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TeloHOOK SIGNED

Nuclear envelope attachment and dynamics of Human telomeres - unravelling nuclear organization

Total Cost €

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EC-Contrib. €

0

Partnership

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 TeloHOOK project word cloud

Explore the words cloud of the TeloHOOK project. It provides you a very rough idea of what is the project "TeloHOOK" about.

temporal    combine    syndromes    linear    anchored    subtelomere    dynamics    expression    cell    gene    undergoes    cycle    function    transiently    nucleus    conserved    organization    replication    imaging    assembly    stage    mechanical    tethering    chromosome    human    premature    mitosis    provides    stability    territories    anchor    live    probes    connected    connection    dependent    view    telomeres    regulation    interphase    compaction    tethered    found    microscopy    plays    combining    interacting    originality    metaphase    post    mammalian    chromosomes    membrane    envelope    molecular    nuclear    scientific    inner    screen    progression    genome    reforming    examine    mediate    confocal    maintains    ends    telomere    biochemistry    suggests    biology    breakdown    mediates    mechanism    maintenance    cells    spatial    aging    extensive    components    map    divisions    organizing    natural    postmitotic    fish    chromatin    understand    integrity    dna    shape    unravel    subset    interaction    association   

Project "TeloHOOK" data sheet

The following table provides information about the project.

Coordinator
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS 

Organization address
address: RUE MICHEL ANGE 3
city: PARIS
postcode: 75794
website: www.cnrs.fr

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country France [FR]
 Total cost 1˙795˙010 €
 EC max contribution 1˙795˙010 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2016-STG
 Funding Scheme ERC-STG
 Starting year 2017
 Duration (year-month-day) from 2017-11-01   to  2022-10-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS FR (PARIS) coordinator 1˙795˙010.00

Map

 Project objective

The spatial and temporal organization of the nucleus and its components are essential for genome regulation. During interphase of mammalian cells the nuclear envelope maintains the shape and the mechanical integrity of the nucleus, but also provides an anchor for chromatin that is connected to its inner side. This interaction mediates the regulation of gene expression, DNA replication and the maintenance of genome stability. In human cells I found that a large subset of telomeres, the natural ends of linear chromosomes, are transiently anchored to the nuclear envelope specifically during postmitotic nuclear assembly. Chromatin organization undergoes extensive changes during progression through the cell cycle, particularly during mitosis with the nuclear envelope breakdown and the compaction of chromatin into metaphase chromosomes. The interaction between chromosome ends and the nuclear envelope at the stage where the nucleus is reforming post-mitosis suggests a new role for telomeres in nuclear organization. My aims are 1) to screen for interacting partners that mediate the cell-cycle dependent telomere tethering to the nuclear membrane; 2) to unravel the molecular mechanism of telomere-nuclear envelope association over the cell cycle by combining biochemistry and state-of-the-art microscopy; 3) to map the subset of chromosomes which ends are tethered using subtelomere specific FISH probes and determine whether they are conserved throughout cell divisions and if it plays a role in organizing chromosome territories; 4) to examine telomere dynamics in cells from premature aging syndromes affecting the nuclear envelope integrity using live imaging confocal microscopy, and understand the connection between telomeres, nuclear envelope, and aging. The originality of my scientific approach is to combine state-of-the-art cell biology, biochemistry, and molecular biology for an integrated view of human telomere function in nuclear organization.

 Publications

year authors and title journal last update
List of publications.
2018 Michal Sobecki, Charbel Souaid, Jocelyne Boulay, Vincent Guerineau, Daan Noordermeer, Laure Crabbe
MadID, a Versatile Approach to Map Protein-DNA Interactions, Highlights Telomere-Nuclear Envelope Contact Sites in Human Cells
published pages: 2891-2903.e5, ISSN: 2211-1247, DOI: 10.1016/j.celrep.2018.11.027
Cell Reports 25/10 2019-06-11

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