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Multidimensional Analysis of Axis Patterning in Plant Embryo

Total Cost €


EC-Contrib. €






 MAAP project word cloud

Explore the words cloud of the MAAP project. It provides you a very rough idea of what is the project "MAAP" about.

biology    apical    patterns    examine    developmental    answering    shared    species    origins    pattering    interplay    immobile    spatial    quantify    bilateral    quantitative    patterning    core    embryogenesis    gene    group    restricted    positional    shoot    unanswered    radial    small    individual    embryonic    signal    phabulosa    genes    symmetry    expression    microrna    map    phv    data    regulatory    brassicaceae    cellular    spatio    homeobox    proteins    image    models    body    initially    4d    regulation    lack    embryo    reveal    phavoluta    quality    embryos    plants    arabidopsis    phb    insights    cells    fundamental    geometry    thaliana    generate    morphological    mechanistic    diversity    instances    soon    newly    genetic    microscopy    homogeneous    continues    protein    relationship    earliest    emerge    basal    plant    signaling    regulate    simplest    functions    reflecting    division    extract    switches    computer    axis    question    mechanism    host    temporal    latest   

Project "MAAP" data sheet

The following table provides information about the project.


Organization address
postcode: 80539
website: n.a.

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Project website
 Total cost 159˙460 €
 EC max contribution 159˙460 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2016
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2017
 Duration (year-month-day) from 2017-08-01   to  2019-07-31


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 


 Project objective

Plant cells are immobile, therefore positional signaling is essential for body patterning. While many genes involved in positional signaling in plants are known, we currently lack a mechanistic understanding of their functions. Embryonic axis pattering is the earliest and simplest instances of positional signaling. In Arabidopsis thaliana, embryo is initially radial symmetry. Soon after, the embryo switches to bilateral symmetry and development continues along the newly-established axis. How these patterns emerge from a small group of homogeneous cells remains a fundamental unanswered question in developmental biology. Answering this question requires an in-depth analysis of the spatio-temporal relationship between gene expression and cellular patterns. Today, advanced microscopy and latest image analysis allow us to quantify division, growth and gene expression in individual cells throughout embryogenesis. The host group has been studying the regulatory role of homeobox proteins, PHABULOSA (PHB) and PHAVOLUTA (PHV). Distribution of PHB/PHV protein is restricted by microRNA to apical embryo, triggering embryonic shoot formation. If the PHB/PHV distribution is a positional signal reflecting apical-basal axis, how do they regulate cellular growth and division patterns to establish axis? I will generate a 4D map of axis patterning, extract high quality quantitative data to develop spatial computer models, and examine the interplay between geometry and genetic regulation on axis patterning. I will also apply same approaches to study embryos in other Brassicaceae species. Such comparative developmental analysis will reveal the core mechanism of axis formation shared among these species and also provide insights into the origins of their embryonic morphological diversity.


year authors and title journal last update
List of publications.
2019 Petra Marhava, Lukas Hoermayer, Saiko Yoshida, Peter Marhavý, Eva Benková, Jiří Friml
Re-activation of Stem Cell Pathways for Pattern Restoration in Plant Wound Healing
published pages: 957-969.e13, ISSN: 0092-8674, DOI: 10.1016/j.cell.2019.04.015
Cell 177/4 2019-11-25

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The information about "MAAP" are provided by the European Opendata Portal: CORDIS opendata.

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