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STIPED SIGNED

Transcranial brain stimulation as innovative therapy for chronic pediatric neuropsychiatric disorder – STIPED

Total Cost €

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EC-Contrib. €

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Partnership

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 STIPED project word cloud

Explore the words cloud of the STIPED project. It provides you a very rough idea of what is the project "STIPED" about.

modern    tdcs    personalized    spectrum    due    combination    dependent    children    chronic    brain    opens    autism    neurocognitive    avenue    option    daily    behavioral    neurophysiology    function    stimulation    functional    health    telemental    home    disorders    trial    transcranial    neuropsychiatric    systematically    disorder    effect    modeling    compliance    applicability    urgent    blind    predict    families    fifth    interventions    additional    service    lack    individual    safety    core    entire    regions    safe    clinical    mechanisms    adhd    protocols    responder    asd    direct    routine    integration    alternative    treatment    age    sizes    insufficient    time    iia    innovative    sham    setting    tested    standard    first    electric    rate    adults    adolescents    individualized    hyperactivity    paediatric    randomized    biomarkers    flexible    deficit    double    ethical    shown    neuroimaging    cognitive    population    proven    outcomes    anatomical   

Project "STIPED" data sheet

The following table provides information about the project.

Coordinator
EVANGELISCHES KLINIKUM BETHEL GGMBH 

Organization address
address: KANTENSIEK 11
city: BIELEFELD
postcode: 33617
website: n.a.

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Project website http://www.stiped.eu
 Total cost 6˙195˙231 €
 EC max contribution 6˙195˙231 € (100%)
 Programme 1. H2020-EU.3.1.3. (Treating and managing disease)
 Code Call H2020-SC1-2016-RTD
 Funding Scheme RIA
 Starting year 2017
 Duration (year-month-day) from 2017-01-01   to  2021-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    EVANGELISCHES KLINIKUM BETHEL GGMBH DE (BIELEFELD) coordinator 644˙260.00
2    CHRISTIAN-ALBRECHTS-UNIVERSITAET ZU KIEL DE (KIEL) participant 1˙389˙845.00
3    JOHANN WOLFGANG GOETHE-UNIVERSITATFRANKFURT AM MAIN DE (FRANKFURT AM MAIN) participant 1˙141˙675.00
4    NEUROELECTRICS BARCELONA SL ES (BARCELONA) participant 765˙625.00
5    UNIVERSIDADE DE COIMBRA PT (COIMBRA) participant 495˙376.00
6    ARTTIC FR (PARIS) participant 380˙500.00
7    STARLAB BARCELONA SL ES (BARCELONA) participant 378˙125.00
8    OTTO-VON-GUERICKE-UNIVERSITAET MAGDEBURG DE (MAGDEBURG) participant 375˙733.00
9    ZENTRUM FUER INTEGRATIVE PSYHIATRIE DE (KIEL) participant 262˙031.00
10    CENTRE HOSPITALIER REGIONAL UNIVERSITAIRE DE TOURS FR (TOURS CEDEX 9) participant 184˙251.00
11    REGION HOVEDSTADEN DK (HILLEROD) participant 176˙435.00
12    FUNDACAO DA FACULDADE DE CIENCIAS DA UNIVERSIDADE DE LISBOA FP PT (LISBOA) participant 743.00
13    FCIENCIAS.ID - ASSOCIACAO PARA A INVESTIGACAO E DESENVOLVIMENTO DE CIENCIAS PT (LISBON) participant 629.00

Map

 Project objective

Due to lack of targeted interventions, compliance issues, insufficient effect sizes and a high non-responder rate to currently available interventions, there is an urgent need to develop innovative and new interventions for chronic paediatric neuropsychiatric disorders, such as Attention-Deficit/Hyperactivity Disorder (ADHD) and Autism Spectrum Disorder (ASD). Transcranial direct current stimulation (tDCS) has been shown to be an innovative, effective and safe alternative treatment approach for neuropsychiatric disorders in adults. Here, for the first time, the effect of tDCS on core neurocognitive and behavioral outcomes will be proven in children and adolescents. First, effect sizes and safety of standard tDCS in the clinical setting targeting core brain regions and disorder specific cognitive tasks will be established by three phase-IIa randomized, double blind, sham-controlled studies in ADHD and ASD. Second, the impact of brain development and age-dependent anatomical / functional features on effects of tDCS will be studied systematically using methods of modern neurophysiology, neuroimaging and electric current modeling. This involves an additional phase-I clinical trial. Third, mechanisms of tDCS on brain function will be studied, and biomarkers will be developed in order to predict individual response to standard and individualized stimulation protocols. Finally, the applicability of tDCS in children and adolescents will be improved by developing an innovative personalized home-based treatment option in combination with a telemental health service, which will be tested by a fifth, phase-IIa clinical trial. Throughout the entire project, ethical concerns of the target population will be addressed. This project opens a new avenue for the application of tDCS as an alternative treatment for a great number of chronic neuropsychiatric disorders in children and adolescents and will allow flexible integration of tDCS in the daily routine of families.

 Deliverables

List of deliverables.
Launch of website and social media accounts Websites, patent fillings, videos etc. 2020-04-08 14:19:26
Report on Stakeholder Involvement after Kick-Off Meeting Websites, patent fillings, videos etc. 2020-04-08 14:19:26
Press release for every partner Websites, patent fillings, videos etc. 2020-04-08 14:19:26

Take a look to the deliverables list in detail:  detailed list of STIPED deliverables.

