also technical aspects have to be solved.

The European Training Network (ETN) OXYTRAIN is a joint academic/non-academic training initiative supporting the convergence of biochemistry, enzyme engineering and biotechnology. The consortium's mutual goal is developing a new generation of innovative and entrepreneurial early stage researchers (ESRs) to satisfy the need for knowledge and skills to produce and apply oxidative enzymes. This will be achieved by setting up a network and intersectoral programme in which multiple disciplines will be integrated and exploited. By bringing together 7 academic beneficiaries that are experts in the field of individual oxygenase groups, the network will provide perfect conditions for cross-fertilization of knowledge, while the 3 industrial beneficiaries and 5 partner organisations will add to the consortium by translating the generated knowledge into real industrial applications, such as textiles, pharmaceuticals and biorefineries.

 Deliverables

List of deliverables.
Generation and transfer of six SSB mutant libraries to the RWTH/TUG partners for screening Demonstrators, pilots, prototypes 2020-03-23 11:29:33
Libraries of enzyme mutants prepared Documents, reports 2020-03-23 11:29:33
Cofactor-independent oxygenases with few new functions identified within the tautomerase superfamily Documents, reports 2020-03-23 11:29:33
Identification of substrates and inhibitors of HPP oxygenase Documents, reports 2020-03-23 11:29:33
PQS-cleaving cofactor-independent dioxygenases purified and functionally characterised Documents, reports 2020-03-23 11:29:33
Libraries of LPMO mutants prepared Demonstrators, pilots, prototypes 2020-03-23 11:29:33
Identification of amino acid positions that govern selectivity of three heme-dependent monooxygenases Documents, reports 2020-03-23 11:29:33
Flavin-dependent monooxygenases produced and purified Documents, reports 2020-03-23 11:29:33
OXYTRAIN vacancies advertised Other 2020-03-23 11:29:32
Project Website Websites, patent fillings, videos etc. 2020-03-23 11:29:32

Take a look to the deliverables list in detail:  detailed list of OXYTRAIN deliverables.

 Publications

year authors and title journal last update
List of publications.
2019 Nico D. Fessner
P450 Monooxygenases Enable Rapid Late-Stage Diversification of Natural Products via C−H Bond Activation
published pages: , ISSN: 1867-3880, DOI: 10.1002/cctc.201801829
ChemCatChem 2020-03-23
2019 Nikola Lončar, Filippo Fiorentini, Gautier Bailleul, Simone Savino, Elvira Romero, Andrea Mattevi, Marco W. Fraaije
Characterization of a thermostable flavin-containing monooxygenase from Nitrincola lacisaponensis (NiFMO)
published pages: 1755-1764, ISSN: 0175-7598, DOI: 10.1007/s00253-018-09579-w
Applied Microbiology and Biotechnology 103/4 2020-03-23

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The information about "OXYTRAIN" are provided by the European Opendata Portal: CORDIS opendata.

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