Opendata, web and dolomites


Targeting IRE1 in disease

Total Cost €


EC-Contrib. €






Project "INSPIRED" data sheet

The following table provides information about the project.


Organization address
city: Galway
postcode: H91

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Ireland [IE]
 Project website
 Total cost 886˙500 €
 EC max contribution 832˙500 € (94%)
 Programme 1. H2020-EU.1.3.3. (Stimulating innovation by means of cross-fertilisation of knowledge)
 Code Call H2020-MSCA-RISE-2016
 Funding Scheme MSCA-RISE
 Starting year 2017
 Duration (year-month-day) from 2017-01-01   to  2020-12-31


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    NATIONAL UNIVERSITY OF IRELAND GALWAY IE (Galway) coordinator 364˙500.00
5    GOETEBORGS UNIVERSITET SE (GOETEBORG) participant 13˙500.00
6    METASYSX GMBH DE (POTSDAM) participant 9˙000.00
8    ORINOVE INC US (NEWBURY PARK) partner 0.00


 Project objective

The overarching objective of this Interfere to Suppress or Promote IRE1 (INSPIRED) RISE programme is to drive research and innovation in cell stress and drug development for cancer and neurodegenerative diseases by forming an interdisciplinary and intersectoral network of experts with strong, dynamic and productive interactions. The partners will work together, each bringing their unique expertise, to develop new classes of therapeutics for these common diseases. By fostering a shared culture of research, innovation and collaboration, the participants will accelerate advances in the field of cell stress responses. The staff members who participate in the programme will develop new skills, learn new technologies and be exposed to new environments which will considerably enhance their career opportunities. Advancing drug development in the stress response field has potential translational and commercial opportunities for the participants and will benefit European society as a whole from economic and health perspectives. IRE1 is a stress sensor and signal transducer, activated in response to the accumulation of misfolded proteins in the endoplasmic reticulum (ER). Its activation is part of a process termed the unfolded protein response (UPR) that determines the fate of cells in response to ER stress. The INSPIRED consortium will focus on understanding IRE1 signalling and its role in the stress response in order to target it in specific diseases such as cancers and neurodegenerative disorders where aberrant IRE1 signalling occurs. Research carried out by INSPIRED partners will develop new IRE1 modulators and generate preclinical data to support targeting IRE1 in cancers and neurodegenerative disease.


List of deliverables.
Consortium web site established Websites, patent fillings, videos etc. 2019-08-30 13:19:40
Creation of Facebook & Twitter accounts Websites, patent fillings, videos etc. 2019-08-30 13:19:40

Take a look to the deliverables list in detail:  detailed list of INSPIRED deliverables.


