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CapBed SIGNED

Engineered Capillary Beds for Successful Prevascularization of Tissue Engineering Constructs

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 CapBed project word cloud

Explore the words cloud of the CapBed project. It provides you a very rough idea of what is the project "CapBed" about.

virtually    anastomosed    solution    technologies    innovative    prime    none    irrigation    demand    capillaries    angiogenic    engineering    proposing    fluid    first    scientific    3d    simultaneously    intricate    irrigate    millions    transplantation    flow    capillary    tissue    perfusion    printing    micropatterned    adipose    time    medical    vessels    massive    microfluidics    vascular    laser    tools    cell    fraction    human    organs    ing    beds    fabricate    stromal    suitable    blood    strategy    vastly    fabrication    thousands    supply    levels    axis    hold    inability    cutting    capbed    outnumbers    potential    vitro    photoablation    suggests    reached    matrix    listed    populations    economical    prevascularization    prevascularize    rendering    termed    techniques    bed    survival    dynamic    engineered    engineer    suffering    body    assure    edge    collagen    functional    mimic    correct    people    elusive    integrate    disruptive    yielded    circulation    structure    donated    network    fast    death    patient    sheets    tissues    cells   

Project "CapBed" data sheet

The following table provides information about the project.

Coordinator
UNIVERSIDADE DO MINHO 

Organization address
address: LARGO DO PACO
city: BRAGA
postcode: 4704 553
website: www.uminho.pt

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Portugal [PT]
 Total cost 1˙499˙940 €
 EC max contribution 1˙499˙940 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2018-STG
 Funding Scheme ERC-STG
 Starting year 2018
 Duration (year-month-day) from 2018-11-01   to  2023-10-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSIDADE DO MINHO PT (BRAGA) coordinator 1˙499˙940.00

Map

 Project objective

The demand for donated organs vastly outnumbers the supply, leading each year to the death of thousands of people and the suffering of millions more. Engineered tissues and organs following Tissue Engineering approaches are a possible solution to this problem. However, a prevascularization solution to irrigate complex engineered tissues and assure their survival after transplantation is currently elusive. In the human body, complex organs and tissues irrigation is achieved by a network of blood vessels termed capillary bed which suggests such a structure is needed in engineered tissues. Previous approaches to engineer capillary beds reached different levels of success but none yielded a fully functional one due to the inability in simultaneously addressing key elements such as correct angiogenic cell populations, a suitable matrix and dynamic conditions that mimic blood flow. CapBed aims at proposing a new technology to fabricate in vitro capillary beds that include a vascular axis that can be anastomosed with a patient circulation. Such capillary beds could be used as prime tools to prevascularize in vitro engineered tissues and provide fast perfusion of those after transplantation to a patient. Cutting edge techniques will be for the first time integrated in a disruptive approach to address the requirements listed above. Angiogenic cell sheets of human Adipose-derived Stromal Vascular fraction cells will provide the cell populations that integrate the capillaries and manage its intricate formation, as well as the collagen required to build the matrix that will hold the capillary beds. Innovative fabrication technologies such as 3D printing and laser photoablation will be used for the fabrication of the micropatterned matrix that will allow fluid flow through microfluidics. The resulting functional capillary beds can be used with virtually every tissue engineering strategy rendering the proposed strategy with massive economical, scientific and medical potential

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The information about "CAPBED" are provided by the European Opendata Portal: CORDIS opendata.

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