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MAAP

Multidimensional Analysis of Axis Patterning in Plant Embryo

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 MAAP project word cloud

Explore the words cloud of the MAAP project. It provides you a very rough idea of what is the project "MAAP" about.

image    microrna    emerge    switches    quality    spatial    generate    soon    patterning    mechanistic    quantitative    cells    shared    4d    positional    gene    bilateral    embryos    homeobox    homogeneous    phv    initially    division    restricted    immobile    biology    patterns    radial    embryo    regulatory    models    data    embryonic    simplest    lack    genes    arabidopsis    pattering    small    individual    mechanism    thaliana    plant    signal    relationship    morphological    plants    microscopy    symmetry    axis    extract    latest    signaling    spatio    map    interplay    host    question    continues    shoot    examine    unanswered    newly    apical    origins    diversity    phavoluta    reveal    brassicaceae    expression    computer    phb    species    embryogenesis    reflecting    functions    developmental    phabulosa    geometry    body    earliest    basal    regulation    group    quantify    temporal    insights    protein    core    regulate    cellular    genetic    answering    proteins    instances    fundamental   

Project "MAAP" data sheet

The following table provides information about the project.

Coordinator
MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV 

Organization address
address: HOFGARTENSTRASSE 8
city: MUENCHEN
postcode: 80539
website: n.a.

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Project website https://www.mpipz.mpg.de/tsiantis
 Total cost 159˙460 €
 EC max contribution 159˙460 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2016
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2017
 Duration (year-month-day) from 2017-08-01   to  2019-07-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV DE (MUENCHEN) coordinator 159˙460.00

Map

 Project objective

Plant cells are immobile, therefore positional signaling is essential for body patterning. While many genes involved in positional signaling in plants are known, we currently lack a mechanistic understanding of their functions. Embryonic axis pattering is the earliest and simplest instances of positional signaling. In Arabidopsis thaliana, embryo is initially radial symmetry. Soon after, the embryo switches to bilateral symmetry and development continues along the newly-established axis. How these patterns emerge from a small group of homogeneous cells remains a fundamental unanswered question in developmental biology. Answering this question requires an in-depth analysis of the spatio-temporal relationship between gene expression and cellular patterns. Today, advanced microscopy and latest image analysis allow us to quantify division, growth and gene expression in individual cells throughout embryogenesis. The host group has been studying the regulatory role of homeobox proteins, PHABULOSA (PHB) and PHAVOLUTA (PHV). Distribution of PHB/PHV protein is restricted by microRNA to apical embryo, triggering embryonic shoot formation. If the PHB/PHV distribution is a positional signal reflecting apical-basal axis, how do they regulate cellular growth and division patterns to establish axis? I will generate a 4D map of axis patterning, extract high quality quantitative data to develop spatial computer models, and examine the interplay between geometry and genetic regulation on axis patterning. I will also apply same approaches to study embryos in other Brassicaceae species. Such comparative developmental analysis will reveal the core mechanism of axis formation shared among these species and also provide insights into the origins of their embryonic morphological diversity.

 Publications

year authors and title journal last update
List of publications.
2019 Petra Marhava, Lukas Hoermayer, Saiko Yoshida, Peter Marhavý, Eva Benková, Jiří Friml
Re-activation of Stem Cell Pathways for Pattern Restoration in Plant Wound Healing
published pages: 957-969.e13, ISSN: 0092-8674, DOI: 10.1016/j.cell.2019.04.015
Cell 177/4 2019-11-25

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