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GaMePLAY

Gut microbiota impact on brain development and plasticity.

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 GaMePLAY project word cloud

Explore the words cloud of the GaMePLAY project. It provides you a very rough idea of what is the project "GaMePLAY" about.

interaction    cortical    ocular    live    maturation    environment    v1    vivo    modulate    environmental    ft    neurons    behaviors    transplantation    intestinal    free    first    mediators    hopefully    mice    standard    subjected    primary    perturb    morphological    neuronal    unexplored    microbiome    metabolism    microorganisms    ages    functions    reared    developmental    molecular    psychiatric    gut    host    bacteria    influence    modulates    diseases    excitatory    suggested    stimuli    dominance    transcriptome    spine    perform    visual    discovery    st    stress    function    abx    microbiota    effect    mechanism    p60    cortex    undiscovered    brain    p15    inhibitory    plasticity    shape    immune    biomarkers    photon    adulthood    fecal    largely    relatively    composition    treatment    symbiosis    p28    emotional    exact    territory    revealing    commensals    circuits    variety    model    neurodevelopmental    antibiotic    ee    play    dendritic    substantial    timeline    time    adult    body    mouse    mechanisms    imaging    dynamics    enriched    germ    weaning   

Project "GaMePLAY" data sheet

The following table provides information about the project.

Coordinator
SCUOLA NORMALE SUPERIORE 

Organization address
address: PIAZZA DEI CAVALIERI 7
city: PISA
postcode: 56126
website: www.sns.it

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Italy [IT]
 Project website https://www.facebook.com/Gameplay-Horizon-2020-111062813661432/
 Total cost 168˙277 €
 EC max contribution 168˙277 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2016
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2017
 Duration (year-month-day) from 2017-09-01   to  2019-08-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    SCUOLA NORMALE SUPERIORE IT (PISA) coordinator 168˙277.00

Map

 Project objective

The gut microbiota is characterized by a variety of microorganisms that live in symbiosis with our body and that play a key role in host immune system development and metabolism. Studies in adult germ-free mice suggested the influence of gut commensals on emotional behaviors and stress responses. However, the exact mechanism through which these bacteria affect brain function is largely undiscovered and, their impact on brain development is still a relatively unexplored territory. In my project I propose to investigate how the gut microbiota modulates brain development and plasticity using the established model of mouse developing visual cortex. To find if development and environmental stimuli affect intestinal bacteria, the gut microbiome of mice reared in standard condition (ST) or in an enriched environment (EE) that is known to modulate visual development, will be analyzed at different ages: before weaning (P15), after weaning (P28) and in adulthood (P60) providing for the first time a developmental timeline of the gut microbiota in mice. Then, I will perturb the microbiota composition through antibiotic treatment (ABX) or fecal transplantation (FT) in ST and EE mice, and assess visual cortical function maturation and ocular dominance plasticity. Dendritic spine dynamics analyzed by in vivo two-photon imaging and formation of inhibitory and excitatory neurons will be assessed in the primary visual cortex (V1) as morphological biomarkers of visual cortical development. Finally, in order to find the molecular mechanisms and mediators of gut commensals effect on neuronal circuits, I will perform a transcriptome analysis in V1 of ST and EE mice treated with ABX, or subjected to FT. My research will bring a substantial advancement in the field, revealing how the early interaction between microbiome and host can shape cortical functions, hopefully enabling the discovery of biomarkers for facing neurodevelopmental and psychiatric diseases.

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The information about "GAMEPLAY" are provided by the European Opendata Portal: CORDIS opendata.

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