Opendata, web and dolomites

SynPCP SIGNED

Synapse formation and maturity through planar cell polarity pathway

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

 SynPCP project word cloud

Explore the words cloud of the SynPCP project. It provides you a very rough idea of what is the project "SynPCP" about.

proteins    cytoskeleton    physiological    actin    adhesions    individual    segregation    mechanisms    training    circuit    mutations    nanoscale    resolution    complexes    establishment    defects    fundamental    assembly    offers    scribble    conceptual    pcp    neuropathies    spine    biochemistry    signaling    plasticity    interaction    dendritic    morpho    deciphering    adhesion    interdisciplinary    underlying    neurocampus    molecular    integration    localization    interplay    dependent    morphogenesis    setup    super    basic    fonctional    scrib    synapse    msca    dendrite    molecules    biophysics    scientific    cell    maturation    critical    synaptogenesis    levels    compartment    protein    neuroscience    macromolecular    specification    dynamics    techniques    functional    hypothesize    contribution    normal    trans    synpcp    multilevel    microscopy    coupling    3d    function    bordeaux    insights    evidences    polarity    synapses    cellular    ef    cadherin    understand    autism    hippocampus    optical    pathological    human    plan    spines    brain    suggest    organization    spatiotemporal    connection    synaptic    career    neuronal    linked    planar    subcellular   

Project "SynPCP" data sheet

The following table provides information about the project.

Coordinator
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE 

Organization address
address: RUE DE TOLBIAC 101
city: PARIS
postcode: 75654
website: www.inserm.fr

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country France [FR]
 Total cost 173˙076 €
 EC max contribution 173˙076 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2016
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2018
 Duration (year-month-day) from 2018-03-01   to  2020-04-13

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE FR (PARIS) coordinator 173˙076.00

Map

 Project objective

SynPCP is a MSCA-IF-EF project in Neuroscience aimed at deciphering spatiotemporal mechanisms controlled by the planar cell polarity (PCP) protein Scribble (Scrib) in spine during specification and morpho-fonctional plasticity that depend on the dynamics of the actin cytoskeleton and trans-synaptic adhesions. Growing evidences suggest that PCP signaling is fundamental for neuronal development mechanisms, including dendrite morphogenesis and synaptogenesis. PCP signaling defects have been linked to a number of human neuropathies such as autism. Because of its subcellular compartment localization and interaction with actin, we hypothesize that Scrib nanoscale organization within the spine could control cytoskeleton and/or adhesion dynamics. To address this, I plan to study the coupling or interplay between Scrib-dependent signaling and the assembly of actin cytoskeleton macromolecular complexes and its connection to cadherin-adhesion molecules using biochemistry, biophysics and 3D super-resolution optical microscopy techniques, in normal and pathological conditions. This project will provide novel conceptual insights into the nanoscale segregation of PCP proteins in spines and how individual PCP proteins control the actin cytoskeleton to build functional synapses. This project will offer a multilevel and interdisciplinary approach to understand the consequences of mutations of PCP signaling at the nanoscale, cellular and physiological levels, on the establishment, maturation and function of the basic functional unit of neuronal integration in the complex circuit of the hippocampus: the dendritic spine. SynPCP will be setup at the Bordeaux Neurocampus which is well known for its contribution to synapse development and brain function. This project offers a scientific and training program critical for my career but also for the general understanding of the molecular mechanisms underlying the normal and pathological brain.

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "SYNPCP" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "SYNPCP" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.3.2.)

CIGNUS (2019)

CuInGaSe Nanowires Under the Sun

Read More  

RETHEIR (2019)

The return of the heirs

Read More  

Topo-circuit (2019)

Exploring topological phenomenon in RF circuits

Read More