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Multidimensional Analysis of Axis Patterning in Plant Embryo

Total Cost €


EC-Contrib. €






 MAAP project word cloud

Explore the words cloud of the MAAP project. It provides you a very rough idea of what is the project "MAAP" about.

plant    diversity    earliest    reflecting    answering    morphological    radial    genetic    symmetry    origins    arabidopsis    patterning    computer    quality    generate    quantify    instances    cellular    apical    mechanistic    shared    quantitative    restricted    reveal    soon    examine    newly    thaliana    protein    continues    phavoluta    embryogenesis    interplay    image    homogeneous    embryonic    basal    core    phabulosa    individual    microscopy    map    plants    group    regulatory    geometry    pattering    simplest    phb    temporal    developmental    host    embryos    signaling    mechanism    bilateral    data    proteins    functions    spatial    fundamental    question    expression    homeobox    gene    lack    phv    patterns    biology    insights    unanswered    small    relationship    microrna    positional    regulation    models    initially    body    genes    extract    emerge    cells    embryo    species    latest    signal    4d    regulate    shoot    immobile    brassicaceae    axis    spatio    division    switches   

Project "MAAP" data sheet

The following table provides information about the project.


Organization address
postcode: 80539
website: n.a.

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Project website
 Total cost 159˙460 €
 EC max contribution 159˙460 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2016
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2017
 Duration (year-month-day) from 2017-08-01   to  2019-07-31


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 


 Project objective

Plant cells are immobile, therefore positional signaling is essential for body patterning. While many genes involved in positional signaling in plants are known, we currently lack a mechanistic understanding of their functions. Embryonic axis pattering is the earliest and simplest instances of positional signaling. In Arabidopsis thaliana, embryo is initially radial symmetry. Soon after, the embryo switches to bilateral symmetry and development continues along the newly-established axis. How these patterns emerge from a small group of homogeneous cells remains a fundamental unanswered question in developmental biology. Answering this question requires an in-depth analysis of the spatio-temporal relationship between gene expression and cellular patterns. Today, advanced microscopy and latest image analysis allow us to quantify division, growth and gene expression in individual cells throughout embryogenesis. The host group has been studying the regulatory role of homeobox proteins, PHABULOSA (PHB) and PHAVOLUTA (PHV). Distribution of PHB/PHV protein is restricted by microRNA to apical embryo, triggering embryonic shoot formation. If the PHB/PHV distribution is a positional signal reflecting apical-basal axis, how do they regulate cellular growth and division patterns to establish axis? I will generate a 4D map of axis patterning, extract high quality quantitative data to develop spatial computer models, and examine the interplay between geometry and genetic regulation on axis patterning. I will also apply same approaches to study embryos in other Brassicaceae species. Such comparative developmental analysis will reveal the core mechanism of axis formation shared among these species and also provide insights into the origins of their embryonic morphological diversity.


year authors and title journal last update
List of publications.
2019 Petra Marhava, Lukas Hoermayer, Saiko Yoshida, Peter Marhavý, Eva Benková, Jiří Friml
Re-activation of Stem Cell Pathways for Pattern Restoration in Plant Wound Healing
published pages: 957-969.e13, ISSN: 0092-8674, DOI: 10.1016/j.cell.2019.04.015
Cell 177/4 2019-11-25

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The information about "MAAP" are provided by the European Opendata Portal: CORDIS opendata.

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