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MAAP

Multidimensional Analysis of Axis Patterning in Plant Embryo

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 MAAP project word cloud

Explore the words cloud of the MAAP project. It provides you a very rough idea of what is the project "MAAP" about.

fundamental    extract    initially    quantify    protein    computer    morphological    restricted    core    temporal    diversity    data    radial    origins    regulatory    genetic    examine    host    phavoluta    map    small    earliest    cells    brassicaceae    plant    patterning    genes    reveal    embryogenesis    quantitative    basal    unanswered    reflecting    immobile    continues    soon    answering    regulation    microscopy    symmetry    mechanistic    body    patterns    newly    homeobox    image    phb    apical    gene    mechanism    group    homogeneous    signaling    emerge    simplest    embryo    embryonic    quality    4d    positional    switches    developmental    spatial    regulate    functions    lack    arabidopsis    relationship    biology    expression    phv    axis    latest    instances    proteins    shared    microrna    insights    question    pattering    phabulosa    species    spatio    signal    interplay    plants    thaliana    bilateral    shoot    generate    embryos    geometry    models    division    individual    cellular   

Project "MAAP" data sheet

The following table provides information about the project.

Coordinator
MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV 

Organization address
address: HOFGARTENSTRASSE 8
city: MUENCHEN
postcode: 80539
website: n.a.

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Project website https://www.mpipz.mpg.de/tsiantis
 Total cost 159˙460 €
 EC max contribution 159˙460 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2016
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2017
 Duration (year-month-day) from 2017-08-01   to  2019-07-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV DE (MUENCHEN) coordinator 159˙460.00

Map

 Project objective

Plant cells are immobile, therefore positional signaling is essential for body patterning. While many genes involved in positional signaling in plants are known, we currently lack a mechanistic understanding of their functions. Embryonic axis pattering is the earliest and simplest instances of positional signaling. In Arabidopsis thaliana, embryo is initially radial symmetry. Soon after, the embryo switches to bilateral symmetry and development continues along the newly-established axis. How these patterns emerge from a small group of homogeneous cells remains a fundamental unanswered question in developmental biology. Answering this question requires an in-depth analysis of the spatio-temporal relationship between gene expression and cellular patterns. Today, advanced microscopy and latest image analysis allow us to quantify division, growth and gene expression in individual cells throughout embryogenesis. The host group has been studying the regulatory role of homeobox proteins, PHABULOSA (PHB) and PHAVOLUTA (PHV). Distribution of PHB/PHV protein is restricted by microRNA to apical embryo, triggering embryonic shoot formation. If the PHB/PHV distribution is a positional signal reflecting apical-basal axis, how do they regulate cellular growth and division patterns to establish axis? I will generate a 4D map of axis patterning, extract high quality quantitative data to develop spatial computer models, and examine the interplay between geometry and genetic regulation on axis patterning. I will also apply same approaches to study embryos in other Brassicaceae species. Such comparative developmental analysis will reveal the core mechanism of axis formation shared among these species and also provide insights into the origins of their embryonic morphological diversity.

 Publications

year authors and title journal last update
List of publications.
2019 Petra Marhava, Lukas Hoermayer, Saiko Yoshida, Peter Marhavý, Eva Benková, Jiří Friml
Re-activation of Stem Cell Pathways for Pattern Restoration in Plant Wound Healing
published pages: 957-969.e13, ISSN: 0092-8674, DOI: 10.1016/j.cell.2019.04.015
Cell 177/4 2019-11-25

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