Explore the words cloud of the IniReg project. It provides you a very rough idea of what is the project "IniReg" about.
The following table provides information about the project.
KONINKLIJKE NEDERLANDSE AKADEMIE VAN WETENSCHAPPEN - KNAW
|Coordinator Country||Netherlands [NL]|
|Total cost||1˙500˙000 €|
|EC max contribution||1˙500˙000 € (100%)|
1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
|Duration (year-month-day)||from 2017-04-01 to 2022-03-31|
Take a look of project's partnership.
|1||KONINKLIJKE NEDERLANDSE AKADEMIE VAN WETENSCHAPPEN - KNAW||NL (AMSTERDAM)||coordinator||1˙307˙544.00|
|2||MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV||DE (MUENCHEN)||participant||192˙455.00|
Injury poses a key threat to all multicellular organisms. However, while some animals can fully restore lost body parts, others can only prevent further damage by mere wound healing. Which molecular mechanisms determine whether regeneration is induced or not is an unsettled fundamental question. I will use whole body regeneration, one of the most fascinating biological processes, as an experimental paradigm to identify the mechanisms of regeneration initiation. As a model organism I will employ planarians, flatworms with extraordinary plasticity that regenerate every piece of their body within a few days. I will mechanistically dissect how these animals rapidly induce an efficient regeneration program in response to tissue loss and define the key switches that determine whether a wound regenerates. Combining the astonishing regenerative abilities of planarians with new technologies I will first comprehensively describe the molecular changes occurring during the amputation response. Second, with a powerful novel assay developed in my lab - dormant fragments - that allows for the first time the separation of wounding from tissue loss in a single planarian, I will analyze the dynamics of the earliest regenerative events. Third, I will functionally characterize the regeneration-initiating signals and their target pathways combining in vivo RNAi and phenotypic assays. Fourth, with a regeneration-deficient planarian species, I will test whether the identified key regulators act as network nodes that can be utilized to rescue regeneration. Importantly, using vertebrate paradigms, such as the regenerating zebrafish fin, I will investigate conserved roles of these network nodes and validate general principles of regeneration initiation. This project will not only uncover conserved mechanisms of regeneration initiation but will also identify the switches that must be levered to induce regeneration in non-regenerating animals.
|year||authors and title||journal||last update|
Andrei Rozanski, HongKee Moon, Holger Brandl, JosÃ© M MartÃn-DurÃ¡n, Markus A Grohme, Katja HÃ¼ttner, Kerstin Bartscherer, Ian Henry, Jochen C Rink
PlanMine 3.0â€”improvements to a mineable resource of flatworm biology and biodiversity
published pages: D812-D820, ISSN: 0305-1048, DOI: 10.1093/nar/gky1070
|Nucleic Acids Research 47/D1||2019-11-22|
David Schmidt, Hanna Reuter, Katja HÃ¼ttner, Larissa Ruhe, Franziska Rabert, Florian Seebeck, Manuel Irimia, Jordi Solana, Kerstin Bartscherer
The Integrator complex regulates differential snRNA processing and fate of adult stem cells in the highly regenerative planarian Schmidtea mediterranea
published pages: e1007828, ISSN: 1553-7404, DOI: 10.1371/journal.pgen.1007828
|PLOS Genetics 14/12||2019-11-22|
Suthira Owlarn, Felix Klenner, David Schmidt, Franziska Rabert, Antonio Tomasso, Hanna Reuter, Medhanie A. Mulaw, SÃ¶ren Moritz, Luca Gentile, Gilbert Weidinger, Kerstin Bartscherer
Generic wound signals initiate regeneration in missing-tissue contexts
published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-017-02338-x
|Nature Communications 8/1||2019-09-02|
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The information about "INIREG" are provided by the European Opendata Portal: CORDIS opendata.
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