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MEMORIS SIGNED

Maternal Enteric Microbiota for Offspring's Repertoire development and Illness Susceptibility

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 MEMORIS project word cloud

Explore the words cloud of the MEMORIS project. It provides you a very rough idea of what is the project "MEMORIS" about.

repertoire    adaptive    read    host    genetically    exposure    bacterial    illness    mice    later    showed    colonise    dynamic    metagenomic    earlier    diabetes    fatty    gene    coli    opportunity    gestational    memoris    life    birth    metabolomic    adult    susceptibility    window    107    diseases    opens    influenced    signals    lab    elusive    elucidate    neonatal    microbiota    metabolic    commensal    alcoholic    grow    outs    innate    reveal    offspring    drives    microbial    versus    maternal    enteric    begins    mouse    emerged    gestation    profiling    microbes    gestationally    engineered    immunglobulin    strain    colonisation    autoimmune    disease    pregnancy    colonised    persist    dams    maturation    composition    transcriptional    diet    prevent    modeling    immune    vivo    sequencing    pregnant    germ    free    cytometric    recently    demonstrated    instruct    flow    fat    transient    metabolism    education    intestinal    nod    facs    vitro    liver    cues    metatranscriptomic   

Project "MEMORIS" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITAET BERN 

Organization address
address: HOCHSCHULSTRASSE 6
city: BERN
postcode: 3012
website: http://www.unibe.ch

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Switzerland [CH]
 Total cost 187˙419 €
 EC max contribution 187˙419 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2016
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2018
 Duration (year-month-day) from 2018-03-01   to  2020-05-27

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITAET BERN CH (BERN) coordinator 187˙419.00

Map

 Project objective

Recently, it has emerged that early life exposure to commensal microbes is crucial to instruct our immune system and prevent later life autoimmune and metabolic diseases. The host lab now showed that this education begins even earlier – during gestation by signals from the maternal intestinal microbiota. Using the E. coli strain HA 107, genetically engineered to grow in vitro without the ability to persist in vivo, they demonstrated that transient intestinal colonisation of pregnant germ-free mouse dams drives neonatal innate immune maturation. However, the long-term consequences of maternal microbiota cues especially for the adaptive immune system of the adult offspring remain elusive.

The MEMORIS project (Maternal Enteric Microbiota for Offspring's Repertoire development & Illness Susceptibility) shall elucidate the long-term consequences of maternal microbial signals for the offspring’s adaptive immune system and disease susceptibility.

My specific aims are to reveal the consequences of gestational colonisation for the offspring’s (1) own intestinal microbiota composition and metabolism; (2) adaptive immune repertoire development; and (3) susceptibility to autoimmune and metabolic diseases. For this, I will colonise offspring of gestationally colonised versus germ-free mouse dams at birth and by (1) metagenomic, metatranscriptomic and metabolomic read-outs assess its dynamic microbiota development. (2) Flow cytometric and transcriptional profiling, immunglobulin gene sequencing and bacterial FACS will reveal adaptive immune repertoire maturation. Based on these results I will (3) elucidate the role of maternal microbiota signals for disease susceptibility using NOD mice modeling type 1 diabetes and high fat diet-induced non-alcoholic fatty liver disease. I would like to establish the concept that our susceptibility to autoimmune and metabolic diseases is influenced during a “window of opportunity” that opens – not just at birth – but already during pregnancy.

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The information about "MEMORIS" are provided by the European Opendata Portal: CORDIS opendata.

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