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SynPCP SIGNED

Synapse formation and maturity through planar cell polarity pathway

Total Cost €

0

EC-Contrib. €

0

Partnership

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 SynPCP project word cloud

Explore the words cloud of the SynPCP project. It provides you a very rough idea of what is the project "SynPCP" about.

optical    neuroscience    basic    trans    integration    biochemistry    functional    scribble    synapse    complexes    defects    actin    spines    normal    hippocampus    circuit    contribution    maturation    neuronal    fonctional    polarity    pathological    ef    offers    molecular    morpho    spatiotemporal    compartment    interplay    specification    mechanisms    plasticity    cell    nanoscale    fundamental    plan    hypothesize    adhesion    3d    setup    interaction    neurocampus    autism    subcellular    critical    cytoskeleton    individual    dependent    segregation    establishment    macromolecular    neuropathies    conceptual    coupling    super    career    biophysics    suggest    protein    brain    mutations    microscopy    cellular    synaptic    dendrite    deciphering    msca    human    function    linked    dynamics    signaling    resolution    organization    pcp    techniques    dendritic    understand    assembly    spine    synaptogenesis    underlying    planar    scientific    training    molecules    cadherin    synapses    morphogenesis    scrib    connection    levels    proteins    adhesions    physiological    insights    synpcp    multilevel    bordeaux    interdisciplinary    evidences    localization   

Project "SynPCP" data sheet

The following table provides information about the project.

Coordinator		 INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE 

Organization address
address: RUE DE TOLBIAC 101
city: PARIS
postcode: 75654
website: www.inserm.fr

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.
 Coordinator Country France [FR]
 Total cost 173˙076 €
 EC max contribution 173˙076 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2016
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2018
 Duration (year-month-day) from 2018-03-01   to  2020-04-13

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE FR (PARIS) coordinator 173˙076.00

Map

 Project objective

SynPCP is a MSCA-IF-EF project in Neuroscience aimed at deciphering spatiotemporal mechanisms controlled by the planar cell polarity (PCP) protein Scribble (Scrib) in spine during specification and morpho-fonctional plasticity that depend on the dynamics of the actin cytoskeleton and trans-synaptic adhesions. Growing evidences suggest that PCP signaling is fundamental for neuronal development mechanisms, including dendrite morphogenesis and synaptogenesis. PCP signaling defects have been linked to a number of human neuropathies such as autism. Because of its subcellular compartment localization and interaction with actin, we hypothesize that Scrib nanoscale organization within the spine could control cytoskeleton and/or adhesion dynamics. To address this, I plan to study the coupling or interplay between Scrib-dependent signaling and the assembly of actin cytoskeleton macromolecular complexes and its connection to cadherin-adhesion molecules using biochemistry, biophysics and 3D super-resolution optical microscopy techniques, in normal and pathological conditions. This project will provide novel conceptual insights into the nanoscale segregation of PCP proteins in spines and how individual PCP proteins control the actin cytoskeleton to build functional synapses. This project will offer a multilevel and interdisciplinary approach to understand the consequences of mutations of PCP signaling at the nanoscale, cellular and physiological levels, on the establishment, maturation and function of the basic functional unit of neuronal integration in the complex circuit of the hippocampus: the dendritic spine. SynPCP will be setup at the Bordeaux Neurocampus which is well known for its contribution to synapse development and brain function. This project offers a scientific and training program critical for my career but also for the general understanding of the molecular mechanisms underlying the normal and pathological brain.

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The information about "SYNPCP" are provided by the European Opendata Portal: CORDIS opendata.

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