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MultiSense SIGNED

Multisensory signal processing: From brain-wide neuronal circuits to behavior

Total Cost €

0

EC-Contrib. €

0

Partnership

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 MultiSense project word cloud

Explore the words cloud of the MultiSense project. It provides you a very rough idea of what is the project "MultiSense" about.

neurons    learning    vestibular    impairment    combine    smallest    schizophrenia    our    centers    functions    stimuli    structures    circuit    optically    neuronal    units    seamless    levels    submitted    coded    platform    record    motion    cognitive    compensate    neuro    implicated    eye    zebrafish    motor    arena    experimental    complexity    pilot    cell    performs    ubiquitous    neural    clear    reflex    restrained    decision    multisensory    visual    network    interpret    behavior    self    principles    transparent    gaze    exception    pathologies    genetics    operates    constantly    computation    drive    vision    flight    statistical    effort    simulator    representation    inherently    constitute    autism    interdisciplinary    physics    senses    small    stabilization    primary    invaluable    multiple    uses    reduce    integration    subcortical    binding    cortices    brain    world    larva    circuits    conserved    detected    obtain    movements    extract    sensory    models    fuse    subserving    larvae    associative    single    model    optical    dynamics    data    coherent    vertebrates    animal    view    basic    resolved    insights   

Project "MultiSense" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITE PIERRE ET MARIE CURIE - PARIS 6 

There are not information about this coordinator. Please contact Fabio for more information, thanks.

 Coordinator Country France [FR]
 Total cost 1˙371˙250 €
 EC max contribution 1˙371˙250 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2016-STG
 Funding Scheme ERC-STG
 Starting year 2017
 Duration (year-month-day) from 2017-03-01   to  2022-02-28

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    SORBONNE UNIVERSITE FR (PARIS) coordinator 1˙371˙250.00
2    UNIVERSITE PIERRE ET MARIE CURIE - PARIS 6 FR (PARIS) coordinator 0.00

Map

 Project objective

Our brain needs to constantly fuse sensory information detected by our multiple senses in order to produce a seamless coherent representation of the world. Rather than being the exception, this binding process is ubiquitous to sensory-motor integration and is implicated in most cognitive functions. Its impairment is a cause of various pathologies, such as schizophrenia or autism. Multisensory processing operates on all brain levels from primary cortices over subcortical structures up to higher associative centers, while the smallest operational units are single multisensory neurons.

In an interdisciplinary effort, we combine optical developments, genetics and neuro-computation to obtain new insights into the activity of brain-wide neural circuits that process multisensory information. To reduce the complexity, we study the small transparent brain of zebrafish larvae as a model system. We focus on gaze stabilization as an inherently multisensory model task that is conserved among all vertebrates. This reflex uses both vestibular and visual information to drive eye movements in order to compensate for self-motion and maintain clear vision. We will build a novel experimental platform in which a restrained larva will be submitted to vestibular and visual stimuli, as a pilot in a flight simulator. We will optically record the activity of all 100,000 neurons of the animal brain as it performs multisensory integration tasks. To extract basic principles of how behavior is coded in multisensory neuronal circuits we will interpret the brain-wide activity and the observed behavior with methods from statistical physics. No other system can today provide a similar brain-scale, yet cell-resolved view on the neuronal network dynamics subserving such a complex integration process. Thus, our data will constitute an invaluable arena to test circuit-based models for sensory-motor integration, decision-making and multisensory-motor learning.

 Publications

year authors and title journal last update
List of publications.
2018 Geoffrey Migault, Thijs L. van der Plas, Hugo Trentesaux, Thomas Panier, Raphaël Candelier, Rémi Proville, Bernhard Englitz, Georges Debrégeas, Volker Bormuth
Whole-Brain Calcium Imaging during Physiological Vestibular Stimulation in Larval Zebrafish
published pages: 3723-3735.e6, ISSN: 0960-9822, DOI: 10.1016/j.cub.2018.10.017
Current Biology 28/23 2019-11-07

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "MULTISENSE" project.

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Send me an  email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

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The information about "MULTISENSE" are provided by the European Opendata Portal: CORDIS opendata.

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