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GLYCONEOBRAIN TERMINATED

Exploring glycosidic neo-epitopes of degenerative hippocampal granules in aged mice and humans: implications for ageing and dementia

Total Cost €

0

EC-Contrib. €

0

Partnership

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 GLYCONEOBRAIN project word cloud

Explore the words cloud of the GLYCONEOBRAIN project. It provides you a very rough idea of what is the project "GLYCONEOBRAIN" about.

express    removal    humans    patterns    histological    composition    analytical    recognise    memory    ms    schiff    potentional    treatment    positive    techniques    stain    found    granules    million    bodies    igm    serum    data    ultimately    epitopes    dementia    neoepitopes    adjacent    pathological    natural    neuronal    impairments    age    prevention    neurodegenerative    contains    imaging    will    granule    underlying    correlate    periodic    employ    brain    structures    hallmark    multidisciplinary    capture    reported    igms    astrocytes    anti    describe    accordingly    human    mechanism    generate    hippocampal    technologies    additionally    molecular    disease    ageing    structure    granular    people    hippocampus    glycomics    strategies    therapeutic    glycosidic    model    originate    mouse    binding    insights    epitope    goals    appears    laser    suggesting    acid    microdissection    neo    mice    antibodies    maldi    edge    expression    explored    diseases    neurobiology    lafora    fatal    degenerative    biomarkers   

Project "GLYCONEOBRAIN" data sheet

The following table provides information about the project.

Coordinator
THE UNIVERSITY OF LIVERPOOL 

Organization address
address: BROWNLOW HILL 765 FOUNDATION BUILDING
city: LIVERPOOL
postcode: L69 7ZX
website: www.liverpool.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Total cost 183˙454 €
 EC max contribution 183˙454 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2015
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2017
 Duration (year-month-day) from 2017-09-01   to  2019-08-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    THE UNIVERSITY OF LIVERPOOL UK (LIVERPOOL) coordinator 183˙454.00

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 Project objective

Ageing is the main correlate of dementia and several other neurodegenerative diseases which currently affect more than 6 million people in Europe. Molecular understanding of these brain conditions is important for their prevention and treatment. In mice, pathological granular structures positive for periodic acid-Schiff stain have been found in the hippocampus with increasing age. The degenerative process of granule formation appears to originate in astrocytes, but adjacent neuronal structures are affected and, accordingly, associated memory impairments have been described. Recent studies reported that granules express glycosidic neo-epitopes, a hallmark of the degenerative granule formation process. This neo-epitope has additionally been found in Lafora bodies of a mouse model of Lafora disease, a fatal neurodegenerative condition. On the other hand, mice serum contains natural IgM antibodies that recognise the glycosidic neo-epitope, suggesting a potentional removal mechanism. In this project, I aim to describe the structure of the glycosidic neo-epitopes of the hippocampal granules as well as the composition of the degenerative granules and Lafora bodies. To achieve these goals, I will employ a multidisciplinary approach exploiting glycomics and neurobiology, with the application of leading-edge technologies that include histological methods, analytical techniques, MALDI-MS imaging and laser-capture microdissection. Moreover, the binding patterns of the anti-neo-epitope natural IgMs will also be explored. Finally and importantly, the expression of the glycosidic neo-epitope in human brain will be assessed. Overall, the knowledge generated will provide new data on brain degenerative processes underlying age-related memory impairments in humans. Ultimately this project will generate new insights for the use of glycosidic neoepitopes as biomarkers for ageing and neurodegenerative diseases, and for prevention and therapeutic strategies using natural antibodies.

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lastchecktime (2022-11-26 12:14:58) correctly updated