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Gut microbiota impact on brain development and plasticity.

Total Cost €


EC-Contrib. €






 GaMePLAY project word cloud

Explore the words cloud of the GaMePLAY project. It provides you a very rough idea of what is the project "GaMePLAY" about.

reared    adulthood    brain    plasticity    metabolism    excitatory    time    developmental    hopefully    vivo    morphological    antibiotic    imaging    cortical    photon    cortex    environmental    visual    interaction    unexplored    live    transplantation    stress    bacteria    function    modulate    mechanisms    st    adult    germ    microbiota    v1    fecal    inhibitory    perturb    behaviors    environment    body    dendritic    neuronal    molecular    relatively    functions    influence    perform    abx    enriched    emotional    territory    first    timeline    stimuli    subjected    symbiosis    microbiome    treatment    effect    circuits    standard    revealing    microorganisms    largely    diseases    host    maturation    transcriptome    biomarkers    ee    mice    dominance    psychiatric    neurodevelopmental    undiscovered    immune    mechanism    primary    commensals    variety    mediators    p60    shape    weaning    dynamics    p15    ages    neurons    spine    ft    ocular    intestinal    modulates    mouse    play    p28    discovery    gut    model    suggested    free    substantial    composition    exact   

Project "GaMePLAY" data sheet

The following table provides information about the project.


Organization address
city: PISA
postcode: 56126

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Italy [IT]
 Project website
 Total cost 168˙277 €
 EC max contribution 168˙277 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2016
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2017
 Duration (year-month-day) from 2017-09-01   to  2019-08-31


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    SCUOLA NORMALE SUPERIORE IT (PISA) coordinator 168˙277.00


 Project objective

The gut microbiota is characterized by a variety of microorganisms that live in symbiosis with our body and that play a key role in host immune system development and metabolism. Studies in adult germ-free mice suggested the influence of gut commensals on emotional behaviors and stress responses. However, the exact mechanism through which these bacteria affect brain function is largely undiscovered and, their impact on brain development is still a relatively unexplored territory. In my project I propose to investigate how the gut microbiota modulates brain development and plasticity using the established model of mouse developing visual cortex. To find if development and environmental stimuli affect intestinal bacteria, the gut microbiome of mice reared in standard condition (ST) or in an enriched environment (EE) that is known to modulate visual development, will be analyzed at different ages: before weaning (P15), after weaning (P28) and in adulthood (P60) providing for the first time a developmental timeline of the gut microbiota in mice. Then, I will perturb the microbiota composition through antibiotic treatment (ABX) or fecal transplantation (FT) in ST and EE mice, and assess visual cortical function maturation and ocular dominance plasticity. Dendritic spine dynamics analyzed by in vivo two-photon imaging and formation of inhibitory and excitatory neurons will be assessed in the primary visual cortex (V1) as morphological biomarkers of visual cortical development. Finally, in order to find the molecular mechanisms and mediators of gut commensals effect on neuronal circuits, I will perform a transcriptome analysis in V1 of ST and EE mice treated with ABX, or subjected to FT. My research will bring a substantial advancement in the field, revealing how the early interaction between microbiome and host can shape cortical functions, hopefully enabling the discovery of biomarkers for facing neurodevelopmental and psychiatric diseases.

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The information about "GAMEPLAY" are provided by the European Opendata Portal: CORDIS opendata.

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