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funcSOFI-PD

Quantitative super-resolution optical fluctuation and phase microscopy for structural and functional imaging of Parkinson's disease

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EC-Contrib. €

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Partnership

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 funcSOFI-PD project word cloud

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Project "funcSOFI-PD" data sheet

The following table provides information about the project.

Coordinator
ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE 

Organization address
address: BATIMENT CE 3316 STATION 1
city: LAUSANNE
postcode: 1015
website: www.epfl.ch

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
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 Coordinator Country Switzerland [CH]
 Project website https://kgrussmayer.bitbucket.io/
 Total cost 175˙419 €
 EC max contribution 175˙419 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2016
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2017
 Duration (year-month-day) from 2017-04-01   to  2019-07-29

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE CH (LAUSANNE) coordinator 175˙419.00

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 Project objective

The changing demographic is one of the greatest challenges in Europe. With an expected 25% of the population over 65 by 2030, the incidence of neurodegenerative age-linked diseases like Alzheimer’s and Parkinson’s is likely to increase. They severely impact quality of life and to date, therapies can only treat the symptoms. Oligomerization and aggregation of the protein α-synuclein is a hallmark of Parkinson’s disease. Still, the underlying molecular mechanism of cellular dysfunction due to toxic forms of this protein remains unclear. Most studies aiming to uncover α-synuclein induced neurodegeneration in vivo are using indirect biochemical detection methods. Bridging neurobiology and life science with advanced microscopy and image analysis allows the direct monitoring of Parkinson compromised primary hippocampal neurons. I will combine multi-color 3D super-resolution optical fluctuation imaging with quantitative phase tomography in a multi-plane microscope, to allow structural and fast functional imaging. This innovative imaging concept is used (1) to elucidate α-synuclein aggregation at the cell membrane and in the cytosol and (2) to uncover the induced cytoskeleton alterations. Ultimately, molecule-specific readout will be complemented by (3) label-free, quantitative phase imaging of membrane dynamics and overall cell morphology at up to 100Hz. I am a biophysicist with a specialization in single molecule spectroscopy and my previous work on photon statistics has led to several high quality publications. This fellowship expands my quantitative microscopy expertise to 3D imaging while enlarging my biologocal scope to neurodegenerative diseases. I will extend my competences by managing the project, following complementary skills courses, and organizing public outreach activities. While performing interdisciplinary research on neurodegenerative disease, I will develop an independent research profile to further enhance the European research landscape.

 Publications

year authors and title journal last update
List of publications.
2018 A. Descloux, K. S. Grußmayer, E. Bostan, T. Lukes, A. Bouwens, A. Sharipov, S. Geissbuehler, A.-L. Mahul-Mellier, H. A. Lashuel, M. Leutenegger, T. Lasser
Combined multi-plane phase retrieval and super-resolution optical fluctuation imaging for 4D cell microscopy
published pages: 165-172, ISSN: 1749-4885, DOI: 10.1038/s41566-018-0109-4
Nature Photonics 12/3 2020-01-27
2019 A. Descloux, K. S. Grußmayer, A. Radenovic
Parameter-free image resolution estimation based on decorrelation analysis
published pages: 918-924, ISSN: 1548-7091, DOI: 10.1038/s41592-019-0515-7
Nature Methods 16/9 2020-01-27
2019 K S Gruβmayer, K Yserentant, D-P Herten
Photons in - numbers out: perspectives in quantitative fluorescence microscopy for in situ protein counting
published pages: 12003, ISSN: 2050-6120, DOI: 10.1088/2050-6120/aaf2eb
Methods and Applications in Fluorescence 7/1 2020-01-27

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