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INTERCELLAR SIGNED

The role of the symplast in host-pathogen interactions – how does the symplastic, intercellular exchange of molecules regulate the outcomes of defence and infection?

Total Cost €

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EC-Contrib. €

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Project "INTERCELLAR" data sheet

The following table provides information about the project.

Coordinator
JOHN INNES CENTRE 

Organization address
address: NORWICH RESEARCH PARK COLNEY
city: NORWICH
postcode: NR4 7UH
website: www.jic.bbsrc.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
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fax: n.a.

 Coordinator Country United Kingdom [UK]
 Total cost 2˙162˙500 €
 EC max contribution 2˙162˙500 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2016-COG
 Funding Scheme ERC-COG
 Starting year 2017
 Duration (year-month-day) from 2017-06-01   to  2022-05-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    JOHN INNES CENTRE UK (NORWICH) coordinator 2˙162˙500.00

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 Project objective

Cell-to-cell communication is fundamental to multicellular organisms. The exchange of information and resources between cells and tissues enables co-ordination of responses to environmental and developmental signals. In plants, the cytoplasm of adjacent cells is connected by plasma membrane-line pores called plasmodesmata (PD) that cross the cell wall, generating cytoplasmic continuity between cells and tissues. This interconnected cytoplasm is termed the symplast and is unique to plants. In plants, growing evidence suggests that innate immune responses rely on regulation of symplastic connectivity. My group previously discovered that regulation of PD (whether they are open or closed) is critical for immune responses. Further, we have shown that pathogens suppress host regulation of PD in an effort to maintain symplastic continuity between cells. We don’t know why the host regulates the symplast during defence: while data suggests that different defence responses might differently exploit the symplast, we don’t understand how the symplast defines the success of a response. Similarly, we don’t know how a pathogen benefits from maintaining connectivity with surrounding host cells – is this to allow the movement of molecules to suppress defence, or is it to optimise access to host resources? This programme will investigate the question of how the symplast contributes to defence and infection strategies. We aim to understand how these strategies play out in an infection context. We will use experimental and computational approaches to generate models that allow us to predict the outcome of infection upon the basis of symplastic processes and PD regulation. Ultimately, this will create a framework for novel strategies to enhance pathogen resistance.

 Publications

year authors and title journal last update
List of publications.
2019 Cheval, C., Samwald, S., Johnston, M., Liu, X., Bellandi, A., Breakspear, A., Kadota, Y., Zipfel, C., Faulkner, C
Chitin perception in plasmodesmata identifies subcellular, context-specific immune signalling in plants
published pages: , ISSN: , DOI: 10.1101/611582
2020-01-30
2018 Cecilia Cheval, Christine Faulkner
Plasmodesmal regulation during plant-pathogen interactions
published pages: 62-67, ISSN: 0028-646X, DOI: 10.1111/nph.14857
New Phytologist 217/1 2019-05-15

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