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N2B-patch SIGNED

Nose to Brain Delivery of antibodies via the Olfactory Region for the Treatment of Multiple Sclerosis Using Novel Multi-functional Biomaterials Combined with a Medical Device

Total Cost €

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EC-Contrib. €

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Partnership

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 N2B-patch project word cloud

Explore the words cloud of the N2B-patch project. It provides you a very rough idea of what is the project "N2B-patch" about.

bioavailabilty    api    aid    chronic    synthesis    consist    apis    co    loaded    innovative    enormous    safe    chitosan    demyelinating    sufficiently    patch    mab    nogoa    formulation    glycolic    permeation    closure    cross    device    offers    drug    bioavailability    stroke    blocking    hyaluronic    epithelium    bbb    ph    minimally    diseases    neurodegenerative    nervous    mucoadhesive    route    container    active    treatment    mode    biodegradable    monoclonal    subsequent    cord    coating    central    derivatives    polylactic    cns    initial    sustainable    brain    deposited    acid    polymer    integrity    direct    101    indications    biomaterial    particles    remyelation    nasal    invasive    proven    largely    pharmaceutical    galenic    ms    practical    onto    plga    equipped    n2b    data    cavity    ccs    exploited    matrix    tumours    hydrogel    olfactory    clinical    sensitive    proof    platform    antagonist    axonal    transport    antibodies    ingredient    medical    release    bypassing    region    environment    contact    disorders    ng    particle    drugs    adhesion    spinal   

Project "N2B-patch" data sheet

The following table provides information about the project.

Coordinator
FRAUNHOFER GESELLSCHAFT ZUR FOERDERUNG DER ANGEWANDTEN FORSCHUNG E.V. 

Organization address
address: HANSASTRASSE 27C
city: MUNCHEN
postcode: 80686
website: www.fraunhofer.de

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Project website https://n2b-patch.eu/
 Total cost 6˙472˙998 €
 EC max contribution 5˙325˙498 € (82%)
 Programme 1. H2020-EU.2.1.3. (INDUSTRIAL LEADERSHIP - Leadership in enabling and industrial technologies - Advanced materials)
 Code Call H2020-NMBP-2016-two-stage
 Funding Scheme RIA
 Starting year 2017
 Duration (year-month-day) from 2017-01-01   to  2020-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    FRAUNHOFER GESELLSCHAFT ZUR FOERDERUNG DER ANGEWANDTEN FORSCHUNG E.V. DE (MUNCHEN) coordinator 783˙095.00
2    HOCHSCHULE BIBERACH DE (BIBERACH) participant 1˙102˙398.00
3    BEITER GMBH GO KG DE (SIGMARINGENDORF) participant 728˙125.00
4    JENSONR+ LIMITED UK (BARNSTAPLE DEVON) participant 611˙700.00
5    MJR PHARMJET GMBH DE (UBERHERRM) participant 559˙137.00
6    ETHNIKO KENTRO EREVNAS KAI TECHNOLOGIKIS ANAPTYXIS EL (THERMI THESSALONIKI) participant 495˙000.00
7    CONTIPRO AS CZ (DOLNI DOBROUC) participant 400˙000.00
8    LGI CONSULTING FR (PARIS) participant 291˙250.00
9    LABORATORIO EUROPEO DI SPETTROSCOPIE NON LINEARI IT (Sesto-Fiorentino (FI)) participant 227˙500.00
10    THE EUROPEAN MULTIPLE SCLEROSIS PLATFORM AISBL BE (BRUXELLES) participant 127˙292.00
11    NOVAGO THERAPEUTICS AG CH (SCHLIEREN) participant 0.00
12    UNIVERSITAET BERN CH (BERN) participant 0.00

