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Lifebrain SIGNED

Healthy minds from 0-100 years: Optimising the use of European brain imaging cohorts

Total Cost €

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EC-Contrib. €

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Partnership

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Project "Lifebrain" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITETET I OSLO 

Organization address
address: PROBLEMVEIEN 5-7
city: OSLO
postcode: 313
website: www.uio.no

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Norway [NO]
 Project website http://www.lifebrain.uio.no
 Total cost 10˙768˙225 €
 EC max contribution 10˙000˙000 € (93%)
 Programme 1. H2020-EU.3.1.1. (Understanding health, wellbeing and disease)
 Code Call H2020-SC1-2016-RTD
 Funding Scheme RIA
 Starting year 2017
 Duration (year-month-day) from 2017-01-01   to  2021-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITETET I OSLO NO (OSLO) coordinator 2˙410˙087.00
2    VITAS AS NO (OSLO) participant 1˙617˙360.00
3    UNIVERSITAET zu LUEBECK DE (LUBECK) participant 1˙277˙775.00
4    MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV DE (MUENCHEN) participant 682˙875.00
5    FOLKEHELSEINSTITUTTET NO (OSLO) participant 681˙685.00
6    UMEA UNIVERSITET SE (UMEA) participant 643˙725.00
7    REGION HOVEDSTADEN DK (HILLEROD) participant 624˙406.00
8    THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD UK (OXFORD) participant 533˙775.00
9    STICHTING VUMC NL (AMSTERDAM) participant 526˙402.00
10    UNIVERSITAT DE BARCELONA ES (BARCELONA) participant 435˙028.00
11    THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE UK (CAMBRIDGE) participant 417˙505.00
12    Stiftelsen Frischsenteret for samfunnsøkonomisk forskning NO (Oslo) participant 149˙375.00
13    MEDICAL RESEARCH COUNCIL UK (SWINDON) participant 0.00
14    UNIVERSITE DE GENEVE CH (GENEVE) participant 0.00

Map

 Project objective

Our main objective is to identify determinants of brain, cognitive and mental health at different stages of life. By integration, harmonisation and enrichment of major European neuroimaging studies of age differences and changes, we will obtain an unparalleled database of fine-grained brain, cognitive and mental health measures of more than 6.000 individuals. Longitudinal brain imaging, genetic and health data are available for a major part, as well as cognitive/mental health measures for extensively broader cohorts, exceeding 40.000 examinations in total. By linking these data, also to additional databases and biobanks, including birth registries, national and regional archives, and by enriching them with new online data collection and novel measures, we will address risk and protective factors of brain, cognitive and mental health throughout the lifespan. We will identify the pathways through which risk and protective factors work and their moderators. Through exploitation of, and synergies with, existing European infrastructures and initiatives, this approach of integrating, harmonising and enriching brain imaging datasets will make major conceptual, methodological and analytical contributions towards large integrative cohorts and their efficient exploitation. We will thus provide novel information on brain, cognitive and mental health maintenance, onset and course of brain, cognitive and mental disorders, and lay a foundation for earlier diagnosis of brain disorders, aberrant development and decline of brain, cognitive and mental health, as well as future preventive and therapeutic strategies. Working with stakeholders and health authorities, the project will provide the evidence base for policy strategies for prevention and intervention, improving clinical practice and public health policy for brain, cognitive and mental health. This project is realized by a close collaboration of small and medium-sized enterprise (SME) and major European brain research centres

