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NONCODRIVERS SIGNED

Finding noncoding cancer drivers

Total Cost €

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EC-Contrib. €

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Partnership

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Project "NONCODRIVERS" data sheet

The following table provides information about the project.

Coordinator
FUNDACIO INSTITUT DE RECERCA BIOMEDICA (IRB BARCELONA) 

Organization address
address: CARRER BALDIRI REIXAC 10-12 PARC SCIENTIFIC DE BARCELONA
city: BARCELONA
postcode: 8028
website: www.irbbarcelona.org

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Spain [ES]
 Project website http://bbglab.irbbarcelona.org
 Total cost 1˙995˙828 €
 EC max contribution 1˙995˙828 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2015-CoG
 Funding Scheme ERC-COG
 Starting year 2016
 Duration (year-month-day) from 2016-12-01   to  2021-11-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    FUNDACIO INSTITUT DE RECERCA BIOMEDICA (IRB BARCELONA) ES (BARCELONA) coordinator 1˙995˙828.00

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 Project objective

Finding the mutations, genes and pathways directly involved in cancer is of paramount importance to understand the mechanisms of tumour development and devise therapeutic strategies to overcome the disease. Due to their role in cancer development and maintenance, the proteins encoded by cancer genes are candidate therapeutic targets. Indeed, in recent years we have witnessed the development of successful cancer-targeting therapies to counteract the effect of driver mutations. Although the coding part of the human genome has now largely been explored in the search for cancer driver mutations in most frequent cancer types, the extent of involvement of noncoding mutations in cancer development remains a mystery. The main challenges faced are: 1) the functional role of most noncoding regions is unknown, and 2) tumours often have thousands of somatic mutations, so that distinguishing cancer driver mutations from bystanders is like finding the proverbial needle in a haystack. To overcome these two challenges I propose to analyse the pattern of somatic mutations across thousands of tumours in noncoding regions to identify signals of positive selection. These signals are an indication that mutations in the region have been positively selected during tumour evolution and are thus directly involved in the tumour phenotype. The large scale analysis proposed here will allow us to create a catalogue of noncoding elements involved in different types of cancer upon mutations. We will study in detail a selected set of driver elements to uncover their specific function and role in the tumourigenic process. Furthermore, we will explore possibilities of counteracting their driver effect with targeted drugs. The results of this project may boost our understanding of the biological role of noncoding regions, help to unravel novel molecular causes of cancer and provide novel targeted therapeutic opportunities for cancer patients.

 Publications

year authors and title journal last update
List of publications.
2017 Sabarinathan R, Pich O, Martincorena I, Rubio-Perez C, Juul M, Wala J, Schumacher S, Shapira O, Sidiropoulos N, Waszak S, Tamborero D, Mularoni L, Rheinbay E, Hornshoj H, Deu-Pons J, Muinos F, Bertl J, Guo Q, Weischenfeldt J, Korbel JO, Getz G, Campbell PJ, Pedersen JS, Beroukhim R, Perez-Gonzalez A, Lopez-Bigas N, PCAWG Drivers and Functional Interpretation Group, ICGC/TCGA Pan-Cancer Analysis of
The whole-genome panorama of cancer drivers
published pages: , ISSN: , DOI: 10.1101/190330
Pre print 2019-08-29
2017 Esther Rheinbay, Morten Muhlig Nielsen, Federico Abascal, Grace Tiao, Henrik Hornshøj, Julian M. Hess, Randi Istrup Pedersen, Lars Feuerbach, Radhakrishnan Sabarinathan, Tobias Madsen, Jaegil Kim, Loris Mularoni, Shimin Shuai, Andrés Lanzós, Carl Herrmann, Yosef E. Maruvka, Ciyue Shen, Samirkumar B. Amin, Johanna Bertl, Priyanka Dhingra, Klev Diamanti, Abel Gonzalez-Perez, Qia
Discovery and characterization of coding and non-coding driver mutations in more than 2,500 whole cancer genomes
published pages: , ISSN: , DOI: 10.1101/237313
pre print 2019-08-29
2018 Oriol Pich, Ferran Muiños, Radhakrishnan Sabarinathan, Iker Reyes-Salazar, Abel Gonzalez-Perez, Nuria Lopez-Bigas
Somatic and Germline Mutation Periodicity Follow the Orientation of the DNA Minor Groove around Nucleosomes
published pages: 1074-1087.e18, ISSN: 0092-8674, DOI: 10.1016/j.cell.2018.10.004
Cell 175/4 2019-08-29
2018 Francisco Martínez-Jiménez, Ferran Muiños, Erika Lopez-Arribillaga, Nuria Lopez-Bigas, Abel Gonzalez-Perez
Disruption of ubiquitin mediated proteolysis is a widespread mechanism of tumorigenesis
published pages: , ISSN: , DOI: 10.1101/507764
Pre print 2019-08-29
2019 Claudia Arnedo-Pac, Loris Mularoni, Ferran Muiños, Abel Gonzalez-Perez, Nuria Lopez-Bigas
OncodriveCLUSTL: a sequence-based clustering method to identify cancer drivers
published pages: , ISSN: 1367-4803, DOI: 10.1093/bioinformatics/btz501
Bioinformatics 2019-09-02
2019 Abel Gonzalez-Perez, Radhakrishnan Sabarinathan, Nuria Lopez-Bigas
Local Determinants of the Mutational Landscape of the Human Genome
published pages: 101-114, ISSN: 0092-8674, DOI: 10.1016/j.cell.2019.02.051
Cell 177/1 2019-08-06
2018 Francisco Martínez-Jiménez, Ferran Muiños, Erika Lopez-Arribillaga, Nuria Lopez-Bigas, Abel Gonzalez-Perez
Disruption of ubiquitin mediated proteolysis is a widespread mechanism of tumorigenesis
published pages: , ISSN: , DOI: 10.1101/507764
Pre print 2019-08-06
2018 David Tamborero, Carlota Rubio-Perez, Ferran Muiños, Radhakrishnan Sabarinathan, Josep M. Piulats, Aura Muntasell, Rodrigo Dienstmann, Nuria Lopez-Bigas, Abel Gonzalez-Perez
A Pan-cancer Landscape of Interactions between Solid Tumors and Infiltrating Immune Cell Populations
published pages: 3717-3728, ISSN: 1078-0432, DOI: 10.1158/1078-0432.ccr-17-3509
Clinical Cancer Research 24/15 2019-05-22

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