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Maternal Enteric Microbiota for Offspring's Repertoire development and Illness Susceptibility

Total Cost €


EC-Contrib. €






 MEMORIS project word cloud

Explore the words cloud of the MEMORIS project. It provides you a very rough idea of what is the project "MEMORIS" about.

engineered    transient    versus    profiling    immune    elucidate    diet    maternal    transcriptional    composition    begins    enteric    107    mouse    lab    earlier    vitro    illness    maturation    metabolic    fatty    persist    pregnancy    memoris    fat    susceptibility    metabolism    autoimmune    opens    colonisation    immunglobulin    dams    read    diabetes    adaptive    free    cues    vivo    intestinal    repertoire    sequencing    life    reveal    birth    prevent    host    liver    microbiota    outs    facs    later    genetically    flow    signals    strain    bacterial    microbial    microbes    metabolomic    gestation    adult    neonatal    commensal    offspring    alcoholic    exposure    window    grow    pregnant    gene    gestationally    innate    drives    cytometric    coli    elusive    metagenomic    mice    diseases    nod    emerged    colonised    disease    demonstrated    germ    instruct    dynamic    recently    colonise    modeling    showed    gestational    education    opportunity    metatranscriptomic    influenced   

Project "MEMORIS" data sheet

The following table provides information about the project.


Organization address
city: BERN
postcode: 3012

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Switzerland [CH]
 Total cost 187˙419 €
 EC max contribution 187˙419 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2016
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2018
 Duration (year-month-day) from 2018-03-01   to  2020-05-27


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITAET BERN CH (BERN) coordinator 187˙419.00


 Project objective

Recently, it has emerged that early life exposure to commensal microbes is crucial to instruct our immune system and prevent later life autoimmune and metabolic diseases. The host lab now showed that this education begins even earlier – during gestation by signals from the maternal intestinal microbiota. Using the E. coli strain HA 107, genetically engineered to grow in vitro without the ability to persist in vivo, they demonstrated that transient intestinal colonisation of pregnant germ-free mouse dams drives neonatal innate immune maturation. However, the long-term consequences of maternal microbiota cues especially for the adaptive immune system of the adult offspring remain elusive.

The MEMORIS project (Maternal Enteric Microbiota for Offspring's Repertoire development & Illness Susceptibility) shall elucidate the long-term consequences of maternal microbial signals for the offspring’s adaptive immune system and disease susceptibility.

My specific aims are to reveal the consequences of gestational colonisation for the offspring’s (1) own intestinal microbiota composition and metabolism; (2) adaptive immune repertoire development; and (3) susceptibility to autoimmune and metabolic diseases. For this, I will colonise offspring of gestationally colonised versus germ-free mouse dams at birth and by (1) metagenomic, metatranscriptomic and metabolomic read-outs assess its dynamic microbiota development. (2) Flow cytometric and transcriptional profiling, immunglobulin gene sequencing and bacterial FACS will reveal adaptive immune repertoire maturation. Based on these results I will (3) elucidate the role of maternal microbiota signals for disease susceptibility using NOD mice modeling type 1 diabetes and high fat diet-induced non-alcoholic fatty liver disease. I would like to establish the concept that our susceptibility to autoimmune and metabolic diseases is influenced during a “window of opportunity” that opens – not just at birth – but already during pregnancy.

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The information about "MEMORIS" are provided by the European Opendata Portal: CORDIS opendata.

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