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Rafts4Biotech SIGNED

Synthetic bacterial lipid rafts to optimize industrial bioprocesses

Total Cost €

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EC-Contrib. €

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Partnership

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Project "Rafts4Biotech" data sheet

The following table provides information about the project.

Coordinator
AGENCIA ESTATAL CONSEJO SUPERIOR DEINVESTIGACIONES CIENTIFICAS 

Organization address
address: CALLE SERRANO 117
city: MADRID
postcode: 28006
website: http://www.csic.es

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Spain [ES]
 Project website http://rafts4biotech.eu/
 Total cost 7˙484˙630 €
 EC max contribution 6˙733˙580 € (90%)
 Programme 1. H2020-EU.2.1.4. (INDUSTRIAL LEADERSHIP - Leadership in enabling and industrial technologies – Biotechnology)
 Code Call H2020-NMBP-BIO-2016
 Funding Scheme RIA
 Starting year 2017
 Duration (year-month-day) from 2017-01-01   to  2020-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    AGENCIA ESTATAL CONSEJO SUPERIOR DEINVESTIGACIONES CIENTIFICAS ES (MADRID) coordinator 1˙569˙778.00
2    GEORG-AUGUST-UNIVERSITAT GOTTINGENSTIFTUNG OFFENTLICHEN RECHTS DE (GOTTINGEN) participant 700˙000.00
3    RIJKSUNIVERSITEIT GRONINGEN NL (GRONINGEN) participant 613˙706.00
4    INSTITUT PASTEUR FR (PARIS CEDEX 15) participant 600˙250.00
5    FAKULTNI NEMOCNICE U SV. ANNY V BRNE CZ (Brno) participant 600˙007.00
6    BIOSYNTIA APS DK (HORSHOLM) participant 555˙250.00
7    NAICONS SRL IT (SARONNO VA) participant 555˙000.00
8    UNIVERSITATSMEDIZIN GREIFSWALD KORPERSCHAFT DES OFFENTLICHEN RECHTS DE (GREIFSWALD) participant 446˙250.00
9    ENGENES BIOTECH GMBH AT (WIEN) participant 434˙450.00
10    ENANTIS SRO CZ (BRNO) participant 369˙250.00
11    SCIENSEED SL ES (MADRID) participant 289˙637.00
12    EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH CH (ZUERICH) participant 0.00

Map

 Project objective

Genetic tractability of bacterial cells allows generating synthetic microbial chassis platforms (SMCPs) with remarkable biotechnological applications but their functionality currently faces important off-genome limitations due to deficient protein-protein interactions, unfavorable protein stoichiometry or generation of toxic intermediates that ultimately compromise the industrial production processes. To solve this problem, Rafts4Biotech project will take advantage of our recent discovery, that bacteria are able to organize subcellular membrane compartments similar to the so-called lipid rafts of eukaryotic cells, to improve/protect specific cellular processes. Rafts4Biotech project will engineer bacterial cells to confine biotechnologically relevant reactions into bacterial lipid rafts to optimize their stoichiometry and protect cells from undesirable metabolic interferences. Hence, the Rafts4Biotech project will produce new generation reliable and robust SMCPs in which industrial production processes are confined in bacterial lipid rafts, released from their classical off-genome limitations and optimized for industrial production. Moreover, this concept can be applied to many prokaryotes, since lipid rafts happens to occur in many bacterial species. Based on this versatility, Raft4Biotech project will use two biotechnologically relevant biosystems, Bacillus subtilis and Escherichia coli, to engineer synthetic bacterial lipid rafts to optimize the performance of three challenging biochemical processes in the fields of pharmaceutical, cosmetics and feed industrial sectors. To achieve this, Rafts4Biotech consortium combines different expertise in synthetic biology, systems biology and mathematical modeling and it includes a number of SMEs that will actively work in this project and will translate this technology into market application. The technology developed by Rafts4Biotec will optimize multistep industrial processes and invigorate European research.

 Deliverables

List of deliverables.
Iterative loop 1 Other 2020-04-24 23:47:16
Study cases promotional material Websites, patent fillings, videos etc. 2020-04-24 23:46:45
Description of the design of capillary microfluidic device and related software for automated control of bioreactor device Other 2020-04-24 23:47:01
Metabolomic data analyses Demonstrators, pilots, prototypes 2020-04-24 23:46:10
Proteomic data analyses and comparison studies Demonstrators, pilots, prototypes 2020-04-24 23:45:55
Iterative loop 2 Other 2020-04-24 23:45:25
Transcriptomics data analyses and comparison studies Demonstrators, pilots, prototypes 2020-04-24 23:45:41
Mid-project communication and engagement material Websites, patent fillings, videos etc. 2020-04-24 23:46:26
Project management guideline meeting for project overall and WPs Websites, patent fillings, videos etc. 2020-03-20 18:23:10
Initial communication material Websites, patent fillings, videos etc. 2020-03-20 18:23:10
Presentation of Data Management Plan Demonstrators, pilots, prototypes 2020-03-20 18:23:10
Description of the optimal design of the microfluidic chip and the related software for transforming chip data into kinetic values Other 2020-03-20 18:23:10
Visual identity, website and social networks Websites, patent fillings, videos etc. 2020-03-20 18:23:10

Take a look to the deliverables list in detail:  detailed list of Rafts4Biotech deliverables.

 Publications

year authors and title journal last update
List of publications.
2017 Daniel R. Reuß, Fabian M. Commichau, Jörg Stülke
The contribution of bacterial genome engineering to sustainable development
published pages: 1259-1263, ISSN: 1751-7915, DOI: 10.1111/1751-7915.12784
Microbial Biotechnology 10/5 2020-03-20
2018 Stanislav Mazurenko, Jan Stourac, Antonin Kunka, Sava Nedeljković, David Bednar, Zbynek Prokop, Jiri Damborsky
CalFitter: a web server for analysis of protein thermal denaturation data
published pages: W344-W349, ISSN: 0305-1048, DOI: 10.1093/nar/gky358
Nucleic Acids Research 46/W1 2020-03-20
2018 Lenka Sumbalova, Jan Stourac, Tomas Martinek, David Bednar, Jiri Damborsky
HotSpot Wizard 3.0: web server for automated design of mutations and smart libraries based on sequence input information
published pages: W356-W362, ISSN: 0305-1048, DOI: 10.1093/nar/gky417
Nucleic Acids Research 46/W1 2020-03-20
2018 Auke J van Heel, Anne de Jong, Chunxu Song, Jakob H Viel, Jan Kok, Oscar P Kuipers
BAGEL4: a user-friendly web server to thoroughly mine RiPPs and bacteriocins
published pages: , ISSN: 0305-1048, DOI: 10.1093/nar/gky383
Nucleic Acids Research 2020-03-20
2018 Antonin Kunka, Jiri Damborsky, Zbynek Prokop
Haloalkane Dehalogenases From Marine Organisms
published pages: 203-251, ISSN: 0076-6879, DOI: 10.1016/bs.mie.2018.03.005
Methods in Enzymology 2020-03-20
2017 Pavel Dvořák, Pablo I. Nikel, Jiří Damborský, Víctor de Lorenzo
Bioremediation 3 . 0 : Engineering pollutant-removing bacteria in the times of systemic biology
published pages: 845-866, ISSN: 0734-9750, DOI: 10.1016/j.biotechadv.2017.08.001
Biotechnology Advances 35/7 2020-03-20

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The information about "RAFTS4BIOTECH" are provided by the European Opendata Portal: CORDIS opendata.

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