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IniReg SIGNED

Mechanisms of Regeneration Initiation

Total Cost €

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EC-Contrib. €

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Partnership

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 IniReg project word cloud

Explore the words cloud of the IniReg project. It provides you a very rough idea of what is the project "IniReg" about.

uncover    analyze    induce    paradigms    time    technologies    body    unsettled    organisms    fin    deficient    mechanisms    wounding    validate    paradigm    regenerates    assays    fundamental    species    switches    functionally    dynamics    planarians    roles    phenotypic    fascinating    earliest    principles    regenerative    experimental    initiating    vivo    fourth    restore    parts    regenerate    events    employ    utilized    dissect    damage    threat    biological    regenerating    describe    fragments    act    combining    lab    powerful    dormant    days    flatworms    assay    comprehensively    levered    model    regulators    piece    mechanistically    molecular    organism    lost    conserved    rescue    healing    separation    mere    astonishing    few    prevent    efficient    planarian    vertebrate    single    signals    rnai    first    tissue    amputation    zebrafish    question    plasticity    wound    extraordinary    initiation    poses    multicellular    occurring    nodes    injury    network    regeneration    animals   

Project "IniReg" data sheet

The following table provides information about the project.

Coordinator
KONINKLIJKE NEDERLANDSE AKADEMIE VAN WETENSCHAPPEN - KNAW 

Organization address
address: KLOVENIERSBURGWAL 29 HET TRIPPENHUIS
city: AMSTERDAM
postcode: 1011 JV
website: www.knaw.nl

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Netherlands [NL]
 Total cost 1˙500˙000 €
 EC max contribution 1˙500˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2016-STG
 Funding Scheme ERC-STG
 Starting year 2017
 Duration (year-month-day) from 2017-04-01   to  2022-03-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    KONINKLIJKE NEDERLANDSE AKADEMIE VAN WETENSCHAPPEN - KNAW NL (AMSTERDAM) coordinator 1˙307˙544.00
2    MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV DE (MUENCHEN) participant 192˙455.00

Map

 Project objective

Injury poses a key threat to all multicellular organisms. However, while some animals can fully restore lost body parts, others can only prevent further damage by mere wound healing. Which molecular mechanisms determine whether regeneration is induced or not is an unsettled fundamental question. I will use whole body regeneration, one of the most fascinating biological processes, as an experimental paradigm to identify the mechanisms of regeneration initiation. As a model organism I will employ planarians, flatworms with extraordinary plasticity that regenerate every piece of their body within a few days. I will mechanistically dissect how these animals rapidly induce an efficient regeneration program in response to tissue loss and define the key switches that determine whether a wound regenerates. Combining the astonishing regenerative abilities of planarians with new technologies I will first comprehensively describe the molecular changes occurring during the amputation response. Second, with a powerful novel assay developed in my lab - dormant fragments - that allows for the first time the separation of wounding from tissue loss in a single planarian, I will analyze the dynamics of the earliest regenerative events. Third, I will functionally characterize the regeneration-initiating signals and their target pathways combining in vivo RNAi and phenotypic assays. Fourth, with a regeneration-deficient planarian species, I will test whether the identified key regulators act as network nodes that can be utilized to rescue regeneration. Importantly, using vertebrate paradigms, such as the regenerating zebrafish fin, I will investigate conserved roles of these network nodes and validate general principles of regeneration initiation. This project will not only uncover conserved mechanisms of regeneration initiation but will also identify the switches that must be levered to induce regeneration in non-regenerating animals.

 Publications

year authors and title journal last update
List of publications.
2018 Andrei Rozanski, HongKee Moon, Holger Brandl, José M Martín-Durán, Markus A Grohme, Katja Hüttner, Kerstin Bartscherer, Ian Henry, Jochen C Rink
PlanMine 3.0—improvements to a mineable resource of flatworm biology and biodiversity
published pages: D812-D820, ISSN: 0305-1048, DOI: 10.1093/nar/gky1070
Nucleic Acids Research 47/D1 2019-11-22
2018 David Schmidt, Hanna Reuter, Katja Hüttner, Larissa Ruhe, Franziska Rabert, Florian Seebeck, Manuel Irimia, Jordi Solana, Kerstin Bartscherer
The Integrator complex regulates differential snRNA processing and fate of adult stem cells in the highly regenerative planarian Schmidtea mediterranea
published pages: e1007828, ISSN: 1553-7404, DOI: 10.1371/journal.pgen.1007828
PLOS Genetics 14/12 2019-11-22
2017 Suthira Owlarn, Felix Klenner, David Schmidt, Franziska Rabert, Antonio Tomasso, Hanna Reuter, Medhanie A. Mulaw, Sören Moritz, Luca Gentile, Gilbert Weidinger, Kerstin Bartscherer
Generic wound signals initiate regeneration in missing-tissue contexts
published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-017-02338-x
Nature Communications 8/1 2019-09-02

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The information about "INIREG" are provided by the European Opendata Portal: CORDIS opendata.

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