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AMYPAD SIGNED

Amyloid imaging to Prevent Alzheimer’s Disease – Sofia ref.: 115952

Total Cost €

EC-Contrib. €

Partnership

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Outcomes and
results

AMYPAD project word cloud

Explore the words cloud of the AMYPAD project. It provides you a very rough idea of what is the project "AMYPAD" about.

tomography secondary followed procedure true vu network ad cohorts workup clear vivo cognitive stratify preclinical diagnostic memory prevention org patients outcomes spectrum goals neurodegeneration close depiction select intervention imaging deposition positron reimbursed 2000 synergistic sufficient prodromal expertise elusive quantify pet opportunity clinical disease trial repeat severity population unprecedented normal suspected clinics tracer homogenous alzheimer brain active 4000 word management accurately sites strategy amypad dynamics clinicians team surrogate provides efficient aging constituting benefit groups class industry emission reimbursement decline treatment relevance onset vumc beta subjects brings academics risk rationale diagnosis n amyloid epad ep

Project "AMYPAD" data sheet

The following table provides information about the project.

Coordinator	STICHTING VUMC Organization address address: DE BOELELAAN 1117 city: AMSTERDAM postcode: 1081 HV website: www.vumc.nl contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Netherlands [NL]
Project website	https://amypad.eu/
Total cost	27˙329˙288 €
EC max contribution	11˙999˙886 € (44%)
Programme	1. H2020-EU.3.1.7. (Innovative Medicines Initiative 2 (IMI2))
Code Call	H2020-JTI-IMI2-2015-05-two-stage
Funding Scheme	IMI2-RIA
Starting year	2016
Duration (year-month-day)	from 2016-10-01 to 2021-09-30

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	STICHTING VUMC STICHTING VUMC Organization address address: DE BOELELAAN 1117 city: AMSTERDAM postcode: 1081 HV website: www.vumc.nl contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (AMSTERDAM)	coordinator	4˙699˙355.00
2	FUNDACIO BARCELONABETA BRAIN RESEARCH CENTER FUNDACIO BARCELONABETA BRAIN RESEARCH CENTER Organization address address: CALLE WELLINGTON 30 city: BARCELONA postcode: 8005 website: www.fpmaragall.org contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	ES (BARCELONA)	participant	1˙417˙125.00
3	IXICO TECHNOLOGIES LIMITED IXICO TECHNOLOGIES LIMITED Organization address address: 4TH FLOOR GRIFFIN COURT 15 LONG LANE city: LONDON postcode: EC1A 9PN website: www.ixico.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (LONDON)	participant	1˙196˙136.00
4	UNIVERSITY COLLEGE LONDON UNIVERSITY COLLEGE LONDON Organization address address: GOWER STREET city: LONDON postcode: WC1E 6BT website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (LONDON)	participant	981˙375.00
5	CENTRE HOSPITALIER UNIVERSITAIRE DE TOULOUSE CENTRE HOSPITALIER UNIVERSITAIRE DE TOULOUSE Organization address address: RUE VIGUERIE 2 HOTEL DIEU SAINT JACQUES city: TOULOUSE CEDEX 3 postcode: 31052 website: www.chu-toulouse.fr contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FR (TOULOUSE CEDEX 3)	participant	803˙145.00
6	KAROLINSKA INSTITUTET KAROLINSKA INSTITUTET Organization address address: Nobels Vag 5 city: STOCKHOLM postcode: 17177 website: www.ki.se contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	SE (STOCKHOLM)	participant	753˙375.00
7	KLINIKUM DER UNIVERSITAET ZU KOELN KLINIKUM DER UNIVERSITAET ZU KOELN Organization address address: Kerpener Strasse 62 city: KOELN postcode: 50937 website: www.uk-koeln.de contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (KOELN)	participant	697˙125.00
8	SYNAPSE RESEARCH MANAGEMENT PARTNERS SL SYNAPSE RESEARCH MANAGEMENT PARTNERS SL Organization address address: CALLE VELAZQUEZ 94 PLANTA 1 city: MADRID postcode: 28006 website: www.synapse-managers.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	ES (MADRID)	participant	557˙750.00
9	THE UNIVERSITY OF EDINBURGH THE UNIVERSITY OF EDINBURGH Organization address address: OLD COLLEGE, SOUTH BRIDGE city: EDINBURGH postcode: EH8 9YL website: www.ed.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (EDINBURGH)	participant	519˙000.00
10	ALZHEIMER EUROPE ALZHEIMER EUROPE Organization address address: RUE DICKS 14 city: LUXEMBOURG postcode: 1417 website: www.alzheimer-europe.org contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	LU (LUXEMBOURG)	participant	200˙500.00
11	STICHTING KATHOLIEKE UNIVERSITEIT STICHTING KATHOLIEKE UNIVERSITEIT Organization address address: GEERT GROOTEPLEIN NOORD 9 city: NIJMEGEN postcode: 6525 EZ website: www.radboudumc.nl contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (NIJMEGEN)	participant	175˙000.00
12	GE HEALTHCARE LIMITED GE HEALTHCARE LIMITED Organization address address: AMERSHAM PLACE city: LITTLE CHALFONT postcode: HP7 9NA website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (LITTLE CHALFONT)	participant	0.00
13	JANSSEN PHARMACEUTICA NV JANSSEN PHARMACEUTICA NV Organization address address: TURNHOUTSEWEG 30 city: BEERSE postcode: 2340 website: www.janssenpharmaceutica.be contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	BE (BEERSE)	participant	0.00
14	LIFE MOLECULAR IMAGING LTD LIFE MOLECULAR IMAGING LTD Organization address address: ICENI CENTRE, WARWICK TECHNOLOGY PARK city: WARWICK postcode: CV34 6DA website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (WARWICK)	participant	0.00
15	UNIVERSITE DE GENEVE UNIVERSITE DE GENEVE Organization address address: RUE DU GENERAL DUFOUR 24 city: GENEVE postcode: 1211 website: www.unige.ch contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	CH (GENEVE)	participant	0.00

