Explore the words cloud of the MacAGE project. It provides you a very rough idea of what is the project "MacAGE" about.
The following table provides information about the project.
TECHNISCHE UNIVERSITAET DRESDEN
|Coordinator Country||Germany [DE]|
|Total cost||2˙499˙994 €|
|EC max contribution||2˙499˙994 € (100%)|
1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
|Duration (year-month-day)||from 2017-01-01 to 2021-12-31|
Take a look of project's partnership.
|1||TECHNISCHE UNIVERSITAET DRESDEN||DE (DRESDEN)||coordinator||1˙352˙846.00|
|2||CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS||FR (PARIS)||participant||1˙147˙147.00|
Tissue resident macrophages are essentially present in every organ of the body and perform critical functions in immunity, tissue homeostasis and regeneration. Recent evidence shows that resident macrophages can originate from embryonic progenitors and be maintained in tissues long term by local proliferation independently of monocytes. This self-renewal ability, however, appears to decline with age, with potentially major consequences for the response to infection, the resolution of inflammation and the ability for tissue regeneration. Understanding the decline of self-renewal in the aging macrophage may thus hold key elements for maintaining healthy tissue integrity. Drawing from analogies to stem cell self-renewal we want to decipher the molecular and cellular parameters of macrophage self-renewal and its decline with age. We want to understand the age-associated changes in gene expression and epigenetic identity of tissue macrophage populations with the ultimate goal to reverse age dependent decline in self-renewal and function. Results from my laboratory have identified transcription factors that control the access to a network of self-renewal genes that are also used in stem cells. Using several complementary genetic mouse models tapping into this network we want to investigate whether its activation in resident macrophage population in vivo can rejuvenate their self-renewal capacity and revert aging related changes. These approaches will be complemented by unbiased genome wide screens in vivo using latest generation CRISPR/Cas9 genome editing technology to identify new signaling pathways guiding macrophage self-renewal and aging. Using innovate combinations of genetics and adoptive transfer protocols we will test whether this knowledge can be employed to reverse macrophage dependent loss of immune competence and failed tissue regeneration with age. Our results will lead to new general insight and potential novel cellular therapies for degenerative diseases.
|year||authors and title||journal||last update|
Clara Busch, JÃ©rÃ©my Favret, Laufey GeirsdÃ³ttir, Kaaweh Molawi, Michael Sieweke
Isolation and Long-term Cultivation of Mouse Alveolar Macrophages
published pages: , ISSN: 2331-8325, DOI: 10.21769/bioprotoc.3302
BÃ©rengÃ¨re de Laval, Michael H Sieweke
Trained macrophages support hygiene hypothesis
published pages: 1279-1280, ISSN: 1529-2908, DOI: 10.1038/ni.3874
|Nature Immunology 18/12||2019-09-05|
Francesco Imperatore, Julien Maurizio, Stephanie Vargas Aguilar, Clara J Busch, JÃ©rÃ©my Favret, Elisabeth Kowenzâ€Leutz, Wilfried Cathou, Rebecca Gentek, Pierre Perrin, Achim Leutz, Carole Berruyer, Michael H Sieweke
SIRT1 regulates macrophage selfâ€renewal
published pages: 2353-2372, ISSN: 0261-4189, DOI: 10.15252/embj.201695737
|The EMBO Journal 36/16||2019-09-05|
Noushin Mossadegh-Keller, Michael Sieweke
Characterization of Mouse Adult Testicular Macrophage Populations by Immunofluorescence Imaging and Flow Cytometry
published pages: , ISSN: 2331-8325, DOI: 10.21769/bioprotoc.3178
RenÃ© Rauschmeier, Charlotte Gustafsson, Annika Reinhardt, Noelia Aâ€Gonzalez, Luigi Tortola, Dilay Cansever, Sethuraman Subramanian, Reshma Taneja, Moritz J Rossner, Michael H Sieweke, Melanie Greter, Robert MÃ¥nsson, Meinrad Busslinger, Taras Kreslavsky
Bhlhe40 and Bhlhe41 transcription factors regulate alveolar macrophage selfâ€renewal and identity
published pages: , ISSN: 0261-4189, DOI: 10.15252/embj.2018101233
|The EMBO Journal||2019-09-05|
Noushin Mossadegh-Keller, Rebecca Gentek, Gregory Gimenez, Sylvain Bigot, Sebastien Mailfert, Michael H. Sieweke
Developmental origin and maintenance of distinct testicular macrophage populations
published pages: 2829-2841, ISSN: 0022-1007, DOI: 10.1084/jem.20170829
|The Journal of Experimental Medicine 214/10||2019-09-05|
Noushin Mossadegh-Keller, Michael H. Sieweke
Testicular macrophages: Guardians of fertility
published pages: 120-125, ISSN: 0008-8749, DOI: 10.1016/j.cellimm.2018.03.009
|Cellular Immunology 330||2019-09-05|
Leona GabryÅ¡ovÃ¡, Marisol Alvarez-Martinez, RaphaÃ«lle Luisier, Luke S. Cox, Jan Sodenkamp, Caroline Hosking, DamiÃ¡n PÃ©rez-Mazliah, Charlotte Whicher, Yashaswini Kannan, Krzysztof Potempa, Xuemei Wu, Leena Bhaw, Hagen Wende, Michael H. Sieweke, Greg Elgar, Mark Wilson, James Briscoe, Vicki Metzis, Jean Langhorne, Nicholas M. Luscombe, Anne Oâ€™Garra
c-Maf controls immune responses by regulating disease-specific gene networks and repressing IL-2 in CD4+ T cells
published pages: 497-507, ISSN: 1529-2908, DOI: 10.1038/s41590-018-0083-5
|Nature Immunology 19/5||2019-09-05|
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