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NeuronAgeScreen SIGNED

A Drug Discovery and Target Identification Screening Platform for Age-Associated Neurodegenerative Disorders

Total Cost €

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EC-Contrib. €

0

Partnership

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 NeuronAgeScreen project word cloud

Explore the words cloud of the NeuronAgeScreen project. It provides you a very rough idea of what is the project "NeuronAgeScreen" about.

manipulation    devising    platform    vivo    imaging    diseases    context    discovery    neurons    quality    genetic    throughput    neurodegeneration    pathologies    protection    experimental    human    pressing    identification    versatile    interventions    screening    nature    521    ipr    health    readily    commercialization    betterment    dependability    dementia    drug    prowess    dissected    evolutionary    erc    convenient    platforms    intimately    overarching    linked    societal    nematode    enterprise    decrease    ageing    billion    maladies    stroke    file    ataxias    global    intervention    parkinson    technologies    model    chemical    battling    organisms    innovation    525    neurodegenerative    disease    function    universally    therapeutic    alzheimer    attractive    facets    pervasive    devastating    offers    stage    conserved    microfluidics    disorders    susceptibility    populations    patent    490    uniquely    strategies    neuronage    elegans    prevalence    life    efficient    streamlining    malleable    marked    demonstration    213    manifested    nervous    neuronal    innovative    combating    organism    combines    genes    precisely    course    types    compound   

Project "NeuronAgeScreen" data sheet

The following table provides information about the project.

Coordinator
IDRYMA TECHNOLOGIAS KAI EREVNAS 

Organization address
address: N PLASTIRA STR 100
city: IRAKLEIO
postcode: 70013
website: www.forth.gr

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Greece [EL]
 Total cost 150˙000 €
 EC max contribution 150˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2016-PoC
 Funding Scheme ERC-POC
 Starting year 2017
 Duration (year-month-day) from 2017-05-01   to  2018-10-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    IDRYMA TECHNOLOGIAS KAI EREVNAS EL (IRAKLEIO) coordinator 150˙000.00

Map

 Project objective

Battling human neurodegenerative pathologies, and their pervasive societal impact, is a global multi-billion Euro enterprise. Ageing is universally associated with marked decrease of neuronal function and higher susceptibility to neurodegeneration. In human populations, this is manifested as an ever-increasing prevalence of devastating neurodegenerative conditions, including Alzheimer’s and Parkinson’s disease, stroke, several ataxias, and other types of dementia. Development of therapeutic interventions against such maladies is becoming a pressing priority. Drug discovery and drug target identification are two intimately linked facets of intervention strategies aimed at effectively combating human disorders. Genes linked to human diseases often function in evolutionary conserved pathways, readily dissected in simple model organisms. Such organisms provide attractive platforms for devising and streamlining efficient drug discovery and target identification methodologies. During the course of the ERC project NeuronAge, we developed a convenient and versatile platform for high-throughput chemical compound screening based on the nematode C. elegans (Nature 521: 525; Nature 490: 213). This innovative platform uniquely combines state-of-the-art microfluidics technologies for imaging and manipulation of neurons in vivo, with the experimental prowess of C. elegans, a highly malleable genetic model, which offers a precisely defined nervous system, two features that are not available in any other organism. We propose to: (1) bring this high-throughput compound screening system to pre-demonstration stage; (2) evaluate its dependability for drug target identification and drug discovery; (3) file US and European patent applications for IPR protection; and (4) identify potential commercialization opportunities. The overarching aim is to facilitate the exploitation of the innovation generated in the context of NeuronAge towards the betterment of human health and quality of life.

 Publications

year authors and title journal last update
List of publications.
2018 Athanasios Metaxakis, Dionysia Petratou, Nektarios Tavernarakis
Multimodal sensory processing in Caenorhabditis elegans
published pages: 180049, ISSN: 2046-2441, DOI: 10.1098/rsob.180049
Open Biology 8/6 2019-05-23
2018 Athanasios Metaxakis, Christina Ploumi, Nektarios Tavernarakis
Autophagy in Age-Associated Neurodegeneration
published pages: 37, ISSN: 2073-4409, DOI: 10.3390/cells7050037
Cells 7/5 2019-05-23
2018 Ioanna Daskalaki, Ilias Gkikas, Nektarios Tavernarakis
Hypoxia and Selective Autophagy in Cancer Development and Therapy
published pages: , ISSN: 2296-634X, DOI: 10.3389/fcell.2018.00104
Frontiers in Cell and Developmental Biology 6 2019-05-23
2018 Vassiliki Nikoletopoulou, Nektarios Tavernarakis
Regulation and Roles of Autophagy at Synapses
published pages: 646-661, ISSN: 0962-8924, DOI: 10.1016/j.tcb.2018.03.006
Trends in Cell Biology 28/8 2019-05-23
2018 Ilias Gkikas, Konstantinos Palikaras, Nektarios Tavernarakis
The Role of Mitophagy in Innate Immunity
published pages: , ISSN: 1664-3224, DOI: 10.3389/fimmu.2018.01283
Frontiers in Immunology 9 2019-05-23
2018 Nikos Kourtis, Nektarios Tavernarakis
Small heat shock proteins and neurodegeneration: recent developments
published pages: 94-102, ISSN: 1868-5021, DOI: 10.1515/bmc-2018-0009
Biomolecular Concepts 9/1 2019-05-23
2018 Matthias Rieckher, Maria Markaki, Andrea Princz, Björn Schumacher, Nektarios Tavernarakis
Maintenance of Proteostasis by P Body-Mediated Regulation of eIF4E Availability during Aging in Caenorhabditis elegans
published pages: 199-211.e6, ISSN: 2211-1247, DOI: 10.1016/j.celrep.2018.09.009
Cell Reports 25/1 2019-05-23

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