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reLIVE SIGNED

Unraveling complex organ regeneration through live imaging and molecular profiling approaches

Total Cost €

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EC-Contrib. €

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Partnership

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 reLIVE project word cloud

Explore the words cloud of the reLIVE project. It provides you a very rough idea of what is the project "reLIVE" about.

regeneration    regenerate    mediated    emerge    temporal    limited    glia    shared    lineage    differentiated    poorly    hawaiensis    underpin    development    medical    unipotent    represented    crispr    crustacean    regenerating    animals    way    flatworms    functional    muscle    questions    tendons    periods    vertebrates    time    types    imaging    behaviors    many    organ    limbs    undifferentiated    stem    flies    animal    injury    tools    edge    neurons    advantage    profiling    history    organisms    tracking    embryonic    relive    transcriptional    marking    classic    answer    nematodes    adult    morphogenesis    biological    parts    genetic    fish    body    cells    amputation    reconstruction    combines    live    arise    combine    novo    crustaceans    week    individual    spatial    scales    first    multipotent    explores    parhyale    fundamental    progenitors    centuries    epidermis    regenerative    extensive    model    cutting    groups    differ    limb    diverse    continuous    mammals    cell    evolutionary    de    molecular    contrast    unanswered    course    committed   

Project "reLIVE" data sheet

The following table provides information about the project.

Coordinator
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS 

Organization address
address: RUE MICHEL ANGE 3
city: PARIS
postcode: 75794
website: www.cnrs.fr

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country France [FR]
 Total cost 2˙571˙694 €
 EC max contribution 2˙571˙694 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2015-AdG
 Funding Scheme ERC-ADG
 Starting year 2017
 Duration (year-month-day) from 2017-01-01   to  2021-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS FR (PARIS) coordinator 2˙571˙694.00

Map

 Project objective

Many animals have the ability to regenerate parts of their body following injury or amputation. While there is great biological and medical interest in this process, many fundamental questions remain unanswered, because complex organ regeneration is poorly represented in classic model organisms; flies, nematodes and mammals have limited regenerative abilities, in contrast to flatworms, crustaceans and fish.

reLIVE explores fundamental questions on regeneration in an emerging crustacean model, Parhyale hawaiensis, which combines extensive regenerative abilities, advanced genetic tools and live imaging.

The project will address the following fundamental, centuries-old questions on regeneration: 1) Which are the progenitors that underpin complex organ regeneration? Do epidermis, tendons, neurons, glia and muscle arise de novo from undifferentiated adult stem cells, or do they emerge from differentiated cell types? Are the progenitors unipotent/committed or multipotent? Which are their molecular responses and behaviors during the course of regeneration? 2) Do diverse animal groups regenerate in the same way? Do the regenerative progenitors of crustaceans have common molecular and functional properties with those of vertebrates and flatworms? Do they have a shared evolutionary history? 3) How does regeneration differ from development? Are these processes operating on comparable temporal and spatial scales? How similar are the transcriptional responses and cell behaviors that underpin embryonic and regenerative morphogenesis of the limb?

To answer these questions, reLIVE will take advantage of the unique opportunities offered by Parhyale limb regeneration and, for the first time, combine four cutting-edge approaches: a) CRISPR-mediated marking of specific cell types, b) continuous live imaging and cell tracking in regenerating limbs over week-long periods, c) a novel method of cell lineage reconstruction, and d) transcriptional profiling on individual cells.

 Publications

year authors and title journal last update
List of publications.
2019 M. Weigert, U. Schmidt, R. Haase, K. Sugawara, G. Myers
Star-convex Polyhedra for 3D Object Detection and Segmentation in Microscopy
published pages: , ISSN: , DOI:
arXiv arXiv:1908.03636 2019-08-29
2019 C. Sinigaglia, M. Averof
The multifaceted role of nerves in animal regeneration
published pages: , ISSN: 0959-437X, DOI:
Curr Op Genet & Dev accepted for publication 2019-08-29

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