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GaMePLAY

Gut microbiota impact on brain development and plasticity.

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 GaMePLAY project word cloud

Explore the words cloud of the GaMePLAY project. It provides you a very rough idea of what is the project "GaMePLAY" about.

primary    diseases    emotional    treatment    morphological    reared    transplantation    gut    mice    excitatory    timeline    enriched    ee    neurons    live    unexplored    fecal    neurodevelopmental    p60    vivo    adult    body    weaning    photon    immune    mechanisms    microbiome    intestinal    biomarkers    psychiatric    adulthood    molecular    first    functions    modulate    play    territory    relatively    stimuli    brain    cortical    visual    modulates    ft    revealing    model    bacteria    imaging    antibiotic    germ    free    v1    symbiosis    dynamics    environmental    standard    function    microbiota    microorganisms    subjected    suggested    host    neuronal    exact    shape    plasticity    influence    developmental    effect    mediators    substantial    commensals    perform    largely    p28    maturation    hopefully    mechanism    st    stress    dendritic    discovery    perturb    mouse    variety    abx    p15    behaviors    circuits    ocular    time    dominance    spine    interaction    cortex    inhibitory    transcriptome    environment    ages    metabolism    composition    undiscovered   

Project "GaMePLAY" data sheet

The following table provides information about the project.

Coordinator
SCUOLA NORMALE SUPERIORE 

Organization address
address: PIAZZA DEI CAVALIERI 7
city: PISA
postcode: 56126
website: www.sns.it

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Italy [IT]
 Project website https://www.facebook.com/Gameplay-Horizon-2020-111062813661432/
 Total cost 168˙277 €
 EC max contribution 168˙277 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2016
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2017
 Duration (year-month-day) from 2017-09-01   to  2019-08-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    SCUOLA NORMALE SUPERIORE IT (PISA) coordinator 168˙277.00

Map

 Project objective

The gut microbiota is characterized by a variety of microorganisms that live in symbiosis with our body and that play a key role in host immune system development and metabolism. Studies in adult germ-free mice suggested the influence of gut commensals on emotional behaviors and stress responses. However, the exact mechanism through which these bacteria affect brain function is largely undiscovered and, their impact on brain development is still a relatively unexplored territory. In my project I propose to investigate how the gut microbiota modulates brain development and plasticity using the established model of mouse developing visual cortex. To find if development and environmental stimuli affect intestinal bacteria, the gut microbiome of mice reared in standard condition (ST) or in an enriched environment (EE) that is known to modulate visual development, will be analyzed at different ages: before weaning (P15), after weaning (P28) and in adulthood (P60) providing for the first time a developmental timeline of the gut microbiota in mice. Then, I will perturb the microbiota composition through antibiotic treatment (ABX) or fecal transplantation (FT) in ST and EE mice, and assess visual cortical function maturation and ocular dominance plasticity. Dendritic spine dynamics analyzed by in vivo two-photon imaging and formation of inhibitory and excitatory neurons will be assessed in the primary visual cortex (V1) as morphological biomarkers of visual cortical development. Finally, in order to find the molecular mechanisms and mediators of gut commensals effect on neuronal circuits, I will perform a transcriptome analysis in V1 of ST and EE mice treated with ABX, or subjected to FT. My research will bring a substantial advancement in the field, revealing how the early interaction between microbiome and host can shape cortical functions, hopefully enabling the discovery of biomarkers for facing neurodevelopmental and psychiatric diseases.

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The information about "GAMEPLAY" are provided by the European Opendata Portal: CORDIS opendata.

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