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IniReg SIGNED

Mechanisms of Regeneration Initiation

Total Cost €

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EC-Contrib. €

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Partnership

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 IniReg project word cloud

Explore the words cloud of the IniReg project. It provides you a very rough idea of what is the project "IniReg" about.

vivo    unsettled    principles    switches    single    few    piece    biological    mechanisms    multicellular    amputation    model    regenerative    conserved    tissue    experimental    regenerate    induce    regeneration    time    levered    extraordinary    prevent    flatworms    regulators    organisms    question    plasticity    fin    occurring    events    regenerates    planarians    restore    species    first    utilized    uncover    nodes    comprehensively    fourth    regenerating    dynamics    parts    healing    initiation    efficient    injury    deficient    body    initiating    earliest    mechanistically    roles    paradigms    signals    organism    planarian    rescue    astonishing    functionally    poses    fragments    phenotypic    fundamental    dormant    employ    rnai    damage    lab    combining    fascinating    assays    separation    analyze    technologies    act    days    lost    powerful    molecular    zebrafish    wound    wounding    mere    vertebrate    describe    threat    dissect    paradigm    network    animals    validate    assay   

Project "IniReg" data sheet

The following table provides information about the project.

Coordinator
KONINKLIJKE NEDERLANDSE AKADEMIE VAN WETENSCHAPPEN - KNAW 

Organization address
address: KLOVENIERSBURGWAL 29 HET TRIPPENHUIS
city: AMSTERDAM
postcode: 1011 JV
website: www.knaw.nl

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Netherlands [NL]
 Total cost 1˙500˙000 €
 EC max contribution 1˙500˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2016-STG
 Funding Scheme ERC-STG
 Starting year 2017
 Duration (year-month-day) from 2017-04-01   to  2022-03-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    KONINKLIJKE NEDERLANDSE AKADEMIE VAN WETENSCHAPPEN - KNAW NL (AMSTERDAM) coordinator 1˙307˙544.00
2    MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV DE (MUENCHEN) participant 192˙455.00

Map

 Project objective

Injury poses a key threat to all multicellular organisms. However, while some animals can fully restore lost body parts, others can only prevent further damage by mere wound healing. Which molecular mechanisms determine whether regeneration is induced or not is an unsettled fundamental question. I will use whole body regeneration, one of the most fascinating biological processes, as an experimental paradigm to identify the mechanisms of regeneration initiation. As a model organism I will employ planarians, flatworms with extraordinary plasticity that regenerate every piece of their body within a few days. I will mechanistically dissect how these animals rapidly induce an efficient regeneration program in response to tissue loss and define the key switches that determine whether a wound regenerates. Combining the astonishing regenerative abilities of planarians with new technologies I will first comprehensively describe the molecular changes occurring during the amputation response. Second, with a powerful novel assay developed in my lab - dormant fragments - that allows for the first time the separation of wounding from tissue loss in a single planarian, I will analyze the dynamics of the earliest regenerative events. Third, I will functionally characterize the regeneration-initiating signals and their target pathways combining in vivo RNAi and phenotypic assays. Fourth, with a regeneration-deficient planarian species, I will test whether the identified key regulators act as network nodes that can be utilized to rescue regeneration. Importantly, using vertebrate paradigms, such as the regenerating zebrafish fin, I will investigate conserved roles of these network nodes and validate general principles of regeneration initiation. This project will not only uncover conserved mechanisms of regeneration initiation but will also identify the switches that must be levered to induce regeneration in non-regenerating animals.

 Publications

year authors and title journal last update
List of publications.
2018 Andrei Rozanski, HongKee Moon, Holger Brandl, José M Martín-Durán, Markus A Grohme, Katja Hüttner, Kerstin Bartscherer, Ian Henry, Jochen C Rink
PlanMine 3.0—improvements to a mineable resource of flatworm biology and biodiversity
published pages: D812-D820, ISSN: 0305-1048, DOI: 10.1093/nar/gky1070
Nucleic Acids Research 47/D1 2019-11-22
2018 David Schmidt, Hanna Reuter, Katja Hüttner, Larissa Ruhe, Franziska Rabert, Florian Seebeck, Manuel Irimia, Jordi Solana, Kerstin Bartscherer
The Integrator complex regulates differential snRNA processing and fate of adult stem cells in the highly regenerative planarian Schmidtea mediterranea
published pages: e1007828, ISSN: 1553-7404, DOI: 10.1371/journal.pgen.1007828
PLOS Genetics 14/12 2019-11-22
2017 Suthira Owlarn, Felix Klenner, David Schmidt, Franziska Rabert, Antonio Tomasso, Hanna Reuter, Medhanie A. Mulaw, Sören Moritz, Luca Gentile, Gilbert Weidinger, Kerstin Bartscherer
Generic wound signals initiate regeneration in missing-tissue contexts
published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-017-02338-x
Nature Communications 8/1 2019-09-02

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The information about "INIREG" are provided by the European Opendata Portal: CORDIS opendata.

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