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Micro-physiological circadian platform for safety and efficacy assessment of drugs and cosmetics

Total Cost €


EC-Contrib. €






 mP-CSE project word cloud

Explore the words cloud of the mP-CSE project. It provides you a very rough idea of what is the project "mP-CSE" about.

companies    stress    69    treatment    incorporation    chips    human    animals    ultimately    pharmaceutical    tissue    patients    drugs    company    animal    5b    microphysiological    proven    latest    tests    safe    roi    cosmetic    humans    platform    drug    scaled    70    food    technologies    hire       heart    market    turn    smart    brain    detect    withdrawal    innovation    precise       chip    seeking    cagr    huge    compounds    circadian    13    liver    2025    adjusting    physiological    3d    vascular    reduce    function    tested    commercialization    laboratory    time    alternative    dynamics    medicines    groundbreaking    schemes    models    organs    helping    moc    costly    rate    body    limitations    single    billion    administration    multiple    toxic    efficacy    medications    rhythms    organ    risky    mimic    functionally    kidney    enhances    ltd    platforms    employees    effect    uses    dose    predicting    biotechnology    sensing    maximum    global    rhythm   

Project "mP-CSE" data sheet

The following table provides information about the project.


Organization address
postcode: 91904
website: n.a.

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Israel [IL]
 Project website
 Total cost 71˙429 €
 EC max contribution 50˙000 € (70%)
 Programme 1. H2020-EU.3. (PRIORITY 'Societal challenges)
2. H2020-EU.2.3. (INDUSTRIAL LEADERSHIP - Innovation In SMEs)
3. H2020-EU.2.1. (INDUSTRIAL LEADERSHIP - Leadership in enabling and industrial technologies)
 Code Call H2020-SMEInst-2018-2020-1
 Funding Scheme SME-1
 Starting year 2018
 Duration (year-month-day) from 2018-08-01   to  2018-11-30


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    TISSUE DYNAMICS LTD IL (JERUSALEM) coordinator 50˙000.00


 Project objective

Tissue Dynamics Ltd. is a groundbreaking biotechnology company focused on developing smart microphysiological platform technologies for drug, food, and cosmetic development. Pharmaceutical and cosmetic companies face huge costs of developing and testing new products (an average of €2.5B to develop a single drug), which is increasing over the years. Traditionally, these tests have been carried out in animal models whose limitations in predicting human responses are significant (70% of drugs toxic to humans are not toxic to animals). These limitations lead to the withdrawal of many drugs in the market, making drug development a costly risky process. Organ-on-chip platforms, developed in recent years, have proven to be a better alternative to current laboratory models, offering more physiological and similar characteristics to the human body. Tissue Dynamics goal is to provide a functionally scaled Multi Organ-on-Chip (MOC) platform that uses real-time sensing of tissue function to detect the effect of drug-induced physiological stress in multiple 3D vascular organs (liver, heart, brain, kidney). Our latest innovation has been the incorporation of factors that mimic circadian rhythms in the organs, which is essential to test the physiological impact of the compounds tested. On the other hand, the incorporation of the circadian rhythm in our chips enhances the development of treatment schemes, adjusting in a more precise way the dose and the time of administration of the medications, seeking the maximum efficacy of them. The global Organ-on-Chip market is a rapidly-growing, estimated to reach $6.13 Billion by 2025, with an expected growth rate of CAGR 69.4%. Our platform will reduce the cost of new drugs development ultimately, helping patients by making more safe and effective medicines reach the market. In turn we expect ROI of 5 after five years of commercialization and hire 10 new employees.

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The information about "MP-CSE" are provided by the European Opendata Portal: CORDIS opendata.

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