 Publications

year authors and title journal last update
List of publications.
2020 Oula Puonti, Guilherme B. Saturnino, Kristoffer H. Madsen, Axel Thielscher
Value and limitations of intracranial recordings for validating electric field modeling for transcranial brain stimulation
published pages: 116431, ISSN: 1053-8119, DOI: 10.1016/j.neuroimage.2019.116431
NeuroImage 208 2020-04-08
2020 Carolin Breitling, Tino Zaehle, Moritz Dannhauer, Jana Tegelbeckers, Hans-Henning Flechtner, Kerstin Krauel
Comparison between conventional and HD-tDCS of the right inferior frontal gyrus in children and adolescents with ADHD
published pages: , ISSN: 1388-2457, DOI: 10.1016/j.clinph.2019.12.412
Clinical Neurophysiology 2020-04-08
2019 David Ibáñez-Soria, Aureli Soria-Frisch, Jordi Garcia-Ojalvo, Giulio Ruffini
Characterization of the non-stationary nature of steady-state visual evoked potentials using echo state networks
published pages: e0218771, ISSN: 1932-6203, DOI: 10.1371/journal.pone.0218771
PLOS ONE 14/7 2020-04-08
2019 Maike Splittgerber, Natia Japaridze, Anna Sierawska, Sandra Gimenez, Rafal Nowak, Michael Siniatchkin, Vera Moliadze
First generalized tonic clonic seizure in the context of pediatric tDCS – A case report
published pages: , ISSN: 0987-7053, DOI: 10.1016/j.neucli.2019.11.002
Neurophysiologie Clinique 2020-04-08
2019 David Ibanez-Soria1*, Eleni Kroupi1, Andrés Rojas1, Marta Castellano1, Jacobo Picardo2, Gloria García- Banda2, Belen Saez2, Mateu Servera2, Giulio Ruffini1,3, Aureli Soria-Frisch1.
Resting Eyes Closed Beta-Phase High Gamma-Amplitude Coupling Deficits in Children with Attention Deficit Hyperactivity Disorder
published pages: , ISSN: 2049-3630, DOI: 10.1101/598003
bioRxiv the reprint server for biology 2020-04-08
2019 Anna Sierawska, Alexander Prehn-Kristensen, Vera Moliadze, Kerstin Krauel, Rafal Nowak, Christine M. Freitag, Michael Siniatchkin, Alena Buyx
Unmet Needs in Children With Attention Deficit Hyperactivity Disorder—Can Transcranial Direct Current Stimulation Fill the Gap? Promises and Ethical Challenges
published pages: , ISSN: 1664-0640, DOI: 10.3389/fpsyt.2019.00334
Frontiers in Psychiatry 10 2020-04-08
2018 João Castelhano, Paula Tavares, Susana Mouga, Guiomar Oliveira, Miguel Castelo-Branco
Stimulus dependent neural oscillatory patterns show reliable statistical identification of autism spectrum disorder in a face perceptual decision task
published pages: 981-989, ISSN: 1388-2457, DOI: 10.1016/j.clinph.2018.01.072
Clinical Neurophysiology 129/5 2020-04-08
2019 Oula Puonti, Guilherme B. Saturnino,Kristoffer H. Madsen, Axel Thielscher
Comparing and Validating Automated Tools for Individualized Electric Field Simulations in the Human Head
published pages: , ISSN: 2049-3630, DOI:
biorxiv 2020-04-08
2018 Hannah Brauer, Navah Ester Kadish, Anya Pedersen, Michael Siniatchkin, Vera Moliadze
No Modulatory Effects when Stimulating the Right Inferior Frontal Gyrus with Continuous 6 Hz tACS and tRNS on Response Inhibition: A Behavioral Study
published pages: 1-11, ISSN: 2090-5904, DOI: 10.1155/2018/3156796
Neural Plasticity 2018 2020-04-08
2018 Guilherme B Saturnino*1,2, Oula Puonti*1, Jesper D Nielsen1,3 , Daria Antonenko4, Kristoffer H Madsen1,3 , and Axel Thielscher1,2
SimNIBS 2.1: A Comprehensive Pipeline for Individualized Electric Field Modelling for Transcranial Brain Stimulation
published pages: , ISSN: 2049-3630, DOI:
bioRxiv 2020-04-08
2018 Picardo, Jacobo; Garcia-Ojalvo, Jordi; Garcia-Banda, Gloria; Servera, Mateu; Ruffini, Giulio; Soria-Frisch, Aureli; Soria, David
Hypoarousal non-stationary ADHD biomarker based on echo-state networks
published pages: , ISSN: , DOI: 10.1101/271858
2 2020-04-08
2018 Marco Simões, Miguel Bernardes, Fernando Barros, Miguel Castelo-Branco
Virtual Travel Training for Autism Spectrum Disorder: Proof-of-Concept Interventional Study
published pages: e5, ISSN: 2291-9279, DOI: 10.2196/games.8428
JMIR Serious Games 6/1 2020-04-08
2018 D. Ibáñez-Soria, J. Garcia-Ojalvo, A. Soria-Frisch, G. Ruffini
Detection of generalized synchronization using echo state networks
published pages: 33118, ISSN: 1054-1500, DOI: 10.1063/1.5010285
Chaos: An Interdisciplinary Journal of Nonlinear Science 28/3 2020-04-08
2018 Gilberto Silva, Isabel Catarina Duarte, Inês Bernardino, Tânia Marques, Inês R. Violante, Miguel Castelo-Branco
Oscillatory motor patterning is impaired in neurofibromatosis type 1: a behavioural, EEG and fMRI study
published pages: , ISSN: 1866-1947, DOI: 10.1186/s11689-018-9230-4
Journal of Neurodevelopmental Disorders 10/1 2020-04-08

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