Explore the words cloud of the GaMePLAY project. It provides you a very rough idea of what is the project "GaMePLAY" about.
The following table provides information about the project.
SCUOLA NORMALE SUPERIORE
|Coordinator Country||Italy [IT]|
|Total cost||168˙277 €|
|EC max contribution||168˙277 € (100%)|
1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
|Duration (year-month-day)||from 2017-09-01 to 2019-08-31|
Take a look of project's partnership.
|1||SCUOLA NORMALE SUPERIORE||IT (PISA)||coordinator||168˙277.00|
The gut microbiota is characterized by a variety of microorganisms that live in symbiosis with our body and that play a key role in host immune system development and metabolism. Studies in adult germ-free mice suggested the influence of gut commensals on emotional behaviors and stress responses. However, the exact mechanism through which these bacteria affect brain function is largely undiscovered and, their impact on brain development is still a relatively unexplored territory. In my project I propose to investigate how the gut microbiota modulates brain development and plasticity using the established model of mouse developing visual cortex. To find if development and environmental stimuli affect intestinal bacteria, the gut microbiome of mice reared in standard condition (ST) or in an enriched environment (EE) that is known to modulate visual development, will be analyzed at different ages: before weaning (P15), after weaning (P28) and in adulthood (P60) providing for the first time a developmental timeline of the gut microbiota in mice. Then, I will perturb the microbiota composition through antibiotic treatment (ABX) or fecal transplantation (FT) in ST and EE mice, and assess visual cortical function maturation and ocular dominance plasticity. Dendritic spine dynamics analyzed by in vivo two-photon imaging and formation of inhibitory and excitatory neurons will be assessed in the primary visual cortex (V1) as morphological biomarkers of visual cortical development. Finally, in order to find the molecular mechanisms and mediators of gut commensals effect on neuronal circuits, I will perform a transcriptome analysis in V1 of ST and EE mice treated with ABX, or subjected to FT. My research will bring a substantial advancement in the field, revealing how the early interaction between microbiome and host can shape cortical functions, hopefully enabling the discovery of biomarkers for facing neurodevelopmental and psychiatric diseases.
Are you the coordinator (or a participant) of this project? Plaese send me more information about the "GAMEPLAY" project.
For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.
Send me an email (firstname.lastname@example.org) and I put them in your project's page as son as possible.
Thanks. And then put a link of this page into your project's website.
The information about "GAMEPLAY" are provided by the European Opendata Portal: CORDIS opendata.
Communists into Liberals: The Transformation and Demise of the Left as Precursor to the Illiberal Turn in PolandRead More
Combinatorial Antibody Synthesis for the Discovery of New Anti-Tumour ImmunomodulatorsRead More
The PIDE and Portuguese Society under the Salazar Dictatorship 1945-1974: Fear, Self-Policing, Accommodation.Read More