Map

Project objective

Beta-amyloid (β-amyloid) deposition is considered to be a necessary - but not sufficient - step on the path towards Alzheimer’s disease (AD). Depiction of brain β-amyloid in vivo can support an early diagnosis, and even provide an opportunity for consider secondary prevention of AD. Currently, however, the value of β-amyloid PET remains elusive, reason why this procedure is typically not reimbursed.

Understanding the value of imaging of β-amyloid using positron emission tomography (PET) provides a unique opportunity to achieve 3 major goals: 1) improve the diagnostic workup of patients suspected of AD and their managementÍ¾ 2) stratify risk for AD and select homogenous groups for interventionÍ¾ and 3) quantify treatment effects more accurately.

AMYPAD will address the above objectives by studying the onset, dynamics, and clinical relevance of brain β-amyloid in the spectrum from normal aging to preclinical and prodromal AD. We will use β-amyloid-PET in an unprecedented large number of subjects (n=4000) from population studies, as well as memory clinics cohorts, with repeat imaging in up to 2000. In close collaboration with EPAD (www.ep-ad.org), the cohorts will be followed with to determine (surrogate) outcomes of cognitive decline and neurodegeneration.

Lead from VU-VUmc, the Consortium brings together a word-class team of highly synergistic partners from across Europe constituting a highly experienced and efficient β-amyloid imaging network including the most active European PET sites, to ensure effective tracer delivery, access to patients and expertise to technical knowledge and disease modelling.

AMYPAD will establish the true value of β-amyloid PET across the severity range of AD. Patients and clinicians will benefit from better and cost-effective diagnostic procedures and management, while academics and industry will benefit from better disease understanding, clear reimbursement strategy and more rationale and efficient clinical trial design.

