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FNS-4-NAMOSAT

Development of fluorescence nanospectroscopy to elucidate the roles of nanoscale molecular segregation in the activation of T-cells

Total Cost €

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EC-Contrib. €

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Partnership

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 FNS-4-NAMOSAT project word cloud

Explore the words cloud of the FNS-4-NAMOSAT project. It provides you a very rough idea of what is the project "FNS-4-NAMOSAT" about.

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Project "FNS-4-NAMOSAT" data sheet

The following table provides information about the project.

Coordinator
THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD 

Organization address
address: WELLINGTON SQUARE UNIVERSITY OFFICES
city: OXFORD
postcode: OX1 2JD
website: www.ox.ac.uk

contact info
title: n.a.
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surname: n.a.
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 Coordinator Country United Kingdom [UK]
 Total cost 195˙454 €
 EC max contribution 195˙454 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2015
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2016
 Duration (year-month-day) from 2016-10-01   to  2018-09-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD UK (OXFORD) coordinator 195˙454.00

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 Project objective

BACKGROUND Nanoscale protein and lipid heterogeneities, e.g. lipid rafts, have been detected in numerous membrane-related cellular processes, including the initiation of the immune response upon T-cell activation. However, the interplay of protein and lipid segregation remains unclear.

PROBLEM Super-resolution fluorescence microscopy can localize such supramolecular structures, but reveals little information on their identity. In contrast, (micro)spectroscopies with environment-sensitive probes can identify local molecular properties, but lack the appropriate spatial resolution for their localization.

AIM The main research goal of the Action is to establish an original method with suitable resolution and sensitivity to improve our understanding of lipid reorganization during the activation of T-cells.

SOLUTION We will develop fluorescence nanospectroscopy (FNS) by combining STED microscopy, spectral detection, and environment-sensitive probes, to achieve the sensitivity to local molecular properties with nanoscale spatial resolution.

IMPACT Besides new insights into molecular mechanisms of immunity, FNS will importantly complement the available methods by probing local molecular order, facilitating FRET measurements, super-resolved spectral imaging etc. It will enable further advances in numerous fields of molecular and cell biology where membrane proteins and lipids act in a precisely coordinated manner.

TRAINING The Researcher will be enrolled in the world-leading environment in the fields of STED microscopy, membrane structure and dynamics, and immunology. The acquired deep knowledge on the subjects of research, gained solid experimental and leadership skills from the Supervisor, invaluable experience from a cross-sectoral visit in the collaborating company, as well as his integration into the network within the scientific communities of planned multidisciplinary research activities, will decisively boost his future career as an independent life scientist.

 Publications

year authors and title journal last update
List of publications.
2017 Erdinc Sezgin, Falk Schneider, Victoria Zilles, Iztok Urbančič, Esther Garcia, Dominic Waithe, Andrey S. Klymchenko, Christian Eggeling
Polarity-Sensitive Probes for Superresolution Stimulated Emission Depletion Microscopy
published pages: 1321-1330, ISSN: 0006-3495, DOI: 10.1016/j.bpj.2017.06.050
Biophysical Journal 113/6 2019-04-18
2018 Iztok Urbančič, Juliane Brun, Dilip Shrestha, Dominic Waithe, Christian Eggeling, Jakub Chojnacki
Lipid Composition but not Curvature Is the Determinant Factor for the Low Molecular Mobility Observed on the Membrane of Virus-Like Vesicles
published pages: 415, ISSN: 1999-4915, DOI: 10.3390/v10080415
Viruses 10/8 2019-04-18
2018 Ana Mafalda Santos, Aleks Ponjavic, Marco Fritzsche, Ricardo A. Fernandes, Jorge Bernardino de la Serna, Martin J. Wilcock, Falk Schneider, Iztok Urbančič, James McColl, Consuelo Anzilotti, Kristina A. Ganzinger, Meike Aßmann, David Depoil, Richard J. Cornall, Michael L. Dustin, David Klenerman, Simon J. Davis, Christian Eggeling, Steven F. Lee
Capturing resting T cells: the perils of PLL
published pages: 203-205, ISSN: 1529-2908, DOI: 10.1038/s41590-018-0048-8
Nature Immunology 19/3 2019-04-18
2018 Iztok Urbančič, Maja Garvas, Boštjan Kokot, Hana Majaron, Polona Umek, Hilary Cassidy, Miha Škarabot, Falk Schneider, Silvia Galiani, Zoran Arsov, Tilen Koklic, David Matallanas, Miran Čeh, Igor Muševič, Christian Eggeling, Janez Štrancar
Nanoparticles Can Wrap Epithelial Cell Membranes and Relocate Them Across the Epithelial Cell Layer
published pages: 5294-5305, ISSN: 1530-6984, DOI: 10.1021/acs.nanolett.8b02291
Nano Letters 18/8 2019-04-18

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