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Biomechanical Characterization of Carotid Plaque Rupture

Total Cost €


EC-Contrib. €






Project "BIO-CAPTURE" data sheet

The following table provides information about the project.


Organization address
postcode: 3015 GD

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Netherlands [NL]
 Project website
 Total cost 165˙598 €
 EC max contribution 165˙598 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2016
 Funding Scheme MSCA-IF-EF-RI
 Starting year 2017
 Duration (year-month-day) from 2017-07-01   to  2019-06-30


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 


 Project objective

Stroke is the second leading cause of mortality worldwide. Most stroke events are triggered by an atherosclerotic plaque rupture in a carotid artery. Current clinical decisions for the carotid plaque removal surgery are made without assessing the plaque rupture risk as no reliable means exists today. Biomechanics can help to develop such risk assessment tools; yet, the fundamental knowledge on biomechanical descriptors of plaque rupture is missing. This project aims to provide biomechanical characteristics of atherosclerotic plaque rupture. This will be done by combining experimental work, high-end plaque imaging and computational modeling. First, non-existing biomechanical plaque rupture data will be collected from a novel experimental approach of physiological, ex-vivo inflation/rupture tests with atherosclerotic human carotid arteries. The pre-rupture and rupture strain distributions in plaques during the tests will be assessed in 3D via a cutting-edge high frequency ultrasound technique. With a novel inverse finite element (FE) technique, heterogeneous material properties of the plaques will be identified. This unique material information will be used in plaque-specific FE models to compute 3D pre-rupture and rupture stress distributions in the plaques. The assessed plaque strain and stress fingerprints will be evaluated for their predictive value of plaque rupture. The essential knowledge on biomechanical characteristics of plaque rupture will aid making more accurate surgical treatment decisions to prevent stroke-related mortality and morbidity. Besides the high-impact research, this fellowship will also result in enhancement of the applicant’s skill set through the valuable training on ultrasound imaging, histology and pathomorphology examination. Furthermore, the fellowship will allow him to return to the EU research environment, and bring back his expertise in tissue experimentation and modeling, and advanced FE analysis.


year authors and title journal last update
List of publications.
2017 Ali C. Akyildiz, Lambert Speelman, Bas van Velzen, Raoul R. F. Stevens, Antonius F. W. van der Steen, Wouter Huberts, Frank J. H. Gijsen
Intima heterogeneity in stress assessment of atherosclerotic plaques
published pages: 20170008, ISSN: 2042-8898, DOI: 10.1098/rsfs.2017.0008
Interface Focus 8/1 2019-10-10
2017 Ali C. Akyildiz, Chen-Ket Chai, Cees W.J. Oomens, Aad van der Lugt, Frank P.T. Baaijens, Gustav J. Strijkers, Frank J.H. Gijsen
3D Fiber Orientation in Atherosclerotic Carotid Plaques
published pages: 28-35, ISSN: 1047-8477, DOI: 10.1016/j.jsb.2017.08.003
Journal of Structural Biology 200/1 2019-10-10
2019 Hilary E. Barrett, Kim Van der Heiden, Eric Farrell, Frank J.H. Gijsen, Ali C. Akyildiz
Calcifications in atherosclerotic plaques and impact on plaque biomechanics
published pages: 1-12, ISSN: 0021-9290, DOI: 10.1016/j.jbiomech.2019.03.005
Journal of Biomechanics 87 2019-10-10

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The information about "BIO-CAPTURE" are provided by the European Opendata Portal: CORDIS opendata.

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