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RADoTE

Remote-Activated Delivery of Therapeutic Exosomes (RADoTE) via an Injectable PEG Hydrogel Carrier

Total Cost €

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EC-Contrib. €

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Partnership

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Project "RADoTE" data sheet

The following table provides information about the project.

Coordinator
IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE 

Organization address
address: SOUTH KENSINGTON CAMPUS EXHIBITION ROAD
city: LONDON
postcode: SW7 2AZ
website: http://www.imperial.ac.uk/

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Project website http://www.imperial.ac.uk/people/s.skaalure/research.html
 Total cost 183˙454 €
 EC max contribution 183˙454 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2015
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2016
 Duration (year-month-day) from 2016-11-01   to  2018-10-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE UK (LONDON) coordinator 183˙454.00

Map

 Project objective

As a Marie Skłodowska-Curie Fellow, I will develop and demonstrate remote-activated delivery of biological therapeutics loaded into an injectable hydrogel, where delivery is triggered by applying near-infrared (NIR) light that safely and non-invasively penetrates deep into living tissues. The hydrogel carrier will be designed to deliver and stabilize cell-derived exosomes and microvesicles, together referred to as extracellular vesicles (EVs), which have recently gained attention for their ability to effectively deliver biological information and cargo directly to target cells. Developing sophisticated delivery systems for EVs will streamline their translation to clinical application, enabling the huge potential for this novel biological therapeutic to be fully realized. This system will be advantageous in simultaneously providing localized delivery, enhanced EV stability, and crucially, externally triggered release. This project will provide the first demonstration of localized and controlled delivery of EVs, with the added novelty of an externally NIR-triggered delivery system. By combining my expertise in designer hydrogel chemistry, the supervision of Prof. Molly Stevens at Imperial College London (ICL) who runs a world-class interdisciplinary biomaterials-focused group, and a secondment with The Technology Partnership (TTP) specializing in technology translation, this project is ideally situated to deliver the highest quality results.

 Publications

year authors and title journal last update
List of publications.
2018 James P. K. Armstrong, Jennifer L. Puetzer, Andrea Serio, Anne Géraldine Guex, Michaella Kapnisi, Alexandre Breant, Yifan Zong, Valentine Assal, Stacey C. Skaalure, Oisín King, Tara Murty, Christoph Meinert, Amanda C. Franklin, Philip G. Bassindale, Madeleine K. Nichols, Cesare M. Terracciano, Dietmar W. Hutmacher, Bruce W. Drinkwater, Travis J. Klein, Adam W. Perriman, Molly M. Stevens
Engineering Anisotropic Muscle Tissue using Acoustic Cell Patterning
published pages: 1802649, ISSN: 0935-9648, DOI: 10.1002/adma.201802649
Advanced Materials 30/43 2019-05-23
2017 Charalambos Kallepitis, Mads S. Bergholt, Manuel M. Mazo, Vincent Leonardo, Stacey C. Skaalure, Stephanie A. Maynard, Molly M. Stevens
Quantitative volumetric Raman imaging of three dimensional cell cultures
published pages: 14843, ISSN: 2041-1723, DOI: 10.1038/ncomms14843
Nature Communications 8 2019-05-23
2017 Shih-Ting Wang, Yiyang Lin, Ryan K. Spencer, Michael R. Thomas, Andy I. Nguyen, Nadav Amdursky, E. Thomas Pashuck, Stacey C. Skaalure, Cheng Yu Song, Paresh A. Parmar, Rhodri M. Morgan, Peter Ercius, Shaul Aloni, Ronald N. Zuckermann, Molly M. Stevens
Sequence-Dependent Self-Assembly and Structural Diversity of Islet Amyloid Polypeptide-Derived β-Sheet Fibrils
published pages: 8579-8589, ISSN: 1936-0851, DOI: 10.1021/acsnano.7b02325
ACS Nano 11/9 2019-05-23
2019 Yiyang Lin, Manuel M. Mazo, Stacey C. Skaalure, Michael R. Thomas, Simon R. Schultz, Molly M. Stevens
Activatable cell–biomaterial interfacing with photo-caged peptides
published pages: , ISSN: 2041-6520, DOI: 10.1039/C8SC04725A
Chemical Science 2019-05-23

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