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SynPCP SIGNED

Synapse formation and maturity through planar cell polarity pathway

Total Cost €

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EC-Contrib. €

0

Partnership

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 SynPCP project word cloud

Explore the words cloud of the SynPCP project. It provides you a very rough idea of what is the project "SynPCP" about.

mechanisms    microscopy    insights    neuroscience    protein    basic    scribble    signaling    scrib    neuropathies    pcp    segregation    plan    setup    super    cadherin    spines    subcellular    dendrite    human    pathological    molecules    cellular    coupling    scientific    specification    ef    underlying    molecular    career    fundamental    nanoscale    deciphering    dependent    suggest    evidences    dynamics    neuronal    synapse    resolution    synpcp    understand    hippocampus    multilevel    actin    spine    connection    integration    function    morphogenesis    fonctional    normal    polarity    autism    trans    synapses    physiological    morpho    dendritic    linked    planar    interplay    conceptual    defects    synaptogenesis    compartment    levels    establishment    interaction    assembly    optical    offers    adhesions    complexes    organization    macromolecular    proteins    individual    interdisciplinary    maturation    critical    biochemistry    contribution    mutations    circuit    neurocampus    hypothesize    functional    spatiotemporal    cytoskeleton    bordeaux    techniques    adhesion    plasticity    msca    training    3d    brain    cell    synaptic    biophysics    localization   

Project "SynPCP" data sheet

The following table provides information about the project.

Coordinator
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE 

Organization address
address: RUE DE TOLBIAC 101
city: PARIS
postcode: 75654
website: www.inserm.fr

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country France [FR]
 Total cost 173˙076 €
 EC max contribution 173˙076 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2016
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2018
 Duration (year-month-day) from 2018-03-01   to  2020-04-13

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE FR (PARIS) coordinator 173˙076.00

Map

 Project objective

SynPCP is a MSCA-IF-EF project in Neuroscience aimed at deciphering spatiotemporal mechanisms controlled by the planar cell polarity (PCP) protein Scribble (Scrib) in spine during specification and morpho-fonctional plasticity that depend on the dynamics of the actin cytoskeleton and trans-synaptic adhesions. Growing evidences suggest that PCP signaling is fundamental for neuronal development mechanisms, including dendrite morphogenesis and synaptogenesis. PCP signaling defects have been linked to a number of human neuropathies such as autism. Because of its subcellular compartment localization and interaction with actin, we hypothesize that Scrib nanoscale organization within the spine could control cytoskeleton and/or adhesion dynamics. To address this, I plan to study the coupling or interplay between Scrib-dependent signaling and the assembly of actin cytoskeleton macromolecular complexes and its connection to cadherin-adhesion molecules using biochemistry, biophysics and 3D super-resolution optical microscopy techniques, in normal and pathological conditions. This project will provide novel conceptual insights into the nanoscale segregation of PCP proteins in spines and how individual PCP proteins control the actin cytoskeleton to build functional synapses. This project will offer a multilevel and interdisciplinary approach to understand the consequences of mutations of PCP signaling at the nanoscale, cellular and physiological levels, on the establishment, maturation and function of the basic functional unit of neuronal integration in the complex circuit of the hippocampus: the dendritic spine. SynPCP will be setup at the Bordeaux Neurocampus which is well known for its contribution to synapse development and brain function. This project offers a scientific and training program critical for my career but also for the general understanding of the molecular mechanisms underlying the normal and pathological brain.

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The information about "SYNPCP" are provided by the European Opendata Portal: CORDIS opendata.

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