year authors and title journal last update
List of publications.
2018 Denisse Sepulveda, Diego Rojas-Rivera, Diego A. Rodríguez, Jody Groenendyk, Andres Köhler, Cynthia Lebeaupin, Shinya Ito, Hery Urra, Amado Carreras-Sureda, Younis Hazari, Mireille Vasseur-Cognet, Maruf M.U. Ali, Eric Chevet, Gisela Campos, Patricio Godoy, Tomas Vaisar, Béatrice Bailly-Maitre, Kazuhiro Nagata, Marek Michalak, Jimena Sierralta, Claudio Hetz
Interactome Screening Identifies the ER Luminal Chaperone Hsp47 as a Regulator of the Unfolded Protein Response Transducer IRE1α
published pages: 238-252.e7, ISSN: 1097-2765, DOI: 10.1016/j.molcel.2017.12.028
Molecular Cell 69/2 2019-08-30
2018 Stéphanie Lhomond, Tony Avril, Nicolas Dejeans, Konstantinos Voutetakis, Dimitrios Doultsinos, Mari McMahon, Raphaël Pineau, Joanna Obacz, Olga Papadodima, Florence Jouan, Heloise Bourien, Marianthi Logotheti, Gwénaële Jégou, Néstor Pallares‐Lupon, Kathleen Schmit, Pierre‐Jean Le Reste, Amandine Etcheverry, Jean Mosser, Kim Barroso, Elodie Vauléon, Marion Maurel, Afshin Samali, John B Patterson, Olivier Pluquet, Claudio Hetz, Véronique Quillien, Aristotelis Chatziioannou, Eric Chevet
Dual IRE1 RNase functions dictate glioblastoma development
published pages: e7929, ISSN: 1757-4676, DOI: 10.15252/emmm.201707929
EMBO Molecular Medicine 10/3 2019-08-30
2017 Philippe Pihán, Amado Carreras-Sureda, Claudio Hetz
BCL-2 family: integrating stress responses at the ER to control cell demise
published pages: 1478-1487, ISSN: 1350-9047, DOI: 10.1038/cdd.2017.82
Cell Death and Differentiation 24/9 2019-08-30
2018 Hery Urra, Daniel R. Henriquez, José Cánovas, David Villarroel-Campos, Amado Carreras-Sureda, Eduardo Pulgar, Emiliano Molina, Younis M. Hazari, Celia M. Limia, Sebastián Alvarez-Rojas, Ricardo Figueroa, Rene L. Vidal, Diego A. Rodriguez, Claudia A. Rivera, Felipe A. Court, Andrés Couve, Ling Qi, Eric Chevet, Ryoko Akai, Takao Iwawaki, Miguel L. Concha, Álvaro Glavic, Christian Gonzalez-Billault, Claudio Hetz
IRE1α governs cytoskeleton remodelling and cell migration through a direct interaction with filamin A
published pages: 942-953, ISSN: 1465-7392, DOI: 10.1038/s41556-018-0141-0
Nature Cell Biology 20/8 2019-08-30
2019 Aitor Almanza, Antonio Carlesso, Chetan Chintha, Stuart Creedican, Dimitrios Doultsinos, Brian Leuzzi, Andreia Luís, Nicole McCarthy, Luigi Montibeller, Sanket More, Alexandra Papaioannou, Franziska Püschel, Maria Livia Sassano, Josip Skoko, Patrizia Agostinis, Jackie de Belleroche, Leif A. Eriksson, Simone Fulda, Adrienne M. Gorman, Sandra Healy, Andrey Kozlov, Cristina Muñoz-Pinedo, Markus Rehm, Eric Chevet, Afshin Samali
Endoplasmic reticulum stress signalling - from basic mechanisms to clinical applications
published pages: 241-278, ISSN: 1742-464X, DOI: 10.1111/febs.14608
The FEBS Journal 286/2 2019-08-30
2017 Gabriela Mercado, Claudio Hetz
Drug repurposing to target proteostasis and prevent neurodegeneration: accelerating translational efforts
published pages: 1544-1547, ISSN: 0006-8950, DOI: 10.1093/brain/awx107
Brain 140/6 2019-08-30
2018 Eoghan McGrath, Susan Logue, Katarzyna Mnich, Shane Deegan, Richard Jäger, Adrienne Gorman, Afshin Samali
The Unfolded Protein Response in Breast Cancer
published pages: 344, ISSN: 2072-6694, DOI: 10.3390/cancers10100344
Cancers 10/10 2019-08-30
2017 Danilo B. Medinas, Jose V. González, Paulina Falcon, Claudio Hetz
Fine-Tuning ER Stress Signal Transducers to Treat Amyotrophic Lateral Sclerosis
published pages: , ISSN: 1662-5099, DOI: 10.3389/fnmol.2017.00216
Frontiers in Molecular Neuroscience 10 2019-08-30
2017 Leslie Bargsted, Danilo B. Medinas, Francisca Martínez Traub, Pablo Rozas, Natalia Muñoz, Melissa Nassif, Carolina Jerez, Alejandra Catenaccio, Felipe A. Court, Claudio Hetz, Soledad Matus
Disulfide cross-linked multimers of TDP-43 and spinal motoneuron loss in a TDP-43A315T ALS/FTD mouse model
published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-017-14399-5
Scientific Reports 7/1 2019-08-30
2018 Claudio Hetz, Feroz R. Papa
The Unfolded Protein Response and Cell Fate Control
published pages: 169-181, ISSN: 1097-2765, DOI: 10.1016/j.molcel.2017.06.017
Molecular Cell 69/2 2019-08-30
2017 Amado Carreras-Sureda, Philippe Pihán, Claudio Hetz
The Unfolded Protein Response: At the Intersection between Endoplasmic Reticulum Function and Mitochondrial Bioenergetics
published pages: , ISSN: 2234-943X, DOI: 10.3389/fonc.2017.00055
Frontiers in Oncology 7 2019-08-30
2018 Susan E. Logue, Eoghan P. McGrath, Patricia Cleary, Stephanie Greene, Katarzyna Mnich, Aitor Almanza, Eric Chevet, Róisín M. Dwyer, Anup Oommen, Patrick Legembre, Florence Godey, Emma C. Madden, Brian Leuzzi, Joanna Obacz, Qingping Zeng, John B. Patterson, Richard Jäger, Adrienne M. Gorman, Afshin Samali
Inhibition of IRE1 RNase activity modulates the tumor cell secretome and enhances response to chemotherapy
published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-018-05763-8
Nature Communications 9/1 2019-08-30
2017 Joanna Obacz, Tony Avril, Camila Rubio-Patiño, Jozef P. Bossowski, Aeid Igbaria, Jean-Ehrland Ricci, Eric Chevet
Regulation of tumor-stroma interactions by the unfolded protein response
published pages: , ISSN: 1742-464X, DOI: 10.1111/febs.14359
The FEBS Journal 2019-08-30

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