Explore the words cloud of the MITODYN project. It provides you a very rough idea of what is the project "MITODYN" about.
The following table provides information about the project.
THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE
|United Kingdom [UK]
|EC max contribution
|183˙454 € (100%)
1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
|from 2017-07-01 to 2019-06-30
Take a look of project's partnership.
|THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE
Mitochondria house hundreds of biochemical reactions involved in processes critical for the survival and homeostatic adaptation of the cell. Mitochondria are highly dynamic organelles, which adapt their shape and network depending on the cellular needs. As mitochondria play a central and unique role in metabolism, our understanding of the complex network of interrelations between mitochondria and other organelles has crucially changed our view on the cell biology of mitochondria and a new biology and pathophysiology of this organelle are emerging. Mitochondria are in dynamic contact with the endoplasmic reticulum (ER) and this specialized contact is essential for a number of relevant processes, including mitochondrial dynamics, lipid exchange, calcium homeostasis and apoptosis. The Mitochondrial Calcium Uniporter (MCU) and some of its regulators (MICU1-3, EMRE) have recently been identified as the key complex regulating mitochondrial calcium uptake with some already identified functions. The goal of this project is to define the complete interactome of the Mitochondrial Calcium Uptake Machinery (MCUM) in different physiological conditions and to characterize the functions associated to this complex. To address these goals, an unbiased proteomic analysis will be performed, both in cellulo (human cells) and in vivo (zebrafish), to identify the interactors of the MCUM at steady state and under different cellular stresses using the BioID technic. The mechanisms involving the MCUM in the regulation of mitochondrial dynamics, apoptosis and cell migration will be unravelled using molecular and cell biology experiments coupled with the most recent advances in microscopic analysis. Finally, we will explore the relevance of these findings in the physiopathology associated to mitochondrial diseases using cell lines derived from patients harbouring a MCUM dysfunction.
|authors and title
Lisa Tilokani, Shun Nagashima, Vincent Paupe, Julien Prudent
Mitochondrial dynamics: overview of molecular mechanisms
published pages: 341-360, ISSN: 0071-1365, DOI: 10.1042/ebc20170104
|Essays In Biochemistry 62/3
Are you the coordinator (or a participant) of this project? Plaese send me more information about the "MITODYN" project.
For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.
Send me an email (email@example.com) and I put them in your project's page as son as possible.
Thanks. And then put a link of this page into your project's website.
The information about "MITODYN" are provided by the European Opendata Portal: CORDIS opendata.