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TeloHOOK SIGNED

Nuclear envelope attachment and dynamics of Human telomeres - unravelling nuclear organization

Total Cost €

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EC-Contrib. €

0

Partnership

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 TeloHOOK project word cloud

Explore the words cloud of the TeloHOOK project. It provides you a very rough idea of what is the project "TeloHOOK" about.

human    ends    temporal    post    spatial    mediates    cell    confocal    expression    cycle    probes    gene    subtelomere    dynamics    chromosome    integrity    mechanical    envelope    membrane    shape    tethering    molecular    view    nuclear    postmitotic    stability    cells    interaction    combining    provides    mediate    found    suggests    maintenance    assembly    territories    chromosomes    unravel    syndromes    plays    telomeres    scientific    chromatin    replication    reforming    connected    interacting    divisions    biochemistry    undergoes    metaphase    premature    anchored    imaging    subset    mechanism    breakdown    transiently    natural    biology    aging    screen    microscopy    interphase    mammalian    function    organization    components    combine    organizing    map    mitosis    tethered    maintains    examine    genome    extensive    fish    association    live    dna    connection    originality    anchor    progression    regulation    compaction    dependent    conserved    telomere    understand    linear    stage    nucleus    inner   

Project "TeloHOOK" data sheet

The following table provides information about the project.

Coordinator
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS 

Organization address
address: RUE MICHEL ANGE 3
city: PARIS
postcode: 75794
website: www.cnrs.fr

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country France [FR]
 Total cost 1˙795˙010 €
 EC max contribution 1˙795˙010 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2016-STG
 Funding Scheme ERC-STG
 Starting year 2017
 Duration (year-month-day) from 2017-11-01   to  2022-10-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS FR (PARIS) coordinator 1˙795˙010.00

Map

 Project objective

The spatial and temporal organization of the nucleus and its components are essential for genome regulation. During interphase of mammalian cells the nuclear envelope maintains the shape and the mechanical integrity of the nucleus, but also provides an anchor for chromatin that is connected to its inner side. This interaction mediates the regulation of gene expression, DNA replication and the maintenance of genome stability. In human cells I found that a large subset of telomeres, the natural ends of linear chromosomes, are transiently anchored to the nuclear envelope specifically during postmitotic nuclear assembly. Chromatin organization undergoes extensive changes during progression through the cell cycle, particularly during mitosis with the nuclear envelope breakdown and the compaction of chromatin into metaphase chromosomes. The interaction between chromosome ends and the nuclear envelope at the stage where the nucleus is reforming post-mitosis suggests a new role for telomeres in nuclear organization. My aims are 1) to screen for interacting partners that mediate the cell-cycle dependent telomere tethering to the nuclear membrane; 2) to unravel the molecular mechanism of telomere-nuclear envelope association over the cell cycle by combining biochemistry and state-of-the-art microscopy; 3) to map the subset of chromosomes which ends are tethered using subtelomere specific FISH probes and determine whether they are conserved throughout cell divisions and if it plays a role in organizing chromosome territories; 4) to examine telomere dynamics in cells from premature aging syndromes affecting the nuclear envelope integrity using live imaging confocal microscopy, and understand the connection between telomeres, nuclear envelope, and aging. The originality of my scientific approach is to combine state-of-the-art cell biology, biochemistry, and molecular biology for an integrated view of human telomere function in nuclear organization.

 Publications

year authors and title journal last update
List of publications.
2018 Michal Sobecki, Charbel Souaid, Jocelyne Boulay, Vincent Guerineau, Daan Noordermeer, Laure Crabbe
MadID, a Versatile Approach to Map Protein-DNA Interactions, Highlights Telomere-Nuclear Envelope Contact Sites in Human Cells
published pages: 2891-2903.e5, ISSN: 2211-1247, DOI: 10.1016/j.celrep.2018.11.027
Cell Reports 25/10 2019-06-11

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