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GaMePLAY

Gut microbiota impact on brain development and plasticity.

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 GaMePLAY project word cloud

Explore the words cloud of the GaMePLAY project. It provides you a very rough idea of what is the project "GaMePLAY" about.

relatively    largely    st    inhibitory    microbiota    functions    brain    live    maturation    host    developmental    body    revealing    abx    vivo    undiscovered    standard    imaging    stimuli    antibiotic    immune    perturb    mouse    function    emotional    excitatory    commensals    environmental    ocular    p60    spine    microbiome    molecular    dynamics    v1    ft    symbiosis    variety    model    effect    mediators    photon    free    fecal    biomarkers    primary    time    cortical    mechanism    gut    modulate    plasticity    diseases    metabolism    ages    neurodevelopmental    shape    enriched    substantial    adulthood    neuronal    bacteria    weaning    discovery    morphological    p28    adult    territory    cortex    dominance    visual    perform    influence    play    composition    dendritic    microorganisms    behaviors    modulates    stress    unexplored    ee    intestinal    first    circuits    neurons    reared    environment    psychiatric    timeline    exact    p15    mechanisms    treatment    transplantation    transcriptome    interaction    suggested    hopefully    germ    mice    subjected   

Project "GaMePLAY" data sheet

The following table provides information about the project.

Coordinator
SCUOLA NORMALE SUPERIORE 

Organization address
address: PIAZZA DEI CAVALIERI 7
city: PISA
postcode: 56126
website: www.sns.it

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Italy [IT]
 Project website https://www.facebook.com/Gameplay-Horizon-2020-111062813661432/
 Total cost 168˙277 €
 EC max contribution 168˙277 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2016
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2017
 Duration (year-month-day) from 2017-09-01   to  2019-08-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    SCUOLA NORMALE SUPERIORE IT (PISA) coordinator 168˙277.00

Map

 Project objective

The gut microbiota is characterized by a variety of microorganisms that live in symbiosis with our body and that play a key role in host immune system development and metabolism. Studies in adult germ-free mice suggested the influence of gut commensals on emotional behaviors and stress responses. However, the exact mechanism through which these bacteria affect brain function is largely undiscovered and, their impact on brain development is still a relatively unexplored territory. In my project I propose to investigate how the gut microbiota modulates brain development and plasticity using the established model of mouse developing visual cortex. To find if development and environmental stimuli affect intestinal bacteria, the gut microbiome of mice reared in standard condition (ST) or in an enriched environment (EE) that is known to modulate visual development, will be analyzed at different ages: before weaning (P15), after weaning (P28) and in adulthood (P60) providing for the first time a developmental timeline of the gut microbiota in mice. Then, I will perturb the microbiota composition through antibiotic treatment (ABX) or fecal transplantation (FT) in ST and EE mice, and assess visual cortical function maturation and ocular dominance plasticity. Dendritic spine dynamics analyzed by in vivo two-photon imaging and formation of inhibitory and excitatory neurons will be assessed in the primary visual cortex (V1) as morphological biomarkers of visual cortical development. Finally, in order to find the molecular mechanisms and mediators of gut commensals effect on neuronal circuits, I will perform a transcriptome analysis in V1 of ST and EE mice treated with ABX, or subjected to FT. My research will bring a substantial advancement in the field, revealing how the early interaction between microbiome and host can shape cortical functions, hopefully enabling the discovery of biomarkers for facing neurodevelopmental and psychiatric diseases.

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The information about "GAMEPLAY" are provided by the European Opendata Portal: CORDIS opendata.

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