Map

 Project objective

The overall aim of N2B-patch is the development of a new innovative N2B drug delivery technology based on the synthesis of a biomaterial-based innovative galenic formulation that will be applied with the aid of a novel medical device equipped with a container closure system (CCS) as a hydrogel patch to the nasal olfactory region for the chronic treatment of MS. The galenic formulation will consist of drug loaded biodegradable polymer particles (e.g., chitosan, polylactic-co-glycolic acid, PLGA) embedded into a biodegradable hydrogel matrix (e.g., hyaluronic acid (HA)-based) to be deposited as a patch onto the olfactory region. A pH-sensitive, mucoadhesive particle coating (e.g., chitosan, chitosan derivatives) will ensure an environment-specific adhesion to the olfactory epithelium. This novel technology will largely enhance the controlled and sustainable delivery of drugs and increase the drug bioavailabilty to the CNS. NogoA antagonist NG-101 will be used as an active pharmaceutical ingredient (API). Proof of concept studies and initial clinical data have proven the enormous potential of blocking NogoA for spinal cord remyelation and axonal integrity. However, monoclonal antibodies (mAb) like NG-101, do not sufficiently cross the BBB. The sustainable and controlled release of NG-101 to the CNS will be achieved via the transport of embedded polymer particles to the olfactory epithelium, the subsequent release of API and permeation through the olfactory region, the only part of the nasal epithelium which is in direct contact with the brain. The direct transport route from the nasal cavity to the brain, bypassing the BBB, offers an exciting mode of central nervous system (CNS) drug delivery not only for demyelinating disorders but also for other CNS indications, e.g., stroke, neurodegenerative diseases or tumours. The proposed new innovative N2B drug delivery platform is a practical, safe, and minimally invasive technology. It will be exploited for NG-101 and has the potential to be implemented with other APIs with a low CNS bioavailability.

 Publications

year authors and title journal last update
List of publications.
2019 Simone Ladel, Patrick Schlossbauer, Johannes Flamm, Harald Luksch, Boris Mizaikoff, Katharina Schindowski
Improved In Vitro Model for Intranasal Mucosal Drug Delivery: Primary Olfactory and Respiratory Epithelial Cells Compared with the Permanent Nasal Cell Line RPMI 2650
published pages: 367, ISSN: 1999-4923, DOI: 10.3390/pharmaceutics11080367
Pharmaceutics 11/8 2020-04-14
2018 Aleck H. Alexopoulos, Costas Kiparissides
A Computational Model for the Analysis of Spreading of Viscoelastic Droplets over Flat Surfaces
published pages: 78, ISSN: 2311-5521, DOI: 10.3390/fluids3040078
Fluids 3/4 2020-04-14
2018 Simone Ladel, Johannes Flamm, Arghavan Soleimani Zadeh, Dorothea Filzwieser, Julia-Christina Walter, Patrick Schlossbauer, Ralf Kinscherf, Katharina Lischka, Harald Luksch, Katharina Schindowski
Allogenic Fc Domain-Facilitated Uptake of IgG in Nasal Lamina Propria: Friend or Foe for Intranasal CNS Delivery?
published pages: 107, ISSN: 1999-4923, DOI: 10.3390/pharmaceutics10030107
Pharmaceutics 10/3 2020-04-14
2018 Bourganis, Vassilis; Kammona, Olga; Alexopoulos, Aleck; Kiparissides, Costas
Recent advances in carrier mediated nose-to-brain delivery of pharmaceutics
published pages: 337-362, ISSN: 0939-6411, DOI: 10.5281/zenodo.1256646
European Journal of Pharmaceutics and Biopharmaceutics 128 2020-04-14
2018 Gruber-Traub C, Ullrich J.
»N2B-Patch« – Nose-to-Brain Delivery of an Active Pharmaceutical Ingredient via the Olfactory Region
published pages: , ISSN: 2637-4706, DOI:
Drug Designing & Intellectual Properties International Journal 2020-04-14
2018 Stella Gänger, Katharina Schindowski
Tailoring Formulations for Intranasal Nose-to-Brain Delivery: A Review on Architecture, Physico-Chemical Characteristics and Mucociliary Clearance of the Nasal Olfactory Mucosa
published pages: 116, ISSN: 1999-4923, DOI: 10.3390/pharmaceutics10030116
Pharmaceutics 10/3 2020-04-14

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