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MetResistance SIGNED

The role of tumour microenvironment in metastatic hormone-refractory prostate cancer

Total Cost €

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EC-Contrib. €

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Partnership

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Project "MetResistance" data sheet

The following table provides information about the project.

Coordinator
THE UNIVERSITY OF EDINBURGH 

Organization address
address: OLD COLLEGE, SOUTH BRIDGE
city: EDINBURGH
postcode: EH8 9YL
website: www.ed.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Total cost 1˙498˙176 €
 EC max contribution 1˙498˙176 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2016-STG
 Funding Scheme ERC-STG
 Starting year 2017
 Duration (year-month-day) from 2017-04-01   to  2022-03-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    THE UNIVERSITY OF EDINBURGH UK (EDINBURGH) coordinator 1˙498˙176.00

Map

 Project objective

The goal of this proposal is to investigate the role of tumor microenvironment in metastatic hormone-refractory prostate cancer (mHRPC). Prostate Cancer (PC) is the most common malignancy in men in Europe while mHRPC is the most lethal form of the disease, causing over 95% of PC related deaths. Extensive clinical and preclinical research using state-of-the-art tumour models has led to the development of several new therapeutics that, unfortunately, provide only marginal patient benefit. One key element missing in standard preclinical models is the relevant metastasis microenvironment associated with mHRPC that may dramatically affect disease outcome. Here, I plan to significantly advance our understanding in mHRPC associated microenvironment with the first androgen dependent PC bone metastasis model I developed that mimics both the pathology and disease progression in patients. My preliminary data indicate that metastasis associated stromal cells may form a unique bone metastasis microenvironment that promotes mHRPC. I aim to identify the underlying molecular mechanisms using a multidisciplinary approach combining intra-vital microscopy, dynamic ADT resistance reporter system, innovative adoptive transfer approach and genetic tools of lineage specific knockout. This work is also designed to translate findings made in mouse models into human disease using innovative humanized in vivo models of mHRPC. The findings generated in this project will lead to innovative therapeutic approaches that can effectively treat mHRPC thus relieve this lethal threat on European societies. MetResistance will make a step change in the field of cancer medicine research by providing new standards to study therapy resistance of metastatic cancer an area representing the number one challenge in cancer research and patient care.

 Publications

year authors and title journal last update
List of publications.
2017 Cao J, Liu J, Xu R, Zhu X, Zhao X, Qian BZ
Prognostic role of tumour-associated macrophages and macrophage scavenger receptor 1 in prostate cancer: A systematic review and meta-analysis.
published pages: , ISSN: 1949-2553, DOI:
Oncotarget 2020-01-27
2018 Wu SQ, Xu R, Li XF, Zhao X, Qian BZ
Prognostic roles of tumor associated macrophages in bladder cancer: a system review and meta-analysis.
published pages: , ISSN: 1949-2553, DOI:
Oncotarget 2020-01-27
2017 Qian BZ
Inflammation fires up cancer metastasis.
published pages: , ISSN: 1044-579X, DOI:
Seminars in Cancer Biology 2020-01-27
2017 Laura Gómez-Cuadrado, Natasha Tracey, Ruoyu Ma, Binzhi Qian, Valerie G. Brunton
Mouse models of metastasis: progress and prospects
published pages: 1061-1074, ISSN: 1754-8403, DOI: 10.1242/dmm.030403
Disease Models & Mechanisms 10/9 2020-01-27

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The information about "METRESISTANCE" are provided by the European Opendata Portal: CORDIS opendata.

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