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theEoE

A novel drug candidate for the treatment of Eosinophilic Esophagitis - an innovative solution for a significant unmet medical need

Total Cost €

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EC-Contrib. €

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Partnership

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 Outcomes and results

 theEoE project word cloud

Explore the words cloud of the theEoE project. It provides you a very rough idea of what is the project "theEoE" about.

cells    benefit    toxicology    inflammatory    embryo    physicians    topical    investing    symptoms    proprietary    people    causing    possibly    thelitetm    integrity    persistent    patients    cell    decision    cellular    inflammation    local    revolutionary    white    injury    uncontrolled    treatment    reduces    patented    health    offers    regurgitation    nausea    applies    time    bioavailability    diseases    thelial    modulation    elicited    approved    candidate    series    disease    generating    payers    thanks    healthier    barriers    efficacy    persists    complications    line    theeoe    fewer    clinical    modulating    prioritized    difficulty    blood    points    eosinophils    therapy    tissue    risk    spending    indications    necessarily    fly    polarity    technologies    drug    modifies    swallowing    discovery    foods    lower    revenue    environmental    28    eosinophilic    cure    pain    innovation    platform    company    epithelial    progression    smarter    wellbeing    manufacturing    pathologies    perfectly    remodeling    eoe    europe2020    occurs    first    promotion    accumulate    allergens    fits    esophagus    compounds    ip    sustainable    esophagitis    vomiting   

Project "theEoE" data sheet

The following table provides information about the project.

Coordinator		 THELIAL TECHNOLOGIES SA 

Organization address
address: PARQUE TECNOLOGICO DE CANTANHEDE, NUCLEO 4, LOTE 3
city: CANTANHEDE
postcode: 3060197
website: n.a.

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.
 Coordinator Country Portugal [PT]
 Project website http://www.thelial.com
 Total cost 71˙429 €
 EC max contribution 50˙000 € (70%)
 Programme 1. H2020-EU.3.1.3. (Treating and managing disease)
 Code Call H2020-SMEINST-1-2016-2017
 Funding Scheme SME-1
 Starting year 2016
 Duration (year-month-day) from 2016-12-01   to  2017-04-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    THELIAL TECHNOLOGIES SA PT (CANTANHEDE) coordinator 50˙000.00

Map

 Project objective

Thelial Technologies, S.A. is a revenue generating drug discovery company that applies its unique, proprietary fly embryo-based technology to find new candidate compounds for the treatment of diseases that can be addressed by cell polarity modulation. By modulating cell polarity it is possible to specifically target a series of indications, where reduced integrity of epithelial cellular barriers is a key to pathologies. Using Thelial’s patented discovery platform theLiTETM the company has identified 28 candidate compounds, of which one – theEoE has been prioritized for further development based on toxicology, efficacy, bioavailability, IP and manufacturing decision points. theEoE will be the first approved product for treatment of Eosinophilic Esophagitis (EoE). EoE is an inflammatory disease of the esophagus elicited by foods and possibly environmental allergens. It occurs when a type of white blood cells, eosinophils, accumulate in the esophagus and persists, causing local injury and inflammation. Currently, there are no specific cure for the EoE, causing patients’ reduced wellbeing due to uncontrolled and persistent symptoms (e.g. high difficulty in swallowing, pain, nausea, regurgitation, and vomiting). Thelial offers a targeted topical treatment that reduces the clinical symptoms, modifies disease progression through tissue remodeling, and increases the duration of treatment response. These features will allow physicians, patients and payers to benefit from a revolutionary new treatment with fewer side-effects, and lower risk of health complications thanks to a better management of the disease over time. By promoting a first in line targeted therapy for EoE, Thelial’s innovation project perfectly fits the “Europe2020 challenges – for a healthier EU” 1) spending smarter but not necessarily more in sustainable health systems and 2) investing in people’s health, particularly through health-promotion programmes.

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The information about "THEEOE" are provided by the European Opendata Portal: CORDIS opendata.

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