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RADoTE

Remote-Activated Delivery of Therapeutic Exosomes (RADoTE) via an Injectable PEG Hydrogel Carrier

Total Cost €

EC-Contrib. €

Partnership

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Outcomes and
results

RADoTE project word cloud

Explore the words cloud of the RADoTE project. It provides you a very rough idea of what is the project "RADoTE" about.

ev cell molly london marie advantageous chemistry realized world expertise deep highest stevens interdisciplinary translation crucially release added ttp biomaterials biological living huge gained activated safely first class simultaneously runs quality therapeutic novelty cargo fellow group evs localized tissues loaded odowska nir situated imperial curie designer therapeutics cells sophisticated carrier streamline invasively near infrared ideally exosomes extracellular stabilize vesicles sk externally microvesicles demonstration college combining designed hydrogel supervision triggered remote stability as partnership icl penetrates specializing prof secondment light injectable enhanced clinical

Project "RADoTE" data sheet

The following table provides information about the project.

Coordinator	IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE Organization address address: SOUTH KENSINGTON CAMPUS EXHIBITION ROAD city: LONDON postcode: SW7 2AZ website: http://www.imperial.ac.uk/ contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	United Kingdom [UK]
Project website	http://www.imperial.ac.uk/people/s.skaalure/research.html
Total cost	183˙454 €
EC max contribution	183˙454 € (100%)
Programme	1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
Code Call	H2020-MSCA-IF-2015
Funding Scheme	MSCA-IF-EF-ST
Starting year	2016
Duration (year-month-day)	from 2016-11-01 to 2018-10-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE Organization address address: SOUTH KENSINGTON CAMPUS EXHIBITION ROAD city: LONDON postcode: SW7 2AZ website: http://www.imperial.ac.uk/ contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (LONDON)	coordinator	183˙454.00

Map

Project objective

As a Marie SkÅ‚odowska-Curie Fellow, I will develop and demonstrate remote-activated delivery of biological therapeutics loaded into an injectable hydrogel, where delivery is triggered by applying near-infrared (NIR) light that safely and non-invasively penetrates deep into living tissues. The hydrogel carrier will be designed to deliver and stabilize cell-derived exosomes and microvesicles, together referred to as extracellular vesicles (EVs), which have recently gained attention for their ability to effectively deliver biological information and cargo directly to target cells. Developing sophisticated delivery systems for EVs will streamline their translation to clinical application, enabling the huge potential for this novel biological therapeutic to be fully realized. This system will be advantageous in simultaneously providing localized delivery, enhanced EV stability, and crucially, externally triggered release. This project will provide the first demonstration of localized and controlled delivery of EVs, with the added novelty of an externally NIR-triggered delivery system. By combining my expertise in designer hydrogel chemistry, the supervision of Prof. Molly Stevens at Imperial College London (ICL) who runs a world-class interdisciplinary biomaterials-focused group, and a secondment with The Technology Partnership (TTP) specializing in technology translation, this project is ideally situated to deliver the highest quality results.

Publications

List of publications.
year	authors and title	journal	last update
2018	James P. K. Armstrong, Jennifer L. Puetzer, Andrea Serio, Anne GÃ©raldine Guex, Michaella Kapnisi, Alexandre Breant, Yifan Zong, Valentine Assal, Stacey C. Skaalure, OisÃn King, Tara Murty, Christoph Meinert, Amanda C. Franklin, Philip G. Bassindale, Madeleine K. Nichols, Cesare M. Terracciano, Dietmar W. Hutmacher, Bruce W. Drinkwater, Travis J. Klein, Adam W. Perriman, Molly M. Stevens Engineering Anisotropic Muscle Tissue using Acoustic Cell Patterning published pages: 1802649, ISSN: 0935-9648, DOI: 10.1002/adma.201802649	Advanced Materials 30/43	2019-05-23
2017	Charalambos Kallepitis, Mads S. Bergholt, Manuel M. Mazo, Vincent Leonardo, Stacey C. Skaalure, Stephanie A. Maynard, Molly M. Stevens Quantitative volumetric Raman imaging of three dimensional cell cultures published pages: 14843, ISSN: 2041-1723, DOI: 10.1038/ncomms14843	Nature Communications 8	2019-05-23
2017	Shih-Ting Wang, Yiyang Lin, Ryan K. Spencer, Michael R. Thomas, Andy I. Nguyen, Nadav Amdursky, E. Thomas Pashuck, Stacey C. Skaalure, Cheng Yu Song, Paresh A. Parmar, Rhodri M. Morgan, Peter Ercius, Shaul Aloni, Ronald N. Zuckermann, Molly M. Stevens Sequence-Dependent Self-Assembly and Structural Diversity of Islet Amyloid Polypeptide-Derived Î²-Sheet Fibrils published pages: 8579-8589, ISSN: 1936-0851, DOI: 10.1021/acsnano.7b02325	ACS Nano 11/9	2019-05-23
2019	Yiyang Lin, Manuel M. Mazo, Stacey C. Skaalure, Michael R. Thomas, Simon R. Schultz, Molly M. Stevens Activatable cellâ€“biomaterial interfacing with photo-caged peptides published pages: , ISSN: 2041-6520, DOI: 10.1039/C8SC04725A	Chemical Science	2019-05-23

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The information about "RADOTE" are provided by the European Opendata Portal: CORDIS opendata.