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Macrophage aging and rejuvenation

Total Cost €


EC-Contrib. €






 MacAGE project word cloud

Explore the words cloud of the MacAGE project. It provides you a very rough idea of what is the project "MacAGE" about.

cells    degenerative    decline    macrophage    independently    expression    reverse    adoptive    inflammation    crispr    critical    tissues    revert    identity    ultimate    dependent    laboratory    population    mouse    gene    cellular    network    innovate    appears    stem    populations    models    complementary    organ    genes    genetic    tissue    maintained    regeneration    embryonic    generation    guiding    therapies    immune    shows    potentially    body    activation    originate    signaling    macrophages    complemented    essentially    aging    epigenetic    analogies    proliferation    decipher    functions    age    editing    self    renewal    drawing    cas9    monocytes    healthy    genetics    capacity    unbiased    combinations    protocols    maintaining    immunity    resident    transcription    employed    understand    perform    local    integrity    failed    competence    tapping    infection    genome    cell    hold    function    diseases    resolution    vivo    rejuvenate    molecular    latest    transfer    progenitors    homeostasis    screens   

Project "MacAGE" data sheet

The following table provides information about the project.


Organization address
postcode: 1069

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Total cost 2˙499˙994 €
 EC max contribution 2˙499˙994 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2015-AdG
 Funding Scheme ERC-ADG
 Starting year 2017
 Duration (year-month-day) from 2017-01-01   to  2021-12-31


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 


 Project objective

Tissue resident macrophages are essentially present in every organ of the body and perform critical functions in immunity, tissue homeostasis and regeneration. Recent evidence shows that resident macrophages can originate from embryonic progenitors and be maintained in tissues long term by local proliferation independently of monocytes. This self-renewal ability, however, appears to decline with age, with potentially major consequences for the response to infection, the resolution of inflammation and the ability for tissue regeneration. Understanding the decline of self-renewal in the aging macrophage may thus hold key elements for maintaining healthy tissue integrity. Drawing from analogies to stem cell self-renewal we want to decipher the molecular and cellular parameters of macrophage self-renewal and its decline with age. We want to understand the age-associated changes in gene expression and epigenetic identity of tissue macrophage populations with the ultimate goal to reverse age dependent decline in self-renewal and function. Results from my laboratory have identified transcription factors that control the access to a network of self-renewal genes that are also used in stem cells. Using several complementary genetic mouse models tapping into this network we want to investigate whether its activation in resident macrophage population in vivo can rejuvenate their self-renewal capacity and revert aging related changes. These approaches will be complemented by unbiased genome wide screens in vivo using latest generation CRISPR/Cas9 genome editing technology to identify new signaling pathways guiding macrophage self-renewal and aging. Using innovate combinations of genetics and adoptive transfer protocols we will test whether this knowledge can be employed to reverse macrophage dependent loss of immune competence and failed tissue regeneration with age. Our results will lead to new general insight and potential novel cellular therapies for degenerative diseases.


year authors and title journal last update
List of publications.
2019 Clara Busch, Jérémy Favret, Laufey Geirsdóttir, Kaaweh Molawi, Michael Sieweke
Isolation and Long-term Cultivation of Mouse Alveolar Macrophages
published pages: , ISSN: 2331-8325, DOI: 10.21769/bioprotoc.3302
BIO-PROTOCOL 9/14 2019-09-13
2017 Bérengère de Laval, Michael H Sieweke
Trained macrophages support hygiene hypothesis
published pages: 1279-1280, ISSN: 1529-2908, DOI: 10.1038/ni.3874
Nature Immunology 18/12 2019-09-05
2017 Francesco Imperatore, Julien Maurizio, Stephanie Vargas Aguilar, Clara J Busch, Jérémy Favret, Elisabeth Kowenz‐Leutz, Wilfried Cathou, Rebecca Gentek, Pierre Perrin, Achim Leutz, Carole Berruyer, Michael H Sieweke
SIRT1 regulates macrophage self‐renewal
published pages: 2353-2372, ISSN: 0261-4189, DOI: 10.15252/embj.201695737
The EMBO Journal 36/16 2019-09-05
2019 Noushin Mossadegh-Keller, Michael Sieweke
Characterization of Mouse Adult Testicular Macrophage Populations by Immunofluorescence Imaging and Flow Cytometry
published pages: , ISSN: 2331-8325, DOI: 10.21769/bioprotoc.3178
BIO-PROTOCOL 9/5 2019-09-05
2019 René Rauschmeier, Charlotte Gustafsson, Annika Reinhardt, Noelia A‐Gonzalez, Luigi Tortola, Dilay Cansever, Sethuraman Subramanian, Reshma Taneja, Moritz J Rossner, Michael H Sieweke, Melanie Greter, Robert Månsson, Meinrad Busslinger, Taras Kreslavsky
Bhlhe40 and Bhlhe41 transcription factors regulate alveolar macrophage self‐renewal and identity
published pages: , ISSN: 0261-4189, DOI: 10.15252/embj.2018101233
The EMBO Journal 2019-09-05
2017 Noushin Mossadegh-Keller, Rebecca Gentek, Gregory Gimenez, Sylvain Bigot, Sebastien Mailfert, Michael H. Sieweke
Developmental origin and maintenance of distinct testicular macrophage populations
published pages: 2829-2841, ISSN: 0022-1007, DOI: 10.1084/jem.20170829
The Journal of Experimental Medicine 214/10 2019-09-05
2018 Noushin Mossadegh-Keller, Michael H. Sieweke
Testicular macrophages: Guardians of fertility
published pages: 120-125, ISSN: 0008-8749, DOI: 10.1016/j.cellimm.2018.03.009
Cellular Immunology 330 2019-09-05
2018 Leona Gabryšová, Marisol Alvarez-Martinez, Raphaëlle Luisier, Luke S. Cox, Jan Sodenkamp, Caroline Hosking, Damián Pérez-Mazliah, Charlotte Whicher, Yashaswini Kannan, Krzysztof Potempa, Xuemei Wu, Leena Bhaw, Hagen Wende, Michael H. Sieweke, Greg Elgar, Mark Wilson, James Briscoe, Vicki Metzis, Jean Langhorne, Nicholas M. Luscombe, Anne O’Garra
c-Maf controls immune responses by regulating disease-specific gene networks and repressing IL-2 in CD4+ T cells
published pages: 497-507, ISSN: 1529-2908, DOI: 10.1038/s41590-018-0083-5
Nature Immunology 19/5 2019-09-05

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