Explore the words cloud of the RADoTE project. It provides you a very rough idea of what is the project "RADoTE" about.
The following table provides information about the project.
IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE
|Coordinator Country||United Kingdom [UK]|
|Total cost||183˙454 €|
|EC max contribution||183˙454 € (100%)|
1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
|Duration (year-month-day)||from 2016-11-01 to 2018-10-31|
Take a look of project's partnership.
|1||IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE||UK (LONDON)||coordinator||183˙454.00|
As a Marie SkÅ‚odowska-Curie Fellow, I will develop and demonstrate remote-activated delivery of biological therapeutics loaded into an injectable hydrogel, where delivery is triggered by applying near-infrared (NIR) light that safely and non-invasively penetrates deep into living tissues. The hydrogel carrier will be designed to deliver and stabilize cell-derived exosomes and microvesicles, together referred to as extracellular vesicles (EVs), which have recently gained attention for their ability to effectively deliver biological information and cargo directly to target cells. Developing sophisticated delivery systems for EVs will streamline their translation to clinical application, enabling the huge potential for this novel biological therapeutic to be fully realized. This system will be advantageous in simultaneously providing localized delivery, enhanced EV stability, and crucially, externally triggered release. This project will provide the first demonstration of localized and controlled delivery of EVs, with the added novelty of an externally NIR-triggered delivery system. By combining my expertise in designer hydrogel chemistry, the supervision of Prof. Molly Stevens at Imperial College London (ICL) who runs a world-class interdisciplinary biomaterials-focused group, and a secondment with The Technology Partnership (TTP) specializing in technology translation, this project is ideally situated to deliver the highest quality results.
|year||authors and title||journal||last update|
James P. K. Armstrong, Jennifer L. Puetzer, Andrea Serio, Anne GÃ©raldine Guex, Michaella Kapnisi, Alexandre Breant, Yifan Zong, Valentine Assal, Stacey C. Skaalure, OisÃn King, Tara Murty, Christoph Meinert, Amanda C. Franklin, Philip G. Bassindale, Madeleine K. Nichols, Cesare M. Terracciano, Dietmar W. Hutmacher, Bruce W. Drinkwater, Travis J. Klein, Adam W. Perriman, Molly M. Stevens
Engineering Anisotropic Muscle Tissue using Acoustic Cell Patterning
published pages: 1802649, ISSN: 0935-9648, DOI: 10.1002/adma.201802649
|Advanced Materials 30/43||2019-05-23|
Charalambos Kallepitis, Mads S. Bergholt, Manuel M. Mazo, Vincent Leonardo, Stacey C. Skaalure, Stephanie A. Maynard, Molly M. Stevens
Quantitative volumetric Raman imaging of three dimensional cell cultures
published pages: 14843, ISSN: 2041-1723, DOI: 10.1038/ncomms14843
|Nature Communications 8||2019-05-23|
Shih-Ting Wang, Yiyang Lin, Ryan K. Spencer, Michael R. Thomas, Andy I. Nguyen, Nadav Amdursky, E. Thomas Pashuck, Stacey C. Skaalure, Cheng Yu Song, Paresh A. Parmar, Rhodri M. Morgan, Peter Ercius, Shaul Aloni, Ronald N. Zuckermann, Molly M. Stevens
Sequence-Dependent Self-Assembly and Structural Diversity of Islet Amyloid Polypeptide-Derived Î²-Sheet Fibrils
published pages: 8579-8589, ISSN: 1936-0851, DOI: 10.1021/acsnano.7b02325
|ACS Nano 11/9||2019-05-23|
Yiyang Lin, Manuel M. Mazo, Stacey C. Skaalure, Michael R. Thomas, Simon R. Schultz, Molly M. Stevens
Activatable cellâ€“biomaterial interfacing with photo-caged peptides
published pages: , ISSN: 2041-6520, DOI: 10.1039/C8SC04725A
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