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SmartCells SIGNED

Smart Lab-On-Chips for the Real -Time Control of Cells

Total Cost €


EC-Contrib. €






Project "SmartCells" data sheet

The following table provides information about the project.


There are not information about this coordinator. Please contact Fabio for more information, thanks.

 Coordinator Country France [FR]
 Total cost 2˙198˙150 €
 EC max contribution 2˙198˙150 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2016-COG
 Funding Scheme ERC-COG
 Starting year 2017
 Duration (year-month-day) from 2017-04-01   to  2022-03-31


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITE DE PARIS FR (PARIS) coordinator 2˙198˙150.00


 Project objective

Cells are complex, autonomous genetic machines with rich information processing capabilities. Synthetic Biology builds on these properties to design novel, synthetic genetic programs in cells with the aim of benefiting humans. Yet, safety and efficiency issues require creation of synthetic circuits that are reliable over a large range of operating conditions and stable to all sorts of perturbations. This is a tremendous challenge for synthetic biologists, as the robustness of any circuit is limited by their high dependence on the cellular host machinery and the fundamental stochastic nature of gene expression. Taking inspiration from physics and engineering we have imagined a computer-based feedback loop that can remotely, in real-time, control the state of a synthetic genetic program running in cells. Here, we will combine microfluidics, optogenetics, structured illumination, inference methods and control algorithm into such a real time control device of gene expression for yeast cells. We will then study how cells can be controlled at different scales and with increasing levels of complexity from a simple circuit to a simple multicellular ecosystem. Specifically, we aim at:

(1) Understanding the potential and limits of such a control method. We will ask to what extent robust control can be achieved at the single cell level over a broad range of operating conditions. (2) Taking control of complex circuits. In particular, we will take control of key genes of the large regulatory network in charge of yeast adaptation to osmotic stress and dissect their roles in setting the mechano-biology properties of yeast. (3) Taking control of multicellular systems. We will control the collective dynamics of a population of cells via single cell control at selected locations.

This framework will establish solid scientific and technological foundations of a novel research area combining physics, engineering and synthetic biology to take control of living systems.


List of deliverables.
Data Management Plan (V2) Open Research Data Pilot 2020-04-08 21:31:20
Data Management Plan (V1) Open Research Data Pilot 2020-04-08 21:31:20

Take a look to the deliverables list in detail:  detailed list of SmartCells deliverables.


year authors and title journal last update
List of publications.
2019 Zacchari Ben Meriem, Yasmine Khalil, Pascal Hersen, Emmanuelle Fabre
Hyperosmotic Stress Response Memory is Modulated by Gene Positioning in Yeast
published pages: 582, ISSN: 2073-4409, DOI: 10.3390/cells8060582
Cells 8/6 2020-04-08
2019 Zoran S Marinkovic, Clément Vulin, Mislav Acman, Xiaohu Song, Jean-Marc Di Meglio, Ariel B Lindner, Pascal Hersen
A microfluidic device for inferring metabolic landscapes in yeast monolayer colonies
published pages: , ISSN: 2050-084X, DOI: 10.7554/elife.47951
eLife 8 2020-04-08
2017 Jean-Baptiste Lugagne, Sebastián Sosa Carrillo, Melanie Kirch, Agnes Köhler, Gregory Batt, Pascal Hersen
Balancing a genetic toggle switch by real-time feedback control and periodic forcing
published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-017-01498-0
Nature Communications 8/1 2020-04-08
2018 Lugagne, Jean-Baptiste; Jain, Srajan; Ivanovitch, Pierre; Ben Meriem, Zacchary; Vulin, Clément; Fracassi, Chiara; Batt, Gregory; Hersen, Pascal
Identification of individual cells from z-stacks of bright-field microscopy images
published pages: , ISSN: 2045-2322, DOI: 10.3929/ethz-b-000280906
Scientific Reports 1 2020-04-08

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The information about "SMARTCELLS" are provided by the European Opendata Portal: CORDIS opendata.

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