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ONCOGENEVOL SIGNED

The evolutionary history of oncogenic and non-oncogenic papillomaviruses

Total Cost €

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EC-Contrib. €

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Partnership

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 ONCOGENEVOL project word cloud

Explore the words cloud of the ONCOGENEVOL project. It provides you a very rough idea of what is the project "ONCOGENEVOL" about.

thereafter    combining    generate    modern    acquiring    directed    alphapv    ancestral    lab    e5    medicine    exception    dna    fragmentary    occurred    infections    sharing    history    evolution    asymptomatic    oropharynx    infection    oncogenes    oncogenic    small    human    pv    virtually    deep    genome    arose    e6    resurrect    experimentally    lesions    roots    immune    public    back    cancers    suppressor    fraction    vagina    anal    carcinogenesis    despite    explore    humans    relationships    cancer    share    clinical    responsible    appearance    encode    enigma    species    tumor    events    certain    unfortunate    functions    efforts    actually    emergence    phenotype    cervical    allowed    regarding    silico    proteins    function    ancestor    e7    evade    domains    integration    wart    proto    health    resurrected    hypotheses    scenario    oncogene    evolutionary    pvs    benign    tracking    contexts    few    acquired    penis    wet    environmental    paving    host    hosts    manifestations    vulva    origin    ultimate    became    understand    papillomaviruses    genes    viruses   

Project "ONCOGENEVOL" data sheet

The following table provides information about the project.

Coordinator
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS 

Organization address
address: RUE MICHEL ANGE 3
city: PARIS
postcode: 75794
website: www.cnrs.fr

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country France [FR]
 Project website http://virostyle.cnrs.fr/projects/oncogenevol/
 Total cost 185˙076 €
 EC max contribution 185˙076 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2016
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2017
 Duration (year-month-day) from 2017-06-01   to  2019-07-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS FR (PARIS) coordinator 185˙076.00

Map

 Project objective

Certain papillomaviruses (PVs) are a major public health concern as in humans they are responsible for virtually all cases of cervical and anal cancer, and for a fraction of cancers on the penis, vagina, vulva and oropharynx. But oncogenic PVs are actually an unfortunate exception, as most PVs cause asymptomatic infections, and a few cause benign, wart-like lesions. Despite the efforts directed towards the understanding of the different clinical manifestations of infection, our knowledge on PV evolution remains fragmentary. Oncogenic human PVs arose recently, after acquiring the E5, E6 and E7 genes. The integration of the E5 proto-oncogene in the ancestral AlphaPV genome allowed viruses to evade host immune response. Thereafter E6 and E7 acquired the ability to target essential tumor suppressor proteins, paving the way for carcinogenesis. Tracking the evolutionary history of the E5, E6 and E7 oncogenes will thus help understand the emergence of oncogenic human PVs. Regarding the deep roots of PVs, small DNA viruses may share a common ancestor as they encode proteins sharing similar functions and domains, but their evolutionary origin is still an enigma. Here I propose to apply an evolutionary medicine approach, combining in silico and wet-lab approaches, to study key events that occurred during PV genome evolution. We will go back into history and study how and when certain PVs became oncogenic. We will resurrect the ancestral oncogenes, and experimentally test hypotheses about the function of the resurrected proteins in different environmental contexts. We will then generate a comprehensive scenario modelling the appearance of the modern PV genome and the emergence of the oncogenic phenotype of certain PVs. Finally we will explore the relationships between small DNA viruses and test whether they may have a common origin. Our ultimate aim is to understand why a few PVs are oncogenic for a few host species, while most PVs cause asymptomatic infections in most hosts.

 Publications

year authors and title journal last update
List of publications.
2019 Anouk Willemsen, Marta Félez-Sánchez, Ignacio G Bravo
Genome Plasticity in Papillomaviruses and De Novo Emergence of E5 Oncogenes
published pages: 1602-1617, ISSN: 1759-6653, DOI: 10.1093/gbe/evz095
Genome Biology and Evolution 11/6 2019-09-02
2019 Anouk Willemsen, Ignacio G. Bravo
Origin and evolution of papillomavirus (onco)genes and genomes
published pages: 20180303, ISSN: 0962-8436, DOI: 10.1098/rstb.2018.0303
Philosophical Transactions of the Royal Society B: Biological Sciences 374/1773 2019-06-06

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