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TeloHOOK SIGNED

Nuclear envelope attachment and dynamics of Human telomeres - unravelling nuclear organization

Total Cost €

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EC-Contrib. €

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Partnership

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 TeloHOOK project word cloud

Explore the words cloud of the TeloHOOK project. It provides you a very rough idea of what is the project "TeloHOOK" about.

extensive    stage    subtelomere    connected    view    interacting    probes    premature    divisions    function    ends    cells    organization    linear    human    territories    suggests    membrane    interaction    dependent    transiently    conserved    regulation    maintains    progression    breakdown    microscopy    syndromes    mitosis    natural    expression    anchored    stability    cell    nucleus    telomere    live    organizing    genome    scientific    mediates    shape    fish    cycle    aging    found    anchor    metaphase    imaging    reforming    association    integrity    compaction    molecular    unravel    examine    envelope    nuclear    telomeres    interphase    plays    temporal    replication    assembly    connection    combine    mechanism    screen    tethering    gene    biochemistry    components    spatial    dynamics    combining    tethered    chromosome    maintenance    mammalian    mechanical    map    confocal    post    postmitotic    inner    undergoes    chromosomes    subset    understand    dna    originality    biology    mediate    provides    chromatin   

Project "TeloHOOK" data sheet

The following table provides information about the project.

Coordinator
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS 

Organization address
address: RUE MICHEL ANGE 3
city: PARIS
postcode: 75794
website: www.cnrs.fr

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country France [FR]
 Total cost 1˙795˙010 €
 EC max contribution 1˙795˙010 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2016-STG
 Funding Scheme ERC-STG
 Starting year 2017
 Duration (year-month-day) from 2017-11-01   to  2022-10-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS FR (PARIS) coordinator 1˙795˙010.00

Map

 Project objective

The spatial and temporal organization of the nucleus and its components are essential for genome regulation. During interphase of mammalian cells the nuclear envelope maintains the shape and the mechanical integrity of the nucleus, but also provides an anchor for chromatin that is connected to its inner side. This interaction mediates the regulation of gene expression, DNA replication and the maintenance of genome stability. In human cells I found that a large subset of telomeres, the natural ends of linear chromosomes, are transiently anchored to the nuclear envelope specifically during postmitotic nuclear assembly. Chromatin organization undergoes extensive changes during progression through the cell cycle, particularly during mitosis with the nuclear envelope breakdown and the compaction of chromatin into metaphase chromosomes. The interaction between chromosome ends and the nuclear envelope at the stage where the nucleus is reforming post-mitosis suggests a new role for telomeres in nuclear organization. My aims are 1) to screen for interacting partners that mediate the cell-cycle dependent telomere tethering to the nuclear membrane; 2) to unravel the molecular mechanism of telomere-nuclear envelope association over the cell cycle by combining biochemistry and state-of-the-art microscopy; 3) to map the subset of chromosomes which ends are tethered using subtelomere specific FISH probes and determine whether they are conserved throughout cell divisions and if it plays a role in organizing chromosome territories; 4) to examine telomere dynamics in cells from premature aging syndromes affecting the nuclear envelope integrity using live imaging confocal microscopy, and understand the connection between telomeres, nuclear envelope, and aging. The originality of my scientific approach is to combine state-of-the-art cell biology, biochemistry, and molecular biology for an integrated view of human telomere function in nuclear organization.

 Publications

year authors and title journal last update
List of publications.
2018 Michal Sobecki, Charbel Souaid, Jocelyne Boulay, Vincent Guerineau, Daan Noordermeer, Laure Crabbe
MadID, a Versatile Approach to Map Protein-DNA Interactions, Highlights Telomere-Nuclear Envelope Contact Sites in Human Cells
published pages: 2891-2903.e5, ISSN: 2211-1247, DOI: 10.1016/j.celrep.2018.11.027
Cell Reports 25/10 2019-06-11

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