Opendata, web and dolomites

DIRECtA SIGNED

Targeting the Endocannabinoid System within Islets of Langerhans to Protect against Immune Destruction.

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

 DIRECtA project word cloud

Explore the words cloud of the DIRECtA project. It provides you a very rough idea of what is the project "DIRECtA" about.

mass    disease    damage    manipulation    preserving    destruction    cb1    mitochondrial    neuropathy    metabolism    synergy    inflammation    cure    strategy    life    develops    reactivity    diseases    protecting    ameliorated    capita    cb2    inflammatory    europe    prevalence    receptors    progressive    autophagy    autoimmune    diabetic    modulating    pharmacological    islets    purpose    cardiovascular    patients    obese    levels    function    highest    regulators    children    preventing    producing    themselves    knockout    glucose    diabetes    incidence    langerhans    gpr55    renal    model    cells    prolonged    activation    prevented    mice    antagonist    infiltration    proposes    insulitis    administration    blockade    exogenous    signalling    secretion    thereby    action    intend    beneficial    peripheral    reported    cannabidiol    therapies    spontaneously    infections    challenged    alters    risk    t1d    treating    play    interaction    absolute    proliferation    reducing    blood    generate    beta    immune    uncontrolled    endocannabinoid    ecrs    mouse    insulin    cell    pancreas    additionally   

Project "DIRECtA" data sheet

The following table provides information about the project.

Coordinator
FUNDACION PUBLICA ANDALUZA PARA LA INVESTIGACION DE MALAGA EN BIOMEDICINA Y SALUD 

Organization address
address: CALLE DOCTOR MIGUEL DIAZ RECIO 28 PLANTA BAJA
city: MALAGA
postcode: 29010
website: n.a.

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Spain [ES]
 Total cost 158˙121 €
 EC max contribution 158˙121 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2016
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2018
 Duration (year-month-day) from 2018-01-03   to  2020-01-02

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    FUNDACION PUBLICA ANDALUZA PARA LA INVESTIGACION DE MALAGA EN BIOMEDICINA Y SALUD ES (MALAGA) coordinator 158˙121.00

Map

 Project objective

Europe has the highest prevalence per capita of children with type 1 diabetes (T1D), an autoimmune disease with no cure that results in progressive destruction, and finally an absolute loss, of insulin-producing beta (β) cells in islets of Langerhans in the pancreas. This means that patients require exogenous insulin administration for life. Additionally, prolonged uncontrolled blood glucose levels increase the risk of cardiovascular diseases, peripheral neuropathy, renal failure and numerous infections. The endocannabinoid receptors (ECRs) CB1, CB2 and GPR55 are regulators of metabolism and immune action and are also present on β cells. Cannabidiol, a CB1 antagonist, reduced the incidence of T1D in mice by reducing insulitis, thereby preserving β cell mass. Additionally, blockade of CB1 alters insulin secretion, increasing proliferation and autophagy in β cells. Importantly, β cell-specific CB1 knockout mice have no T-cell infiltration in islets when their pancreas is challenged. Furthermore, activation of GPR55 and CB2 are reported to be beneficial in protecting from inflammation. In this project we intend to study the interaction of the ECRs and their potential synergy for protecting β cells from insulitis. For this purpose, we will generate a non-obese diabetic (spontaneously develops autoimmune insulitis) β cell-specific CB1 knockout mouse, and use pharmacological approaches to enhance GPR55 and CB2 signalling to determine if the diabetic condition can be prevented/ameliorated. We will assess β cell damage together with mitochondrial function, autophagy, and inflammatory responses in our mouse model and after pharmacological manipulation. Thus, this project proposes a new strategy, not focusing on the immune system but on the role that β cells themselves play in modulating their own reactivity, for the development of new therapies for preventing and/or treating T1D.

 Publications

year authors and title journal last update
List of publications.
2020 Silvana Y. Romero-Zerbo, María García-Fernández, Vanesa Espinosa-Jimenez, Macarena Pozo-Morales, Alejandro Escamilla-Sánchez, Lourdes Sánchez-Salido, Estrella Lara, Nadia Cobo-Vuilleumier, Alex Rafacho, Gabriel Olveira, Gemma Rojo-Martínez, Benoit R. Gauthier, Isabel González-Mariscal and Francisco J. Bermúdez-Silva
THE ATYPICAL CANNABINOID ABN-CBD REDUCES INFLAMMATION AND PROTECTS LIVER, PANCREAS AND ADIPOSE TISSUE IN A MOUSE MODEL OF PREDIABETES AND NON-ALCOHOLIC FATTY LIVER DISEASE
published pages: , ISSN: 1664-2392, DOI: 10.3389/fendo.2020.00103
Frontiers in Endocrinology 2020-03-05

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "DIRECTA" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "DIRECTA" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.3.2.)

MAREITA (2018)

Mapping Remediation in Italian Literature Beyond the Digital Revolution

Read More  

NPsVLCD (2019)

Natural Product-Inspired Therapies for Leishmaniasis and Chagas Disease

Read More  

SIMIS (2020)

Strongly Interacting Mass Imbalanced Superfluid with ultracold fermions

Read More