Publications

List of publications.
year	authors and title	journal	last update
2019	Fiona Heeman, Maqsood Yaqub, Isadora Lopes Alves, Kerstin Heurling, Johannes Berkhof, Juan Domingo Gispert, Santiago Bullich, Christopher Foley, Adriaan A. Lammertsma Optimized dual-time-window protocols for quantitative [18F]flutemetamol and [18F]florbetaben PET studies published pages: , ISSN: 2191-219X, DOI: 10.1186/s13550-019-0499-4	EJNMMI Research 9/1	2020-03-17
2020	Frank Jessen, Rebecca E Amariglio, Rachel F Buckley, Wiesje M van der Flier, Ying Han, JosÃ© Luis Molinuevo, Laura Rabin, Dorene M Rentz, Octavio Rodriguez-Gomez, Andrew J Saykin, Sietske A M Sikkes, Colette M Smart, Steffen Wolfsgruber, Michael Wagner The characterisation of subjective cognitive decline published pages: 271-278, ISSN: 1474-4422, DOI: 10.1016/s1474-4422(19)30368-0	The Lancet Neurology 19/3	2020-03-17
2019	Enrico Fantoni, Lyduine Collij, Isadora Lopes Alves, Christopher Buckley, Gill Farrar The spatial-temporal ordering of amyloid pathology and opportunities for PET imaging published pages: jnumed.119.23587, ISSN: 0161-5505, DOI: 10.2967/jnumed.119.235879	Journal of Nuclear Medicine	2020-03-17
2018	Mara ten Kate, Silvia Ingala, Adam J. Schwarz, Nick C. Fox, GaÃ«l ChÃ©telat, Bart N. M. van Berckel, Michael Ewers, Christopher Foley, Juan Domingo Gispert, Derek Hill, Michael C. Irizarry, Adriaan A. Lammertsma, JosÃ© Luis Molinuevo, Craig Ritchie, Philip Scheltens, Mark E. Schmidt, Pieter Jelle Visser, Adam Waldman, Joanna Wardlaw, Sven Haller, Frederik Barkhof Secondary prevention of Alzheimerâ€™s dementia: neuroimaging contributions published pages: , ISSN: 1758-9193, DOI: 10.1186/s13195-018-0438-z	Alzheimer\'s Research & Therapy 10/1	2020-03-17
2017	Giovanni B Frisoni, Marina Boccardi, Frederik Barkhof, Kaj Blennow, Stefano Cappa, Konstantinos Chiotis, Jean-Francois DÃ©monet, Valentina Garibotto, Panteleimon Giannakopoulos, Anton Gietl, Oskar Hansson, Karl Herholz, Clifford R Jack, Flavio Nobili, Agneta Nordberg, Heather M Snyder, Mara Ten Kate, Andrea Varrone, Emiliano Albanese, Stefanie Becker, Patrick Bossuyt, Maria C Carrillo, Chiara Cera Strategic roadmap for an early diagnosis of Alzheimer\'s disease based on biomarkers published pages: 661-676, ISSN: 1474-4422, DOI: 10.1016/S1474-4422(17)30159-X	The Lancet Neurology 16/8	2020-03-17
2017	Matthias J. Ehrhardt, Pawel J. Markiewicz, Peter RichtÃ¡rik, Jonathan Schott, Antonin Chambolle, Carola-Bibiane Schoenlieb Faster PET reconstruction with a stochastic primal-dual hybrid gradient method published pages: 58, ISSN: 1061-2464, DOI: 10.1117/12.2272946	Wavelets and Sparsity XVII Proceedings Volume 10394, Wavel	2020-03-17
2018	JosÃ© Luis Molinuevo, Carolina Minguillon, Lorena Rami, Juan Domingo Gispert The Rationale Behind the New Alzheimerâ€™s Disease Conceptualization: Lessons Learned During the Last Decades published pages: 1067-1077, ISSN: 1387-2877, DOI: 10.3233/JAD-170698	Journal of Alzheimer\'s Disease 62/3	2020-03-17
2019	Giovanni B Frisoni, Isadora Lopes Alves, Frederik Barkhof IDEAS becoming reality on the roadmap for biomarker validation in Alzheimer\'s disease published pages: 519-520, ISSN: 1474-4422, DOI: 10.1016/s1474-4422(19)30166-8	The Lancet Neurology 18/6	2020-03-17
2019	Lyduine E. Collij, Elles Konijnenberg, Juhan Reimand, Mara ten Kate, Anouk den Braber, Isadora Lopes Alves, Marissa Zwan, Maqsood Yaqub, DaniÃ«lle M.E. van Assema, Alle Meije Wink, Adriaan A. Lammertsma, Philip Scheltens, Pieter Jelle Visser, Frederik Barkhof, Bart N.M. van Berckel Assessing Amyloid Pathology in Cognitively Normal Subjects Using 18 F-Flutemetamol PET: Comparing Visual Reads and Quantitative Methods published pages: 541-547, ISSN: 0161-5505, DOI: 10.2967/jnumed.118.211532	Journal of Nuclear Medicine 60/4	2020-03-17
2019	Damiano Archetti, Silvia Ingala, Vikram Venkatraghavan, Viktor Wottschel, Alexandra L. Young, Maura Bellio, Esther E. Bron, Stefan Klein, Frederik Barkhof, Daniel C. Alexander, Neil P. Oxtoby, Giovanni B. Frisoni, Alberto Redolfi Multi-study validation of data-driven disease progression models to characterize evolution of biomarkers in Alzheimer\'s disease published pages: 101954, ISSN: 2213-1582, DOI: 10.1016/j.nicl.2019.101954	NeuroImage: Clinical 24	2020-03-17
2018	Pawel J. Markiewicz, Matthias J. Ehrhardt, Kjell Erlandsson, Philip J. Noonan, Anna Barnes, Jonathan M. Schott, David Atkinson, Simon R. Arridge, Brian F. Hutton, Sebastien Ourselin NiftyPET: a High-throughput Software Platform for High Quantitative Accuracy and Precision PET Imaging and Analysis published pages: 95-115, ISSN: 1539-2791, DOI: 10.1007/s12021-017-9352-y	Neuroinformatics 16/1	2020-03-17
2018	Giovanni B. Frisoni, Frederik Barkhof, Daniele Altomare, Johannes Berkhof, Marina Boccardi, Elisa Canzoneri, Lyduine Collij, Alexander Drzezga, Gill Farrar, Valentina Garibotto, Rossella Gismondi, Juan-Domingo Gispert, Frank Jessen, Miia Kivipelto, Isadora Lopes Alves, JosÃ©-Luis Molinuevo, Agneta Nordberg, Pierre Payoux, Craig Ritchie, Irina Savicheva, Philip Scheltens, Mark E. Schmidt, Jonathan Schott, Andrew Stephens, Bart van Berckel, Bruno Vellas, Zuzana Walker, Nicola Raffa AMYPAD Diagnostic and Patient Management Study: Rationale and design published pages: , ISSN: 1552-5260, DOI: 10.1016/j.jalz.2018.09.003	Alzheimer\'s & Dementia	2020-03-17

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