Explore the words cloud of the NeuronAgeScreen project. It provides you a very rough idea of what is the project "NeuronAgeScreen" about.
The following table provides information about the project.
IDRYMA TECHNOLOGIAS KAI EREVNAS
|Coordinator Country||Greece [EL]|
|Total cost||150˙000 €|
|EC max contribution||150˙000 € (100%)|
1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
|Duration (year-month-day)||from 2017-05-01 to 2018-10-31|
Take a look of project's partnership.
|1||IDRYMA TECHNOLOGIAS KAI EREVNAS||EL (IRAKLEIO)||coordinator||150˙000.00|
Battling human neurodegenerative pathologies, and their pervasive societal impact, is a global multi-billion Euro enterprise. Ageing is universally associated with marked decrease of neuronal function and higher susceptibility to neurodegeneration. In human populations, this is manifested as an ever-increasing prevalence of devastating neurodegenerative conditions, including Alzheimer’s and Parkinson’s disease, stroke, several ataxias, and other types of dementia. Development of therapeutic interventions against such maladies is becoming a pressing priority. Drug discovery and drug target identification are two intimately linked facets of intervention strategies aimed at effectively combating human disorders. Genes linked to human diseases often function in evolutionary conserved pathways, readily dissected in simple model organisms. Such organisms provide attractive platforms for devising and streamlining efficient drug discovery and target identification methodologies. During the course of the ERC project NeuronAge, we developed a convenient and versatile platform for high-throughput chemical compound screening based on the nematode C. elegans (Nature 521: 525; Nature 490: 213). This innovative platform uniquely combines state-of-the-art microfluidics technologies for imaging and manipulation of neurons in vivo, with the experimental prowess of C. elegans, a highly malleable genetic model, which offers a precisely defined nervous system, two features that are not available in any other organism. We propose to: (1) bring this high-throughput compound screening system to pre-demonstration stage; (2) evaluate its dependability for drug target identification and drug discovery; (3) file US and European patent applications for IPR protection; and (4) identify potential commercialization opportunities. The overarching aim is to facilitate the exploitation of the innovation generated in the context of NeuronAge towards the betterment of human health and quality of life.
|year||authors and title||journal||last update|
Athanasios Metaxakis, Dionysia Petratou, Nektarios Tavernarakis
Multimodal sensory processing in Caenorhabditis elegans
published pages: 180049, ISSN: 2046-2441, DOI: 10.1098/rsob.180049
|Open Biology 8/6||2019-05-23|
Athanasios Metaxakis, Christina Ploumi, Nektarios Tavernarakis
Autophagy in Age-Associated Neurodegeneration
published pages: 37, ISSN: 2073-4409, DOI: 10.3390/cells7050037
Ioanna Daskalaki, Ilias Gkikas, Nektarios Tavernarakis
Hypoxia and Selective Autophagy in Cancer Development and Therapy
published pages: , ISSN: 2296-634X, DOI: 10.3389/fcell.2018.00104
|Frontiers in Cell and Developmental Biology 6||2019-05-23|
Vassiliki Nikoletopoulou, Nektarios Tavernarakis
Regulation and Roles of Autophagy at Synapses
published pages: 646-661, ISSN: 0962-8924, DOI: 10.1016/j.tcb.2018.03.006
|Trends in Cell Biology 28/8||2019-05-23|
Ilias Gkikas, Konstantinos Palikaras, Nektarios Tavernarakis
The Role of Mitophagy in Innate Immunity
published pages: , ISSN: 1664-3224, DOI: 10.3389/fimmu.2018.01283
|Frontiers in Immunology 9||2019-05-23|
Nikos Kourtis, Nektarios Tavernarakis
Small heat shock proteins and neurodegeneration: recent developments
published pages: 94-102, ISSN: 1868-5021, DOI: 10.1515/bmc-2018-0009
|Biomolecular Concepts 9/1||2019-05-23|
Matthias Rieckher, Maria Markaki, Andrea Princz, BjÃ¶rn Schumacher, Nektarios Tavernarakis
Maintenance of Proteostasis by P Body-Mediated Regulation of eIF4E Availability during Aging in Caenorhabditis elegans
published pages: 199-211.e6, ISSN: 2211-1247, DOI: 10.1016/j.celrep.2018.09.009
|Cell Reports 25/1||2019-05-23|
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