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IniReg SIGNED

Mechanisms of Regeneration Initiation

Total Cost €

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EC-Contrib. €

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Partnership

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 IniReg project word cloud

Explore the words cloud of the IniReg project. It provides you a very rough idea of what is the project "IniReg" about.

few    single    employ    planarian    uncover    phenotypic    mere    injury    fragments    lost    plasticity    dissect    paradigms    events    poses    roles    initiating    fourth    signals    comprehensively    biological    organisms    efficient    zebrafish    regenerate    threat    fascinating    levered    rescue    initiation    rnai    mechanistically    earliest    dynamics    multicellular    model    parts    astonishing    regenerating    utilized    lab    powerful    mechanisms    separation    wound    occurring    fin    wounding    piece    induce    validate    describe    restore    switches    flatworms    species    regenerates    question    animals    act    healing    unsettled    extraordinary    principles    dormant    first    body    regulators    nodes    conserved    paradigm    experimental    tissue    regenerative    fundamental    functionally    damage    planarians    assay    analyze    vertebrate    molecular    technologies    combining    assays    days    organism    time    regeneration    network    deficient    amputation    prevent    vivo   

Project "IniReg" data sheet

The following table provides information about the project.

Coordinator
KONINKLIJKE NEDERLANDSE AKADEMIE VAN WETENSCHAPPEN - KNAW 

Organization address
address: KLOVENIERSBURGWAL 29 HET TRIPPENHUIS
city: AMSTERDAM
postcode: 1011 JV
website: www.knaw.nl

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Netherlands [NL]
 Total cost 1˙500˙000 €
 EC max contribution 1˙500˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2016-STG
 Funding Scheme ERC-STG
 Starting year 2017
 Duration (year-month-day) from 2017-04-01   to  2022-03-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    KONINKLIJKE NEDERLANDSE AKADEMIE VAN WETENSCHAPPEN - KNAW NL (AMSTERDAM) coordinator 1˙307˙544.00
2    MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV DE (MUENCHEN) participant 192˙455.00

Map

 Project objective

Injury poses a key threat to all multicellular organisms. However, while some animals can fully restore lost body parts, others can only prevent further damage by mere wound healing. Which molecular mechanisms determine whether regeneration is induced or not is an unsettled fundamental question. I will use whole body regeneration, one of the most fascinating biological processes, as an experimental paradigm to identify the mechanisms of regeneration initiation. As a model organism I will employ planarians, flatworms with extraordinary plasticity that regenerate every piece of their body within a few days. I will mechanistically dissect how these animals rapidly induce an efficient regeneration program in response to tissue loss and define the key switches that determine whether a wound regenerates. Combining the astonishing regenerative abilities of planarians with new technologies I will first comprehensively describe the molecular changes occurring during the amputation response. Second, with a powerful novel assay developed in my lab - dormant fragments - that allows for the first time the separation of wounding from tissue loss in a single planarian, I will analyze the dynamics of the earliest regenerative events. Third, I will functionally characterize the regeneration-initiating signals and their target pathways combining in vivo RNAi and phenotypic assays. Fourth, with a regeneration-deficient planarian species, I will test whether the identified key regulators act as network nodes that can be utilized to rescue regeneration. Importantly, using vertebrate paradigms, such as the regenerating zebrafish fin, I will investigate conserved roles of these network nodes and validate general principles of regeneration initiation. This project will not only uncover conserved mechanisms of regeneration initiation but will also identify the switches that must be levered to induce regeneration in non-regenerating animals.

 Publications

year authors and title journal last update
List of publications.
2018 Andrei Rozanski, HongKee Moon, Holger Brandl, José M Martín-Durán, Markus A Grohme, Katja Hüttner, Kerstin Bartscherer, Ian Henry, Jochen C Rink
PlanMine 3.0—improvements to a mineable resource of flatworm biology and biodiversity
published pages: D812-D820, ISSN: 0305-1048, DOI: 10.1093/nar/gky1070
Nucleic Acids Research 47/D1 2019-11-22
2018 David Schmidt, Hanna Reuter, Katja Hüttner, Larissa Ruhe, Franziska Rabert, Florian Seebeck, Manuel Irimia, Jordi Solana, Kerstin Bartscherer
The Integrator complex regulates differential snRNA processing and fate of adult stem cells in the highly regenerative planarian Schmidtea mediterranea
published pages: e1007828, ISSN: 1553-7404, DOI: 10.1371/journal.pgen.1007828
PLOS Genetics 14/12 2019-11-22
2017 Suthira Owlarn, Felix Klenner, David Schmidt, Franziska Rabert, Antonio Tomasso, Hanna Reuter, Medhanie A. Mulaw, Sören Moritz, Luca Gentile, Gilbert Weidinger, Kerstin Bartscherer
Generic wound signals initiate regeneration in missing-tissue contexts
published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-017-02338-x
Nature Communications 8/1 2019-09-02

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The information about "INIREG" are provided by the European Opendata Portal: CORDIS opendata.

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