Opendata, web and dolomites

IniReg SIGNED

Mechanisms of Regeneration Initiation

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

 IniReg project word cloud

Explore the words cloud of the IniReg project. It provides you a very rough idea of what is the project "IniReg" about.

injury    deficient    combining    comprehensively    vertebrate    earliest    network    planarians    plasticity    organism    restore    flatworms    regenerating    powerful    mere    assay    mechanisms    dynamics    molecular    organisms    mechanistically    induce    time    rnai    levered    validate    paradigms    unsettled    regeneration    dormant    poses    fundamental    utilized    lost    question    technologies    vivo    model    conserved    planarian    employ    phenotypic    paradigm    fourth    rescue    initiating    analyze    body    astonishing    efficient    act    fin    multicellular    nodes    experimental    wound    piece    amputation    extraordinary    roles    damage    separation    single    regenerative    fascinating    principles    events    describe    regenerates    healing    first    lab    regenerate    few    switches    zebrafish    tissue    wounding    dissect    fragments    regulators    biological    prevent    species    functionally    days    initiation    uncover    assays    signals    occurring    parts    threat    animals   

Project "IniReg" data sheet

The following table provides information about the project.

Coordinator
KONINKLIJKE NEDERLANDSE AKADEMIE VAN WETENSCHAPPEN - KNAW 

Organization address
address: KLOVENIERSBURGWAL 29 HET TRIPPENHUIS
city: AMSTERDAM
postcode: 1011 JV
website: www.knaw.nl

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Netherlands [NL]
 Total cost 1˙500˙000 €
 EC max contribution 1˙500˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2016-STG
 Funding Scheme ERC-STG
 Starting year 2017
 Duration (year-month-day) from 2017-04-01   to  2022-03-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    KONINKLIJKE NEDERLANDSE AKADEMIE VAN WETENSCHAPPEN - KNAW NL (AMSTERDAM) coordinator 1˙307˙544.00
2    MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV DE (MUENCHEN) participant 192˙455.00

Map

 Project objective

Injury poses a key threat to all multicellular organisms. However, while some animals can fully restore lost body parts, others can only prevent further damage by mere wound healing. Which molecular mechanisms determine whether regeneration is induced or not is an unsettled fundamental question. I will use whole body regeneration, one of the most fascinating biological processes, as an experimental paradigm to identify the mechanisms of regeneration initiation. As a model organism I will employ planarians, flatworms with extraordinary plasticity that regenerate every piece of their body within a few days. I will mechanistically dissect how these animals rapidly induce an efficient regeneration program in response to tissue loss and define the key switches that determine whether a wound regenerates. Combining the astonishing regenerative abilities of planarians with new technologies I will first comprehensively describe the molecular changes occurring during the amputation response. Second, with a powerful novel assay developed in my lab - dormant fragments - that allows for the first time the separation of wounding from tissue loss in a single planarian, I will analyze the dynamics of the earliest regenerative events. Third, I will functionally characterize the regeneration-initiating signals and their target pathways combining in vivo RNAi and phenotypic assays. Fourth, with a regeneration-deficient planarian species, I will test whether the identified key regulators act as network nodes that can be utilized to rescue regeneration. Importantly, using vertebrate paradigms, such as the regenerating zebrafish fin, I will investigate conserved roles of these network nodes and validate general principles of regeneration initiation. This project will not only uncover conserved mechanisms of regeneration initiation but will also identify the switches that must be levered to induce regeneration in non-regenerating animals.

 Publications

year authors and title journal last update
List of publications.
2018 Andrei Rozanski, HongKee Moon, Holger Brandl, José M Martín-Durán, Markus A Grohme, Katja Hüttner, Kerstin Bartscherer, Ian Henry, Jochen C Rink
PlanMine 3.0—improvements to a mineable resource of flatworm biology and biodiversity
published pages: D812-D820, ISSN: 0305-1048, DOI: 10.1093/nar/gky1070
Nucleic Acids Research 47/D1 2019-11-22
2018 David Schmidt, Hanna Reuter, Katja Hüttner, Larissa Ruhe, Franziska Rabert, Florian Seebeck, Manuel Irimia, Jordi Solana, Kerstin Bartscherer
The Integrator complex regulates differential snRNA processing and fate of adult stem cells in the highly regenerative planarian Schmidtea mediterranea
published pages: e1007828, ISSN: 1553-7404, DOI: 10.1371/journal.pgen.1007828
PLOS Genetics 14/12 2019-11-22
2017 Suthira Owlarn, Felix Klenner, David Schmidt, Franziska Rabert, Antonio Tomasso, Hanna Reuter, Medhanie A. Mulaw, Sören Moritz, Luca Gentile, Gilbert Weidinger, Kerstin Bartscherer
Generic wound signals initiate regeneration in missing-tissue contexts
published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-017-02338-x
Nature Communications 8/1 2019-09-02

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "INIREG" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "INIREG" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.1.)

T-GRAND-SLAM (2019)

Translating the Global Refined Analysis of Newly transcribed RNA and Decay rates by SLAM-seq

Read More  

CN Identity (2019)

Comprehensive anatomical, genetic and functional identification of cerebellar nuclei neurons and their roles in sensorimotor tasks

Read More  

MATCH (2020)

Discovering a novel allergen immunotherapy in house dust mite allergy tolerance research

Read More