 Deliverables

List of deliverables.
DEC strategy and Operative plan – Update Documents, reports 2020-04-02 12:20:21
Lifebrain conference in Berlin Documents, reports 2020-04-02 12:20:34
Policy reviews on cognitive & mental well-being across all age groups - I Documents, reports 2020-04-02 12:19:56
Enrichment of existing cohorts by administration of buccal swabs for epigenetic analyses across WP4 tasks 2-6 Documents, reports 2020-04-02 09:25:13
Exploitation and IP management strategy - I Documents, reports 2020-04-02 12:20:08
Online platform for collection of questionnaire and test data for data enrichment Documents, reports 2020-04-02 09:25:55
DBS assays for relevant biomarkers for data enrichment Documents, reports 2020-04-02 09:26:14
Enrichment of existing cohorts by home collection of DBS to be analysed across WP4 tasks 2-6 Documents, reports 2020-04-02 09:24:53
GWAS data and harmonization of genetic data across samples for genetic analyses across WP4 tasks 2-6 Documents, reports 2020-04-02 09:25:34
Lifebrain gender equity report (R) Documents, reports 2020-02-20 09:42:24
DEC Strategy, Operative Plan and SOPs for the Lifebrain project Documents, reports 2020-02-20 09:42:24
Kick-off meeting completed; advisory board, safety board, executive board instantiated Documents, reports 2020-02-20 09:42:24
Risk and protective factors for cognitive and mental health in broader epidemiological samples Documents, reports 2020-02-20 09:42:24
Online/mobile tools for stakeholder engagement conceptualized and developed Documents, reports 2020-02-20 09:42:24
List of relevant stakeholders for project engagement Documents, reports 2020-02-20 09:42:24
Multi-modal MRI-data processing stream which allows for a state-of-the art central integration of data across sites Documents, reports 2020-02-20 09:42:24
Data obtained from national registries; incl standardization, integration, quality control and pooling with existing data across sites Documents, reports 2020-02-20 09:42:24
Input to the Dissemination, Exploitation and Communication(DEC) plan (T5.1) Documents, reports 2020-02-20 09:42:24
Novel longitudinal statistical tools, allowing to tackle challenges associated with multi-side mixed model lifespan data Documents, reports 2020-02-20 09:42:24
Communication management routines and infrastructure implemented Documents, reports 2020-02-20 09:42:24
Data storage and processing system to share data, manage data access and integrated analysis Documents, reports 2020-02-20 09:42:24
Dissemination tools and communication strategies - I Documents, reports 2020-02-20 09:42:24
Tool for post hoc harmonization of MRI data across sites, to allow integration of data from different scanners/sites Documents, reports 2020-02-20 09:42:24
Enrichment of existing cohorts by online data collection Documents, reports 2020-02-20 09:42:24
Financial and legal management routines implemented Documents, reports 2020-02-20 09:42:24
Data harmonization guidelines and standardized data management/processing protocol across sites Documents, reports 2020-02-20 09:42:24

Take a look to the deliverables list in detail:  detailed list of Lifebrain deliverables.

