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MAAP

Multidimensional Analysis of Axis Patterning in Plant Embryo

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 MAAP project word cloud

Explore the words cloud of the MAAP project. It provides you a very rough idea of what is the project "MAAP" about.

expression    extract    4d    shared    radial    proteins    question    instances    relationship    newly    phavoluta    axis    embryonic    phv    answering    origins    body    apical    reflecting    positional    spatio    developmental    map    mechanistic    restricted    spatial    embryogenesis    plant    cells    gene    fundamental    lack    brassicaceae    patterning    geometry    genetic    shoot    regulation    continues    generate    core    soon    phb    insights    immobile    thaliana    regulate    small    plants    biology    phabulosa    latest    pattering    computer    switches    arabidopsis    unanswered    functions    signaling    embryos    bilateral    morphological    image    emerge    embryo    quantitative    microscopy    homogeneous    homeobox    basal    models    data    initially    signal    microrna    mechanism    genes    quality    reveal    interplay    cellular    regulatory    quantify    symmetry    examine    protein    division    earliest    diversity    individual    species    host    group    temporal    patterns    simplest   

Project "MAAP" data sheet

The following table provides information about the project.

Coordinator
MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV 

Organization address
address: HOFGARTENSTRASSE 8
city: MUENCHEN
postcode: 80539
website: n.a.

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Project website https://www.mpipz.mpg.de/tsiantis
 Total cost 159˙460 €
 EC max contribution 159˙460 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2016
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2017
 Duration (year-month-day) from 2017-08-01   to  2019-07-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV DE (MUENCHEN) coordinator 159˙460.00

Map

 Project objective

Plant cells are immobile, therefore positional signaling is essential for body patterning. While many genes involved in positional signaling in plants are known, we currently lack a mechanistic understanding of their functions. Embryonic axis pattering is the earliest and simplest instances of positional signaling. In Arabidopsis thaliana, embryo is initially radial symmetry. Soon after, the embryo switches to bilateral symmetry and development continues along the newly-established axis. How these patterns emerge from a small group of homogeneous cells remains a fundamental unanswered question in developmental biology. Answering this question requires an in-depth analysis of the spatio-temporal relationship between gene expression and cellular patterns. Today, advanced microscopy and latest image analysis allow us to quantify division, growth and gene expression in individual cells throughout embryogenesis. The host group has been studying the regulatory role of homeobox proteins, PHABULOSA (PHB) and PHAVOLUTA (PHV). Distribution of PHB/PHV protein is restricted by microRNA to apical embryo, triggering embryonic shoot formation. If the PHB/PHV distribution is a positional signal reflecting apical-basal axis, how do they regulate cellular growth and division patterns to establish axis? I will generate a 4D map of axis patterning, extract high quality quantitative data to develop spatial computer models, and examine the interplay between geometry and genetic regulation on axis patterning. I will also apply same approaches to study embryos in other Brassicaceae species. Such comparative developmental analysis will reveal the core mechanism of axis formation shared among these species and also provide insights into the origins of their embryonic morphological diversity.

 Publications

year authors and title journal last update
List of publications.
2019 Petra Marhava, Lukas Hoermayer, Saiko Yoshida, Peter Marhavý, Eva Benková, Jiří Friml
Re-activation of Stem Cell Pathways for Pattern Restoration in Plant Wound Healing
published pages: 957-969.e13, ISSN: 0092-8674, DOI: 10.1016/j.cell.2019.04.015
Cell 177/4 2019-11-25

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