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theEoE

A novel drug candidate for the treatment of Eosinophilic Esophagitis - an innovative solution for a significant unmet medical need

Total Cost €

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EC-Contrib. €

0

Partnership

0

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 theEoE project word cloud

Explore the words cloud of the theEoE project. It provides you a very rough idea of what is the project "theEoE" about.

patented    integrity    line    eosinophilic    elicited    tissue    efficacy    cure    occurs    discovery    diseases    fits    indications    white    nausea    symptoms    polarity    local    28    regurgitation    payers    embryo    revolutionary    patients    proprietary    points    reduces    spending    persistent    eosinophils    disease    time    eoe    lower    topical    candidate    smarter    accumulate    barriers    allergens    foods    healthier    pain    uncontrolled    people    applies    compounds    causing    fly    innovation    epithelial    inflammatory    possibly    clinical    esophagus    progression    vomiting    therapy    risk    cells    europe2020    health    bioavailability    approved    technologies    treatment    thelial    first    difficulty    swallowing    modulation    modulating    fewer    series    company    ip    prioritized    toxicology    inflammation    esophagitis    modifies    pathologies    thelitetm    cellular    investing    necessarily    benefit    drug    cell    theeoe    promotion    revenue    thanks    complications    blood    environmental    decision    perfectly    remodeling    offers    generating    wellbeing    physicians    injury    sustainable    platform    persists    manufacturing   

Project "theEoE" data sheet

The following table provides information about the project.

Coordinator
THELIAL TECHNOLOGIES SA 

Organization address
address: PARQUE TECNOLOGICO DE CANTANHEDE, NUCLEO 4, LOTE 3
city: CANTANHEDE
postcode: 3060197
website: n.a.

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Portugal [PT]
 Project website http://www.thelial.com
 Total cost 71˙429 €
 EC max contribution 50˙000 € (70%)
 Programme 1. H2020-EU.3.1.3. (Treating and managing disease)
 Code Call H2020-SMEINST-1-2016-2017
 Funding Scheme SME-1
 Starting year 2016
 Duration (year-month-day) from 2016-12-01   to  2017-04-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    THELIAL TECHNOLOGIES SA PT (CANTANHEDE) coordinator 50˙000.00

Map

 Project objective

Thelial Technologies, S.A. is a revenue generating drug discovery company that applies its unique, proprietary fly embryo-based technology to find new candidate compounds for the treatment of diseases that can be addressed by cell polarity modulation. By modulating cell polarity it is possible to specifically target a series of indications, where reduced integrity of epithelial cellular barriers is a key to pathologies. Using Thelial’s patented discovery platform theLiTETM the company has identified 28 candidate compounds, of which one – theEoE has been prioritized for further development based on toxicology, efficacy, bioavailability, IP and manufacturing decision points. theEoE will be the first approved product for treatment of Eosinophilic Esophagitis (EoE). EoE is an inflammatory disease of the esophagus elicited by foods and possibly environmental allergens. It occurs when a type of white blood cells, eosinophils, accumulate in the esophagus and persists, causing local injury and inflammation. Currently, there are no specific cure for the EoE, causing patients’ reduced wellbeing due to uncontrolled and persistent symptoms (e.g. high difficulty in swallowing, pain, nausea, regurgitation, and vomiting). Thelial offers a targeted topical treatment that reduces the clinical symptoms, modifies disease progression through tissue remodeling, and increases the duration of treatment response. These features will allow physicians, patients and payers to benefit from a revolutionary new treatment with fewer side-effects, and lower risk of health complications thanks to a better management of the disease over time. By promoting a first in line targeted therapy for EoE, Thelial’s innovation project perfectly fits the “Europe2020 challenges – for a healthier EU” 1) spending smarter but not necessarily more in sustainable health systems and 2) investing in people’s health, particularly through health-promotion programmes.

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The information about "THEEOE" are provided by the European Opendata Portal: CORDIS opendata.

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