 Publications

year authors and title journal last update
List of publications.
2018 Alexa M. Morcom, Richard N.A. Henson
Increased Prefrontal Activity with Aging Reflects Nonspecific Neural Responses Rather than Compensation
published pages: 7303-7313, ISSN: 0270-6474, DOI: 10.1523/jneurosci.1701-17.2018
The Journal of Neuroscience 38/33 2020-03-05
2019 Sana Suri, Anya Topiwala, Michael A. Chappell, Thomas W. Okell, Eniko Zsoldos, Archana Singh-Manoux, Mika Kivimäki, Clare E. Mackay, Klaus P. Ebmeier
Association of Midlife Cardiovascular Risk Profiles With Cerebral Perfusion at Older Ages
published pages: e195776, ISSN: 2574-3805, DOI: 10.1001/jamanetworkopen.2019.5776
JAMA Network Open 2/6 2020-03-05
2019 Kathy Y. Liu, Julio Acosta-Cabronero, Arturo Cardenas-Blanco, Clare Loane, Alex J. Berry, Matthew J. Betts, Rogier A. Kievit, Richard N. Henson, Emrah Düzel, Robert Howard, Dorothea Hämmerer
In vivo visualization of age-related differences in the locus coeruleus
published pages: 101-111, ISSN: 0197-4580, DOI: 10.1016/j.neurobiolaging.2018.10.014
Neurobiology of Aging 74 2020-03-05
2019 Barbara Bodorkos Friedman, Sana Suri, Cristina Solé-Padullés, Sandra Düzel, Christian A Drevon, William F C Baaré, David Bartrés-Faz, Anders M Fjell, Heidi Johansen-Berg, Kathrine S Madsen, Lars Nyberg, Brenda W J H Penninx, Claire Sexton, Kristine B Walhovd, Enikő Zsoldos, Isabelle Budin-Ljøsne
Are People Ready for Personalized Brain Health? Perspectives of Research Participants in the Lifebrain Consortium
published pages: , ISSN: 0016-9013, DOI: 10.1093/geront/gnz155
The Gerontologist 2020-03-05
2019 Anders M Fjell, Øystein Sørensen, Inge K Amlien, David Bartrés-Faz, Didac Maciá Bros, Nikolaus Buchmann, Ilja Demuth, Christian A Drevon, Sandra Düzel, Klaus P Ebmeier, Ane-Victoria Idland, Tim C Kietzmann, Rogier Kievit, Simone Kühn, Ulman Lindenberger, Athanasia M Mowinckel, Lars Nyberg, Darren Price, Claire E Sexton, Cristina Solé-Padullés, Sara Pudas, Donatas Sederevicius, Sana Suri, G
Self-reported sleep relates to hippocampal atrophy across the adult lifespan – results from the Lifebrain consortium
published pages: , ISSN: 0161-8105, DOI: 10.1093/sleep/zsz280
Sleep 2020-03-05
2019 Delia Fuhrmann, David Nesbitt, Meredith Shafto, James B. Rowe, Darren Price, Andrew Gadie, Rogier A. Kievit, Lorraine K. Tyler, Carol Brayne, Edward T. Bullmore, Andrew C. Calder, Rhodri Cusack, Tim Dalgleish, John Duncan, Richard N. Henson, Fiona E. Matthews, William D. Marslen-Wilson, James B. Rowe, Meredith A. Shafto, Karen Campbell, Teresa Cheung, Simon Davis, Linda Geerligs, Rogier Kievit, An
Strong and specific associations between cardiovascular risk factors and white matter micro- and macrostructure in healthy aging
published pages: 46-55, ISSN: 0197-4580, DOI: 10.1016/j.neurobiolaging.2018.10.005
Neurobiology of Aging 74 2020-03-05
2019 Ross Jacobucci, Andreas M. Brandmaier, Rogier A. Kievit
A Practical Guide to Variable Selection in Structural Equation Modeling by Using Regularized Multiple-Indicators, Multiple-Causes Models
published pages: 55-76, ISSN: 2515-2459, DOI: 10.1177/2515245919826527
Advances in Methods and Practices in Psychological Science 2/1 2020-03-05
2020 Paolo Ghisletta, Fabio Mason, Timo von Oertzen, Christopher Hertzog, Lars-Göran Nilsson, Ulman Lindenberger
On the use of growth models to study normal cognitive aging
published pages: 88-96, ISSN: 0165-0254, DOI: 10.1177/0165025419851576
International Journal of Behavioral Development 44/1 2020-03-05
2018 M. Anatürk, N. Demnitz, K.P. Ebmeier, C.E. Sexton
A systematic review and meta-analysis of structural magnetic resonance imaging studies investigating cognitive and social activity levels in older adults
published pages: 71-84, ISSN: 0149-7634, DOI: 10.1016/j.neubiorev.2018.06.012
Neuroscience & Biobehavioral Reviews 93 2020-02-20
2018 , Cam-Can; Henson, Richard; Valenzuela, Michael; Spink, Molly; Matthews, Fiona; Shafto, Meredith; Chan, Dennis; Kievit, Rogier
Lifestyle activities in mid-life contribute to cognitive reserve in late-life, independent of education, occupation and late-life activities
published pages: , ISSN: , DOI: 10.1101/267831
1 2020-02-20
2018 Kristine B. Walhovd, Anders M. Fjell, René Westerhausen, Lars Nyberg, Klaus P. Ebmeier, Ulman Lindenberger, David Bartrés-Faz, William F.C. Baaré, Hartwig R. Siebner, Richard Henson, Christian A. Drevon, Gun Peggy Strømstad Knudsen, Isabelle Budin Ljøsne, Brenda W.J.H. Penninx, Paolo Ghisletta, Ole Rogeberg, Lorraine Tyler, Lars Bertram
Healthy minds 0–100 years: Optimising the use of European brain imaging cohorts (“Lifebrain”)
published pages: 47-56, ISSN: 0924-9338, DOI: 10.1016/j.eurpsy.2017.12.006
European Psychiatry 50 2020-02-20
2017 Rogier A. Kievit, Andreas M. Brandmaier, Gabriel Ziegler, Anne-Laura van Harmelen, Susanne M.M. de Mooij, Michael Moutoussis, Ian M. Goodyer, Ed Bullmore, Peter B. Jones, Peter Fonagy, Ulman Lindenberger, Raymond J. Dolan
Developmental cognitive neuroscience using latent change score models: A tutorial and applications
published pages: , ISSN: 1878-9293, DOI: 10.1016/j.dcn.2017.11.007
Developmental Cognitive Neuroscience 2020-02-20
2018 Susanne M.M. de Mooij, Richard N.A. Henson, Lourens J. Waldorp, Rogier A. Kievit
Age Differentiation within Gray Matter, White Matter, and between Memory and White Matter in an Adult Life Span Cohort
published pages: 5826-5836, ISSN: 0270-6474, DOI: 10.1523/jneurosci.1627-17.2018
The Journal of Neuroscience 38/25 2020-02-20

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The information about "LIFEBRAIN" are provided by the European Opendata Portal: CORDIS opendata.

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