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GLYCONEOBRAIN TERMINATED

Exploring glycosidic neo-epitopes of degenerative hippocampal granules in aged mice and humans: implications for ageing and dementia

Total Cost €

0

EC-Contrib. €

0

Partnership

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 GLYCONEOBRAIN project word cloud

Explore the words cloud of the GLYCONEOBRAIN project. It provides you a very rough idea of what is the project "GLYCONEOBRAIN" about.

stain    schiff    will    lafora    positive    mechanism    multidisciplinary    igms    molecular    million    glycosidic    found    igm    goals    expression    originate    neuronal    contains    generate    hallmark    pathological    human    technologies    epitopes    impairments    suggesting    neoepitopes    explored    prevention    epitope    neo    reported    therapeutic    age    acid    underlying    describe    neurobiology    microdissection    model    histological    natural    biomarkers    potentional    strategies    serum    mice    structures    laser    edge    degenerative    glycomics    removal    antibodies    imaging    structure    binding    mouse    adjacent    diseases    brain    hippocampus    ms    astrocytes    patterns    anti    granules    treatment    insights    granule    disease    composition    periodic    techniques    appears    fatal    express    hippocampal    recognise    ultimately    capture    ageing    dementia    granular    accordingly    additionally    data    memory    maldi    people    correlate    humans    analytical    neurodegenerative    bodies    employ   

Project "GLYCONEOBRAIN" data sheet

The following table provides information about the project.

Coordinator
THE UNIVERSITY OF LIVERPOOL 

Organization address
address: BROWNLOW HILL 765 FOUNDATION BUILDING
city: LIVERPOOL
postcode: L69 7ZX
website: www.liverpool.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Total cost 183˙454 €
 EC max contribution 183˙454 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2015
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2017
 Duration (year-month-day) from 2017-09-01   to  2019-08-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    THE UNIVERSITY OF LIVERPOOL UK (LIVERPOOL) coordinator 183˙454.00

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 Project objective

Ageing is the main correlate of dementia and several other neurodegenerative diseases which currently affect more than 6 million people in Europe. Molecular understanding of these brain conditions is important for their prevention and treatment. In mice, pathological granular structures positive for periodic acid-Schiff stain have been found in the hippocampus with increasing age. The degenerative process of granule formation appears to originate in astrocytes, but adjacent neuronal structures are affected and, accordingly, associated memory impairments have been described. Recent studies reported that granules express glycosidic neo-epitopes, a hallmark of the degenerative granule formation process. This neo-epitope has additionally been found in Lafora bodies of a mouse model of Lafora disease, a fatal neurodegenerative condition. On the other hand, mice serum contains natural IgM antibodies that recognise the glycosidic neo-epitope, suggesting a potentional removal mechanism. In this project, I aim to describe the structure of the glycosidic neo-epitopes of the hippocampal granules as well as the composition of the degenerative granules and Lafora bodies. To achieve these goals, I will employ a multidisciplinary approach exploiting glycomics and neurobiology, with the application of leading-edge technologies that include histological methods, analytical techniques, MALDI-MS imaging and laser-capture microdissection. Moreover, the binding patterns of the anti-neo-epitope natural IgMs will also be explored. Finally and importantly, the expression of the glycosidic neo-epitope in human brain will be assessed. Overall, the knowledge generated will provide new data on brain degenerative processes underlying age-related memory impairments in humans. Ultimately this project will generate new insights for the use of glycosidic neoepitopes as biomarkers for ageing and neurodegenerative diseases, and for prevention and therapeutic strategies using natural antibodies.

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